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Fundus autofluorescence in central serous chorioretinopathy: association with spectral-domain optical coherence tomography and fluorescein angiography 被引量:7
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作者 Peng Zhang Hai-Yan Wang +4 位作者 Zi-Feng Zhang Dong-Jie Sun Jin-Ting Zhu Juan Li Yu-Sheng Wang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2015年第5期1003-1007,共5页
and FA for identifying pathological abnormalities in CSC. The characteristics of IA AF in CSC were attributable to the modification of melanin in the RPE. IR- AIM: To evaluate the correlation among changes in fundus a... and FA for identifying pathological abnormalities in CSC. The characteristics of IA AF in CSC were attributable to the modification of melanin in the RPE. IR- AIM: To evaluate the correlation among changes in fundus autofluorescence (AF) measured using infrared fundus AF (IR -AF) and short-wave length fundus AF (SW -AF) with changes in spectral -domain optical coherence tomography (SD -OCT) and fluorescein angiography (FA) in central serous chorioretinopathy (CSC). METHODS: Two hundred and twenty consecutive patients with CSC were included. In addition to AF, patients were assessed by means of SD -OCT and FA. Abnormalities in images of IA -AF, SW -AF, FA were analyzed and correlated with the corresponding outer retinal alterations in SD-OCT findings. RESULTS: Eyes with abnormalities on either IR-AF or SW-AF were found in 256 eyes (58.18%), among them 256 eyes (100%) showed abnormal IR -AF, but SW-AF abnormalities were present only in 213 eyes (83.20%). The hypo-IR-AF corresponded to accumulation of subretinal liquid, collapse of retinal pigment epithelium (APE) or detachment of APE with or without RPE leakage point in the corresponding area. The hyper -IR -AF corresponded to the area with loss of the ellipsoid portion of the inner segments and sub -sensory retinal deposits or focal melanogenesis under sensory retina. The hypo-SW-AF corresponded to accumulation of subretinal liquid or atrophy of RPE. The hyper -SW -AF associated with sub -sensory retinal deposits, detachment of RPE and focal melanogenesis. CONCLUSION: IR-AF was more sensitive than SW-AF AF should be used as a common diagnostic tool for identifying pathological lesion in CSC. 展开更多
关键词 central serous chorioretinopathy fluorescein angiography fundus autofluorescence optical coherence tomography
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Lipofuscin-and Melanin-related Fundus Autofluorescence in Patients with Submacular Idiopathic Choroidal Neovascularization 被引量:2
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作者 Xijia Peng Wenfang Zhang 《Eye Science》 CAS 2012年第3期138-142,共5页
Purpose:.To compare melanin-related near-infrared fundus autofluorescence (NIA; excitation 787 nm, emission> 800 nm) with lipofuscin-related fundus autofluorescence (FAF; excitation 488 nm, emission > 500 nm) in... Purpose:.To compare melanin-related near-infrared fundus autofluorescence (NIA; excitation 787 nm, emission> 800 nm) with lipofuscin-related fundus autofluorescence (FAF; excitation 488 nm, emission > 500 nm) in patients with idiopathic choroidal neovascularization (ICNV). Methods: FAF, NIA, fundus fluorescein angiography (FFA) and indocyanine green angiography.(ICGA).were obtained using a confocal scanning laser Ophthalmoscope HRA2 (Heidelberg Retina Angiograph 2).in 18 eyes of 18 patients with ICNV. Results:.Eighteen eyes had classic CNV, and autofluorescence imaging showed hypoautofluorescence at the site of CNV..A well-defined hyperautofluorescent ring was detected surrounding the CNV in all 18 eyes with NIA imaging. In our sample,.the FAF patterns around the CNV were classified as normal (n=1,.5.56%), well-defined hyperautofluorescent ring (n=7,.38.89%), or ill-defined hyperautofluorescent ring (n=10, 55.56%). Conclusion:.The patterns of FAF and NIA indicated different involvement of lipofuscin and melanin in the pathophysiological process of ICNV. Compared to FAF imaging, NIA imaging appears to be a superior noninvasive method for in vivo visualization of retinal pigment epithelium (RPE) abnormalities in ICNV patients. 展开更多
