Construction of the underlying circRNA-miRNA-mRNA regulatory network and a new diagnostic model in ulcerative colitis by bioinformatics analysis

BACKGROUND Circular RNAs(circRNAs)are involved in the pathogenesis of many diseases through competing endogenous RNA(ceRNA)regulatory mechanisms.AIM To investigate a circRNA-related ceRNA regulatory network and a new predictive model by circRNA to understand the diagnostic mechanism of circRNAs in ulcerative colitis(UC).METHODS We obtained gene expression profiles of circRNAs,miRNAs,and mRNAs in UC from the Gene Expression Omnibus dataset.The circRNA-miRNA-mRNA network was constructed based on circRNA-miRNA and miRNA-mRNA interactions.Functional enrichment analysis was performed to identify the biological mechanisms involved in circRNAs.We identified the most relevant differential circRNAs for diagnosing UC and constructed a new predictive nomogram,whose efficacy was tested with the C-index,receiver operating characteristic curve(ROC),and decision curve analysis(DCA).RESULTS A circRNA-miRNA-mRNA regulatory network was obtained,containing 12 circRNAs,three miRNAs,and 38 mRNAs.Two optimal prognostic-related differentially expressed circRNAs,hsa_circ_0085323 and hsa_circ_0036906,were included to construct a predictive nomogram.The model showed good discrimination,with a C-index of 1(>0.9,high accuracy).ROC and DCA suggested that the nomogram had a beneficial diagnostic ability.CONCLUSION This novel predictive nomogram incorporating hsa_circ_0085323 and hsa_circ_0036906 can be conveniently used to predict the risk of UC.The circRNa-miRNA-mRNA network in UC could be more clinically significant.

Electromechanical Transient Modeling Analysis of Large-Scale New Energy Grid Connection

The synchronous virtual machine uses inverter power to imitate the performance of the conventional synchronous machine.It also has the same inertia,damping,frequency,voltage regulation,and other external performance as the generator.It is the key technology to realize new energy grid connections’stable and reliable operation.This project studies a dynamic simulation model of an extensive new energy power system based on the virtual synchronous motor.A new energy storage method is proposed.The mathematical energy storage model is established by combining the fixed rotor model of a synchronous virtual machine with the charge-discharge power,state of charge,operation efficiency,dead zone,and inverter constraint.The rapid conversion of energy storage devices absorbs the excess instantaneous kinetic energy caused by interference.The branch transient of the critical cut set in the system can be confined to a limited area.Thus,the virtual synchronizer’s kinetic and potential energy can be efficiently converted into an instantaneous state.The simulation of power system analysis software package(PSASP)verifies the correctness of the theory and algorithm in this paper.This paper provides a theoretical basis for improving the transient stability of new energy-connected power grids.

Study on the Construction and Evaluation System of Clinical Midwifery Teaching Faculty under the New Nursing Model

Objective:To explore the impact of the construction of a clinical midwifery teaching faculty and the development of an evaluation system under the new nursing model on the current teaching quality.Methods:From July 2022 to March 2023,10 clinical teaching teachers and 20 midwifery interns from Beijing Anzhen Hospital affiliated with Capital Medical University were selected as the subjects of this study.The clinical teaching teachers and midwifery interns were divided into an observation group and a control group,with each group including 5 clinical teaching teachers and 10 midwifery interns.The observation group received daily management and evaluation under the new nursing model,while the control group received management and evaluation under the traditional nursing model.The teaching quality evaluation of clinical midwifery teaching teachers by midwifery interns,the exit exam scores of midwifery interns,and the scores of clinical teaching teachers’internship lectures and teaching rounds were compared between the two groups.Results:In the observation group,the scores for teaching attitude,teaching skills,and teaching management in the teaching quality evaluation of clinical midwifery teaching teachers were higher than those in the control group.The professional theory scores(91.28±3.64)and overall nursing comprehensive scores(92.56±4.38)of midwifery interns in the observation group were higher than those of midwifery interns in the control group(81.58±2.27 and 80.29±3.33,respectively).The scores for internship lectures(89.32±4.15)and teaching rounds(90.64±5.52)in the observation group were also significantly higher than those in the control group(80.46±3.28 and 81.24±4.38,respectively),and the differences were statistically significant(P<0.05).Conclusion:The management of the clinical midwifery teaching faculty under the new nursing model effectively improved the quality of clinical teaching.It significantly enhanced the teaching effectiveness of clinical teaching teachers and the proficiency of midwifery interns in clinical operations,making it worthy of promotion and use.

Economic Analysis and Research of New Energy Vehicle Promotion Model

New energy vehicles represent the inevitable trend of future development.Compared to traditional fuel vehicles,they are more energy-saving and environmentally friendly,effectively reducing air pollution and mitigating excessive exploitation of oil resources,a stance strongly supported by governments.However,new energy vehicles possess certain drawbacks in terms of price and usability compared to traditional counterparts.Therefore,external support is imperative for their development.This paper delineates four main sections:the background of new energy vehicle promotion and application,a comparative analysis of domestic and foreign promotion models,specific promotion suggestions,and future development prospects.By leveraging insights from economic analysis,the optimal promotion model for new energy vehicles is elucidated.

