AIM: To investigate the significance of the preoperative neutrophil-to-lymphocyte ratio(NLR) in the prognosis of patients with gastric cancer(GC). METHODS: The clinical data of 291 GC patients were analysed retrospect...AIM: To investigate the significance of the preoperative neutrophil-to-lymphocyte ratio(NLR) in the prognosis of patients with gastric cancer(GC). METHODS: The clinical data of 291 GC patients were analysed retrospectively; these patients were divided into two groups according to their preoperative NLR: a high-NLR group(NLR ≥ 3.5, 131 cases) and a low-NLR group(NLR < 3.5, 160 cases). The clinicopathological characteristics and five-year survival rates of the two groups were compared. The NLR and other clinicopathological factors were subjected to univariate and multivariate survival analysis to evaluate the effects of the NLR on the prognosis of GC patients. RESULTS: The lowest preoperative NLR among the 291 patients was 0.56, whereas the highest preoperative NLR was 74.5. The mean preoperative NLR was 5.99 ± 8.98. Age, tumour size, T staging, tumour-node-metastasis(TNM) staging and platelet count were significantly different between the highand low-NLR groups(P < 0.05). The five-year survival rate of the high-NLR group was 17.0%, which was significantly lower than that of the low-NLR group(43.6%; 17.0% vs 43.6%, P < 0.05). The univariate analysis results showed that the five-year survival rate was related to age, tumour size, T staging, N staging, TNM staging, carcinoembryonic antigen value and NLR(P < 0.05). Multivariate analysis results showed that the NLR was an independent risk factor that likely affected the five-year survival rate of GC patients(P = 0.003, HR = 0.626, 95%CI: 0.460-0.852). CONCLUSION: The preoperative NLR could be used as a prognostic factor for GC patients; in particular, a high NLR corresponded to poor prognosis of GC patients.展开更多
<strong>Introduction: </strong>Breast cancer had become top leading cause of death in Taiwan and endangered women’s health worldwide. Therefore, we try to invest the peripheral inflammatory cell counts an...<strong>Introduction: </strong>Breast cancer had become top leading cause of death in Taiwan and endangered women’s health worldwide. Therefore, we try to invest the peripheral inflammatory cell counts and neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) from our routine practice for the predictor of prognosis of breast cancer after resection. <strong>Patients and</strong> <strong>Methods: </strong>There were 574 breast cancer patients accepted surgical resection and registered in Cancer Registry Center of our hospital. Patient’s basic profiles, peripheral neutophil, lymphocyte and platelet count were measured for study. The scales of NLR and PLR were derived from the lower and higher normal range in cell count from neutrophil, lymphocyte and platelet respectively. Therefore, the scales for NLR and PLR were ≤1.62, 1.63 - 2.57, ≥2.58 and ≤224, 225 - 253, ≥254 respectively for analysis. <strong>Results: </strong>Poor 5-yr survival rate was found if higher cell counts of neutrophil and platelet (p ≤ 0.05). Three scales of NLR were ≤1.62, 1.63 - 2.57, ≥2.58, and their 5-year survival rates were 94%, 91% and 84% respectively (p = 0.019). In the subgroup of HER-2 (negative), and 3-Negative breast patients had a higher NLR of poor prognosis. But higher PLR was found less in 3-Negative and non in 3-Positive patients (p = 0.039). The PLR was ≤224, 225 - 253, ≥254 and their 5-year survival rates were 92%, 87%, and 64% respectively (p = 0.001);Multivariate Cox regression model for predictor of breast cancer patients who have 3.39 (PLR ≥ 254) and 2.45 (NLR ≥ 2.58 ) times risk (p = 0.02 and p = 0.002) of poor prognosis respectively. <strong>Conclusion: </strong>Peripheral inflammatory cell counts are easily to take in our clinical practice and have a potential role as predictors of prognosis. We have to pay attention to the trends of peripheral inflammatory cell count and their ratio in our clinical practice where possible.展开更多
