Environmental contamination of food is a worldwide public health problem. Folate mediated one- carbon metabolism plays an important role in epigenetic regulation of gene expression and mutagenesis. Many contaminants i...Environmental contamination of food is a worldwide public health problem. Folate mediated one- carbon metabolism plays an important role in epigenetic regulation of gene expression and mutagenesis. Many contaminants in food cause cancer through epigenetic mechanisms and/or DNA instability i.e. default methylation of uracil to thymine, subsequent to the decrease of 5-methylte- trahydrofolate (5 mTHF) pool in the one-carbon metabolism network. Evaluating consequences of an exposure to food contaminants based on systems biology approaches is a promising alternative field of investigation. This report presents a dynamic mathematical modeling for the study of the alteration in the one-carbon metabolism network by environmental factors. It provides a model for predicting “the impact of arbitrary contaminants that can induce the 5 mTHF deficiency. The model allows for a given experimental condition, the analysis of DNA methylation activity and dumping methylation in the de novo pathway of DNA synthesis.展开更多
"Ensuring stability in foreign trade"and"ensuring food security"are essential parts of China's"six priorities"and"stability in six areas".Based on the data of bilateral food..."Ensuring stability in foreign trade"and"ensuring food security"are essential parts of China's"six priorities"and"stability in six areas".Based on the data of bilateral food trade between countries during 1996-2018,using descriptive statistical analysis and social network analysis methods,this paper analyzed the changes of China's trade position in the world food trade network.It reached the following results.(i)China's position in the trade network has undergone a phased process of"remarkable improvement-continuous fluctuation-significant decline-steady growth".(ii)Export participation is better than import participation,the gap between trade export strength and import strength is widening,and the effective scale and constraint index gradually improve.(iii)The change of China's position in the food trade network is affected by geographical,economic,institutional and cultural factors.In view of these findings,it is recommended to improve node centrality,enhance network participation,improve network interconnection,and prevent international market risks,so as to better deal with the complex international environment.展开更多
Both farmers and traders benefit from trade networking, which is crucial for the local economy. Therefore, it is crucial to understand how these networks operate, and how they can be managed more effectively. Througho...Both farmers and traders benefit from trade networking, which is crucial for the local economy. Therefore, it is crucial to understand how these networks operate, and how they can be managed more effectively. Throughout this study, we examine the economic networks formed between farmers and traders through the trade of food products. These networks are analyzed from the perspective of their structure and the factors that influence their development. Using data from 18 farmers and 15 traders, we applied exponential random graph models. The results of our study showed that connectivity, Popularity Spread, activity spread, good transportation systems, and high yields all affected the development of networks. Therefore, farmers’ productivity and high market demand can contribute to local food-crop trade. The network was not affected by reciprocity, open markets, proximity to locations, or trade experience of actors. Policy makers should consider these five factors when formulating policies for local food-crop trade. Additionally, local actors should be encouraged to use these factors to improve their network development. However, it is important to note that these factors alone cannot guarantee success. Policy makers and actors must also consider other factors such as legal frameworks, economic policies, and resource availability. Our approach can be used in future research to determine how traders and farmers can enhance productivity and profit in West Africa. This study addresses a research gap by examining factors influencing local food trade in a developing country.展开更多
As the main food source for humans, the global movement of the three major grains significantly impacts human survival and development. To investigate the evolution of the world cereal trade network and its developmen...As the main food source for humans, the global movement of the three major grains significantly impacts human survival and development. To investigate the evolution of the world cereal trade network and its development trend, a weighted directed dynamic multiplexed network was established using historical data on cereal trade, cereal import dependency ratio, and arable land per capita. Inspired by the MLP framework, we redefined the weight determination method for computing layer weights and edge weights of the target layer, modified the CN, RA, AA, and PA indicators, and proposed the node similarity indicator for weighted directed networks. The AUC metric, which measures the accuracy of the algorithm, has also been improved in order to finally obtain the link prediction results for the grain trading network. The prediction results were processed, such as web-based presentation and community partition. It was found that the number of generalized trade agreements does not have a decisive impact on inter-country cereal trade. The former large grain exporters continue to play an important role in this trade network. In the future, the world trade in cereals will develop in the direction of more frequent intercontinental trade and gradually weaken the intracontinental cereal trade.展开更多
文摘Environmental contamination of food is a worldwide public health problem. Folate mediated one- carbon metabolism plays an important role in epigenetic regulation of gene expression and mutagenesis. Many contaminants in food cause cancer through epigenetic mechanisms and/or DNA instability i.e. default methylation of uracil to thymine, subsequent to the decrease of 5-methylte- trahydrofolate (5 mTHF) pool in the one-carbon metabolism network. Evaluating consequences of an exposure to food contaminants based on systems biology approaches is a promising alternative field of investigation. This report presents a dynamic mathematical modeling for the study of the alteration in the one-carbon metabolism network by environmental factors. It provides a model for predicting “the impact of arbitrary contaminants that can induce the 5 mTHF deficiency. The model allows for a given experimental condition, the analysis of DNA methylation activity and dumping methylation in the de novo pathway of DNA synthesis.
