Eco-friendly synthesis and environmental impact assessment of hierarchical Beta zeolite from kaolinite and recycled mother liquor

The development of sustainable techniques to produce high-performance zeolite is essential to achieve green production in industry.Herein,we report an eco-friendly route to synthesizing hierarchical Beta zeolite from kaolinite and recycled mother liquor.The results reveal that the unutilized species(such as silicon species and Na+)in mother liquor stayed in a stable concentration during eleven recycled experiments.Moreover,the synthesized Beta zeolites still have comparable physicochemical properties and catalytic performance in the esterification of levulinic acid with ethanol over the initial zeolite although eleven recycled experiments.Life cycle assessment exhibits that the synthesis of Beta zeolite with recycled mother liquor can reduce global warming potential by 23%and resource depletion-water use by 36%compared to that without recycled mother liquor.This quantitatively demonstrates that the approach proposed in this work is really a sustainable one,extremely increasing the utilization efficiency of raw materials and decreasing the environmental burden.

Integration of network pharmacology and bone marrow mesenchymal stem cells experimental research to reveal the molecular mechanisms for Hai Honghua medicinal liquor against osteoporosis

Background:Hai Honghua medicinal liquor(HHML)formula has been used in clinical practice for a long time,mainly for the treatment of freshly closed fractures,to promote osteogenesis,to increase bone mass,and thus to promote fracture healing.However,the underlying mechanisms of HHML in the treatment of osteoporosis(OP)are still unclear.Methods:Firstly,Traditional Chinese Medicines Systems Pharmacology Database and Analysis Platform and The Encyclopedia of Traditional Chinese Medicine were used to screen the targets of the active compounds of HHML.At the same time,OP targets were identified through GeneCards,Online Mendelian Inheritance in Man,DisGeNET,Therapeutic Target Database,Comparative Toxicogenomics Database and Human Phenotype Ontology databases.Next,protein-protein interaction and pathway networks were constructed for compound-disease common targets,and core targets and compounds were screened for molecular docking.Furthermore,rat bone marrow mesenchymal stem cells were extracted as model cells,and the osteogenic effects of HHML were verified via in vitro experiments.Results:Total of 343 common targets of HHML-OP and the top 10 target proteins in the protein-protein interaction network are TP53,AKT1,STAT3,HSP90AA1,ESR1,TNF,IL6,MAPK1,MAPK3 and MAPK8.Enrichment analysis yielded that the key molecular pathway was the PI3K/Akt signaling pathway.Molecular docking analysis showed that baicalein,erysodienone and naringenin docked with the target proteins AKT1,STAT3 and TP53,respectively,with low binding energy and high affinity.In addition,In vitro experiments demonstrated that HHML promoted the proliferation of bone marrow mesenchymal stem cells;compared with the control group,HHML-treated cells showed enhanced alkaline phosphatase staining,promoted the expression of OCN,RUNX2,BSP,and COL1 mRNAs as well as the expression of PI3K and AKT phosphorylated proteins.Secondly,the expression of target proteins revealed that HHML promoted the phosphorylation of STAT3 protein and inhibited the expression of P53.Conclusions:Our study investigated that HHML treatment with OP promotes bone formation possibly through activation of the PI3K/Akt signaling pathway and may involve STAT3 and TP53 target interactions.

The mechanistic study on Wa medicine Niang-Mu-Liang medicinal liquor mitigating diabetes mellitus erectile dysfunction in rats by inhibiting ferroptosis