关键词 自体荧光 新生血管 黑色素 脉络膜 脂褐素 眼底 患者 黄斑
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Evaluation of fundus autofluorescence patterns in age-related macular degeneration
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作者 Pradeep Venkatesh Pradeep Sagar +3 位作者 Rohan Chawla Varun Gogia Rajpal Vohra Yog Raj Sharma 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2016年第12期1779-1784,共6页
AIM: To study the various morphological patterns of fundus autofluorescence (FAF) images in patients with age-related macular degeneration (AMD) in Indian population.METHODS: Totally 179 eyes of 104 patients wit... AIM: To study the various morphological patterns of fundus autofluorescence (FAF) images in patients with age-related macular degeneration (AMD) in Indian population.METHODS: Totally 179 eyes of 104 patients with clinical diagnosis of AMD were recruited into the study. Autofluorescence images were captured using confocal scanning laser ophthalmoscope and the patterns of FAF were classified.RESULTS: Of 179 eyes, 27 (15.08%) were early AMD, 58 (32.41%) were intermediate AMD, 94 eyes (52.51%) were late AMD. Of 94 eyes with late AMD, 79 (84.04%) were neovascular AMD and 15 (15.96%) were central geographic atrophy. In eyes with early and intermediate AMD, 9 patterns of FAF were noted. Six patterns (normal, minimal change, focal increased, patchy increased, linear, reticular) were similar to that in the published classification. Two patterns (lacelike and speckled) described in the published classification were not found. Three new patterns (focal hypo-fluorescence, patchy hypo-fluorescence, mixed focal hypo-fluorescence and hyper-fluorescence) were detected. In eyes with neovascular AMD, 6 morphological patterns of FAF were noted. Two patterns (mixed hypo-fluorescence and hyper-fluorescence, central hypo-fluorescence with hyper-fluorescent rim) were similar to that in published classification. Two patterns (normal, near normal or normal background fluorescence in the centre of hypo-fluorescent area) described in the published classification were not found. Four new patterns (minimal change, hypo-fluorescent patch, central hypo-fluorescence with surrounding reticular, bull’s eye) were recognized. In eye with central geographic atrophy 5 morphological patterns were noted and these were similar to that in published classification.CONCLUSION: Phenotypic differences in the pattern of FAF exist in the study population compared to existing classification systems. 展开更多
关键词 age-related macular degeneration fundus autofluorescence LIPOFUSCIN choroidal neovascularization
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Green-light fundus autofluorescence in diabetic macular edema
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作者 Lukas Reznicek Simeon Dabov +3 位作者 Christos Haritoglou Anselm Kampik Marcus Kernt Aljoscha S Neubauer 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2013年第1期75-80,共6页
AIM:To evaluate the role of central green-light fundus autofluorescence (FAF) in diabetic macular edema(DME). METHODS:A consecutive series of 92 study eyes with diabetic retinopathy were included. Out of those, 51 dia... AIM:To evaluate the role of central green-light fundus autofluorescence (FAF) in diabetic macular edema(DME). METHODS:A consecutive series of 92 study eyes with diabetic retinopathy were included. Out of those, 51 diabetic eyes had DME and were compared to 41 diabetic eyes without DME. In all subjects, green-light FAF images were obtained, quantified and