Exploration on New Campus Courier Service Models

Recently,e-commerce develops rapidly,advancing express delivery services,but the whole logistics are incomplete,especially for the issue of ＂the last one-kilometer ＂.For example,the research reviewed status quo and problems of Tianjin Agricultural University and made improvements on campus delivery services to explore the status quo and resolving ways,exploit the hint business opportunity in campus express model,improve efficiency and service attitude and get doublewin of both parties involved.

New lumped-mass-stick model based on modal characteristics of structures: development and application to a nuclear containment building

In this study, a new lumped-mass-stick model （LMSM） is developed based on the modal characteristics of a structure such as eigenvalues and eigenvectors. The simplified model, named the ＂frequency adaptive lumped-massstick model,＂ hasonly a small number of stick elements and nodes to provide the same natural frequencies of the structure and is applied to a nuclear containment building. To investigate the numerical performance of the LMSM, a time history analysis is carried out on both the LMSM and the finite element model （FEM） for a nuclear containment building. A comparison of the results shows that the dynamic responses of the LMSM in terms of displacement and acceleration are almost identical to those of the FEM. In addition, the results in terms of floor response spectra at certain elevations are also in good agreement.

Sodium iodate induced retinal degeneration: new insights from an old model

Studies on the selective retinal degeneration induced by sodium iodate （NaIO3） date back to 1941; Sorsby （1941） described the effect of intravenously injected NaIO3 solution on the rabbit retina. Since then, NaIO3-induced retinal degeneration has been described in different mammalian species including sheep, rabbit, rat and mouse with varying doses and routes of administration. At the present time,

A new expansion method of first order nonlinear ordinary differential equation with at most a sixth-degree nonlinear term and its application to mBBM model

Based on a first order nonlinear ordinary differential equation with at most a sixth-degree nonlinear term which is extended from a type of elliptic equation, and by converting it into a new expansion form, this paper proposes a new algebraic method to construct exact solutions for nonlinear evolution equations. Being concise and straightforward, the method is applied to modified Benjamin-Bona-Mahony （mBBM） model, and some new exact solutions to the system are obtained. The algorithm is of important significance in exploring exact solutions for other nonlinear evolution equations.

New Method of Total Ionizing Dose Compact Modeling in Partially Depleted Silicon-on-Insulator MOSFETs

On the basis of a detailed discussion of the development of total ionizing dose （TID） effect model, a new commercial-model-independent TID modeling approach for partially depleted silicon-on-insulator metal-oxide- semiconductor field effect transistors is developed. An exponential approximation is proposed to simplify the trap charge calculation. Irradiation experiments with 60Co gamma rays for IO and core devices are performed to validate the simulation results. An excellent agreement of measurement with the simulation results is observed.

A New Example of Retrograde Solubility Model for Carbonate Rocks

Objective The dissolution and precipitation of carbonate during burial diagenetic process controls the reservoir property in deep buried strata. The geological process related with it has become a research focus during recent years. The most important dissolution fluids to carbonates are probably H2S and CO2 as byproducts of sulfate reduction in deep-buried setting with sulfate minerals, but carbonates are more soluble in relatively low temperature, which is the so-called retrograde solubility. Several geological processes can result in the decrease of temperature, including the upward migration of thermal fluids and tectonic uplift.

THE EXACT ANALYTICAL SOLUTIONS TO THE NEW MODEL OF RESERVOIR FILTRATION PROBLEM

The present study has obtained the new model of the reservoir filtration problem by taking into account the effect of wellbore storage and skin and by making use of the coupled equations of doubled porous media filtration and consequently has got, through various forms of limits, the exact analytical solutions of the three common reservoirs (fissure, homogeneous and the two-layered) pressure distribution under the conditions of three boundaries, i.e., infinite boundary, sealed finite boundary and the finite boundary at constant pressures.

Selection of New Countryside Construction Model and Enlightenment for Ganlu Town, Zizhong County, Neijiang City

Basic conditions and new countryside construction of Ganlu Town, Zizhong County, Neijiang City were analyzed, SWOT adopted to analyze internal strengths, weaknesses, external opportunities and threats of its new countryside construction. On this basis, positive and practical strategies were put forward to promote the new countryside construction in the local area, and provide references for the new countryside construction in other regions.

Probing the Lightest New Gauge Boson BH in the Littlest Higgs Model via Processes γγ→f■B_H at ILC

The neutral gauge boson BH with the mass of hundreds GeV is the lightest particle predicted by the littlest Higgs （LH） model, and such particle should be the first signal of the LH model at the planed ILC if it exists indeed. In this paper, we study some processes of the BH production associated with the fermion pair at the ILC, i.e., γγ→ ff^- BH. The studies show that the most promising processes to detect BH amongγγ→ ff^- BH are γγ→ l＇^＋l＇^-BH （l＇ = e,μ）, and they can produce the sufficient signals in most parameter space preferred by the electroweak precision data at the ILC. On the other hand, the signal produced via the certain BH decay modes is typical and such signal can be easily identified from the SM background. Therefore, BH, the lightest gauge boson in the LH model, would be detectable at the photon collider realized at the ILC.