Background:This study aims to investigate the therapeutic effect of Wa medicine Niang-Mu-Liang medicinal liquor(NML)on rats with diabetes mellitus erectile dysfunction(DMED)and its impact on the ferroptosis signaling pathway.Methods:Thirty Sprague-Dawley rats were randomly divided into three groups:Control,DMED,and NML.After establishing the DMED model,treatments were administered for 8 weeks.After the administration,apomorphine hydrochloride tests were conducted to measure the mass and organ index of testes and epididymides,sperm concentration and viability in each group.Penile corpus cavernosum tissues were stained with hematoxylin and eosin.Nitric oxide and cyclic guanosine monophosphate levels in the penile corpus cavernosum tissues were determined using biochemical kits and enzyme-linked immunosorbent assay,while the expression of proteins related to the ferroptosis signaling pathway was measured by Western blot.Results:Compared to the DMED group,the DMED rats treated with NML showed significantly increased erection frequency,testicular and epididymal mass and index,sperm count and viability,along with noticeable improvement in the pathological morphology of penile corpus cavernosum.The content of nitric oxide and cyclic guanosine monophosphate,and the expression of ferritin heavy chain,ferritin light chain,and glutathione peroxidase 4 proteins in penile corpus cavernosum tissue were elevated,while the expression of transferrin and STEAP3 proteins was reduced.Conclusion:NML can improve erectile function in DMED rats by inhibiting the ferroptosis signaling pathway.

Production of Partial New-typed Brassica Napus by Introgression of Genomic Components from B. rapa and B. carinata

A breeding strategy for widening the germplasm of Brassica napus was proposed by introgression of the A^r subgenome of B. rapa （A^rA^r） and C^c of B. carinata （B^cB^cC^cC^c） into natural B. napus （AnAncncn）. The progenies with 38 chromosomes that were derived from the self-pollinated seeds of pentaploid hybrids （A^rA^nB^cC^cC^n） were used for further research. Some of the partial new-typed B. napus showed normal meiotic behavior, high portion of germinated pollen and normal embryological development. This indicates that the selected new-typed B. napus had a balanced genetic base. Molecular analysis showed that about 50% of the genome in the new-typed B. napus was replaced by A^r and C^c subgenome from B. rapa and B. carinata. Considering the genetic diversity among different lines of new-typed B. napus, it was deduced that the introgression of the genomic components from B, rapa and B. carinata could widen the genetic diversity of rapeseed.

Spatiotemporal Characteristics of Rural Labor Migration in China: Evidence from the Migration Stability under New-type Urbanization

Although the factors affecting rural-to-urban migration have been discussed and analyzed in detail, few studies have examined the spatiotemporal dynamic characteristics of rural migrants’ employment and working-cities in the post-immigrate era, which is essential for the citizenization and social integration of new-type urbanization in China. This study uses survey data from rural migration laborers across the eastern, central, and western China to construct a comprehensive labor migration stability index, and compares the determinants of the migration stability of rural labor among cities and industries using Geodetector. The results are as follows: 1) Compared with the midwestern cities, eastern cities have attracted younger and more skilled rural labor, and industries with higher technical content have higher migration stability among rural laborers. 2) Rural laborers more often adapt to changes by changing employment instead of changing working-cities. 3) The individual experiences of rural laborers and urban characteristics have significant impacts on the stability of migration, and family and societal guanxi(Chinese interpersonal relationships) enhance migration stability. 4) A unified labor market and convenient transportation have somewhat slowed industrial transfers and labor backflow. This study enhances our understanding of the roles of industrial transfer and new-type urbanization in shaping the labor geography landscape and provides policy implications for the promotion of people-oriented urbanization.

Paleoenvironments Recorded in a New-Type Ferromanganese Crust fromthe East Philippine Sea

We attempt to recover the paleocnvironments recorded in the accretion of a typical newtype hydrogenetic ferromanganese crust from the deep water areas of the East Philippine Sea. From detailed geochemical and U-series chronological studies, analysis of major and minor elements performed by X-ray fluorescence spectrometry （XRF） and inductively coupled plasma-mass spectrometer （ICPMS）, three major accretion periods and corresponding paleocnvironments can be ascertained. The first period is a faster accretion period in the terminal Late Miocene to the Early Pliocene with looser structure and higher volcanic detritus content, corresponding to the active Antarctic bottom waters and depressed temperature from the intermediate Middle Miocene to the Early Pliocene. The second period is a pulse of pelagic clay deposition at the Early to Middle Pliocene, reflecting the shrinkage of the Antarctic bottom waters and the global temperature elevation of this period. The third period is a slower accretion period from the Middle Pliocene, which indicates the more violent activity of Antarctic bottom waters once again and more depressed temperature than the first period, facilitating the accretion of a more compact and pure ferromanganese zone. The paleoceanographic histories of these studied areas had not been made clear in previous research.

