New cheaper human papilloma virus mass screening strategy reduces cervical cancer incidence in Changsha city:A clinical trial

BACKGROUND Cervical cancer is the second leading cause of death in women worldwide,second only to breast cancer.Around 80%of women have been infected with human papillomavirus(HPV)in their lifetime.Early screening and treatment are effective means of preventing cervical cancer,but due to economic reasons,many parts of the world do not have free screening programs to protect women’s health.AIM To increase HPV cervical cancer screening in Changsha and reduce the incidence of cervical cancer.METHODS Cervical cancer screening included gynecological examination,vaginal secretion examination and HPV high-risk typing testing.Cervical cytology examination(ThinPrep cytology test)was performed for individuals who test positive for HPV types other than 16 and 18.Vaginal colposcopy examination was performed for HPV16 and 18 positive individuals,as well as for those who were positive for ThinPrep cytology test.If the results of vaginal colposcopy examination were abnormal,histopathological examination was performed.We conducted a cost-benefit analysis after 4 years.RESULTS From 2019 to 2022,523437 women aged 35-64 years in Changsha city were screened and 73313 were positive,with a 14%positive rate.The detection rate of precancerous lesions of cervical cancer was 0.6%and the detection rate of cervical cancer was 0.037%.Among 311212 patients who underwent two cancers examinations,the incidence rate was reduced by more than half in the second examination.The average screening cost per woman was 120 RMB.The average cost of detecting early cases was 10619 RMB,with an early detection cost coefficient of 0.083.CONCLUSION Our screening strategy was effective and cost-effective,making it valuable for early diagnosis and treatment of cervical cancer.It is worth promoting in economically limited areas.

Entrepreneurial Spirit for China in the New Era and Strategies for Cultivation

What type of entrepreneurial spirit is needed for China’s new era,and how can we unlock its innovation potential?Answers to these questions will unleash vital forces to drive China’s high-quality economic development.After reviewing the theories,dimensions,features,and limitations of the entrepreneurial spirit in the Western context,we concluded that the entrepreneurial spirit in China’s new era,which is characterized by patriotism,innovation,trustworthiness,adherence to the law,fulfillment of social responsibilities,and a global horizon,has overcome the limitations that come with self-interested entrepreneurship in the context of Western economics.This is a major step forward in the development of theories on entrepreneurial spirit.In the development context of the new era,this paper argues that the entrepreneurial spirit should become an important force at the individual level to implement the new development concept,foster the new development paradigm,and promote high-quality development in the new stage.This paper provides answers to the question of what type of entrepreneurial spirit China’s new era requires.Finally,this paper presents basic strategies for cultivating entrepreneurial spirit in the context of China’s new era,emphasizing the importance to promote the healthy growth of young entrepreneurs,ensure their business autonomy,develop a multi-tiered capital market,implement the factor market reforms,improve the business climate,and accelerate the digital transition.

Research on the Education Strategy of College Students’Career Planning in the New Era

Career planning is the key educational content for college students,which is related to students’career choices and future development after graduation.However,there are some common problems related to career planning among college students.At the same time,career planning education itself fails to break through the limitations of traditional education,which,to some extent,hinders the future development planning of college students.Based on this,schools should actively introduce advanced education methods in the new era,combine the characteristics of college students on the basis of summarizing the previous planning experience in education,constantly improve and innovate the content and form of career planning education,promote the improvement of college students’education,and enhance the quality of education.

Innovative Research on Enterprise Marketing Strategies under the Background of New Media

Marketing is one of the comprehensive development strategies for production-oriented and service-oriented enterprises, and it is also an effective path to increase income and revenue for enterprises. By operating and selling the main products, services, cultural concepts, and many more of the enterprise in a market-oriented manner. We aim to deepen the impression of the enterprise among consumers, enhance its market influence, and seek more opportunities for cooperation and development for the enterprise. However, with increasingly fierce market competition, traditional marketing models are no longer able to maximize their effectiveness. This article firstly analyzes the positive impact of new media background on enterprise marketing in expanding the scope of information release, improving marketing targeting, and creating new marketing platforms. Secondly, it explores the problems faced by enterprises in the current marketing process, such as outdated ideological concepts, insufficient team building, and rigid marketing content. Finally, strategies such as updating marketing concepts, strengthening team building, and innovating marketing content were proposed to provide some reference and inspiration for enterprises to smoothly promote marketing work under the background of new media.

Innovative Strategies for Financial Investment Management Strategies of Enterprises in the New Era

With the in-depth development of economic globalization and the continuous emergence of new technologies,the importance of enterprise financial investment management strategy is becoming more and more prominent.The traditional financial investment management strategy can no longer meet the needs of enterprises in the new era and needs to be innovated with the times.For enterprises,the effectiveness and scientificity of financial investment management strategy will directly affect the competitiveness and long-term development of enterprises.Therefore,this study chooses the innovation based on the financial investment management strategy of enterprises in the new era as the research theme,aiming at exploring the innovative strategy to adapt to the needs of enterprises in the new era.

