Although vaccines have been developed,mutations of SARS-CoV-2,especially the dominant B.1.617.2(delta)and B.1.529(omicron)strains with more than 30 mutations on their spike protein,have caused a significant decline in...Although vaccines have been developed,mutations of SARS-CoV-2,especially the dominant B.1.617.2(delta)and B.1.529(omicron)strains with more than 30 mutations on their spike protein,have caused a significant decline in prophylaxis,calling for the need for drug improvement.Antibodies are drugs preferentially used in infectious diseases and are easy to get from immunized organisms.The current study combined molecular modeling and single memory B cell sequencing to assess candidate sequences before experiments,providing a strategy for the fabrication of SARS-CoV-2 neutralizing antibodies.A total of 128 sequences were obtained after sequencing 196 memory B cells,and 42 sequences were left after merging extremely similar ones and discarding incomplete ones,followed by homology modeling of the antibody variable region.Thirteen candidate sequences were expressed,of which three were tested positive for receptor binding domain recognition but only one was confirmed as having broad neutralization against several SARS-CoV-2 variants.The current study successfully obtained a SARS-CoV-2 antibody with broad neutralizing abilities and provided a strategy for antibody development in emerging infectious diseases using single memory B cell BCR sequencing and computer assistance in antibody fabrication.展开更多
To address climate change,the world needs deep decarbonization to achieve carbon neutrality(CN),which implies net-zero human-caused CO_(2) emissions in the atmosphere.This study used emission-side drivers,including so...To address climate change,the world needs deep decarbonization to achieve carbon neutrality(CN),which implies net-zero human-caused CO_(2) emissions in the atmosphere.This study used emission-side drivers,including socioeconomic and net primary productivity(NPP)-based factors,to determine the changes in CN based on vegetation carbon sequestration in the case of China during 2001-2015.Spatial exploratory analysis as well as the combined use of production-theoretical decomposition analysis(PDA)and an econometric model were also utilized.We showed that CN was significantly spatially correlated over the study period;Yunnan,Heilongjiang,and Jilin presented positive spatial autocorrelations,whereas Guizhou showed a negative spatial autocorrelation.More than half of CN declined over the period during which potential energy intensity(PEIE)and energy usage technological change were the largest negative and positive drivers for increasing CN.PEIE played a significantly negative role in increasing CN.We advise policymakers to focus more on emission-side drivers(e.g.,energy intensity)in addition to strengthening NPP management to achieve CN.展开更多
Control of pH neutralization processes is challenging in the chemical process industry because of their inherent strong nonlinearity. In this paper, the model algorithmic control (MAC) strategy is extended to nonlinea...Control of pH neutralization processes is challenging in the chemical process industry because of their inherent strong nonlinearity. In this paper, the model algorithmic control (MAC) strategy is extended to nonlinear processes using Hammerstein model that consists of a static nonlinear polynomial function followed in series by a linear impulse response dynamic element. A new nonlinear Hammerstein MAC algorithm (named NLH-MAC) is presented in detail. The simulation control results of a pH neutralization process show that NLH-MAC gives better control performance than linear MAC and the commonly used industrial nonlinear propotional plus integral plus derivative (PID) controller. Further simulation experiment demonstrates that NLH-MAC not only gives good control response, but also possesses good stability and robustness even with large modeling errors.展开更多
Extensions of Merton’s model(EMM)considering the firm’s payments and generating new types of firm value distribution are suggested.In the open log-value/time space,these distributions evolve from initially normal to...Extensions of Merton’s model(EMM)considering the firm’s payments and generating new types of firm value distribution are suggested.In the open log-value/time space,these distributions evolve from initially normal to negatively skewed ones,and their means are concave-down functions of time.When payments are set to zero or proportional to the firm value,EMM turns into the Geometric Brownian model(GBM).We show that risk-neutral probabilities(RNPs)and the no-arbitraging principle(NAP)follow from GBM.When firm’s payments are considered,RNPs and NAP hold for the entire market for short times only,but for long-term investments,RNPs and NAP just temporarily hold for individual stocks as far as mean year returns of the firms issuing those stocks remain constant,and fail when the mean year returns decline.The developed method is applied to firm valuation to derive continuous-time equations for the firm present value and project NPV.展开更多
The problem of guaranteed cost fuzzy controller is studied for a class of nonlinear time-delay neutral sys-tems with norm-bounded uncertainty based on T-S model. The sufficient conditions are first derived for the exi...The problem of guaranteed cost fuzzy controller is studied for a class of nonlinear time-delay neutral sys-tems with norm-bounded uncertainty based on T-S model. The sufficient conditions are first derived for the existenceof guaranteed cost fuzzy controllers. These sufficient conditions are equivalent to a kind of linear matrix inequalities.Furthermore, a convex optimization problem with LMI constraints is formulated to design the optimal guaranteedcost controller.展开更多