classified into various FAF patterns. Cross-sectional optical coherence tomography (OCT) scans were obtained for evaluation of Inner/Outer segment (IS/OS) layer integrity, measurements of central RPE-IS/OS layer thickness as well as classification of DME into various subtypes. ·RESULTS:Meancentralgreen-lightFAFintensityofeyes with DME (1.289 ±0.140)log did not significantly differ from diabetic patients without DME (1.317 ±0.137)log. Most classifiable FAF patterns were seen in patients with cystoid DME. Mean central retinal thickness (CRT) of all study eyes with DME was (501.9±112.4)μm compared to (328.2±27.0)μm in diabetic patients without DME. Patients with DME had significantly more disrupted photoreceptor IS/OS layers than diabetic patients without DME (28/51 vs 5/41, P 【0.001). Mean RPE-IS/OS thickness of patients with DME (60.7±14.1)μm was significantly (P【0.001) lower than in diabetic eyes without DME (73.5 ±9.4)μm. Correlation analysis revealed non-significant correlations of green-light FAF intensity and OCT parameters in all subtypes of DME. ·CONCLUSION:Our results indicate a poor correlation of central green-light FAF intensity with CRT, IS/OS layer integrity or RPE-IS/OS layer thickness in diabetic patients with or without DME and its various subtypes. Thus, central green-light FAF is not suitable for detection of retinal thickening in DME. 展开更多
关键词 diabetic macular edema fundus autofluorescence optical coherence tomography
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The application of ultra-wide-field fundus autofluorescence in early metastatic choroidal tumor screening
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作者 Pan-Pan Ye Jia Xu +2 位作者 Zhi-Tao Su Xiao-Yun Fang Ke Yao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2019年第12期1978-1981,共4页
I am Dr.Ke Yao,from Eye Center,the Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,China.I write to present three cases with metastatic choroidal tumor using an ultra-wide-field scanning las... I am Dr.Ke Yao,from Eye Center,the Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,China.I write to present three cases with metastatic choroidal tumor using an ultra-wide-field scanning laser ophthalmoscope. 展开更多
关键词 IMAGE The application of ultra-wide-field fundus autofluorescence in early metastatic choroidal tumor screening FAF
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Comparison of autofluorescence and optical coherence tomography findings in acute and chronic central serous chorioretinopathy 被引量:4
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作者 Mehmet Yasin Teke Ufuk Elgin +3 位作者 Pinar Nalcacioglu-Yuksekkaya Emine Sen Pinar Ozdal Faruk Ozturk 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2014年第2期350-354,共5页
AIM:To discuss and compare the fundus autofluorescence(FAF)and optical coherence tomography(OCT)in acute or chronic central serous chorioretinopathy(CSCR).METHODS:Medical records of 100 cases of CSCR were reviewed.Acu... AIM:To discuss and compare the fundus autofluorescence(FAF)and optical coherence tomography(OCT)in acute or chronic central serous chorioretinopathy(CSCR).METHODS:Medical records of 100 cases of CSCR were reviewed.Acute and chronic cases were evaluated according to the duration of decreased visual acuity,serous retinal detachment(RD)and focal leakage on fluorescein angiography(FA).Chi-square test was used for statistical analysis.RESULTS:Forty cases had acute and 60 cases had chronic CSCR.FAF showed focal hypo-autofluorescence in 34(85%)and iso-autofluorescence in 6(15%)of acute cases and hypo-autofluorescence in 51(85%),hyperautofluorescence in 6(10%)and iso-autofluorescence in3(5%)of chronic cases.OCT showed serous RD with distinct borders correlated with FAF findings(hypoautofluorescence)in all acute CSCR cases.In chronic CSCR group,OCT showed serous RD with indistinct borders correlated with FAF findings.The differences between the OCT and FAF findings of the two groups were significant(P=0.000).CONCLUSION:OCT and FAF findings can support the clinical observations in differential diagnosis of acute and chronic CSCR and help clinicians to evaluate retinal pigment epithelium,outer segments of photoreceptors and the components of serous RD. 展开更多
