Post-inhibitory rebound(PIR)spike,which has been widely observed in diverse nervous systems with different physiological functions and simulated in theoretical models with class-2 excitability,presents a counterintuit...Post-inhibitory rebound(PIR)spike,which has been widely observed in diverse nervous systems with different physiological functions and simulated in theoretical models with class-2 excitability,presents a counterintuitive nonlinear phenomenon in that the inhibitory effect can facilitate neural firing behavior.In this study,a PIR spike induced by inhibitory stimulation from the resting state corresponding to class-3 excitability that is not related to bifurcation is simulated in the Morris–Lecar neuron.Additionally,the inhibitory self-feedback mediated by an autapse with time delay can evoke tonic/repetitive spiking from phasic/transient spiking.The dynamical mechanism for the PIR spike and the tonic/repetitive spiking is acquired with the phase plane analysis and the shape of the quasi-separatrix curve.The result extends the counterintuitive phenomenon induced by inhibition to class-3 excitability,which presents a potential function of inhibitory autapse and class-3 neuron in many neuronal systems such as the auditory system.展开更多
基金the National Natural Science Foundation of China(Grant Nos.11802085,11872276,and 12072236)the Science and Technology Project of Guangzhou(Grant No.202102021167)+1 种基金GDAS’Project of Science and Technology Development(Grant No.2021GDASYL20210103088)the Science and Technology Development Program of Henan Province,China(Grant No.212102310827)。
文摘Post-inhibitory rebound(PIR)spike,which has been widely observed in diverse nervous systems with different physiological functions and simulated in theoretical models with class-2 excitability,presents a counterintuitive nonlinear phenomenon in that the inhibitory effect can facilitate neural firing behavior.In this study,a PIR spike induced by inhibitory stimulation from the resting state corresponding to class-3 excitability that is not related to bifurcation is simulated in the Morris–Lecar neuron.Additionally,the inhibitory self-feedback mediated by an autapse with time delay can evoke tonic/repetitive spiking from phasic/transient spiking.The dynamical mechanism for the PIR spike and the tonic/repetitive spiking is acquired with the phase plane analysis and the shape of the quasi-separatrix curve.The result extends the counterintuitive phenomenon induced by inhibition to class-3 excitability,which presents a potential function of inhibitory autapse and class-3 neuron in many neuronal systems such as the auditory system.