目的研究24h血乳酸(Lac)清除率联合外周血中性粒细胞与淋巴细胞比值(NLR)、降钙素原(PCT)对重症监护病房(ICU)重症肺炎患者28 d病死风险的预测价值。方法回顾性选取2017年12月—2021年12月安徽皖北煤电集团总医院78例重症肺炎患者作为...目的研究24h血乳酸(Lac)清除率联合外周血中性粒细胞与淋巴细胞比值(NLR)、降钙素原(PCT)对重症监护病房(ICU)重症肺炎患者28 d病死风险的预测价值。方法回顾性选取2017年12月—2021年12月安徽皖北煤电集团总医院78例重症肺炎患者作为研究对象,根据28d临床结局将其分为病死组27例和存活组51例。比较两组的一般资料、24hLac清除率、NLR、PCT,采用多因素一般Logistic回归模型分析28d内病死的影响因素,采用受试者工作特征(ROC)曲线评估24hLac清除率联合NLR、PCT对28d内病死风险的预测价值。结果两组的性别、年龄、吸烟史、基础疾病、氧合指数、体温、平均动脉压、白细胞计数、血小板计数、抗菌药物使用时间比较,差异均无统计学意义(P>0.05);病死组肺炎严重程度评分(PSI)、急性生理学和慢性健康状况评价Ⅱ(APACHEⅡ)评分、机械通气治疗占比均高于存活组(P<0.05);病死组24 h Lac清除率低于存活组,NLR、PCT水平高于存活组(P<0.05);经多因素一般Logistic回归分析,PSI评分[O^R=9.440(95%CI:4.108,21.697)]、APACHEⅡ评分[O^R=3.904(95%CI:1.699,8.972)]、24 h Lac清除率[O^R=5.068(95%CI:2.205,11.648)]、NLR[O^R=8.199(95%CI:3.567,18.843)]、PCT[O^R=5.766(95%CI:2.509,13.252)]均为28 d内病死的影响因素(P<0.05);ROC曲线分析结果显示,24 h Lac清除率、NLR、PCT预测28 d内病死的最佳截断值为26.10%、5.95和11.27μg/L,敏感性为81.48%(95%CI:0.613,0.930)、59.26%(95%CI:0.390,0.770)、66.67%(95%CI:0.460,0.828),特异性为72.55%(95%CI:0.580,0.837)、82.35%(95%CI:0.686,0.911)、90.20%(95%CI:0.778,0.963),AUC值为0.809(95%CI:0.704,0.889)、0.736(95%CI:0.624,0.830)、0.802(95%CI:0.697,0.884),联合预测的敏感性为92.59%(95%CI:0.742,0.987)、特异性为86.27%(95%CI:0.731,0.938)、AUC值为0.946(95%CI:0.871,0.985)。结论ICU重症肺炎28 d内病死患者的24 h Lac清除率、NLR、PCT明显异常变化,其对预后评估具有良好预测价值。展开更多
基金Supported by Nanjing Science and Technology Project,No.201106016
文摘AIM: To investigate the significance of the preoperative neutrophil-to-lymphocyte ratio(NLR) in the prognosis of patients with gastric cancer(GC). METHODS: The clinical data of 291 GC patients were analysed retrospectively; these patients were divided into two groups according to their preoperative NLR: a high-NLR group(NLR ≥ 3.5, 131 cases) and a low-NLR group(NLR < 3.5, 160 cases). The clinicopathological characteristics and five-year survival rates of the two groups were compared. The NLR and other clinicopathological factors were subjected to univariate and multivariate survival analysis to evaluate the effects of the NLR on the prognosis of GC patients. RESULTS: The lowest preoperative NLR among the 291 patients was 0.56, whereas the highest preoperative NLR was 74.5. The mean preoperative NLR was 5.99 ± 8.98. Age, tumour size, T staging, tumour-node-metastasis(TNM) staging and platelet count were significantly different between the highand low-NLR groups(P < 0.05). The five-year survival rate of the high-NLR group was 17.0%, which was significantly lower than that of the low-NLR group(43.6%; 17.0% vs 43.6%, P < 0.05). The univariate analysis results showed that the five-year survival rate was related to age, tumour size, T staging, N staging, TNM staging, carcinoembryonic antigen value and NLR(P < 0.05). Multivariate analysis results showed that the NLR was an independent risk factor that likely affected the five-year survival rate of GC patients(P = 0.003, HR = 0.626, 95%CI: 0.460-0.852). CONCLUSION: The preoperative NLR could be used as a prognostic factor for GC patients; in particular, a high NLR corresponded to poor prognosis of GC patients.
