AIM To evaluate the outcomes in biological treatment and quality of life of psoriatic patients with chronic hepatitis C(CHC) treated with new Direct-Acting Antiviral agents(DAAs) compared to pegylated interferon-2α p...AIM To evaluate the outcomes in biological treatment and quality of life of psoriatic patients with chronic hepatitis C(CHC) treated with new Direct-Acting Antiviral agents(DAAs) compared to pegylated interferon-2α plus ribavirin(P/R) therapy.METHODS This is a retrospective study involving psoriatic patients in biological therapy who underwent anti-hepatitis C virus(HCV) treatment at the Department of Dermatology Galeazzi Orthopaedic Institute Milan, Italy from January 2010 to November 2017. The patients were divided into two groups: patients that underwent therapy with DAAs and patients that underwent HCV treatment with P/R. Patients were assessed by a dermatologist for psoriasis symptoms, collecting Psoriasis Area Severity Index(PASI) scores and the Dermatology Quality of Life Index(DLQI). PASI and DLQI scores were evaluated 24 wk after the end of HCV treatment and were assumed as an outcome of the progression of psoriasis. Switching to a different b DMARD was considered as an inadequate response to biological therapy. The dropout of HCV therapy and sustained virological response(SVR) were considered as outcomes of HCV therapy.RESULTS Fifty-nine psoriatic patients in biological therapy underwent antiviral therapy for CHC. Of this, 27 patients were treated with DAAs and 32 with P/R. After 24 wk post treatment, the DLQI and the PASI scores were significantly lower(P < 0.001 and P < 0.005, respectively) in the DAAs group compared with P/R group. None of the patients in the DAAs group(0/27) compared to 8 patients of the P/R group(8/32) needed a shift in biological treatment.CONCLUSION DAAs seem to be more effective and safe than P/R in HCV-positive psoriatic patients on biological treatment. Fewer dermatological adverse events may be due to interferon-free therapy.展开更多
Through carefully studying the theory of speech acts and the literature concerning it,the author made some new findings which reflects in three aspects:the similarities and differences in Chinese and English in expres...Through carefully studying the theory of speech acts and the literature concerning it,the author made some new findings which reflects in three aspects:the similarities and differences in Chinese and English in expressing the same speech act,the relations between different types of speech acts and the correspondence between sentence sets and sets of speech acts.展开更多
Cyberterrorism poses a significant threat to the national security of the United States of America (USA), with critical infrastructure, such as commercial facilities, dams, emergency services, food and agriculture, he...Cyberterrorism poses a significant threat to the national security of the United States of America (USA), with critical infrastructure, such as commercial facilities, dams, emergency services, food and agriculture, healthcare and public health, and transportation systems virtually at risk. Consequently, this is due primarily to the country’s heavy dependence on computer networks. With both domestic and international terrorists increasingly targeting any vulnerabilities in computer systems and networks, information sharing among security agencies has become critical. Cyberterrorism can be regarded as the purest form of information warfare. This literature review examines cyberterrorism and strategic communications, focusing on domestic cyberterrorism. Notable themes include the meaning of cyberterrorism, how cyberterrorism differs from cybercrime, and the threat posed by cyberterrorism to the USA. Prevention and deterrence of cyberterrorism through information sharing and legislation are also key themes. Finally, gaps in knowledge are identified, and questions warranting additional research are outlined.展开更多
文摘AIM To evaluate the outcomes in biological treatment and quality of life of psoriatic patients with chronic hepatitis C(CHC) treated with new Direct-Acting Antiviral agents(DAAs) compared to pegylated interferon-2α plus ribavirin(P/R) therapy.METHODS This is a retrospective study involving psoriatic patients in biological therapy who underwent anti-hepatitis C virus(HCV) treatment at the Department of Dermatology Galeazzi Orthopaedic Institute Milan, Italy from January 2010 to November 2017. The patients were divided into two groups: patients that underwent therapy with DAAs and patients that underwent HCV treatment with P/R. Patients were assessed by a dermatologist for psoriasis symptoms, collecting Psoriasis Area Severity Index(PASI) scores and the Dermatology Quality of Life Index(DLQI). PASI and DLQI scores were evaluated 24 wk after the end of HCV treatment and were assumed as an outcome of the progression of psoriasis. Switching to a different b DMARD was considered as an inadequate response to biological therapy. The dropout of HCV therapy and sustained virological response(SVR) were considered as outcomes of HCV therapy.RESULTS Fifty-nine psoriatic patients in biological therapy underwent antiviral therapy for CHC. Of this, 27 patients were treated with DAAs and 32 with P/R. After 24 wk post treatment, the DLQI and the PASI scores were significantly lower(P < 0.001 and P < 0.005, respectively) in the DAAs group compared with P/R group. None of the patients in the DAAs group(0/27) compared to 8 patients of the P/R group(8/32) needed a shift in biological treatment.CONCLUSION DAAs seem to be more effective and safe than P/R in HCV-positive psoriatic patients on biological treatment. Fewer dermatological adverse events may be due to interferon-free therapy.
文摘Through carefully studying the theory of speech acts and the literature concerning it,the author made some new findings which reflects in three aspects:the similarities and differences in Chinese and English in expressing the same speech act,the relations between different types of speech acts and the correspondence between sentence sets and sets of speech acts.
文摘Cyberterrorism poses a significant threat to the national security of the United States of America (USA), with critical infrastructure, such as commercial facilities, dams, emergency services, food and agriculture, healthcare and public health, and transportation systems virtually at risk. Consequently, this is due primarily to the country’s heavy dependence on computer networks. With both domestic and international terrorists increasingly targeting any vulnerabilities in computer systems and networks, information sharing among security agencies has become critical. Cyberterrorism can be regarded as the purest form of information warfare. This literature review examines cyberterrorism and strategic communications, focusing on domestic cyberterrorism. Notable themes include the meaning of cyberterrorism, how cyberterrorism differs from cybercrime, and the threat posed by cyberterrorism to the USA. Prevention and deterrence of cyberterrorism through information sharing and legislation are also key themes. Finally, gaps in knowledge are identified, and questions warranting additional research are outlined.