关键词 central serous chorioretinopathy fluorescein angiography fundus autofluorescence optical coherence tomography
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A deep learning model for generating fundus autofluorescence images from color fundus photography 被引量:1
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作者 Fan Song Weiyi Zhang +2 位作者 Yingfeng Zheng Danli Shi Mingguang He 《Advances in Ophthalmology Practice and Research》 2023年第4期192-198,共7页
Background:Fundus Autofluorescence(FAF)is a valuable imaging technique used to assess metabolic alterations in the retinal pigment epithelium(RPE)associated with various age-related and disease-related changes.The pra... Background:Fundus Autofluorescence(FAF)is a valuable imaging technique used to assess metabolic alterations in the retinal pigment epithelium(RPE)associated with various age-related and disease-related changes.The practical uses of FAF are ever-growing.This study aimed to evaluate the effectiveness of a generative deep learning(DL)model in translating color fundus(CF)images into synthetic FAF images and explore its potential for enhancing screening of age-related macular degeneration(AMD).Methods:A generative adversarial network(GAN)model was trained on pairs of CF and FAF images to generate synthetic FAF images.The quality of synthesized FAF images was assessed objectively by common generation metrics.Additionally,the clinical effectiveness of the generated FAF images in AMD classification was evaluated by measuring the area under the curve(AUC),using the LabelMe dataset.Results:A total of 8410 FAF images from 2586 patients were analyzed.The synthesized FAF images exhibited an impressive objectively assessed quality,achieving a multi-scale structural similarity index(MS-SSIM)of 0.67.When evaluated on the LabelMe dataset,the combination of generated FAF images and CF images resulted in a noteworthy improvement in AMD classification accuracy,with the AUC increasing from 0.931 to 0.968.Conclusions:This study presents the first attempt to use a generative deep learning model to create authentic and high-quality FAF images from CF images.The incorporation of the translated FAF images on top of CF images improved the accuracy of AMD classification.Overall,this study presents a promising approach to enhance largescale AMD screening. 展开更多
关键词 Generative adversarial networks Color fundus to fundus autofluorescence GENERATION Age-related macular degeneration Deep learning
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早期检测羟氯喹视网膜病变的研究现状
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作者 付臻 杨静 《中国卫生标准管理》 2024年第10期194-198,共5页
羟氯喹(hydroxychloroquine,HCQ)被越来越多地应用于各种自身免疫性疾病的治疗,然而长期服用HCQ可导致不可逆的视网膜毒性病变,并且随着检测技术的进步,其发病率比以往认知的更高,而早期检测到HCQ所致的视网膜毒性改变可以极大地降低晚... 羟氯喹(hydroxychloroquine,HCQ)被越来越多地应用于各种自身免疫性疾病的治疗,然而长期服用HCQ可导致不可逆的视网膜毒性病变,并且随着检测技术的进步,其发病率比以往认知的更高,而早期检测到HCQ所致的视网膜毒性改变可以极大地降低晚期进展的风险。目前指南推荐的检查方法包括频域光学相干断层扫描(spectral-domain optical coherence tomography,SD-OCT)、眼底自发荧光(fundus autofluorescence,FAF)、多焦视网膜电图和自动视野检查。近年来研究发现,一些新的视网膜成像技术可能有助于识别早期病变,在此总结了目前在HCQ视网膜病变患者中应用的检查方法及新的成像技术,如定量自发荧光、微视野和逆模式成像等,并考虑未来使用这些新兴技术进行早期疾病检测的前景。 展开更多
关键词 羟氯喹 视网膜病变 检测 眼底定量自发荧光 微视野 新技术
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Biological imaging without autofluorescence in the second near-infrared region 被引量:14
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作者 Shuo Diao Guosong Hong +4 位作者 Alexander L. Antaris Jeffrey L. Blackbum Kai Cheng Zhen Cheng Hongjie Dai 《Nano Research》 SCIE EI CAS CSCD 2015年第9期3027-3034,共8页
