The effects of nitroquine on the sporogony of Plasmodium yoelii werestudied with electron microscope.The drug was given by feeding female mosqui-toes directly in the form of mixture with sucrose solution.Scanning elec...The effects of nitroquine on the sporogony of Plasmodium yoelii werestudied with electron microscope.The drug was given by feeding female mosqui-toes directly in the form of mixture with sucrose solution.Scanning electronmicroscopic studies revealed that the oocysts were smaller and markedly degener-ated.Surface of the oocysts was rough and uneven.Under transmission electronmicroscope,the cytoplasm of the affected oocysts contained vacuoles.Mitochondrial and nuclear membrane was damaged.The number of residualbodies increased.Formation of sporoblast did not occur in most of the affectedoocysts.The nuclear membranes of the degenerated sporozoites became thick-ened and the density of nucleus matrix markedly decreased.The results indicatedthat nuclei and the membrane system were mainly affected.展开更多
One hundred and ninety-five mice were used to study the mechanism of the protective ef-fects of folic acid on nitroqine toxicity to the small intestine.After oral administration of nitroquineacetate(570mg/kg×1),i...One hundred and ninety-five mice were used to study the mechanism of the protective ef-fects of folic acid on nitroqine toxicity to the small intestine.After oral administration of nitroquineacetate(570mg/kg×1),intramuscular injection of normal saline was given to one group of mice(NS group)and intramuscular injection of folic acid(8mg/kg×1)to another(NF group).Decrease incells in the crypts were observed in the animals of NS group,but the changes were much milder inthose of NF group even at 96 h after administration.The decrease of DNA content in the tissues ofthe small intestine was dose-and time-dependent.The value of cpm/mg of DNA after ~3H-TdRincorporation were much higher in NF group than in NS group.these rcsults suggest that DNA synthesis in the small intestine may be promoted by folic acid so thatthe renair of the damaged intestinal mucosa is acoelerated.展开更多
文摘The effects of nitroquine on the sporogony of Plasmodium yoelii werestudied with electron microscope.The drug was given by feeding female mosqui-toes directly in the form of mixture with sucrose solution.Scanning electronmicroscopic studies revealed that the oocysts were smaller and markedly degener-ated.Surface of the oocysts was rough and uneven.Under transmission electronmicroscope,the cytoplasm of the affected oocysts contained vacuoles.Mitochondrial and nuclear membrane was damaged.The number of residualbodies increased.Formation of sporoblast did not occur in most of the affectedoocysts.The nuclear membranes of the degenerated sporozoites became thick-ened and the density of nucleus matrix markedly decreased.The results indicatedthat nuclei and the membrane system were mainly affected.
文摘One hundred and ninety-five mice were used to study the mechanism of the protective ef-fects of folic acid on nitroqine toxicity to the small intestine.After oral administration of nitroquineacetate(570mg/kg×1),intramuscular injection of normal saline was given to one group of mice(NS group)and intramuscular injection of folic acid(8mg/kg×1)to another(NF group).Decrease incells in the crypts were observed in the animals of NS group,but the changes were much milder inthose of NF group even at 96 h after administration.The decrease of DNA content in the tissues ofthe small intestine was dose-and time-dependent.The value of cpm/mg of DNA after ~3H-TdRincorporation were much higher in NF group than in NS group.these rcsults suggest that DNA synthesis in the small intestine may be promoted by folic acid so thatthe renair of the damaged intestinal mucosa is acoelerated.