Increasing the production and utilization of shale gas is of great significance for building a clean and low-carbon energy system.Sharp decline of gas production has been widely observed in shale gas reservoirs.How to...Increasing the production and utilization of shale gas is of great significance for building a clean and low-carbon energy system.Sharp decline of gas production has been widely observed in shale gas reservoirs.How to forecast shale gas production is still challenging due to complex fracture networks,dynamic fracture properties,frac hits,complicated multiphase flow,and multi-scale flow as well as data quality and uncertainty.This work develops an integrated framework for evaluating shale gas well production based on data-driven models.Firstly,a comprehensive dominated-factor system has been established,including geological,drilling,fracturing,and production factors.Data processing and visualization are required to ensure data quality and determine final data set.A shale gas production evaluation model is developed to evaluate shale gas production levels.Finally,the random forest algorithm is used to forecast shale gas production.The prediction accuracy of shale gas production level is higher than 95%based on the shale gas reservoirs in China.Forty-one wells are randomly selected to predict cumulative gas production using the optimal regression model.The proposed shale gas production evaluation frame-work overcomes too many assumptions of analytical or semi-analytical models and avoids huge computation cost and poor generalization for numerical modelling.展开更多
We investigated the neutral Higgs boson pair production at the CERN Large Hadron Collider (LHC) in the SM with four families. We found that the gluon-gluon fusion mode is the most dominant one in producing neutral Hig...We investigated the neutral Higgs boson pair production at the CERN Large Hadron Collider (LHC) in the SM with four families. We found that the gluon-gluon fusion mode is the most dominant one in producing neutral Higgs boson pair at the LHC, and it can be used to probe the trilinear Higgs coupling. If the heavy quarks of the fourth generation really exist within the SM, they can manifest their effect on the cross section of the Higgs pair production process at the LHC. Our numerical results show that there will be neutral Higgs boson pair production events per year if the next generation heavy quarks really exist, while there will be only events produced per year if there are only three families in the SM.展开更多
A general research on chiral symmetry restoring phase transitions at zero temperature and finite chemical potentials under electrical neutrality condition has been conducted in a Nambu-Jona-Lasinio model to describe t...A general research on chiral symmetry restoring phase transitions at zero temperature and finite chemical potentials under electrical neutrality condition has been conducted in a Nambu-Jona-Lasinio model to describe twoflavor normal quark matter. Depending on whether mo/A, the ratio of dynamical quark mass in vacuum and the 3D momentum cutoff in the loop integrals, is less or greater than 0.413, the phase transition will be of the second or first order. A complete phase diagram of u quark chemical potential versus mo is given. With the electrical neutrality constraint, the region where the second order phase transition happens will be wider than the one without electrical neutrality limitation. The results also show that, for the value ofmo/A from QCD phenomenology, the phase transition must be of the first order.展开更多
China has paid considerable attention to developing and implementing a carbon labeling system in response to increasing environmental issues such as global warming.This paper aims to provide a theoretical basis for fo...China has paid considerable attention to developing and implementing a carbon labeling system in response to increasing environmental issues such as global warming.This paper aims to provide a theoretical basis for formulating and implementing a carbon labeling system in China through a study of consumer acceptance behavior and its influencing factors.This paper constructed an extended model of consumers’acceptance behavior of carbon neutral labels based on the theories and methods of Unified Theory of Acceptance and Use of Technology(UTAUT)and analyzed the effects of five factors(carbon label cognition,performance expectancy,effort expectancy,social influence,and facilitating factors)on consumer carbon neutral label acceptance and adoption.The structural equation model analysis revealed that carbon label cognition,performance expectancy,social influence,and facilitating factors significantly,and positively impact consumers’acceptance of carbon neutral labels.Moreover,carbon label cognition,performance expectancy,and facilitating factors significantly,and positively affect consumers’carbon neutral label adoption behavior.Meanwhile,carbon label cognition,and effort expectancy have no significant impact on consumers’willingness to accept carbon neutral labels,which in turn significantly impacts consumers’carbon neutral label adoption behavior.According to the research findings,increasing the promotion of carbon labeling and improving the practical strategies and management recommendations for carbon label design are proposed.展开更多
基金supported by the Jiangsu Provincial Key Research and Development Program (Grant No.BE2020616)the National Key R&D Program of China (Grant No.2018YFC1200603)+1 种基金the National Science and Technology Major Project (Grant No.2019SWAQ05-5-4)Jiangsu Key Lab of Cancer Biomarkers,Prevention and Treatment,Collaborative Innovation Center for Cancer Personalized Medicine,Nanjing Medical University.
