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Studies on the Voltammetric Behavior of Nicardipine Hydrochloride and its Voltammetric Determination at the Co/GC Modified Electrode 被引量:1
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作者 ZHI Yao HU Jingbo +1 位作者 LI Qilong HUANG Qingquan 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 1999年第2期36-41,共6页
IntroductionThetechniqueofionimplantationhasbeendevelopedasameansofintroductingforeignatomsintothesurfacelay... IntroductionThetechniqueofionimplantationhasbeendevelopedasameansofintroductingforeignatomsintothesurfacelayersofasolid.Thist... 展开更多
关键词 Ion implantation Modified electrode nicardipine Linearsweep voltammetry
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The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function,atrio-ventricular node function and hemodynamics
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作者 Jingming Zhu Ningning Hui Xiuhong Jiang Huaxing Zhang Chengzhang Fu 《Journal of Nanjing Medical University》 2007年第6期386-389,共4页
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function, atrio-ventricular node function and hemodynamics. Methods:Thirty-two Angora' s rabbits were selected and randomly divide... Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function, atrio-ventricular node function and hemodynamics. Methods:Thirty-two Angora' s rabbits were selected and randomly divided into four groups. U1 group:urapidil 0.25 mg/kg; U2 group:urapidil 0.5 mg/kg; N1 group:nicardipine 10 μg/kg; N2 group: nicardipine 20 μg/kg. All these medicine were administrated within 30 seconds. Measurements were taken before and after the administration of urapidil or nicardipine for the following data: mean blood pressure(MAP), heart rate(HR), sino-atrial conduction time(SACT), maximal sinoatrial recovery time(SNRTmax) corrected sinus node recovery time(CSNRT), index of sinus node recovery time(SNRTI), Wenckebach A-V conduction frequency (WB), and P-R interval. Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine. No significant changes could be found in the rest of the parameters. Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P 〈 0.01); the MAP decreased(P 〈 0.01) and the HR increased drastically(P〈 0.01). Conclusions:Neither urapidil(0.25 mg/kg, 0,5 mg/kg) nor nicardipine(10 μg/kg, 20 μg/kg) has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function. Nicardipine could be a better choice than urapidil for parafunctional sinus node patients. 展开更多
关键词 URAPIDIL nicardipine sinus function A-V node function HEMODYNAMICS
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Effect of nicardipine combined with esmolol on systemic and tissue oxygenation during off-pump coronary artery bypass grafting surgery 被引量:5
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作者 WANGTian-long JIANGYan YANGBa-xian 《Chinese Medical Journal》 SCIE CAS CSCD 2005年第2期130-135,共6页
Background The hemodynamics and oxygenation severely fluctuated during the offpump coronary artery bypass grafting (OPCABG) This study aimed at investigating whether or not nicardipine combined with esmolol (1∶10) ca... Background The hemodynamics and oxygenation severely fluctuated during the offpump coronary artery bypass grafting (OPCABG) This study aimed at investigating whether or not nicardipine combined with esmolol (1∶10) can maintain systemic and tissue oxygenation during OPCABGMethods Twenty patients scheduled for OPCABG were divided ramdomly into Group nicardipine (N) and Group nitroglycerine (X) respectively combined with esmolol (E) (Dosage ratio: 1 to 10) (Group N+E and Group X+E) with 10 patients in each group The mixed solution of N+E or X+E were titrated to maintain mean arterial blood pressure between 70 and 80 mmHg following anesthesia induction The variables of hemodynamics, arterial blood lactate content (Lac) and gastric intramucosal partial pressure of carbon dioxide were measured at the following time points: after induction of anesthesia (T1), prerevascularization (T2), grafting of left anterior descending (T3), right coronary descending (T4) and left coronary circumflexus branches (T5), postrevascularization (T6), the end of operation (T7) The delivery of oxygen (DO2), consumption of oxygen (VO2) and gastric intramucosal pH (pHi) were calculatedResults The cardiac index (CI) in Group N+E was significantly increased (P<005) as compared with T1 during OPCABG, while it was mildly decreased in Group X+E The stroke volumes at T4, T5 in Group N+E and at T3T6 in Group X+E were significantly decreased (P<005) The systemic vascular resistance indices in Group N+E were significantly decreased as compared with T1 (P<005) The heart rates in these two Groups were significantly elevated intraoperatively (P<005) The DO2 after the infusion of N+E was significantly increased (P<005) or leveled to T1, and the Lac were within the normal range But the DO2 in Group X+E was decreased throughout the procedure, reaching significant level at T5 (P<005), and the Lac was significantly increased beyond normal range (P<005) The pHi in Group N+E was maintained above 735 during OPCABG, while it was less than 735 from T4 to T7 in Group X+EConclusion Nicardipine combined with esmolol (1∶10) regimen may maintain systemic and tissue oxygenation during OPCABG 展开更多
关键词 off pump · coronary artery · revascularization · oxygenation · nicardipine · esmolol
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Intravenous injection of nicardipine changed the distribution of coronary artery endothelial shear stress and fluid dynamics in patients with unstable angina 被引量:2
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作者 CHEN Shao-liang HU Zuo-ying ZHANG Jun-jie KAN Jing XU Tian LIU Zhi-zhong XU Hai-mei 《Chinese Medical Journal》 SCIE CAS CSCD 2012年第18期3240-3245,共6页
Background Coronary endothelial shear stress (ESS) triggered the development of atherosclerosis. However, the effect of calcium channel antagonist on the distribution of ESS remained unclear. Methods Twenty consecut... Background Coronary endothelial shear stress (ESS) triggered the development of atherosclerosis. However, the effect of calcium channel antagonist on the distribution of ESS remained unclear. Methods Twenty consecutive patients with acute coronary syndrome (ACS) 48 hours after maximal medication with single left anterior descending artery stenosis 〈50% were studied. Nicardipine was intravenously injected at 1 μg/kg after a bolus of 10 mg in order to achieve mean blood pressure (MBP) reduced by 10% or more, or the heart rate increased by 10-15 beats/min. Hemodynamic variables and angiogram at baseline and during injection of nicardipine were recorded, respectively. Coronary artery 3-D reconstruction was used for the analysis of ESS. Results Distal reference-vessel-diameter and minimal lumen diameter decreased significantly from (2.42±0.41) mm and (1.47±0.49) mm at baseline to (2.22±0.35) mm and (1.35±0.49) mm at maximal drug-dosage (P=0.018 and 0.020, respectively). Nicardipine did not change blood velocity. Lowest mean shear stress at segments 2-mm distal to plaque increased significantly from (0.034±0.519) Pa at baseline to (0.603±0.728) Pa (P=0.013) at peak effect of drug. Conclusions Nicardipine was associated with the constriction of diseased vessel segment that adapted to the reduction of blood pressure, without dynamic change of blood velocity at each stage of whole cardiac cycle. Increased ESS value at segments distal to plaque reflected the cardioprotection by nicardipine (ChiCTR-TRC-10000964). 展开更多
关键词 nicardipine endothelial shear stress blood hemodynamics
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钙拮抗剂抗高血压的研究进展
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作者 赵雅琳 吴国丽 林志 《沈阳医学院学报》 1996年第1期60-63,共4页
钙拮抗剂(Calcium Antagonist)是一类能选择性地阻滞Ca<sup>2+</sup>经细胞膜上的慢通道进入细胞,即减少Ca<sup>2+</sup>内流的药物。近年来钙拮抗剂抗高血压的作用越来越引起人们的重视,已成为目前治疗高血... 钙拮抗剂(Calcium Antagonist)是一类能选择性地阻滞Ca<sup>2+</sup>经细胞膜上的慢通道进入细胞,即减少Ca<sup>2+</sup>内流的药物。近年来钙拮抗剂抗高血压的作用越来越引起人们的重视,已成为目前治疗高血压的主要药物之一。现将其研究和应用情况综述如下。1 展开更多
关键词 钙拮抗剂 硝苯吡啶 高血压患者 抗高血压药物 维拉帕米 左心室肥厚 尼卡地平 冠状动脉粥样硬化 原发性高血压 nicardipine