Analysis of Innovative Paths for Enterprise Marketing Management Development Strategy under the Background of New Media

From the perspective of enterprise marketing strategy planning,innovative research should be conducted based on the current trends in new media.The findings should be applied to practical activities within enterprises to achieve innovation in marketing strategy decision-making in the new media environment.Enterprises should adopt advanced communication transmission technologies and big data processing capabilities to effectively leverage the hidden value and promotional planning advantages of network media platforms.This approach can enhance customer loyalty and increase demand for new products.Enterprises should integrate into the continuously evolving new media landscape,explore their potential business characteristics,and innovate promotional methods.By effectively combining product information with digital media content,companies can ultimately achieve significant increases in corporate interests.

Intelligent Network-Connected New Energy Vehicle Technology and Application Under the Dual-Carbon Strategy

In responding to the“dual carbon”strategy,intelligent networked new energy vehicle technology plays a crucial role.This type of vehicle combines the advantages of new energy technology and intelligent network technology,effectively reduces carbon emissions in the transportation sector,improves energy utilization efficiency,and contributes to the green transportation system through intelligent transportation management and collaborative work between vehicles,making significant contributions.This article aims to explore the development of intelligent network-connected new energy vehicle technology and applications under the dual-carbon strategy and lay the foundation for the future development direction of the automotive industry.

Land Use Situation and Strategies under the Background of New Urbanization in Yunnan Province

Scientific analysis and determination of land use lays foundation for regional sustainable development under the background of new urbanization. The research made a comprehensive analysis on land uses in Yunnan under the background of urbanization and proposed strategies for further development, providing references for land uses scientific decision making.

New strategies against drug resistance to herpes simplex virus

Herpes simplex virus （HSV）, a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir （ACV） and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets （the DNA helicase/primase （H/P） complex）, new types of molecules （nature products） and new antiviral mechanisms （lethal mutagenesis of Janus-type nucleosides） to fight the drug resistance of HSV.

Analysis of new therapeutic strategies for diabetes mellitus based on traditional Chinese medicine'xiaoke'formulae

Objective:To develop new therapeutic strategies for diabetes mellitus(DM)by analyzing the mechanisms of action of traditional Chinese medicine(TCM)'xiaoke'formulae(TCM prescriptions for remedying xiaoke).Methods:We characterized 291 xiaoke formulae,including the herbs contained,chemical composition,constituents'targets,and corresponding genes.Xiaoke-related genes were retrieved based on the relationships of constituents'targets and xiaoke formulae,and a threshold of over 95.88%occurrence of each constituent target in the 291 TCM formulae served as a definition for xiaoke-related genes.Upon comparison with DM-related genes in the DisGeNET database,the genes differing in expression between cases administered TCM and synthetic drugs were explored using a TCM grammar system.Results:The results showed that xiaoke formulae and 14 exclusively xiaoke-related genes were significantly associated with multiple biological processes closely related to DM and diabetic complications(P<.01).Moreover,intervention in the expression of these xiaoke-related genes would affect DM-related genes directly or indirectly.Conclusion:The 14 xiaoke-related genes APEX1,EHMT2,TSHR,CBX1,FEN1,GMNN,JUN,KMT2A,MAPT,POLl,USP1,PIN1,POLB,and POLK can serve as candidate genes for antidiabetic drug design.Compared with DM-related genes in DisGeNET,intervention in the expression of 14 xiaoke-related genes by TCM formulae has the potential to not only lower blood glucose,but also reduce the occurrence of some side effects and inhibit the development of diabetic complications.These findings will contribute to the discovery of new strategies for treating DM.

Ecological and Environmental Protection Requirements in China s Regional Coordinated Development Strategy in the New Era

Starting from the historical evolution of China s regional coordinated development policy and practice,three stages of"enlightenment stage","development stage"and"maturity stage",as well as the connotation,characteristics and content of implementing regional coordinated development strategy were analyzed.On this basis,from different aspects of industrial distribution,pollutant characteristics and regional environmental protection policy,the existing ecological and environmental protection problems in China s regional coordinated development in the new era were analyzed,and some suggestions for the next step were put forward.It is necessary to follow the"four ones"concept from the overall point of view,implement"three lines and one list"from the perspective of the width of the access red line,strengthen"joint prevention and control"from the perspective of the depth of regional regulation,deepen the"planning environmental impact assessment"from the perspective of the breadth of industrial distribution,and promote the"green-way model"from the perspective of ecological low carbon.