文摘<strong>Introduction: </strong>Breast cancer had become top leading cause of death in Taiwan and endangered women’s health worldwide. Therefore, we try to invest the peripheral inflammatory cell counts and neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) from our routine practice for the predictor of prognosis of breast cancer after resection. <strong>Patients and</strong> <strong>Methods: </strong>There were 574 breast cancer patients accepted surgical resection and registered in Cancer Registry Center of our hospital. Patient’s basic profiles, peripheral neutophil, lymphocyte and platelet count were measured for study. The scales of NLR and PLR were derived from the lower and higher normal range in cell count from neutrophil, lymphocyte and platelet respectively. Therefore, the scales for NLR and PLR were ≤1.62, 1.63 - 2.57, ≥2.58 and ≤224, 225 - 253, ≥254 respectively for analysis. <strong>Results: </strong>Poor 5-yr survival rate was found if higher cell counts of neutrophil and platelet (p ≤ 0.05). Three scales of NLR were ≤1.62, 1.63 - 2.57, ≥2.58, and their 5-year survival rates were 94%, 91% and 84% respectively (p = 0.019). In the subgroup of HER-2 (negative), and 3-Negative breast patients had a higher NLR of poor prognosis. But higher PLR was found less in 3-Negative and non in 3-Positive patients (p = 0.039). The PLR was ≤224, 225 - 253, ≥254 and their 5-year survival rates were 92%, 87%, and 64% respectively (p = 0.001);Multivariate Cox regression model for predictor of breast cancer patients who have 3.39 (PLR ≥ 254) and 2.45 (NLR ≥ 2.58 ) times risk (p = 0.02 and p = 0.002) of poor prognosis respectively. <strong>Conclusion: </strong>Peripheral inflammatory cell counts are easily to take in our clinical practice and have a potential role as predictors of prognosis. We have to pay attention to the trends of peripheral inflammatory cell count and their ratio in our clinical practice where possible.
文摘目的研究24h血乳酸(Lac)清除率联合外周血中性粒细胞与淋巴细胞比值(NLR)、降钙素原(PCT)对重症监护病房(ICU)重症肺炎患者28 d病死风险的预测价值。方法回顾性选取2017年12月—2021年12月安徽皖北煤电集团总医院78例重症肺炎患者作为研究对象,根据28d临床结局将其分为病死组27例和存活组51例。比较两组的一般资料、24hLac清除率、NLR、PCT,采用多因素一般Logistic回归模型分析28d内病死的影响因素,采用受试者工作特征(ROC)曲线评估24hLac清除率联合NLR、PCT对28d内病死风险的预测价值。结果两组的性别、年龄、吸烟史、基础疾病、氧合指数、体温、平均动脉压、白细胞计数、血小板计数、抗菌药物使用时间比较,差异均无统计学意义(P>0.05);病死组肺炎严重程度评分(PSI)、急性生理学和慢性健康状况评价Ⅱ(APACHEⅡ)评分、机械通气治疗占比均高于存活组(P<0.05);病死组24 h Lac清除率低于存活组,NLR、PCT水平高于存活组(P<0.05);经多因素一般Logistic回归分析,PSI评分[O^R=9.440(95%CI:4.108,21.697)]、APACHEⅡ评分[O^R=3.904(95%CI:1.699,8.972)]、24 h Lac清除率[O^R=5.068(95%CI:2.205,11.648)]、NLR[O^R=8.199(95%CI:3.567,18.843)]、PCT[O^R=5.766(95%CI:2.509,13.252)]均为28 d内病死的影响因素(P<0.05);ROC曲线分析结果显示,24 h Lac清除率、NLR、PCT预测28 d内病死的最佳截断值为26.10%、5.95和11.27μg/L,敏感性为81.48%(95%CI:0.613,0.930)、59.26%(95%CI:0.390,0.770)、66.67%(95%CI:0.460,0.828),特异性为72.55%(95%CI:0.580,0.837)、82.35%(95%CI:0.686,0.911)、90.20%(95%CI:0.778,0.963),AUC值为0.809(95%CI:0.704,0.889)、0.736(95%CI:0.624,0.830)、0.802(95%CI:0.697,0.884),联合预测的敏感性为92.59%(95%CI:0.742,0.987)、特异性为86.27%(95%CI:0.731,0.938)、AUC值为0.946(95%CI:0.871,0.985)。结论ICU重症肺炎28 d内病死患者的24 h Lac清除率、NLR、PCT明显异常变化,其对预后评估具有良好预测价值。