Cultivating New-type Farmers Based on the Theory of Human Resources Development

Under the direction of theory of human resources development,this thesis analyzes the impact of rural human resources development oncultivating new-type farmers.Firstly,it increases the input of rural basic education;secondly,it reinforces the vocational education and technologytraining;thirdly,it promotes the rural medical and public health services;fourthly,it quickens the rural labor transfer.The status quo of China's ruralhuman resources has been analyzed as follows:in terms of the quantity of rural human resources,the status quo is large and quick-developed baseof rural human resources,high labor participatory rate,and constitution of low age;in terms of the quality of rural human resources,the status quois the ubiquitous low quality of rural human resources,low technological level of rural human resources,and overall low physical quality of farmers;in terms of the structure of rural human resources,the status quo is the irrational industrial structure distribution and imbalanced regional structuredistribution.The thesis also discusses the edification of theory of human resources development in cultivating new-type farmers.First,in terms ofthe control over quantity of rural human resources,it is to keep the stability of family planning policy,and expedite the transfer of rural surplus la-bor;second,in terms of promoting the quality of rural human resources,it is to bolster the development of reserve rural labor force resources,toconstruct the adult educational training system with Chinese characteristics,and to build rural primary health care system;third,in terms of adjus-ting the structure of rural human resources,it is to perfect rural human resources market,and adjust rural economical structure and talents struc-ture.

BUILDING A MODERATELY PROSPEROUS SOCIETY IN ALL RESPECTS——New-Type Industrialization

After announcing the goal of building a moderately prosperous society in all respects by 2020, the Chinese leadership also called for a new path of industrialization, putting a premium on quality and new development concepts. Unlike traditional industrialization in the broad or narrow sense, new-type industrialization features synergy between primary, secondary, and tertiary industries, integration between traditional economy and the new economy, environmental protection, technology progress, and innovation. It represents an inclusive approach to industrial development. At the fundamental level, the success of China’s new-type industrialization can be attributed to China’s inclusive learning and innovations.

Resistance characteristics of the ball packed-bed regenerator of the new-type swirl flow hot blast stove

A renovation project of miniaturization and high efficiency is provided for the hot blast stove .The experimental data tested feasibility of the new-type swirl flow hot blast stove. The normal and hot state experiments have been done through changing the angle of gas entering into the regenerator. Factors influencing pressure drop have been studied and analyzed. The experimental results can be formulated in the form of the Ergun equation. The regression equation is obtained. And two modified coefficients are offered to the regenerator pressure drop of the new-type swirl flow hot blast stove.

Characteristic Town： The Effective Path of New-type Urbanization with Chinese Characteristics Based on the Investigation of Intemet Town Wuzheng, Aficion Chocolate Town Jiashan, Photovoltaic Town Xiuzhou in Zhejiang

The characteristic town is a dynamic and vivid case of experience of Zhejiang. With the internet town Wuzheng, Aficion chocolate town Jiashan, photovoltaic town Xiuzhou in Zhejiang as the research perspective, the concept of development that the production, life and ecology merge together and the development direction and value of New-type urbanization is consistent, and it is the effective path of New-type urbanization development. At the same time, these towns provide a model for the development of the country small town

Dynamic changes and driving factors of land use under new-type urbanization: A case of Guiyang

With the continuous progress of new-type urbanization in Karst mountain area, how to correctly deal with the relationship between urban economy and land use are attracting much attention. Based on the land-use change data, this paper analyzes the characteristics of land use change and its driving factors in Guiyang with the method of land-use dynamic analysis, land utilization and factor correlation analysis. We get the following results:(1) the change of land use was obvious during 2004 and 2012. The area of arable land and other land were decreased, the rate of decrease are 3.89% and 8.24%. In the meantime, a series of construction land and forest area increased a lot, the rate of increase are 3.89% and 8.24%.(2) The integrated land use dynamic degree of two research stages(2004-2009 and 2009-2012) were decreased from 2.12% to 0.34%, this suggests dynamic changes of land tend to be stable.(3) Four kinds of Land use class have a great contribution to the index of land use degree respectively. The composite index of land use degree rose from 229.58 to 247.19 during 2004 and 2012; the land use is still in the development stage.(4) Economy, population, transportation and policy guidance are the main drivers of land use change.

