Resistance to targeted therapy in metastatic colorectal cancer:Current status and new developments

Colorectal cancer(CRC)is one of the most lethal and common malignancies in the world.Chemotherapy has been the conventional treatment for metastatic CRC(mCRC)patients.However,the effects of chemotherapy have been unsatisfactory.With the advent of targeted therapy,the survival of patients with CRC have been prolonged.Over the past 20 years,targeted therapy for CRC has achieved substantial progress.However,targeted therapy has the same challenge of drug resistance as chemotherapy.Consequently,exploring the resistance mechanism and finding strategies to address the resistance to targeted therapy,along with searching for novel effective regimens,is a constant challenge in the mCRC treatment,and it is also a hot research topic.In this review,we focus on the current status on resistance to existing targeted therapies in mCRC and discuss future developments.

Construction of China Osmanthus City and Intellectual Property Right Protection in Xianning City in the Context of Three New Developments

Xianning City of Hubei Province is one of the five major traditional osmanthus producing areas in the world and the hometown of osmanthus in China. Xianning is constructing China Osmanthus City in the whole city. This paper first introduces the main characteristics of the osmanthus industry in Xianning City, and analyzes the characteristics of traditional knowledge, biological genetic resources, new plant varieties, patents, geographical indications, and trademarks. Then, it studies the intellectual property resources of the osmanthus industry, and analyzes the main problems existing in the construction of China Osmanthus City and intellectual property right protection. Finally, it comes up with constructive recommendations including applying for China and Globally Important Agricultural Heritage Systems, developing colored-leaf osmanthus varieties, creating a regional public brand of osmanthus specialty products, and building a new development pattern of osmanthus industry.

New Developments on Existence and Uniqueness of Solutions to Some Models in Atmospheric Dynamics

This survey is concerned with the new developments on existence and uniqueness of solutions of some basic models in atmospheric dynamics, such as two-and three-dimensional quasi-geostrophic models and three-dimensional balanced model. The main aim of this paper is to introduce some results about the global and local (with respect to time) existence of solutions given by the authors in recent years, but others' important contributions and the literature on this subject are also quoted. We discuss briefly the relationships among the existence and uniqueness, physical instability and computational instability. In the appendixes, some key mathematical techniques in obtaining our results are presented, which are of vital importance to other problems in geophysical fluid dynamics as well.

New Developments of Tungsten Technology in China

I.IntroductionIt is well known that China is rich in natural resources of tungsten.Before 1949 there was al-most no tungsten industry in our country except mining and ore dressing.Tremendous changeshave taken place after 1949.We have built our metallurgical industry of tungsten.Especially start-ing from the last decade much progress has been made not only in production technologies and

NEW DEVELOPMENTS IN WESTERN POPULIST POLITICS IN 2016

For Westerners,2016 was a year of frequent 'black swan' events.Following a referendum held on June 23,Britain decided to leave the European Union.On November 8,Donald Trump won the U.S.presidential election unsurprisingly.Another referendum was held in Italy on December

New Developments in Drug Therapy and Research of Cerebral Vasospasm

In this manuscript a comprehensive coverage of recent developments in the drug therapy of vasospasm while providing the background information that neuroscientists need to understand its rationale. The range of new agents available for treatment of cerebral vasospasm is expanding rapidly along with rapid advances in pharmacology and physiology that are uncovering the mechanisms of this disease. Although there are many publications for treatment of cerebral vaso-spasm, most are focusing on different aspects of vasospasm treatment and many have limited value due to insufficient quality. Moreover, the complexity of this, in many cases deleterious condition, is enormous and the information needed to understand drug effects is accordingly often not readily available in a single source. A number of pharmacological and medical therapies are currently in use or being investigated in an attempt to reverse cerebral vasospasm, but only a few have proven to be useful. Current research efforts promise the eventual production of new medical therapies. At last, recommendations for the use of different treatment stages based on currently available clinical data are provided.

Push for New Developments in China's Human Rights

In June 2012,with the approval of the State Council,the State Council Information Office issued the National Human Rights Action Plan(2012-15)(the"Action Plan"),the second national plan under the same theme.In the past two years,under the leadership of the CPC Central Committee and General Secretary Xi Jinping,the Action Plan

New Developments in Family Planning

The numbers of farmers in-terested in learning about human reproduction,living healthy,well-balanced lives,improving standards of living and education,and finding out more about technological pro-duction,are growing daily.They thoroughly approve of,hence sup-port,the new methods,and these methods have also gone a long way toward improving relations between officials and the people.Song Jiyin,who used to be the family planning official for his village,infuriated his neighbors so much by his uncouth manner,they destroyed his fruit trees and vegetable garden on sev-eral occasions.He finally set things right with the community last year by applying the I new,method of combining family planning with economic benefits:he set up a car-pet factory that employed 33 wom-en from single-child families.

