Background:Cervical cancer is the sixth most common cancer in Chinese women.A standard treatment modal?ity for cervical cancer is the combination of surgery,chemotherapy,external?beam radiotherapy and intracavitary br...Background:Cervical cancer is the sixth most common cancer in Chinese women.A standard treatment modal?ity for cervical cancer is the combination of surgery,chemotherapy,external?beam radiotherapy and intracavitary brachytherapy.The aim of this study was to retrospectively assess the long?term treatment outcomes of patients with cervical cancer who were treated with californium?252 neutron brachytherapy combined with external?beam radio?therapy plus concurrent chemotherapy.Methods:We retrospectively analyzed the medical records of 150 patients with primary stages IB?IVB cervical cancer who received neutron brachytherapy combined with external?beam radiotherapy concurrently with cisplatin chemo?therapy.All patients were followed up.Using an actuarial analysis,patient outcomes and treatment?related adverse effects were evaluated and compared.Results:The median overall survival(OS)was 33.2 months.The 3?year progression?free survival rates for patients with stages I–II,III,and IV diseases were 81.0%(68/84),65.0%(39/60),and 0%(0/6),respectively;the 3?year OS rates were 90.5%(76/84),85.0%(51/60),and 16.7%(1/6),respectively.Vaginal bleeding was controlled within the median time of4.0 days.One month after treatment,97.3%of patients achieved short?term local control.The local recurrence rates for patients with stages I–II,III,and IV disease were 4.8%(4/84),11.7%(7/60),and 33.3%(2/6),respectively,and the occurrence rates of distant metastasis were 16.7%(14/84),25.0%(15/60),and 100.0%(6/6),respectively.Cancer stage,tumor size,and lymph node metastasis were identified as prognostic risk factors,but only lymph node metastasis was found to be an independent prognostic factor.The most common adverse effects during treatment were grades 1 and 2 irradiation?related proctitis and radiocystitis.Conclusion:For patients with cervical cancer,neutron brachytherapy combined with external?beam radiotherapy plus concurrent chemotherapy produces a rapid response and greatly improves local control and long?term survival rates with tolerable adverse effects.展开更多
OBJECTIVE To observe the curative effects and complications of californium-252 (252Cf) neutron intraluminal brachytherapy (IBT) combined with external irradiation (El) for treatment of cervical carcinoma. METHODS From...OBJECTIVE To observe the curative effects and complications of californium-252 (252Cf) neutron intraluminal brachytherapy (IBT) combined with external irradiation (El) for treatment of cervical carcinoma. METHODS From December 2000 to December 2004, 128 cases of cervical carcinoma staged intoⅡA-ⅢB according to the International Federation of Gynecology and Obstetrics (FIGO) standards were treated with 2S2Cf neutron IBT using 8-10 Gy per fraction, once a week. The total dose at reference A point was 36-40 Gy in 4-5 fractions. From the second day after 252Cf neutron IBT treatment, the whole pelvic cavity was treated with 60Coγ-ray El, applying 2 Gy per fraction, 4 times per week. After 20-25 Gy of El, the center of the whole pelvic field was blocked with 4 cm of lead in width. The total dose of El was 45-50 Gy. RESULTS The short-term therapeutic effects were CR 95.3% and PR 4.7%. The 3 and 5-year local control rates were 93.5% and 87.9%. The overall 3-year survival rate was 87.5% and for StagesⅡandⅢ, 90.9% and 81.5% respectively; the overall 5-year survival rate was 70% and for StagesⅡandⅢ, 76.2% and 61% respectively. The rate of radiation complications was 4.7% for radiation cystitis, 7.8% for radiation proctitis, 6.3% for vagina contracture and adhesion and 5.5% for protracted radiation proctitis. CONCLUSION An combination of 252Cf neutron IBT with El for treatment of cervical carcinoma can be well -tolerated by cervical carcinoma patients. The rate of local tumor control is high and radiation complications are few.展开更多
This paper presents the calibration of a neutron dose rate meter and the evaluation of its calibration factors(CFs)in several neutron standard fields(i.e.,two standard fields with bare sources of252Cf and241Am-Be,and ...This paper presents the calibration of a neutron dose rate meter and the evaluation of its calibration factors(CFs)in several neutron standard fields(i.e.,two standard fields with bare sources of252Cf and241Am-Be,and five simulated workplace fields with241Am-Be moderated sources).The calibration in standard fields with bare sources was conducted by following the recommendations of the ISO 8529 standard.The measured total neutron ambient dose equivalent rates,denoted as H*(10)tot,were analyzed to obtain direct components,denoted as H*(10)dir,using a reduced fitting method.The CF was then calculated as the ratio between the conventional true value of the neutron ambient dose equivalent rate in a free field,denoted as H*(10)FF,and the value of H*(10)dir.In contrast,in the simulated workplace neutron fields,the calibration of the neutron dose rate meter was conducted by following the ISO 12789 standard.The CF was calculated as the ratio between the values of H*(10)totmeasured by a standard instrument(i.e.,Bonner sphere spectrometer)and the neutron dose rate meter.The CF values were obtained in the range of 0.88–1.0.The standard uncertainties(k=1)of the CFs were determined to be in the range of approximately 6.6–13.1%.展开更多
