The Friedel-Crafts alkylation of indoles with nitroacrylates could provide α- and β-tryptophan nitro-precursors, respectively, in moderate to good yields under Lewis acid catalysis. The diastereoselectivities of the...The Friedel-Crafts alkylation of indoles with nitroacrylates could provide α- and β-tryptophan nitro-precursors, respectively, in moderate to good yields under Lewis acid catalysis. The diastereoselectivities of the reaction were enhanced by using 2-substituted indoles. The alkylation products could be easily transformed to nonnatural tryptophan derivatives.展开更多
基金Project supported by the National Natural Science Foundation of China and the Chinese Academy of Sciences.
文摘The Friedel-Crafts alkylation of indoles with nitroacrylates could provide α- and β-tryptophan nitro-precursors, respectively, in moderate to good yields under Lewis acid catalysis. The diastereoselectivities of the reaction were enhanced by using 2-substituted indoles. The alkylation products could be easily transformed to nonnatural tryptophan derivatives.