Fluorescence imaging is capable of acquiring anatomical and functional infor- mation with high spatial and temporal resolution. This imaging technique has been indispensable in biological research and disease detectio... Fluorescence imaging is capable of acquiring anatomical and functional infor- mation with high spatial and temporal resolution. This imaging technique has been indispensable in biological research and disease detection/diagnosis. Imaging in the visible and to a lesser degree, in the near-infrared (NIR) regions below 900 nm, suffers from autofluorescence arising from endogenous fluorescent molecules in biological tissues. This autofluorescence interferes with fluorescent molecules of interest, causing a high background and low detection sensitivity. Here, we report that fluorescence imaging in the 1,500-1,700-nm region (termed "NIR-IIb") under 808-nm excitation results in nearly zero tissue autofluorescence, allowing for background-free imaging of fluorescent species in otherwise notoriously autofluorescent biological tissues, including liver. Imaging of the intrinsic fluorescence of individual fluorophores, such as a single carbon nanotube, can be readily achieved with high sensitivity and without autofluorescence background in mouse liver within the 1,500-1,700-nm wavelength region. 展开更多
关键词 FLUORESCENCE imaging second near-infrared nanotechnology autofluorescence
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Fundus autofluorescence characteristics in patients with diabetic macular edema 被引量:2
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作者 Shen Yinchen Xu Xun Liu Kun 《Chinese Medical Journal》 SCIE CAS CSCD 2014年第8期1423-1428,共6页
Background Diabetic macular edema (DME) is one of the major causes of visual impairment in patients with diabetes mellitus. DME shows a variety of clinical characteristics with unpredictable results to treatment. Th... Background Diabetic macular edema (DME) is one of the major causes of visual impairment in patients with diabetes mellitus. DME shows a variety of clinical characteristics with unpredictable results to treatment. The purpose of this study was to investigate the characteristics of fundus autofluorescence (FAF) in DME, which is a rapid, noninvasive technique for fundus diseases. Methods A total of 18 patients (30 eyes) with clinically significant macular edema (CSME) were enrolled. FAF imaging was performed with a confocal scanning laser ophthalmoscope. Other ophthalmic examinations included best corrected visual acuity (BCVA), MP-1 microperimetry, and spectral-domain optical coherence tomography (SD-OCT). Main outcome measurements included BCVA, macular sensitivity (MS), central retinal thickness (CRT), central retinal volume (CRV), the integrity of the inner segment-outer segment junction (IS/OS), and the integrity of the external limiting membrane (ELM). Results Among the 30 eyes, four eyes (13.3%) had normal foveal FAF and 26 eyes (86.7%) had abnormal FAF. Abnormal FAF was mainly divided into three types: cystoid increased FAF (iFAF) 16 eyes (53.3%), spot iFAF six eyes (20%), irregular decreased FAF (dFAF) four eyes (13.3%). According to the FAF morphology, patients were categorized into four groups: normal, cystoid iFAF, spot iFAF, and irregular dFAE There was a significant difference in BCVA (P 〈0.001) and MS (P 〈0.05) among the four groups. The visual function of patients with spot iFAF and irregular dFAF was relatively poor. However, there was no difference in CRT (P=-0.186) and CRV (P=0.191) among the four groups. In the normal FAF group, the photoreceptor layers were mostly intact. Regarding the cystoid iFAF group, the photoreceptor layers were relatively intact, while in the other two groups, IS/OS and ELM were disrupted in most patients. No one had intact IS/OS or ELM layer. Conclusions FAF might reflect the damage of the retina and had a relationship with visual function as well as photoreceptor integrity, which gives new insight into the evaluation of DME. Dynamic FAF monitoring helps to better evaluate the disease progression of DME as well as visual function. 展开更多