On Narrative Strategies Embodied in The Known World under New Historical Perspective

With the multiple clues, rambling narrative and multidimensional architecture, Jones, in The Known World, constructs a fairly layered, three-dimensional world and presents a panorama of the entire slave society. The so-called mongline History before is decomposed into a number of linear histories, and history which was non-narrative and non-representational is dismantled into histories narrated by many single narrators. Cultural discourse and historical discourse blend together. Jones shares the same conception on history and literature with New Historical critics who emphasize the complex mix-and-match interaction between history and text.

Research on Modular Manufacture Strategy under New Economic Circumstance

Modularity can simplify the process of complex product design and manufacture effectively,and it can also optimize the supply resource to satisfy the customization needs of customers,which has aroused more and more awareness of people both in management theory research and in enterprise practice recently. In the article,we analyze the difficulty of complex product manufacture,introduce the idea of modular manufacture and research the basic content of modular manufacture strategy. Meanwhile,the significance of modular manufacture strategy to build up core competition and fast innovation for the manufacture industry are studied. At last,we discuss the necessity of building modular manufacture strategy and its modes and process. The studies demonstrate that based on modular manufacture is crucial to establish enterprise strategy and optimize enterprise competence.

Preliminary Analysis of Sea Use Planning Strategies in Coastal Cities:A Case Study of Binhai New Area in Tianjin City

Through investigating current sea use in coastal cities of China,and exploring foreign and domestic researches on sea use,this paper took Binhai New Area of Tianjin City for example to analyze major problems of its sea use in ecological security,planar form,land use layout,specialized planning,management and regulatory mechanism,then proposed strategies from 4 perspectives,namely ecological conservation and restoration,optimization of planning planar form,optimization of planning land use layout,and planning management,in order to provide references and instructions for the sea use planning of Chinese coastal cities.

New Military Revolution and U. S. Global Strategy

Two years have past since September 11 events. Then to what extent has the U. S. global strategy changed? This is still a question in dispute. From the actions taken by U. S. A. and the various American documents published in the past two years, we can find that there have been no much changes in U. S. global strategic objectives. The essence of the disputes over "New Empire" in U. S. A. is how to maintain U. S. hegemonic position as long as possible. Although the pattern

A New Strategy of Insect Pest Control:Down-regulating Cotton Bollworm Gene Expression by Engineering Plant Double Stranded RNA

Cotton bollworm(Helicoverpa armigera) is an important agricultural pest that causes severe yield loss to crops,particularly to cotton.Transgenic Bt crops have been successful in

Strategy research on new urban space development and new deepwater terminal in Hengsha

From a strategic perspective,the paper presents a forward-looking thinking supported by interdisciplinary of modern logistics,estuary and coast,environment and ecology,economic management and mathematical statistics. It leads to a reasonable solution to space expansion by reclamation. Construction of new deepwater terminal is the best usage of land resources and can strengthen the status of Shanghai as an international shipping center,thus support the preparation and strategic decision of future urban development of Shanghai.

Campus Design Strategies Based on Spatial Images： A Case Study of Four New Campuses in Chengdu

From 1999, with the rapid expansion of enrollment scale, colleges have experienced fast development and construction of new campuses. However, the urgency of the demand for campus space at that time led to the shortcomings of paying more attention to speed than connotation during the construction of the new campus. Even now the evaluation of new campuses which have been used for nearly twenty years and whether the space of new campuses has played its due role will affect the display of the heritage and temperament of colleges. This paper uses the typical spatial cognitive concept—spatial image to analyse the elements of spatial images on campuses, summarizes the perceptions of teachers and students towards the space of four new campuses in Chengdu through questionnaire survey and analysis, puts forward the principles of campus space design and the strategies of classification design, and intends to take spatial images as the research cut-in point to provide new ideas and suggestions for the design and improvement of campus space from the perspective of users.

New Urbanization Strategies of Fumin County,Kunming City during the Fourteenth Five-year Plan Period

Fumin County is a satellite town closest to Kunming City,its economic development level has lagged behind that of the city and other districts and counties of the city,and the urbanization rate has been quite low.Through analyzing development conditions and problems of Fumin County,strategies and countermeasures were put forward for the new urbanization of the county during the Fourteenth Five-year Plan.

Community Renewal Strategy for Improving Community Resilience:A Case Study of River Ring Area of Caoyang New Village in Shanghai

In a new round of urban renewal,China’s urban space expansion is shifting from incremental development to inventory mining.Residents’ demands for improvement of community material environment and community cultural identity are increasing.Meantime,affected by the COVID-19 pandemic in 2019,community resilience has become an urgent problem to be solved in urban communities.Based on resilience theory,TOD theory and other planning concepts,the paper analyzes the vulnerability of Shanghai Caoyang river ring area,and puts forward a multi-level community resilience improvement strategy,including increasing diversified public service facilities,building public pedestrian network,and reshaping public open space to improve the stability,adaptability and resilience of the community,in order to build the development path of resilient communities.The study will provide inspiration for future micro-renewal of communities and promote the sustainable development of urban communities.