Early human embryonic development remains mysterious due to drastic species divergences between humans and othermammalian models and limited accessibility to human embryo samples. Recent studies from my laboratory and...Early human embryonic development remains mysterious due to drastic species divergences between humans and othermammalian models and limited accessibility to human embryo samples. Recent studies from my laboratory and others haveshown that under suitable culture conditions human pluripotent stem cells ( hPSCs) can undergo intricate morphogenetic eventsand self-organize to form patterned human embryo-like structures in vitro. These synthetic human embryonic tissueshold great promises for advancing human embryology and reproductive medicine. In this talk,I will describe a hPSC-based,synthetic 3D model of human post-implantation development that recapitulates key developmental landmarks successively,including pro-amniotic cavity formation,amniotic ectoderm-epiblast patterning,primordial germ cell specification,and developmentof the primitive streak with controlled anteroposterior polarity ( Fig.1) . We further show that the amniotic ectoderm,as the first lineage that segregates from the epiblast upon implantation of the human embryo,functions as a signaling centerto trigger primitive streak development in the epiblast. Together,our research has developed a powerful synthetic embryologicalmodel and provided new understandings of previously inaccessible but critical embryogenic events in human development.展开更多
Through the analyses of several typical paradigms of informatization in the countryside,the status of informatization in the countryside and some unresolved issues were studied. A new way was proposed to develop rural...Through the analyses of several typical paradigms of informatization in the countryside,the status of informatization in the countryside and some unresolved issues were studied. A new way was proposed to develop rural information with embedded mobile phone terminal,and to explore an inexpensive and efficient information services paradigm for the future development in the countryside.展开更多
The main features of the foreign language education in the information age are to realize the modernization, informatization, intellectualization and diversification of the foreign language teaching, and to promote th...The main features of the foreign language education in the information age are to realize the modernization, informatization, intellectualization and diversification of the foreign language teaching, and to promote the modernization of the foreign language teaching through the informatization of the foreign language teaching. The new concept of the leapfrogging development in the foreign language teaching should be a hot topic and trend in the study of the foreign language teaching theories and practice in the new era. Under the "New liberal arts" paradigm, students are expected to take part in various activities to promote the transformation of the classroom theoretical knowledge into the specific practical skills and enhance their abilities to solve the practical problems in the real world.展开更多
The P300, an endogenous subcomponent of the event-related potential, is thought to reflect cognitive processes. The event-related potential evoked by the old-new memory recognition task in the oddball paradigm is suit...The P300, an endogenous subcomponent of the event-related potential, is thought to reflect cognitive processes. The event-related potential evoked by the old-new memory recognition task in the oddball paradigm is suitable for examining the neural processes involved in malingered neurocognitive deficits. Forty-four undergraduates were randomly assigned to a simulated malingering group and a truth-telling group, Another 22 patients with head injudes were enrolled as a control group. All participants completed the old-new memory recognition task in the oddball paradigm. The mean P300 amplitude of the simulated malingering group was significantly reduced compared with the truth-telling group （P 〈 0.01）, but was increased compared with the control group （P〈 0.01）. These results revealed that the P300, evoked by the old-new memory recognition task of the oddball paradigm, may be a helpful indicator for determining cognitive malingering.展开更多
Sino-African media cooperation adds another dimension to socio-political understanding MEDIA cooperation between China and Africa shifted into another gear recently when the inaugural Forum on China-Africa Media Coope...Sino-African media cooperation adds another dimension to socio-political understanding MEDIA cooperation between China and Africa shifted into another gear recently when the inaugural Forum on China-Africa Media Cooperation in Beijing, held August 21-25, adopted a raft of rules and agreements laying the groundwork for future partnerships. Meeting under the theme, ＂Exchange, Cooperation and Develop-展开更多
基金supported by the National Science Foundation ( CMMI 1129611 and CBET 1149401)the National Institutes of Health ( R21 HL114011 and R21 EB017078)+3 种基金the American Heart Association ( 12SDG12180025)the Department of Mechanical Engineering at the University of Michigan,Ann ArborThe Lurie Nanofabrication Facility at the University of Michigan,a member of the National Nanotechnology Infrastructure Network ( NNIN)funded by the National Science Foundation,is acknowledged for support in microfabrication
文摘Early human embryonic development remains mysterious due to drastic species divergences between humans and othermammalian models and limited accessibility to human embryo samples. Recent studies from my laboratory and others haveshown that under suitable culture conditions human pluripotent stem cells ( hPSCs) can undergo intricate morphogenetic eventsand self-organize to form patterned human embryo-like structures in vitro. These synthetic human embryonic tissueshold great promises for advancing human embryology and reproductive medicine. In this talk,I will describe a hPSC-based,synthetic 3D model of human post-implantation development that recapitulates key developmental landmarks successively,including pro-amniotic cavity formation,amniotic ectoderm-epiblast patterning,primordial germ cell specification,and developmentof the primitive streak with controlled anteroposterior polarity ( Fig.1) . We further show that the amniotic ectoderm,as the first lineage that segregates from the epiblast upon implantation of the human embryo,functions as a signaling centerto trigger primitive streak development in the epiblast. Together,our research has developed a powerful synthetic embryologicalmodel and provided new understandings of previously inaccessible but critical embryogenic events in human development.
基金Supported by "Twelfth five-year-plan" Science and Technology Supporting System(2011BAD21B03)
文摘Through the analyses of several typical paradigms of informatization in the countryside,the status of informatization in the countryside and some unresolved issues were studied. A new way was proposed to develop rural information with embedded mobile phone terminal,and to explore an inexpensive and efficient information services paradigm for the future development in the countryside.
文摘The main features of the foreign language education in the information age are to realize the modernization, informatization, intellectualization and diversification of the foreign language teaching, and to promote the modernization of the foreign language teaching through the informatization of the foreign language teaching. The new concept of the leapfrogging development in the foreign language teaching should be a hot topic and trend in the study of the foreign language teaching theories and practice in the new era. Under the "New liberal arts" paradigm, students are expected to take part in various activities to promote the transformation of the classroom theoretical knowledge into the specific practical skills and enhance their abilities to solve the practical problems in the real world.
文摘The P300, an endogenous subcomponent of the event-related potential, is thought to reflect cognitive processes. The event-related potential evoked by the old-new memory recognition task in the oddball paradigm is suitable for examining the neural processes involved in malingered neurocognitive deficits. Forty-four undergraduates were randomly assigned to a simulated malingering group and a truth-telling group, Another 22 patients with head injudes were enrolled as a control group. All participants completed the old-new memory recognition task in the oddball paradigm. The mean P300 amplitude of the simulated malingering group was significantly reduced compared with the truth-telling group （P 〈 0.01）, but was increased compared with the control group （P〈 0.01）. These results revealed that the P300, evoked by the old-new memory recognition task of the oddball paradigm, may be a helpful indicator for determining cognitive malingering.
文摘Sino-African media cooperation adds another dimension to socio-political understanding MEDIA cooperation between China and Africa shifted into another gear recently when the inaugural Forum on China-Africa Media Cooperation in Beijing, held August 21-25, adopted a raft of rules and agreements laying the groundwork for future partnerships. Meeting under the theme, ＂Exchange, Cooperation and Develop-
