The relationship between the electronic structures of manganese nitrido complexes and the substituted ligands is investigated by using density functional theory.By designing a series of manganese nitrido complexes [Mn...The relationship between the electronic structures of manganese nitrido complexes and the substituted ligands is investigated by using density functional theory.By designing a series of manganese nitrido complexes [Mn（SalenR）N]＋ with different para ring substituents（R = H,CH_3,NH_2,OCH_3,NMeF,etc） of the ancillary ligand,the properties of manganese-nitrogen bonds were compared for two kinds of electronic structures,of which the radical resides on metal center or the coordinated ring ligand.Our calculation shows that for R = H,CH_3 and NH_2,the [Mn（SalenR）N]＋ complexes have a high-valent Mn（VI） center,and for R = OCH_3 and NMeF,the complexes represent a configuration where the radical delocalizes on the ligand.It is found that the relative energies of these two species depend on electronic properties of the substituent,originating from the intrinsic property of HOMO-LUMO gaps.展开更多
Two new nitrido-188Re complexes were prepared by a modified method in high yield. These complexes were stable in vitro. The biodistribution in normal mice showed that these nitrido-188Re complexes could accumulate in ...Two new nitrido-188Re complexes were prepared by a modified method in high yield. These complexes were stable in vitro. The biodistribution in normal mice showed that these nitrido-188Re complexes could accumulate in liver and dissipate quickly from almost all organs. TAE was performed with the use of lipiodol solutions of two complexes to rabbit VX2 liver tumor models. SPECT images showed that the two lipiodol solutions could remain in tumor for about 9h (188ReN-NEPTDD/lipiodol) and 12h (188ReN-NEMMPTDD/lipiodol),respectively.展开更多
A high efficiency and low toxicity radiosensitizer,OsN(PhenOH)Cl_3,was designed and synthesized through substituent regulation.To the best of our knowledge,this is the first osmium-based coordination complex radiosens...A high efficiency and low toxicity radiosensitizer,OsN(PhenOH)Cl_3,was designed and synthesized through substituent regulation.To the best of our knowledge,this is the first osmium-based coordination complex radiosensitizer.The experimental results shown that this radiosensitizer induced G2/M cell cycle arrest mainly through induction of intracellular ROS overproduction.展开更多
The complex 99m TcN CPDTC(CPDTC: N cyclopropyl dithiocarbamate trihydrate) is synthesized through ligand exchange reaction. The two step procedure involves the initial reaction of 99m TcO - 4 with succinic dihydrazide...The complex 99m TcN CPDTC(CPDTC: N cyclopropyl dithiocarbamate trihydrate) is synthesized through ligand exchange reaction. The two step procedure involves the initial reaction of 99m TcO - 4 with succinic dihydrazide(SDH) as a donor of nitrido ligand(N 3- ) in the presence of stannous chloride dihydrate as reducing agent and propylenediamine tetraacetic acid(PDTA) as complex agent, followed by the addition of sodium N cyclopropyl dithiocarbamate trihydrate. The radiochemical purity(RCP) of the product is over 90% as measured by thin layer chromatography(TLC). It is stable over 6 h at room temperature. Its partition coefficient indicates it is a good lipophilic complex. The biodistribution results in mice indicate that 99m TcN CPDTC is significantly retained into the brain. The brain uptake(%, ID/g) is 4.64, 3 54 and 2.59 and the brain/blood ratio is 1.08, 1.27 and 1.28 at 5, 30 and 60 min post injection respectively. These results suggest potential usefulness of the complex as a brain perfusion imaging agent.展开更多
基金supported by the Project of National Natural Science Foundation of China(No.21573237,21603227,21403242,21703246)Natural Science Foundation of Fujian Province(2017J05032)
文摘The relationship between the electronic structures of manganese nitrido complexes and the substituted ligands is investigated by using density functional theory.By designing a series of manganese nitrido complexes [Mn（SalenR）N]＋ with different para ring substituents（R = H,CH_3,NH_2,OCH_3,NMeF,etc） of the ancillary ligand,the properties of manganese-nitrogen bonds were compared for two kinds of electronic structures,of which the radical resides on metal center or the coordinated ring ligand.Our calculation shows that for R = H,CH_3 and NH_2,the [Mn（SalenR）N]＋ complexes have a high-valent Mn（VI） center,and for R = OCH_3 and NMeF,the complexes represent a configuration where the radical delocalizes on the ligand.It is found that the relative energies of these two species depend on electronic properties of the substituent,originating from the intrinsic property of HOMO-LUMO gaps.
基金grants from Science & Technology Development Foundation of CAEP (2007A02004)
文摘Two new nitrido-188Re complexes were prepared by a modified method in high yield. These complexes were stable in vitro. The biodistribution in normal mice showed that these nitrido-188Re complexes could accumulate in liver and dissipate quickly from almost all organs. TAE was performed with the use of lipiodol solutions of two complexes to rabbit VX2 liver tumor models. SPECT images showed that the two lipiodol solutions could remain in tumor for about 9h (188ReN-NEPTDD/lipiodol) and 12h (188ReN-NEMMPTDD/lipiodol),respectively.
基金supported by the Natural Science Foundation of China(Nos.21701054,21877049)Guangdong Natural Science Foundation(No.2017A030310409)+6 种基金the Open Fund of the Key Laboratory of Functional Molecular Engineering of Guangdong Province(No.2017KF06)Major Program for Tackling Key Problems of Industrial Technology in Guangzhou(No.201902020013)Pearl River Nova Program of Guangzhou(No.201906010077)Dedicated Fund for Promoting High-Quality Marine Economic Development in Guangdong Province(Nos.GDOE-2019-A31,2020-035)Fundamental Research Funds for the Central UniversitiesGuangdong Provincial Key Laboratory Fund of Functional Supramolecular Coordination Materials and ApplicationsK.C.Wong Education Foundation。
文摘A high efficiency and low toxicity radiosensitizer,OsN(PhenOH)Cl_3,was designed and synthesized through substituent regulation.To the best of our knowledge,this is the first osmium-based coordination complex radiosensitizer.The experimental results shown that this radiosensitizer induced G2/M cell cycle arrest mainly through induction of intracellular ROS overproduction.
文摘The complex 99m TcN CPDTC(CPDTC: N cyclopropyl dithiocarbamate trihydrate) is synthesized through ligand exchange reaction. The two step procedure involves the initial reaction of 99m TcO - 4 with succinic dihydrazide(SDH) as a donor of nitrido ligand(N 3- ) in the presence of stannous chloride dihydrate as reducing agent and propylenediamine tetraacetic acid(PDTA) as complex agent, followed by the addition of sodium N cyclopropyl dithiocarbamate trihydrate. The radiochemical purity(RCP) of the product is over 90% as measured by thin layer chromatography(TLC). It is stable over 6 h at room temperature. Its partition coefficient indicates it is a good lipophilic complex. The biodistribution results in mice indicate that 99m TcN CPDTC is significantly retained into the brain. The brain uptake(%, ID/g) is 4.64, 3 54 and 2.59 and the brain/blood ratio is 1.08, 1.27 and 1.28 at 5, 30 and 60 min post injection respectively. These results suggest potential usefulness of the complex as a brain perfusion imaging agent.