关键词 diabetic macular edema fundus autofluorescence optical coherence tomography photoreceptor integrity
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Characteristics of fundus autofluorescence in cystoid macular edema 被引量:1
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作者 PENG Xi-jia SU Lan-ping 《Chinese Medical Journal》 SCIE CAS CSCD 2011年第2期253-257,共5页
Background Fundus autofluorescence (FAF) imaging is a fast and noninvasive technique developed over the last decade.The authors utilized fluorescent properties of lipofuscin to study the health and viability of the ... Background Fundus autofluorescence (FAF) imaging is a fast and noninvasive technique developed over the last decade.The authors utilized fluorescent properties of lipofuscin to study the health and viability of the retinal pigment epithelium (RPE)-photoreceptor complex.Observing the intensity and distribution of FAF of various retinal diseases is helpful for ascertaining diagnosis and evaluating prognosis.In this study,we described the FAF characteristics of cystoid macular edema (CME).Methods Sixty-two patients (70 eyes) with CME were subjected to FAF and fundus fluorescein angiography (FFA) by a confocal scanning laser ophthalmoscope (Heidelberg Retina Angiograph 2 (HRA2)).Characteristics of FAF images were compared with FFA images.Results FAF intensity in normal subjects was highest at the posterior pole and dipped at the fovea.All cases of CME showed fluorescein dye accumulated into honeycomb-like spaces in macular and formated a typical petaloid pattern or atypical petaloid pattern in the late phases of the angiography.Sixty-one eyes with CME on FAF images showed mild or moderate hyperautofluorescence petaloid pattern in fovea,the FAF patterns of these CME was perfectly corresponding with shape in their FFA images;nine eyes with CME secondary to exudative age related macular degeneration (AMD) showed expansion of the hypoautofluorescence without petaloid pattern in macula.Conclusion FAF imaging can be used as a new rapid,non-invasive and ancillary technique in the diagnosis of the majority of CME,except for AMD and small part of other fundus diseases. 展开更多
关键词 cystoid macular edema fundus autofluorescence LIPOFUSCIN retinal pigment epithelium fundus fluorescein angiography
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Near-infrared fundus camera based on polarization switch in stray light elimination 被引量:2
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作者 叶海水 高志山 +1 位作者 秦震宇 王倩雯 《Chinese Optics Letters》 SCIE EI CAS CSCD 2013年第3期56-59,共4页
This letter shows that the human eye fundus tissue has higher reflectivity at the near-infrared (NIR) wavelength, and that some aberrations exist at the pre-optical system from cornea to vitreous. We design a NIR fu... This letter shows that the human eye fundus tissue has higher reflectivity at the near-infrared (NIR) wavelength, and that some aberrations exist at the pre-optical system from cornea to vitreous. We design a NIR fundus camera with inner focusing, which can be applied to the -10 D to 10 D range of vision and has the advantage of ensuring the stability of image when is focused. Considered as Liou's eye aberration model, we correct the integrated aberration to ensure a 100 lp/mm resolution when we complete the assembly and calibration of the fundus camera. Kohler illumination is also applied to obtain uniform fundus illumination. Moreover, we put forward a novel method for stray light elimination based on polarization switch, which inhibits ghost image formation near the focal plane when the illumination beam is reflected by the eyepiece surface. The result shows that this method is effective in ensuring an illumination uniformity of 80%, with the advantage of simple structure and easy assembly. 展开更多