文摘Background:Cervical cancer is the sixth most common cancer in Chinese women.A standard treatment modal?ity for cervical cancer is the combination of surgery,chemotherapy,external?beam radiotherapy and intracavitary brachytherapy.The aim of this study was to retrospectively assess the long?term treatment outcomes of patients with cervical cancer who were treated with californium?252 neutron brachytherapy combined with external?beam radio?therapy plus concurrent chemotherapy.Methods:We retrospectively analyzed the medical records of 150 patients with primary stages IB?IVB cervical cancer who received neutron brachytherapy combined with external?beam radiotherapy concurrently with cisplatin chemo?therapy.All patients were followed up.Using an actuarial analysis,patient outcomes and treatment?related adverse effects were evaluated and compared.Results:The median overall survival(OS)was 33.2 months.The 3?year progression?free survival rates for patients with stages I–II,III,and IV diseases were 81.0%(68/84),65.0%(39/60),and 0%(0/6),respectively;the 3?year OS rates were 90.5%(76/84),85.0%(51/60),and 16.7%(1/6),respectively.Vaginal bleeding was controlled within the median time of4.0 days.One month after treatment,97.3%of patients achieved short?term local control.The local recurrence rates for patients with stages I–II,III,and IV disease were 4.8%(4/84),11.7%(7/60),and 33.3%(2/6),respectively,and the occurrence rates of distant metastasis were 16.7%(14/84),25.0%(15/60),and 100.0%(6/6),respectively.Cancer stage,tumor size,and lymph node metastasis were identified as prognostic risk factors,but only lymph node metastasis was found to be an independent prognostic factor.The most common adverse effects during treatment were grades 1 and 2 irradiation?related proctitis and radiocystitis.Conclusion:For patients with cervical cancer,neutron brachytherapy combined with external?beam radiotherapy plus concurrent chemotherapy produces a rapid response and greatly improves local control and long?term survival rates with tolerable adverse effects.
文摘OBJECTIVE To observe the curative effects and complications of californium-252 (252Cf) neutron intraluminal brachytherapy (IBT) combined with external irradiation (El) for treatment of cervical carcinoma. METHODS From December 2000 to December 2004, 128 cases of cervical carcinoma staged intoⅡA-ⅢB according to the International Federation of Gynecology and Obstetrics (FIGO) standards were treated with 2S2Cf neutron IBT using 8-10 Gy per fraction, once a week. The total dose at reference A point was 36-40 Gy in 4-5 fractions. From the second day after 252Cf neutron IBT treatment, the whole pelvic cavity was treated with 60Coγ-ray El, applying 2 Gy per fraction, 4 times per week. After 20-25 Gy of El, the center of the whole pelvic field was blocked with 4 cm of lead in width. The total dose of El was 45-50 Gy. RESULTS The short-term therapeutic effects were CR 95.3% and PR 4.7%. The 3 and 5-year local control rates were 93.5% and 87.9%. The overall 3-year survival rate was 87.5% and for StagesⅡandⅢ, 90.9% and 81.5% respectively; the overall 5-year survival rate was 70% and for StagesⅡandⅢ, 76.2% and 61% respectively. The rate of radiation complications was 4.7% for radiation cystitis, 7.8% for radiation proctitis, 6.3% for vagina contracture and adhesion and 5.5% for protracted radiation proctitis. CONCLUSION An combination of 252Cf neutron IBT with El for treatment of cervical carcinoma can be well -tolerated by cervical carcinoma patients. The rate of local tumor control is high and radiation complications are few.
基金by the National Foundation for Science and Technology Development of Vietnam(No.103.04-2017.37)。
文摘This paper presents the calibration of a neutron dose rate meter and the evaluation of its calibration factors(CFs)in several neutron standard fields(i.e.,two standard fields with bare sources of252Cf and241Am-Be,and five simulated workplace fields with241Am-Be moderated sources).The calibration in standard fields with bare sources was conducted by following the recommendations of the ISO 8529 standard.The measured total neutron ambient dose equivalent rates,denoted as H*(10)tot,were analyzed to obtain direct components,denoted as H*(10)dir,using a reduced fitting method.The CF was then calculated as the ratio between the conventional true value of the neutron ambient dose equivalent rate in a free field,denoted as H*(10)FF,and the value of H*(10)dir.In contrast,in the simulated workplace neutron fields,the calibration of the neutron dose rate meter was conducted by following the ISO 12789 standard.The CF was calculated as the ratio between the values of H*(10)totmeasured by a standard instrument(i.e.,Bonner sphere spectrometer)and the neutron dose rate meter.The CF values were obtained in the range of 0.88–1.0.The standard uncertainties(k=1)of the CFs were determined to be in the range of approximately 6.6–13.1%.