文摘Although vaccines have been developed,mutations of SARS-CoV-2,especially the dominant B.1.617.2(delta)and B.1.529(omicron)strains with more than 30 mutations on their spike protein,have caused a significant decline in prophylaxis,calling for the need for drug improvement.Antibodies are drugs preferentially used in infectious diseases and are easy to get from immunized organisms.The current study combined molecular modeling and single memory B cell sequencing to assess candidate sequences before experiments,providing a strategy for the fabrication of SARS-CoV-2 neutralizing antibodies.A total of 128 sequences were obtained after sequencing 196 memory B cells,and 42 sequences were left after merging extremely similar ones and discarding incomplete ones,followed by homology modeling of the antibody variable region.Thirteen candidate sequences were expressed,of which three were tested positive for receptor binding domain recognition but only one was confirmed as having broad neutralization against several SARS-CoV-2 variants.The current study successfully obtained a SARS-CoV-2 antibody with broad neutralizing abilities and provided a strategy for antibody development in emerging infectious diseases using single memory B cell BCR sequencing and computer assistance in antibody fabrication.
文摘To address climate change,the world needs deep decarbonization to achieve carbon neutrality(CN),which implies net-zero human-caused CO_(2) emissions in the atmosphere.This study used emission-side drivers,including socioeconomic and net primary productivity(NPP)-based factors,to determine the changes in CN based on vegetation carbon sequestration in the case of China during 2001-2015.Spatial exploratory analysis as well as the combined use of production-theoretical decomposition analysis(PDA)and an econometric model were also utilized.We showed that CN was significantly spatially correlated over the study period;Yunnan,Heilongjiang,and Jilin presented positive spatial autocorrelations,whereas Guizhou showed a negative spatial autocorrelation.More than half of CN declined over the period during which potential energy intensity(PEIE)and energy usage technological change were the largest negative and positive drivers for increasing CN.PEIE played a significantly negative role in increasing CN.We advise policymakers to focus more on emission-side drivers(e.g.,energy intensity)in addition to strengthening NPP management to achieve CN.
文摘Control of pH neutralization processes is challenging in the chemical process industry because of their inherent strong nonlinearity. In this paper, the model algorithmic control (MAC) strategy is extended to nonlinear processes using Hammerstein model that consists of a static nonlinear polynomial function followed in series by a linear impulse response dynamic element. A new nonlinear Hammerstein MAC algorithm (named NLH-MAC) is presented in detail. The simulation control results of a pH neutralization process show that NLH-MAC gives better control performance than linear MAC and the commonly used industrial nonlinear propotional plus integral plus derivative (PID) controller. Further simulation experiment demonstrates that NLH-MAC not only gives good control response, but also possesses good stability and robustness even with large modeling errors.
基金The author is infinitely thankful to his friend and colleague M.Rubinstein for valuable discussions and an invariable interest to his work.The author is also thankful to C.Miller for his high estimation of the author’s efforts.Of course,all errors are author’s full responsibility.
文摘Extensions of Merton’s model(EMM)considering the firm’s payments and generating new types of firm value distribution are suggested.In the open log-value/time space,these distributions evolve from initially normal to negatively skewed ones,and their means are concave-down functions of time.When payments are set to zero or proportional to the firm value,EMM turns into the Geometric Brownian model(GBM).We show that risk-neutral probabilities(RNPs)and the no-arbitraging principle(NAP)follow from GBM.When firm’s payments are considered,RNPs and NAP hold for the entire market for short times only,but for long-term investments,RNPs and NAP just temporarily hold for individual stocks as far as mean year returns of the firms issuing those stocks remain constant,and fail when the mean year returns decline.The developed method is applied to firm valuation to derive continuous-time equations for the firm present value and project NPV.