关键词 near-infrared fundus camera based on polarization switch in stray light elimination NIR
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眼底自发荧光在年龄相关性黄斑变性中的应用指南(2023)
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作者 邵毅 迟玮 +4 位作者 魏雁涛 《眼底自发荧光在年龄相关性黄斑变性中的应用指南(2023)》专家组 中国医药教育协会眼科影像与智能医疗专委会 国际转化医学协会眼科专委会 中国眼科影像研究专家组 《国际眼科杂志》 CAS 北大核心 2023年第8期1235-1241,共7页
眼底自发荧光(FAF)成像是基于视网膜色素上皮和脉络膜中的眼内源性荧光团激发的荧光进行成像的技术,荧光激发物质主要是脂褐质(LF)和黑色素。由于该无创检查技术可通过观察LF和黑色素在眼底的空间分布来反映视网膜色素上皮的功能状况,... 眼底自发荧光(FAF)成像是基于视网膜色素上皮和脉络膜中的眼内源性荧光团激发的荧光进行成像的技术,荧光激发物质主要是脂褐质(LF)和黑色素。由于该无创检查技术可通过观察LF和黑色素在眼底的空间分布来反映视网膜色素上皮的功能状况,在诊断、鉴别和随访年龄相关性黄斑变性(ARMD)上具有独特优势。本指南即对FAF在ARMD不同阶段和分类上的临床应用进行规范和解读。 展开更多
关键词 眼底自发荧光 年龄相关性黄斑变性 临床应用
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非增生型糖尿病视网膜病变超广角眼底彩色照相与眼底自发荧光图像特征分析 被引量:8
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作者 龙婷 杜磊 +1 位作者 赵秋雅 邢怡桥 《眼科新进展》 CAS 北大核心 2019年第4期366-369,共4页
目的分析非增生型糖尿病视网膜病变(non-proliferative diabetic retinopathy,NPDR)超广角眼底彩色照相与眼底自发荧光(fudus autofluorescence,FAF)的图像特征。方法使用欧堡全景200激光扫描检眼镜对40例(80眼)NPDR患者进行免散瞳模式... 目的分析非增生型糖尿病视网膜病变(non-proliferative diabetic retinopathy,NPDR)超广角眼底彩色照相与眼底自发荧光(fudus autofluorescence,FAF)的图像特征。方法使用欧堡全景200激光扫描检眼镜对40例(80眼)NPDR患者进行免散瞳模式下的超广角眼底彩色照相及FAF检查,对所有图像进行分析,得出两种模式下NPDR眼底改变的图像特征及阳性率。结果超广角眼底彩色照相和FAF的图像质量基本一致,均能反映周边部视网膜的情况。在各种典型的眼底病变中,极其微小的血管瘤以及点片状视网膜出血的显影在FAF上有增强,有助于细微病变的诊断。渗出在FAF上的显影并不明显,分辨率不够。视网膜新鲜性光凝斑在两种模式检查上均显影清晰,陈旧性光凝斑在FAF上易与出血混淆,应谨慎诊断。结论超广角眼底彩色照相图像清晰,周边部显示好,可以提供直观的视网膜图像;FAF可以观察到组织结构的细微改变及视网膜色素上皮细胞的代谢情况。两种模式相辅相成,能为NPDR的诊断、分期和治疗提供更好的帮助。 展开更多
关键词 非增生型糖尿病视网膜病变 超广角眼底彩色照相 眼底自发荧光
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两种波长自发荧光在眼底疾病诊断中的应用 被引量:3
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作者 华瑞 柳力敏 +1 位作者 张慧 陈蕾 《眼科新进展》 CAS 北大核心 2010年第11期1048-1053,共6页
目的应用Spectralis OCT联合激光共焦扫描检眼镜对比观察蓝光自发荧光(blue light fundus autofluorescence,BL-FAF,激发光488nm,滤光片>500nm)和近红外波长自发荧光(near-infrared fundus autofluorescence,NIR-FAF,激发光787nm,滤... 目的应用Spectralis OCT联合激光共焦扫描检眼镜对比观察蓝光自发荧光(blue light fundus autofluorescence,BL-FAF,激发光488nm,滤光片>500nm)和近红外波长自发荧光(near-infrared fundus autofluorescence,NIR-FAF,激发光787nm,滤光片>800nm)在眼底疾病诊断中的应用价值。方法选取我院眼科门诊眼底相关疾病患者22例(其中视网膜静脉阻塞5例、中心性渗出脉络膜视网膜炎3例、糖尿病性视网膜病变2例、特发性息肉状脉络膜血管病变2例、高度近视病理性脉络膜新生血管2例、小柳原田病1例、黄斑裂孔2例、青光眼1例、单纯高度近视1例、正常人群3例)共38眼进行BL-FAF、NIA-AF和Spectralis OCT检查,部分患者行眼底照相。眼底荧光血管造影及吲哚菁绿血管造影检查。按病变类型进行分组研究。结果 NIR-FAF显示病变而BL-FAF没有显示病变的有16眼,其中包括视网膜出血2眼、视网膜渗出1眼、玻璃膜疣5眼、黄斑水肿2眼、神经上皮层脱离或恢复2眼、脉络膜新生血管1眼、小柳原田病治疗后2眼、黄斑孔1眼;BL-FAF显示病变而NIR-FAF没有显示病变的有9眼,其中包括视网膜出血2眼、视网膜渗出2眼、玻璃膜疣1眼、CNV3眼、单纯高度近视眼外核层视网膜劈裂1眼。NIR-FAF对累及外界膜、光感受器内节与外节连接带及色素上皮与Bruch膜复合体范围内病变成像优于BL-FAF,NIR-FAF在确定某些疾病的病变范围上优于BL-FAF,而BL-FAF对于累及外核层、外丛状层及视网膜浅层的病变优于NIR-FAF。结论自发荧光由于其易操作性、有效性和无创性,已经越来越多的应用到临床实践。激光共焦扫描检眼镜多种成像模式联合Spect-ralis OCT更有利于眼底疾病的理解和诊断。 展开更多
关键词 蓝光自发荧光 近红外波长自发荧光 Spectralis OCT
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慢性迁延性中心性浆液性脉络膜视网膜病变的两种自发荧光特征 被引量:4
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作者 王志立 李晓华 +2 位作者 李士清 董应丽 李萍 《眼科新进展》 CAS 北大核心 2014年第2期151-154,共4页
目的对脂褐素相关自发荧光(lipofuscin-related fundus autofluorescence,FAF)和黑色素相关近红外自发荧光(melaninrelated near-infrard fundus autofluorescence,NIA)在慢性迁延性中心性浆液性脉络膜视网膜病变(central serous chorio... 目的对脂褐素相关自发荧光(lipofuscin-related fundus autofluorescence,FAF)和黑色素相关近红外自发荧光(melaninrelated near-infrard fundus autofluorescence,NIA)在慢性迁延性中心性浆液性脉络膜视网膜病变(central serous chorioretinopathy,CSC)中的特征进行分析。方法回顾性分析慢性迁延性CSC患者57例63眼的临床资料,对经德国海德堡共焦激光扫描眼底血管造影仪检查的FAF、NIA和荧光素眼底血管造影(fundus fluorescence angiography,FFA)图像进行对比分析。结果 63眼中,FAF异常荧光者47眼(占74.6%),包括弱荧光39眼(占83.0%)、强荧光3眼(占6.4%)、不典型荧光5眼(占10.6%);NIA异常荧光者59眼(占93.7%),包括弱荧光48眼(占81.4%)、斑驳状荧光5眼(占8.5%)、不典型荧光6眼(占10.2%)。63眼神经上皮脱离区自发荧光表现:FAF呈异常荧光者50眼(占79.4%),包括弱荧光15眼(占30.0%)、强荧光35眼(占70.0%);NIA异常荧光57眼(占90.5%),包括颗粒样混杂荧光51眼(占89.5%)、弱荧光6眼(占10.5%)。另外,FAF和NIA显示视网膜神经脱离区病变范围大于FFA者分别有23眼和33眼,分别占36.5%和52.4%。FFA和FAF显示正常的区域而NIA表现异常者3眼,占4.8%。结论 NIA联合FAF适合于观察慢性迁延性CSC视网膜色素上皮的变化。 展开更多