Pudong and New Developments in Shanghai

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Arginine: New and Exciting Developments for an“Old”Amino Acid

Arginine (2-amino-5-guanidino pentanoic acid) was shown in 1895 by Hedin to be present in the proteins of horn. Metabolic nitrogen balance studies, conducted in 1957 by Rose in human adults and in 1959 by Snyderman and coworkers in young infants, revealed that a dietary source of this amino acid was not an obligatory requirement for growth and maintenance of nitrogen homeostasis in healthy individuals. Hence, It was initially classified as a non-essential (dispensable) amino acid and, perhaps, for reasons of this classification arginine did not receivc the earlier atteniion it now deserves, in relation to an understanding of the nutritional biochemistry and physiology of its metabolism in humans subjects. However, there is currently a considerable interest in the cellular and tissue functions, as well as clinical, therapeutic significance, of arginine. In this paper we review the multiple functions of arginlne, including its role in the L-arginine-nitric oxide pathway,cellular regeneration, immune function, protein synthesis and protein breakdown. We then consider some in vivo aspects of the physiology of arginine metabolism, which varies greatly among eukaryotes, with particular reference to humans. Against this background, studies of arginine in the nutrition of humans under various pathophysiological conditions are reviewed briefly. Finally, a new, updated concept for the metabolic basis for the 'conditional essentiality' of arginine is proposed

Intellectual Property Protection and New Development Pattern Construction of Xinjiang Jujube

"Three new developments"is the guiding ideology of Chinese-style high-quality development in the new era.Jujube(Zizyphus jujube Mill.)is a plant of Zizyphus of Rhamnaceae,which originated in China and has been listed as one of the"five fruits"since ancient times.Xinjiang is the most important jujube producing area in China,and its yield has accounted for 50%of the national jujube yield.In the five prefectures and cities of southern Xinjiang,as well as the regimental farms of southern and eastern Xinjiang of Xinjiang Production and Construction Corps,the jujube industry is an advantageous characteristic industry in agriculture.This paper studied Xinjiang jujube industry and its agricultural intellectual property resources,analyzed six major issues to be further implemented,such as the"three new developments"thinking and the strategy of building an intellectual property power,and puts forward eight strategies such as coordinating the two markets and two resources to accelerate the construction of a new development pattern and dual circulation of jujube.

Spatial Differentiation and Convergence Trend of High-quality Development Level of China’s Tourism Economy

This paper aims to interpret the connotation of high-quality development of tourism economy(HQTE)from the perspective of the new development concepts of innovation,coordination,green,openness and sharing,and then to evaluate the spatial differenti-ation of China’s HQTE based on provincial panel data from 2009 to 2018.Specifically,we employ the spatial convergence model to ex-plore the absolute and conditionalβconvergence trends of HQTE in the whole country and the eastern,central and western regions of China.Our empirical results reveal that:1)within the decade,from 2009 to 2018,regions of China with the highest HQTE index is its eastern region followed by the central region and then the western region,but the fastest growing one is the western region of China fol-lowed by the central region and then the eastern region.2)Whether or not the spatial effect is included,there are absolute and condition-alβconvergence in HQTE in the whole country and aforementioned three regions.3)The degree of government attention as well as the level of economic development and location accessibility are the positive driving factors for the convergence of HQTE in the whole country and the three regions.The degree of marketization and human capital have not passed the significance test either in the whole country or in the three regions.The above conclusions could deepen the understanding of the regional imbalance and spatial conver-gence characteristics of HQTE,clarify the primary development objects,and accomplish the goal of China’s HQTE.

