Renal progenitors: Roles in kidney disease and regeneration

Kidney disease is a devastating condition that affects millions of people worldwide, and its prevalence predicted to significantly increase. The kidney is complex organ encompassing many diverse cell type organized in a elaborate tissue architecture, makin regeneration a challenging feat. In recent years, there ha been a surge in the field of stem cell research to develo regenerative therapies for various organ systems. Here we review some recent progressions in characterizing th role of renal progenitors in development, regeneration and kidney disease in mammals. We also discuss how the zebrafish provides a unique experimental anima model that can provide a greater molecular and genet understanding of renal progenitors, which may contribut to the development of potential regenerative therapies fo human renal afflictions.

Regulation of kidney development by the Mdm2/Mdm4-p53 axis

当 p53 活动为瘤抑制被要求时，非强迫的 p53 活动在另一方面对有机体有害，导致不恰当的细胞的死亡或增长缺点。未受阻碍的 p53 活动在发展中的胚胎是致命的，加重对维持在在这个时期期间的 p53 活动的紧密的控制的需要。p53， Mdm2 和 Mdm4 的否定管理者的关键角色，在脊椎动物，开发由在老鼠与 Mdm2 和 Mdm4 基因删除被观察的 embryogenesis 的致命的混乱真相大白。胚胎的致命性仅仅由附加 p53 移动被救。这里，我们总结发生在肾开发的多重步的 Mdm2/Mdm4-p53 轴的贡献。有条件，房间类型特定的删除在肾的形态发生揭示这些蛋白质的不同功能。从指向的基因删除的肾的显型上的严重影响强调 Mdm2/Mdm4-p53 连结在 nephrogenesis 上起的关键作用，并且强调需要为肾函数缺点和联系心血管的机能障碍在这条小径与错误监视病人。