关键词 中心性浆液性脉络膜视网膜病变 视网膜色素上皮细胞 脂褐素相关自发荧光 黑色素相关近红外自发荧光
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慢性中心性浆液性脉络膜视网膜病变眼底自发荧光特点 被引量:7
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作者 宣懿 王诗园 +1 位作者 赵培泉 彭清 《山西医科大学学报》 CAS 2009年第11期1049-1051,共3页
目的观察22例慢性中心性浆液性脉络膜视网膜病变(简称中浆,central serous chorioretinopathy,CSC)患者眼底的自发荧光,探究中浆患者在恢复期眼底自发荧光的特点。方法回顾性随访临床病程超过3个月且曾经眼底荧光血管造影确诊为中心性... 目的观察22例慢性中心性浆液性脉络膜视网膜病变(简称中浆,central serous chorioretinopathy,CSC)患者眼底的自发荧光,探究中浆患者在恢复期眼底自发荧光的特点。方法回顾性随访临床病程超过3个月且曾经眼底荧光血管造影确诊为中心性浆液性脉络膜视网膜病变的患者16例22眼,单眼10例,双眼6例,发病后半年22眼均经海德堡共焦激光扫描镜HRA2-cSLO拍摄眼底自发荧光(fundus autofluorescence,FAF),观察其影像学特点。结果22眼中仅有2眼表现为正常FAF,其余20眼均表现为异常FAF。异常FAF可分为3类:第一类,原发病灶渗漏点处呈不规则形状的低荧光,周围环绕0.5-2DD大小的高荧光区,有8眼占36.3%;第二类,在原发病灶处几乎看不到异常荧光,而在其下方或侧下方可见竖椭圆型,葫芦状或斜条状的高荧光区,中央夹杂有点片状的低荧光有7眼占31.8%;第三类,原发病灶处呈明暗相间的斑驳状的异常荧光有5眼占22.7%。这些不同类型的异常FAF说明自行愈合的中浆患者即使黄斑区视网膜下渗液已经消失但在病灶的原始渗漏部位或病灶周围及下方却出现了RPE细胞功能和代谢的损害。结论未经治疗的中浆患者眼底可出现异常FAF,说明RPE细胞出现了永久损害,故对中浆病人应早期进行干预性治疗。 展开更多
关键词 中心性浆液性脉络膜视网膜病变 眼底自发荧光 视网膜色素上皮细胞
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微脉冲激光阈值下治疗黄斑软性玻璃膜疣和玻璃膜疣性DPED的形态学改变 被引量:4
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作者 陈青山 陈璐 +3 位作者 赵霞 陈妙虹 杨宇航 李志 《国际眼科杂志》 CAS 北大核心 2020年第6期934-939,共6页
目的:分析阈值下微脉冲激光(SMLT)治疗黄斑软性玻璃膜疣与玻璃膜疣性色素上皮脱离(DPED)的形态学改变。方法:回顾性横断面病例系列研究。2016-08/2018-10临床确诊的黄斑软性玻璃膜疣与DPED 14例20眼纳入研究,用577 nm黄激光对黄斑软性... 目的:分析阈值下微脉冲激光(SMLT)治疗黄斑软性玻璃膜疣与玻璃膜疣性色素上皮脱离(DPED)的形态学改变。方法:回顾性横断面病例系列研究。2016-08/2018-10临床确诊的黄斑软性玻璃膜疣与DPED 14例20眼纳入研究,用577 nm黄激光对黄斑软性玻璃膜疣与DPED进行SMLT治疗。观察黄斑软性玻璃膜疣与DPED治疗后BCVA,FAF与SD-OCT测量的纵径,横径,病灶面积的改变。结果:黄斑软性玻璃膜疣治疗后BCVA与基线比较,差异无统计学意义(P=0.260),DPED治疗后BCVA与基线比较无统计学差异(P=0.736)。黄斑软性玻璃膜疣与DPED横径,纵径,截面积治疗后6mo与基线比较,黄斑软性玻璃膜疣纵径高度降低,截面积缩小,与基线比较有显著性差异(P=0.008;0.034)。DPED治疗前后横径,纵径高度与截面积与基线比较无统计学差异。结论:SMLT治疗黄斑软性玻璃膜疣与DPED后BCVA没有下降。黄斑软性玻璃膜疣纵径高度与截面积均较治疗前下降。DPED与基线比较无明显改变。结果表明SMLT治疗黄斑软性玻璃膜疣是有效的,但短期DPED疗效不明显,对黄斑软性玻璃膜疣与DPED视力无损害,但仍需要前瞻性、对照、大样本及长期随访观察。 展开更多
关键词 黄斑玻璃膜疣 玻璃膜疣性色素上皮脱离 阈值下微脉冲激光 自发荧光
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特发性黄斑裂孔眼底自发荧光成像研究 被引量:2
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作者 彭锡嘉 王波 +4 位作者 王登廷 郝保安 高琛 王雅东 苏兰萍 《眼科研究》 CSCD 北大核心 2009年第9期784-787,共4页
目的比较分析特发性黄斑裂孔(IMH)患者眼底自发荧光(FAF)图像及荧光素眼底血管造影(FFA)图像的特征。方法对33例(36眼)IMH患者应用共焦激光扫描检眼镜进行检查,分析FAF图像与FFA图像。另外选取16例正常人作为对照。利用M IG2000图像测... 目的比较分析特发性黄斑裂孔(IMH)患者眼底自发荧光(FAF)图像及荧光素眼底血管造影(FFA)图像的特征。方法对33例(36眼)IMH患者应用共焦激光扫描检眼镜进行检查,分析FAF图像与FFA图像。另外选取16例正常人作为对照。利用M IG2000图像测量系统对黄斑中心凹进行自发荧光强度测定。结果33例(36眼)IMH患者中,全层黄斑裂孔26眼(72.2%),板层黄斑裂孔10眼(27.7%)。黄斑自发荧光的特征:正常眼底中心凹FAF呈局部低荧光;黄斑裂孔表现为高荧光,与FFA的图像相似。6例板层裂孔FAF、FFA均未见异常,其余4例板层孔中心凹处FFA表现为轻度增强的透见荧光,相应部位FAF见轻度增强的自发荧光。全层黄斑裂孔在裂孔处有明显增强的FAF,FFA的"窗样缺损",在位置、面积、形状上与FAF一致。结论FAF检测为黄斑裂孔的诊断提供了一个新的、快速、非创性检查手段。 展开更多
关键词 特发性黄斑裂孔 眼底自发荧光 荧光素眼底血管造影 视网膜色素上皮 共焦激光扫描检眼镜
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近红外自发荧光联合荧光血管造影在黄斑脉络膜裂伤合并视神经钝挫伤中的应用 被引量:3
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作者 李士清 李晓华 +3 位作者 李萍 雷祥 郭慧丽 王志立 《眼科新进展》 CAS 北大核心 2014年第10期934-936,共3页
目的探讨近红外自发荧光(near-infrared autofluorescence,NIA)及眼底荧光血管造影(fundus fluorescein angiography,FFA)检查在黄斑脉络膜裂伤合并视神经钝挫伤中的临床意义。方法对确诊为黄斑脉络膜裂伤合并视神经钝挫伤的16例(16眼)... 目的探讨近红外自发荧光(near-infrared autofluorescence,NIA)及眼底荧光血管造影(fundus fluorescein angiography,FFA)检查在黄斑脉络膜裂伤合并视神经钝挫伤中的临床意义。方法对确诊为黄斑脉络膜裂伤合并视神经钝挫伤的16例(16眼)患者进行NIA和FFA检查,观察其眼底变化特点。结果 12眼黄斑脉络膜裂伤合并视网膜下出血,FFA示部分脉络膜裂伤被视网膜下出血所遮蔽而不能显影;4眼为单纯黄斑脉络膜裂伤,FFA晚期示脉络膜裂伤呈完整的条索状强荧光。16眼的NIA均可穿透斑片状视网膜下出血显示脉络膜裂伤形成的弧形或线形弱荧光。16眼NIA所测脉络膜裂伤长度为(1.47±0.48)mm,较FFA所测脉络膜裂伤长度(0.49±0.25)mm长,差异有统计学意义(t=13.15,P=0.00)。结论 NIA可发现黄斑区视网膜下出血遮蔽的脉络膜裂伤,FFA可显示视神经钝挫伤,两者结合有助于及早确诊黄斑脉络膜裂伤合并视神经钝挫伤,为及时治疗提供帮助。 展开更多
关键词 近红外自发荧光 眼底荧光血管造影 脉络膜裂伤 视神经钝挫伤 黄斑
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