Characterization of Formacell Lignin Derived from Black Liquor as a Potential Green Additive for Advanced Biocomposites

Black liquor is obtained as a by-product of the pulping process,which is used to convert biomass into pulp by removing lignin,hemicelluloses and other extractives from wood to free cellulose fibers.Lignin represents a major constituent in black liquor,with quantities varying from 20%to 30%,of which a very low share is used for manufacturing value-added products,while the rest is mainly burned for energy purposes,thus underestimating its great potential as a raw material.Therefore,it is essential to establish new isolation and extraction methods to increase lignin valorization in the development of bio-based chemicals.The aim of this research work was to determine the effect of KOH or ethanol concentration as an isolation agent on lignin yields and the chemical characteristics of lignin isolated from formacell black liquor of oil palm empty fruit bunch(OPEFB).Isolation of lignin was carried out using KOH with various concentrations ranging from 5%to 15%(w/v).Ethanol was also used to precipitate lignin from black liquor at concentrations varying from 5%to 30%(v/v).The results obtained showed that the addition of KOH solution at 12.5%and 15%concentrations resulted in better lignin yield and chemical properties of lignin,i.e.,pH values of 3.86 and 4.27,lignin yield of 12.78%and 14.95%,methoxyl content of 11.33%and 10.13%,and lignin equivalent weights of 476.25 and 427.03,respectively.Due to its phenolic structure and rich functional groups that are favorable for modifications,lignin has the potential to be used as a green additive in the development of advanced biocomposite products in various applications to replace current fossil fuel-based material,ranging from fillers,fire retardants,formaldehyde scavengers,carbon fibers,aerogels,and wood adhesives.

Numerical calculation of flow and heat transfer process in the new-type external combustion swirl-flowing hot stove

It is clarified that the important method to improve the blast temperature ofthe small and the middle blast furnaces whose production is about two-thirds of total sum of Chinafrom 1000℃ to 1250-1300℃ is to preheat both their combustion-supporting air and coal gas. The airtemperature of blast furnaces can be reached to 1250-1300℃ by burning single blast furnace coal gasif high speed burner is applied to blast furnaces and new-type external combustion swirl-flowinghot stove is used to preheat their combustion-supporting air. The computational results of the flowand heat transfer processions in the hot stove prove that the surface of the bed of the thermalstorage balls there have not eccentric flow and the flow field and temperature field distribution iseven. The computational results of the blast temperature distribution are similar to thosedetermination experiment data. The numerical results also provide references for developing anddesigning the new-type external combustion swirl-flowing hot stoves.

New-type Agent for Fabrics Aftertreatment

A new type of TS series agent for the treatment of fabrics is being made by the Beijing Junsheng Fine Chemical Industry Co., Ltd. with the assistance of the Chemistry Research Institute of the Chinese Academy of Sciences. The product is a highly-effective treatment containing organic silicon

New-Type Inhalation For Bronchial Asthma

Aiqun Brand Bronchial Astnma Inhalation (Kechuan Biwen’an) developed by the Hunan Xiangheng Pharmaceutical Factory is prepared and produced with the elements necessary to the body, and many kinds of traditional Chinese medicinal herbs, according to a scientific prescription. It is used to treat acute and chronic bronchitis, bronchial asthma, pulmonary emphysema, allergic rhinitis, and chronic pharyngitis

Empirical Study on Driving Factors and Countermeasures of New-type Urbanization in China

The ultimate goal of new-type urbanization is to integrate urban and rural areas, which is influenced by various factors such as urban and rural populations, technology, capital, resources, etc. Accordingly, the need and importance of economic, social, cultural, and ecological factors ought to be analyzed to promote new-type urbanization. In this paper, we first describe the driving factors of new-type urbanization, and then we conduct an empirical study on the driving factors of new-type urbanization and analyze the data with Logit model. Finally, it is put forward that more effort should be made to accelerate new-type urbanization in such aspects as top-down design, government support, social interaction, etc.