New Developments on Existence and Uniqueness of Solutions to Some Models in Atmospheric Dynamics

This survey is concerned with the new developments on existence and uniqueness of solutions of some basic models in atmospheric dynamics, such as two-and three-dimensional quasi-geostrophic models and three-dimensional balanced model. The main aim of this paper is to introduce some results about the global and local (with respect to time) existence of solutions given by the authors in recent years, but others' important contributions and the literature on this subject are also quoted. We discuss briefly the relationships among the existence and uniqueness, physical instability and computational instability. In the appendixes, some key mathematical techniques in obtaining our results are presented, which are of vital importance to other problems in geophysical fluid dynamics as well.

A New Model for Correlation between the Marine Benthic Oxygen Isotope and Red Clay Magnetic Susceptibility on the Chinese Loess Plateau

Objective Aeolian sediments on the Chinese Loess Plateau contain some of the best continental archives of palaeoclimate change in the Late Cenozoic. The consensus that alternating MS in loess-paleosols in China was due to the strengthening and weakening of the East Asian palaeomonsoon provides an excellent climate record when correlated with global ice volume. Significantly, new basal dates from the red clay underlying the loess-paleosol sequence indicate that wind-blown dust began to accumulate on the Chinese Loess Plateau at least 22 million years ago. There are differences of opinion,

Teaching Model Integrating Online and Offline in Real Time ——An Exploration of New Teaching Mode for Regular Epidemic Prevention and Control

During epidemic,students in medium-risk or high-risk areas are unable to return to school on time.In response to this new challenge,there is an urgent need to create a new teaching mode to offer on-line courses to those absent from the offline classes,and we propose a model integrating online and offline teaching.It is based on“dual-camera”method,which allows off-campus students to virtually build up a physical classroom scenario on campus through computers and mobile phones.Using this model,students can participate in class remotely.In order to enhance the engagement of off-campus online students,emphasis is placed on interactive teaching.Teachers are required to design their teaching in advance and to work in collaboration with multiple departments,then using information technology and suitable teaching methods to enable students to participate in physical classroom teaching.This model has been tested in practice and has been successful in meeting the challenges.Finally,4 areas for improvement and refinement are identified.

Rheological Behaviour for Polymer Melts and Concentrated Solutions Part Ⅰ:A New Multiple Reptation Model to Predict the Nonlinear Visco-elasticity with Nagai Chain Constraints in Entangled Polymer Melts

An approach of stochastically statistical mechanics and a unified molecular theory of nonlinear viscoelasticity with constraints of Nagai chain entanglement for polymer melts have been proposed. A multimode model structure for a single polymer chain with n tail segments and N reversible entanglement sites on the test polymer chain is developed. Based on the above model structure and the mechanism of molecular flow by the dynamical reorganization of entanglement sites, the probability distribution function of the end-to-end vectr for a single polymer chain at entangled state and the viscoelastic free energy of deformation for polymer melts are calculated by using the method of the stochastically statistical mechanics. The four types of stress-strain relation and the memory function are derived from this thery. The above theoretical relations are verified by the experimentaf data for various polymer melts. These relations are found to be in good agreement with the experimental results

New Model of Predicting Remaining Recoverable Reserves and Application in the Oilfield

As a significant inducement during the development of oil and gas,the role of remaining recoverable reserves is more observable especially in the later phase of development of oilfield.Depended on the production decline method in petroleum reservoir engineering,a new model of predicting recoverable and remaining recoverable reserves has been

New initial condition of the new agegraphic dark energy model

The initial condition Ωde（zini）=n^2（1＋zini）^-2/4 at zini = 2000,widely used to solve the differential equation of the density of the new agegraphic dark energy（NADE） Ωde,makes the NADE model a single-parameter dark-energy cosmological model.However,we find that this initial condition is only applicable in a flat universe with only dark energy and pressureless matter.In fact,in order to obtain more information from current observational data,such as the cosmic microwave background（CMB） and the baryon acoustic oscillations（BAO）,we need to consider the contribution of radiation.For this situation,the initial condition mentioned above becomes invalid.To overcome this shortcoming,we investigate the evolutions of dark energy in matter-dominated and radiation-dominated epochs,and obtain a new initial condition de（zini）=n2（1＋zini）-2（1＋F（zini））2/4 at z ini = 2000,where F（z）≡Ωr0（1＋z）/[Ωm0＋Ωr0（1＋z）] with Ωr0 and Ωm0 being the current density parameters of radiation and pressureless matter,respectively.This revised initial condition is applicable for the differential equation of Ωde obtained in the standard Friedmann-Robertson-Walker（FRW） universe with dark energy,pressureless matter,radiation,and even spatial curvature,and can still keep the NADE model as a single-parameter model.With the revised initial condition and the observational data of type Ia supernova（SNIa）,CMB,and BAO,we finally constrain the NADE model.The results show that the single free parameter n of the NADE model can be constrained tightly.