Influence of new town development on the urban heat island-The case of the Bundang area

Five new towns have been developed around the Seoul metropolitan area since 1996 However, these new towns generate lots of traffic and related problems in the areas including those new towns and Seoul as a result of increases in population and a lack of ecological-self-sufficiency. Currently, construction of another new town is under deliberation, and what should be a major consider is the notion that the new town be located within a wide, green zone. Many studies have revealed that green space can play an important role in improving urban eco-meteorological capability and air quality. In order to analyze the urban heat island which will be created by the new urban development, and to investigate the local thermal environment and its negative effects caused by a change of land use type and urbanization, Landsat TM images were used for extraction of urban surface temperature according to changes of land use over the last 15 years. These data are analyzed together with digital land use and topographic information. As a study result, it was found the urban heat island of the study area from 1985 to 1999 rapidly developed which showed a difference of mean temperature above +2 0 Before the Bundang new town construction the temperature of the residential area was the same as a forest, but during the new town construction in 1991 analysis revealed the creation of an urban heat island. The temperature of a forest whose size is over 50% of the investigation area was lowest, and thus the presence of a forest is believed to have a direct cooling effect on the urban environment and its surroundings. The mean temperature of the residential and commercial areas in the study was found to be +4 5 higher than the forest, and therefore this part of land use is believed to be the main factor causing the temperature increase of the urban heat island.

Exploring Barriers and Opportunities in Adopting Crowdsourcing Based New Product Development in Manufacturing SMEs

Crowdsourcing is an innovative business practice of obtaining needed services, ideas, or content or even funds by soliciting contributions from a large group of people （the ＇Crowd＇）. The potential benefits of utilizing crowdsourcing in product design are well-documented, but little research exists on what are the barriers and opportunities in adopting crowdsourcing in new product development （NPD） of manufacturing SMEs. In order to answer the above questions, a Proof of Market study is carried out on crowdsourcing-based product design under an Innovate UK funded Smart project, which aims at identifying the needs, challenges and future development opportunities associated with adopting crowdsourcing strategies for NPD. The research findings from this study are reported here and can be used to guide future development of crowdsourcing-based collaborative design methods and tools and provide some practical references for industry to adopt this new and emerging collaborative design method in their business.

Investigation Into the Market-Orientated New Product Development Performance

The effect that the market orientation brings to product innovation performance is reported and the degree of product innovativeness is explored. The interdepartmental integration inside the company is also investigated. A series of hypotheses were developed aiming at presenting a conceptual framework to clarify how market orientation contributes to product innovation performance-moderated by the degree of product innovativeness and affected by the interdepartmental integration. Survey data from 36 business units were analyzed based on the respondents in the research. The statistic results suggest a substantial positive effect of market orientation on product innovation performance. Under the condition of incremental innovativeness among the samples, the more innovative the product is, the more improvements in product innovation performance would be achieved. A variety of particular interdepartmental integration mechanisms have been certified to lend more supports to establishing market orientation and improving product innovation performance.

New Progress on the Coal Fines Affecting the Development of Coalbed Methane

Objective The production of coal fines is very common in the development of coalbed methane（CBM）in the eastern margin of the Ordos Basin,China.A large amount of produced coal fines seriously affect the productivity of CBM wells（Wei Yingchun et al.,2013）.Therefore,the production problems of CBM wells caused by coal fines have attracted extensive attention.

Impact of the synergy between technology management and technological capability on new product development:a system dynamics approach

This paper employs system dynamics to explore how the synergy between technology management and technological capability affects new product development.The results show that the synergy between technology management and technological capability has positive impact on new product development.Moreover, the leading synergy processes between technology management and technological capability in different new product development stages are different.This paper deepens the theoretical understanding of how to achieve new product development, and also provides useful guidance for firms to implement new product development.

Water environmental planning for new zone of economic-technological development in China

This paper analyzes the characteristics of water environmental planning in New Zone for EconomicTechnological Development (NZETD) in China and presents the task, procedure and method of the planning study Based on these analyses, the concept of Water Environmental Support Capacity (WESC) is put forward and the corresponding quantitative method is proposed to achieve the objective of coordinating the relationship between water environment and economic development As a case study, a comprehensive analysis and integrated water pollution control planning are made for the New Zone of EconomicTechnological Development in Benxi City in China Based on the costbenefit analysis and feasibility study of the planning alternatives, the comprehensive indexes of WESC are calculated and applied to evaluate the water pollution control planning alternatives

THE PROSPECTIVE OF NEW TECHNOLOGY DEVELOPMENT FOR SUSTAINABLE ELECTRIC POWER SUPPLY IN CHINA

China is a large developing country with rapid growth rate. To the year 2050, its electric power will be increased by six to eight times, reaching 1.5—1.8 TW total installed capacity. The development can not only rely on the existing technology, it is crucial to accelerate the new technology development. This article discusses the perspective of various new technologies from the available energy resources and the required increase of electric power.