An enantioselective NiH-catalyzed hydroalkynylation ofα,β-unsaturated amides is reported.A wide range ofα,β-unsaturated amides and bromoalkynes are suitable substrates for this reaction,which proceeds under mild c...An enantioselective NiH-catalyzed hydroalkynylation ofα,β-unsaturated amides is reported.A wide range ofα,β-unsaturated amides and bromoalkynes are suitable substrates for this reaction,which proceeds under mild conditions,allowing access to a variety of enantioenriched chiralβ-alkynyl amides.β,γ-Unsaturated amides can also be used as substrates and undergo theβ-selective hydroalkynylation with a slightly lower enantiomeric excess.展开更多
基金We thank the financial support from the Natural Science Foundation of Jiangsu Province(No.BK20190281).
文摘An enantioselective NiH-catalyzed hydroalkynylation ofα,β-unsaturated amides is reported.A wide range ofα,β-unsaturated amides and bromoalkynes are suitable substrates for this reaction,which proceeds under mild conditions,allowing access to a variety of enantioenriched chiralβ-alkynyl amides.β,γ-Unsaturated amides can also be used as substrates and undergo theβ-selective hydroalkynylation with a slightly lower enantiomeric excess.