An Analysis of the Degree of Coupling and Coordination of Agricultural Modernization and New-Type Urbanization in the Chengdu-Chongqing Economic Circle

Based on the panel data(2005-2019)of cities(prefectures)in the Chengdu-Chongqing Economic Circle,we have developed an evaluation system for agricultural modernization and new-type urbanization that measures the development level of each city and applies the coupling and coordination model to calculate their coupling and combination levels.The results indicate that the level of comprehensive order parameters of agricultural modernization in various cities(prefectures)in the Chengdu-Chongqing Economic Circle generally displays an upward trend.The areas with high-degree agricultural modernization were mainly distributed in Chengdu from 2005 to 2010,and the center of agricultural modernization was shifted to western areas after 2010,with a stable upward trend in the level of comprehensive order parameters of new-type urbanization.In terms of coupling degree,there was an overall upward trend.Except for Nanchong and Dazhou,other cities(prefectures)progressed from“Undeveloped Coordination”to“Intermediate Coordination.”The imbalanced development of agricultural modernization and new-type urbanization continually improved,with the combination level increasing from“Low-Low”to“Medium-Medium.”

Research of the molecular mechanism of Hai Honghua medicinal liquor in the treatment of fracture based on network pharmacology combined with molecular docking

Background:Hai Honghua medicinal liquor(HHML),a famous hospital formula composed of 19 traditional Chinese medicines,has been successfully applied in treating soft tissue injury,fresh closed fracture,limb dysfunction after fracture healing,shoulder,neck and leg pain,knee joint pain and other clinical multiple diseases for 30 years in clinical.However,research on the material basis of HHML for the treatment of fracture healing-related disorders is still in a gap.Therefore,it is particularly important to explore the active ingredients,core targets and potential pharmacological mechanisms of HHML to promote fracture healing.Methods:We screened the core active components of each traditional Chinese medicine in formula and its action targets through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and Encyclopedia of Traditional Chinese Medicine database.The fracture related targets were retrieved from several different public databases,including GeneCards,Online Mendelian Inheritance in Man,DisGeNET and Therapeutic Target Database.Bioinformatics analysis to obtain key bioactive components,underlying targets and signaling pathways,containing the Venn diagram of the intersection with components and diseases gene targets,protein–protein interaction,as well as the Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes analysis,and finally molecular docking.Results:A total of 249 bioactive ingredients of HHML and 325 HHML-fracture-related targets were screened.The network analysis revealed that quercetin,luteolin,kaempferol,Licochalcone A,naringenin and 8-Isopentenyl-kaempferol may be potential candidate agents.Multiple targets are involved including TP53,MAPK3,STAT3,AKT1,MAPK1,HSP90AA1,ESR1 and PIK3CA may be closely linked targets.PI3K-AKT signaling pathway may play a significant role of HHML in treatment of fracture.What’s more,molecular docking suggested that 8-isopentenyl kaempferol,glycyrrhiza chalcone A,and naringenin bound to AKT1,PIK3CA,and ESR1,respectively,exhibiting lower energy and more stable characteristics.Conclusions:The findings indicate the potential active ingredients,target proteins and molecular mechanisms of HHML for the treatment of fractures to provide the exact idea for the next research on the mechanism of action of HHML formula for fracture treatment.

Speech by Mr. Chen Zongxing at the 2012 Understanding and Cooperation Dialogue Part II: New-type Community and Harmonious Society

正Distinguished guests, ladies and gentlemen, dear friends: Today we meet here in picturesque Hangzhou for the 2012 Understanding and Cooperation Dialogue Part II: New-type Community and Harmonious Society. On behalf of the National Committee

Great Care for Life——New-type of Beijing's rural medical care system

Shi Lianzhen, a 79-year-old villager from rural Beijing, has been suffering from coronary heart disease and myocardial irffarction. On October 15, 2003, she unexpectedly received 10,064 yuan (US$1,215) in subsidies for her diseases from the local government department in charge of rural co-operative medical care. This old female farmer, without any income source, was so excited that she couldn’t put her feeling into words. For the first time in their life, Chinese farmers can enjoy medical care insurance like those wage workers in dries, when their health fails them and their lives are in the menace of death.