Previous pharmacological, human genetics, and animal models have implicated the nicotinic ace- tylcholine receptor α4 subunit （CHRNA4） gene in the pathogenesis of attention deficit/hyperactivity disorder （ADHD）. ...Previous pharmacological, human genetics, and animal models have implicated the nicotinic ace- tylcholine receptor α4 subunit （CHRNA4） gene in the pathogenesis of attention deficit/hyperactivity disorder （ADHD）. The objective of this study is to examine the genetic association between single nucleotide poly- morphisms in the CHRNA4 gene （rs2273502, rs1044396, rs1044397, and rs3827020 loci） and ADHD. Both case-control and family-based designs are used. Children aged 6 to 16 years were interviewed and assessed with the children behavior checklist and the revised conner＇ parent rating scale to identify probands. No significant differences in the frequency distribution of genotypes or alleles were found between the case and control groups. However, further haplotype analyses showed the CCGG haplotype on risk for ADHD in 164 case-control samples and the standard transmission disequilibrium test analyses suggest that the allele C of rs2273502 was over-trensferred in 98 ADHD parent-offspring trios. These findings suggest that the CHRNA4 gene may play a role in the pathogenesis of ADHD.展开更多
Background it has been reported that the nicotinic acetylcholine receptor subunit a4 gene （CHRNA4） might be associated with smoking behaviors in the previous studies. Up to now, there are few reports on the relation...Background it has been reported that the nicotinic acetylcholine receptor subunit a4 gene （CHRNA4） might be associated with smoking behaviors in the previous studies. Up to now, there are few reports on the relationship between CHRNA4 and smoking initiation, in this study, we tried to explore the role of two polymorphisms in CHRNA4 （rs1044396 and rs1044397） in smoking initiation and nicotine dependence in Chinese male smokers. Methods Nine hundred and sixty-six Chinese male lifetime nonsmokers and smokers were assessed by the Fagerstr6m test for nicotine dependence （FTND）, smoking quantity （SQ） and the heaviness of smoking index （HSI）.展开更多
基金Supported by the National Natural Science Foundation of China(No. 30470624)
文摘Previous pharmacological, human genetics, and animal models have implicated the nicotinic ace- tylcholine receptor α4 subunit （CHRNA4） gene in the pathogenesis of attention deficit/hyperactivity disorder （ADHD）. The objective of this study is to examine the genetic association between single nucleotide poly- morphisms in the CHRNA4 gene （rs2273502, rs1044396, rs1044397, and rs3827020 loci） and ADHD. Both case-control and family-based designs are used. Children aged 6 to 16 years were interviewed and assessed with the children behavior checklist and the revised conner＇ parent rating scale to identify probands. No significant differences in the frequency distribution of genotypes or alleles were found between the case and control groups. However, further haplotype analyses showed the CCGG haplotype on risk for ADHD in 164 case-control samples and the standard transmission disequilibrium test analyses suggest that the allele C of rs2273502 was over-trensferred in 98 ADHD parent-offspring trios. These findings suggest that the CHRNA4 gene may play a role in the pathogenesis of ADHD.
基金This study was supported by grants from National Natural Science Foundation of China （No. 30600205） and the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry of China （No. 2008890-19-18）.
文摘Background it has been reported that the nicotinic acetylcholine receptor subunit a4 gene （CHRNA4） might be associated with smoking behaviors in the previous studies. Up to now, there are few reports on the relationship between CHRNA4 and smoking initiation, in this study, we tried to explore the role of two polymorphisms in CHRNA4 （rs1044396 and rs1044397） in smoking initiation and nicotine dependence in Chinese male smokers. Methods Nine hundred and sixty-six Chinese male lifetime nonsmokers and smokers were assessed by the Fagerstr6m test for nicotine dependence （FTND）, smoking quantity （SQ） and the heaviness of smoking index （HSI）.