文摘The problem of guaranteed cost fuzzy controller is studied for a class of nonlinear time-delay neutral sys-tems with norm-bounded uncertainty based on T-S model. The sufficient conditions are first derived for the existenceof guaranteed cost fuzzy controllers. These sufficient conditions are equivalent to a kind of linear matrix inequalities.Furthermore, a convex optimization problem with LMI constraints is formulated to design the optimal guaranteedcost controller.
基金funded by National Natural Science Foundation of China(52004238)China Postdoctoral Science Foundation(2019M663561).
文摘Increasing the production and utilization of shale gas is of great significance for building a clean and low-carbon energy system.Sharp decline of gas production has been widely observed in shale gas reservoirs.How to forecast shale gas production is still challenging due to complex fracture networks,dynamic fracture properties,frac hits,complicated multiphase flow,and multi-scale flow as well as data quality and uncertainty.This work develops an integrated framework for evaluating shale gas well production based on data-driven models.Firstly,a comprehensive dominated-factor system has been established,including geological,drilling,fracturing,and production factors.Data processing and visualization are required to ensure data quality and determine final data set.A shale gas production evaluation model is developed to evaluate shale gas production levels.Finally,the random forest algorithm is used to forecast shale gas production.The prediction accuracy of shale gas production level is higher than 95%based on the shale gas reservoirs in China.Forty-one wells are randomly selected to predict cumulative gas production using the optimal regression model.The proposed shale gas production evaluation frame-work overcomes too many assumptions of analytical or semi-analytical models and avoids huge computation cost and poor generalization for numerical modelling.
基金The project supported in part by National Natural Science Foundation of China
文摘We investigated the neutral Higgs boson pair production at the CERN Large Hadron Collider (LHC) in the SM with four families. We found that the gluon-gluon fusion mode is the most dominant one in producing neutral Higgs boson pair at the LHC, and it can be used to probe the trilinear Higgs coupling. If the heavy quarks of the fourth generation really exist within the SM, they can manifest their effect on the cross section of the Higgs pair production process at the LHC. Our numerical results show that there will be neutral Higgs boson pair production events per year if the next generation heavy quarks really exist, while there will be only events produced per year if there are only three families in the SM.
基金The project supported by National Natural Science Foundation of China under Grant No. 10475113
文摘A general research on chiral symmetry restoring phase transitions at zero temperature and finite chemical potentials under electrical neutrality condition has been conducted in a Nambu-Jona-Lasinio model to describe twoflavor normal quark matter. Depending on whether mo/A, the ratio of dynamical quark mass in vacuum and the 3D momentum cutoff in the loop integrals, is less or greater than 0.413, the phase transition will be of the second or first order. A complete phase diagram of u quark chemical potential versus mo is given. With the electrical neutrality constraint, the region where the second order phase transition happens will be wider than the one without electrical neutrality limitation. The results also show that, for the value ofmo/A from QCD phenomenology, the phase transition must be of the first order.
基金supported by the National Social Science Foundation of China[Grant number.17BXW104]the Innorative School Project in Higher Education of Guangdong,China[Grant number.2016WZDXM025].
文摘China has paid considerable attention to developing and implementing a carbon labeling system in response to increasing environmental issues such as global warming.This paper aims to provide a theoretical basis for formulating and implementing a carbon labeling system in China through a study of consumer acceptance behavior and its influencing factors.This paper constructed an extended model of consumers’acceptance behavior of carbon neutral labels based on the theories and methods of Unified Theory of Acceptance and Use of Technology(UTAUT)and analyzed the effects of five factors(carbon label cognition,performance expectancy,effort expectancy,social influence,and facilitating factors)on consumer carbon neutral label acceptance and adoption.The structural equation model analysis revealed that carbon label cognition,performance expectancy,social influence,and facilitating factors significantly,and positively impact consumers’acceptance of carbon neutral labels.Moreover,carbon label cognition,performance expectancy,and facilitating factors significantly,and positively affect consumers’carbon neutral label adoption behavior.Meanwhile,carbon label cognition,and effort expectancy have no significant impact on consumers’willingness to accept carbon neutral labels,which in turn significantly impacts consumers’carbon neutral label adoption behavior.According to the research findings,increasing the promotion of carbon labeling and improving the practical strategies and management recommendations for carbon label design are proposed.