Colorectal cancer(CRC)is a prevalent malignant tumor,with the global new cases reaching 1.9316 million and deaths reaching 935,200 in 2022.In China,therewere 555,500 new cases of CRC,with an age-standardized incidence...Colorectal cancer(CRC)is a prevalent malignant tumor,with the global new cases reaching 1.9316 million and deaths reaching 935,200 in 2022.In China,therewere 555,500 new cases of CRC,with an age-standardized incidence rate of 24.07 per 10million,and 286,200 deaths.China accounts for approximately 30%of new cases and deaths from CRC worldwide,with East Asia accounting for over 75%.Initially,CRC presents as local tumor growth,but it has the potential to spread to other body parts over time.Perineural infiltration(PNI)is a relatively less discussed route of diffusion,yet it plays a crucial role in the progression and prognosis of CRC.PNI often occurs alongside local lymph nodes and distant metastases,posing challenges for treatment and management.Clinical symptoms,radiographic findings,and histopathological examination can be used to diagnose PNI with skipmetastasis.Symptoms commonly include local pain,paresthesia,andmotor impairment.Imaging helps identify the mass’s location and relationship to nerves,whereas histopathological examination confirms the diagnosis.Treatment of PNI skipmetastases is similar to other CRC metastases,including surgical resection,chemotherapy,radiotherapy,and targeted therapy.Surgical resection is the primary therapeutic approach,but the wider range of metastasis in PNI skip transfer may limit its feasibility.In cases where surgical resection is not possible,chemotherapy,radiotherapy,and targeted therapy are used to control tumor metastasis.In conclusion,PNI skip metastases increase the risk of poor prognosis for CRC,requiring a comprehensive approach with multiple treatments to prevent disease progression.Early detection and treatment are vital to improving prognosis.展开更多
在多年的教学实践中,学生对反意疑问句总是掌握不好。所谓反意疑问句是由两个部分组成的。即由肯定陈述句加简略否定疑问句或否定陈述句加简略肯定疑问句构成的。在这类句子中,疑问部分的主语必须与陈述部分的主语在人称、数、性方面保...在多年的教学实践中,学生对反意疑问句总是掌握不好。所谓反意疑问句是由两个部分组成的。即由肯定陈述句加简略否定疑问句或否定陈述句加简略肯定疑问句构成的。在这类句子中,疑问部分的主语必须与陈述部分的主语在人称、数、性方面保持一致的人称代词。而且疑问部分的作用词一般也要与陈述部分的谓语动词保持人称、数、时态等方面的一致。例如:You are going to see a film,aren’t you?／The earth moves around the sun,doesn’t it?等等。在学生中认为反意疑问句难掌握主要是它的特殊句型。这些特殊的句型主要有:展开更多
Many years ago in India there lived a young couple. The young couplewanted a child very much, and when they finally had a male baby, theyloved him whole-heartedly.
文摘Colorectal cancer(CRC)is a prevalent malignant tumor,with the global new cases reaching 1.9316 million and deaths reaching 935,200 in 2022.In China,therewere 555,500 new cases of CRC,with an age-standardized incidence rate of 24.07 per 10million,and 286,200 deaths.China accounts for approximately 30%of new cases and deaths from CRC worldwide,with East Asia accounting for over 75%.Initially,CRC presents as local tumor growth,but it has the potential to spread to other body parts over time.Perineural infiltration(PNI)is a relatively less discussed route of diffusion,yet it plays a crucial role in the progression and prognosis of CRC.PNI often occurs alongside local lymph nodes and distant metastases,posing challenges for treatment and management.Clinical symptoms,radiographic findings,and histopathological examination can be used to diagnose PNI with skipmetastasis.Symptoms commonly include local pain,paresthesia,andmotor impairment.Imaging helps identify the mass’s location and relationship to nerves,whereas histopathological examination confirms the diagnosis.Treatment of PNI skipmetastases is similar to other CRC metastases,including surgical resection,chemotherapy,radiotherapy,and targeted therapy.Surgical resection is the primary therapeutic approach,but the wider range of metastasis in PNI skip transfer may limit its feasibility.In cases where surgical resection is not possible,chemotherapy,radiotherapy,and targeted therapy are used to control tumor metastasis.In conclusion,PNI skip metastases increase the risk of poor prognosis for CRC,requiring a comprehensive approach with multiple treatments to prevent disease progression.Early detection and treatment are vital to improving prognosis.
文摘在多年的教学实践中,学生对反意疑问句总是掌握不好。所谓反意疑问句是由两个部分组成的。即由肯定陈述句加简略否定疑问句或否定陈述句加简略肯定疑问句构成的。在这类句子中,疑问部分的主语必须与陈述部分的主语在人称、数、性方面保持一致的人称代词。而且疑问部分的作用词一般也要与陈述部分的谓语动词保持人称、数、时态等方面的一致。例如:You are going to see a film,aren’t you?／The earth moves around the sun,doesn’t it?等等。在学生中认为反意疑问句难掌握主要是它的特殊句型。这些特殊的句型主要有:
文摘Many years ago in India there lived a young couple. The young couplewanted a child very much, and when they finally had a male baby, theyloved him whole-heartedly.