基金2021 Graduate Innovation Special Fund Project"Study on Impacts of China's Grain Seed Trade Risk on Grain Supply Security Level"Management Science Project of Jiangxi Province"Study on Measures for Accelerating the Development of Agricultural High-tech Industries in Jiangxi Province".
文摘"Ensuring stability in foreign trade"and"ensuring food security"are essential parts of China's"six priorities"and"stability in six areas".Based on the data of bilateral food trade between countries during 1996-2018,using descriptive statistical analysis and social network analysis methods,this paper analyzed the changes of China's trade position in the world food trade network.It reached the following results.(i)China's position in the trade network has undergone a phased process of"remarkable improvement-continuous fluctuation-significant decline-steady growth".(ii)Export participation is better than import participation,the gap between trade export strength and import strength is widening,and the effective scale and constraint index gradually improve.(iii)The change of China's position in the food trade network is affected by geographical,economic,institutional and cultural factors.In view of these findings,it is recommended to improve node centrality,enhance network participation,improve network interconnection,and prevent international market risks,so as to better deal with the complex international environment.
文摘Both farmers and traders benefit from trade networking, which is crucial for the local economy. Therefore, it is crucial to understand how these networks operate, and how they can be managed more effectively. Throughout this study, we examine the economic networks formed between farmers and traders through the trade of food products. These networks are analyzed from the perspective of their structure and the factors that influence their development. Using data from 18 farmers and 15 traders, we applied exponential random graph models. The results of our study showed that connectivity, Popularity Spread, activity spread, good transportation systems, and high yields all affected the development of networks. Therefore, farmers’ productivity and high market demand can contribute to local food-crop trade. The network was not affected by reciprocity, open markets, proximity to locations, or trade experience of actors. Policy makers should consider these five factors when formulating policies for local food-crop trade. Additionally, local actors should be encouraged to use these factors to improve their network development. However, it is important to note that these factors alone cannot guarantee success. Policy makers and actors must also consider other factors such as legal frameworks, economic policies, and resource availability. Our approach can be used in future research to determine how traders and farmers can enhance productivity and profit in West Africa. This study addresses a research gap by examining factors influencing local food trade in a developing country.
文摘As the main food source for humans, the global movement of the three major grains significantly impacts human survival and development. To investigate the evolution of the world cereal trade network and its development trend, a weighted directed dynamic multiplexed network was established using historical data on cereal trade, cereal import dependency ratio, and arable land per capita. Inspired by the MLP framework, we redefined the weight determination method for computing layer weights and edge weights of the target layer, modified the CN, RA, AA, and PA indicators, and proposed the node similarity indicator for weighted directed networks. The AUC metric, which measures the accuracy of the algorithm, has also been improved in order to finally obtain the link prediction results for the grain trading network. The prediction results were processed, such as web-based presentation and community partition. It was found that the number of generalized trade agreements does not have a decisive impact on inter-country cereal trade. The former large grain exporters continue to play an important role in this trade network. In the future, the world trade in cereals will develop in the direction of more frequent intercontinental trade and gradually weaken the intracontinental cereal trade.