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Management of hypertensive crises in the elderly 被引量:3
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作者 Abbas Alshami Carlos Romero +1 位作者 America Avila Joseph Varon 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2018年第7期514-522,共9页
Hypertensive crises are elevations of blood pressure higher than 180/120 mmHg. These can be urgent or emergent, depending on the presence of end organ damage. The clinical presentation of hypertensive crises is quite ... Hypertensive crises are elevations of blood pressure higher than 180/120 mmHg. These can be urgent or emergent, depending on the presence of end organ damage. The clinical presentation of hypertensive crises is quite variable in elderly patients, and clinicians must be suspicious of non-specific symptoms. Managing hypertensive crises in elderly patients needs meticulous knowledge of the pathophysiological changes in them, pharmacological options, pharmacokinetics of the medications used, their side effects, and their interactions with other medications. Clevidipine, nicardipine, labetalol, esmolol, and fenoldopam are among the preferred choices in the elderly due to their efficacy and tolerability. Nitroprusside, hydralazine, and nifedipine should be avoided, unless there are no other options available, due to the high risk of complications and unpredictable responses. 展开更多
关键词 Beta-blockers Calcium channel blockers CLEVIDIPINE Elderly ESMOLOL FENOLDOPAM Hypertensive crises LABETALOL nicardipine Nitroprusside
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Diagnosis and treatment of hypertensive crises in the elderly patients
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作者 Joseph Varon Neil E. Strickman 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2007年第1期50-55,共6页
Hypertension is a common clinical problem in the elderly worldwide and physicians of all types are likely to encounter patients with hypertensive urgencies and emergencies in these patients. Although various terms hav... Hypertension is a common clinical problem in the elderly worldwide and physicians of all types are likely to encounter patients with hypertensive urgencies and emergencies in these patients. Although various terms have been applied to these conditions, they are all characterized by acute elevations in blood pressure and evidence of end-organ injury. Prompt, but carefully considered therapy is necessary to limit morbidity and mortality. A wide range of pharmacologic alternatives are available to the practitioner to control blood pressure and treat complications in these patients. The management of the elderly patient with hypertensive crises needs to include close monitoring and a gentle decline in blood pressure to avoid catastrophic complications, exacerbation of ischemic myopathy, and vascular insufficiency. 展开更多
关键词 hypertension HYPERTENSIVE crises HYPERTENSIVE encephalopathy aortic dissection BETA-BLOCKER calcium channel blocker CLEVIDIPINE FENOLDOPAM nitroprusside LABETALOL nicardipine elderly
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尾加压素Ⅱ促血管内皮细胞分泌肾上腺髓质素的作用 被引量:12
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作者 石向东 李志梁 +5 位作者 吴宏超 吕永恒 王同汉 傅强 徐春生 唐朝枢 《中华心血管病杂志》 CAS CSCD 北大核心 2005年第9期836-839,共4页
目的研究人尾加压素(humanurotensinⅡ,HUⅡ)对人血管内皮细胞(humanvascularendothelialcells,HVEC)分泌肾上腺髓质素(adrenomedullin,ADM)的影响及可能机制。方法不同浓度的HUⅡ(10-10~10-7mol/L)刺激培养的HVEC,用放射免疫法测定其... 目的研究人尾加压素(humanurotensinⅡ,HUⅡ)对人血管内皮细胞(humanvascularendothelialcells,HVEC)分泌肾上腺髓质素(adrenomedullin,ADM)的影响及可能机制。方法不同浓度的HUⅡ(10-10~10-7mol/L)刺激培养的HVEC,用放射免疫法测定其分泌ADM的量,并加入不同细胞信号转导分子阻滞剂以测定其对分泌的影响。结果HUⅡ呈时间和浓度依赖性的增加HVEC分泌ADM。细胞外信号调节激酶抑制剂PD98059及钙调素依赖性蛋白激酶抑制剂W7、P38蛋白激酶抑制剂SB202190及钙通道阻滞剂nicardipine均能抑制HUⅡ刺激的HVEC对ADM的分泌,其抑制率分别为68%(P<0.01)、78%(P<0.01)及24%(P<0.05)、25%(P<0.05);蛋白激酶C抑制剂H7、钙调神经磷酸酶抑制剂环孢霉素(CsA)对HUⅡ刺激HVEC分泌ADM无明显影响。结论HUⅡ能刺激HVEC分泌ADM,其作用可能与Ca2+、ERKs、CaMPK及P38介导的信号转导通路有关。 展开更多
关键词 内皮 血管 信号传导 尾加压素 肾上腺髓质素 内皮细胞分泌 人血管内皮细胞 尾加压素Ⅱ 细胞外信号调节激酶抑制剂 nicardipine
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