Immunotherapies hold immense potential for achieving durable potency and long-term survival opportunities in cancer therapy.As vital biological mediators,peptides with high tissue penetration and superior selectivity ...Immunotherapies hold immense potential for achieving durable potency and long-term survival opportunities in cancer therapy.As vital biological mediators,peptides with high tissue penetration and superior selectivity offer significant promise for enhancing cancer immunotherapies(CITs).However,physicochemical peptide features such as conformation and stability pose challenges to their on-target efficacy.This review provides a comprehensive overview of recent advancements in therapeutic peptides targeting key steps of the cancer-immunity cycle(CIC),including tumor antigen presentation,immune cell regulation,and immune checkpoint signaling.Particular attention is given to the opportunities and challenges associated with these peptides in boosting CIC within the context of clinical progress.Furthermore,possible future developments in this field are also discussed to provide insights into emerging CITs with robust efficacy and safety profiles.展开更多
基金the National Natural Science Foundation of China(Nos.82322073,82173846,and 82304533)CAMS Innovation Fund for Medical Sciences(CIFMS)(No.2023-I2M-3-009,China)+11 种基金Oriental Scholars of Shanghai Universities(TP2022081,China)China Postdoctoral Science Foundation(No.2021M702215)Jiangxi Province Thousand Talents Program(jxsq2023102168,China)Young Talent Lifting Project of Young Talent Lifting Project of China Association of Chinese Medicine[No.CACM-(2021-QNRC2-A08)]Shanghai Rising-Star Program(No.22QA1409100,China)Shanghai Sailing Program(No.22YF1445000,China)2021 Shanghai Science and Technology Innovation Action Plan(No.21S11902800,China)Three-Year Action Plan for Three-year Action Plan for Shanghai TCM Development and Inheritance Program[No.ZY(2021-2023)-0208 and ZY(2021-2023)-0401,China]High level Key Discipline of National Administration of Traditional Chinese Medicine(No.zyyzdxk-2023071,China)Innovation Team and Talents Cultivation Program of High level Key Discipline of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202004,China)Key project at central government level:The ability establishment of sustainable use for valuable Chinese medicine resources(No.2060302,China)Innovation team of high-level local universities in Shanghai:Strategic Innovation Team of TCM Chemical Biology(China).All figures were created with BioRender.com.
文摘Immunotherapies hold immense potential for achieving durable potency and long-term survival opportunities in cancer therapy.As vital biological mediators,peptides with high tissue penetration and superior selectivity offer significant promise for enhancing cancer immunotherapies(CITs).However,physicochemical peptide features such as conformation and stability pose challenges to their on-target efficacy.This review provides a comprehensive overview of recent advancements in therapeutic peptides targeting key steps of the cancer-immunity cycle(CIC),including tumor antigen presentation,immune cell regulation,and immune checkpoint signaling.Particular attention is given to the opportunities and challenges associated with these peptides in boosting CIC within the context of clinical progress.Furthermore,possible future developments in this field are also discussed to provide insights into emerging CITs with robust efficacy and safety profiles.
