Although disintegrated dolomite,widely distributed across the globe,has conventionally been a focus of research in underground engineering,the issue of slope stability issues in disintegrated dolomite strata is gainin...Although disintegrated dolomite,widely distributed across the globe,has conventionally been a focus of research in underground engineering,the issue of slope stability issues in disintegrated dolomite strata is gaining increasing prominence.This is primarily due to their unique properties,including low strength and loose structure.Current methods for evaluating slope stability,such as basic quality(BQ)and slope stability probability classification(SSPC),do not adequately account for the poor integrity and structural fragmentation characteristic of disintegrated dolomite.To address this challenge,an analysis of the applicability of the limit equilibrium method(LEM),BQ,and SSPC methods was conducted on eight disintegrated dolomite slopes located in Baoshan,Southwest China.However,conflicting results were obtained.Therefore,this paper introduces a novel method,SMRDDS,to provide rapid and accurate assessment of disintegrated dolomite slope stability.This method incorporates parameters such as disintegrated grade,joint state,groundwater conditions,and excavation methods.The findings reveal that six slopes exhibit stability,while two are considered partially unstable.Notably,the proposed method demonstrates a closer match with the actual conditions and is more time-efficient compared with the BQ and SSPC methods.However,due to the limited research on disintegrated dolomite slopes,the results of the SMRDDS method tend to be conservative as a safety precaution.In conclusion,the SMRDDS method can quickly evaluate the current situation of disintegrated dolomite slopes in the field.This contributes significantly to disaster risk reduction for disintegrated dolomite slopes.展开更多
Ahn To develop a high resolution HPLC method for the determination of ondansetron in human plasma and to study the pharmacokinetics of ondansetron in orally disintegrating tablets. Methods HPLC determination involved ...Ahn To develop a high resolution HPLC method for the determination of ondansetron in human plasma and to study the pharmacokinetics of ondansetron in orally disintegrating tablets. Methods HPLC determination involved liquid-liquid extraction, separation on a CN column and ultraviolet detection at 310 ran with granisetron as an internal standard. Pharmacokinetics and bioequivalence of ondansetron in orally disintegrating tablets by direct compression and conventional 8 mg tablets were evaluated and compared in 20 healthy human male volunteers after a single oral dose in a randomized cross-over study. Results The limit of quantification was 0.25 ng· mL^-1. The recovery was about 85 % or over for ondan setron and about 90% for internal standard. Linearity was good within the concentration range of 0.5 - 50 ng·mL^-1 with r^2 ranging from 0.997 1 to 0.999 9. Intra- and inter-assay coefficients of variation ranged from 1.78% to 2.38% and 3.88% -5.19%, respectively. Accuracies for spiked concentrations of 2.0, 10.0, and 30.0 ng·mL^-1 were 104.7% ±4.4%, 102.2% ± 1.1%, and99.51% ±2.34%, respectively. Pharmacokinetic parameters of AUCo-t, AUCo-∞ , Cmax, Tmax, and T1/2 were 230.2 ± 78.0 ng·h·L^-1 , 265.2± 101.5 ng·h·mL^-1, 35.67 ± 8.94 ng·mL^-l, 1.51 ±0.79 h, and 5.00± 1.41 h for orally disintegrating tablets, respectively. The analysis of variance did not show any significant difference between orally disintegrating tablets and conventional tablets, and 90% confidence intervals fell within the acceptable range for bioequivalence. Conclusion High resolution HPLC method has been set up and applied in pharmacokinetic evaluation of ondansetron in orally disintegrating tablets.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.42162026)the Applied Basic Research Foundation of Yunnan Province(Grant No.202201AT070083).
文摘Although disintegrated dolomite,widely distributed across the globe,has conventionally been a focus of research in underground engineering,the issue of slope stability issues in disintegrated dolomite strata is gaining increasing prominence.This is primarily due to their unique properties,including low strength and loose structure.Current methods for evaluating slope stability,such as basic quality(BQ)and slope stability probability classification(SSPC),do not adequately account for the poor integrity and structural fragmentation characteristic of disintegrated dolomite.To address this challenge,an analysis of the applicability of the limit equilibrium method(LEM),BQ,and SSPC methods was conducted on eight disintegrated dolomite slopes located in Baoshan,Southwest China.However,conflicting results were obtained.Therefore,this paper introduces a novel method,SMRDDS,to provide rapid and accurate assessment of disintegrated dolomite slope stability.This method incorporates parameters such as disintegrated grade,joint state,groundwater conditions,and excavation methods.The findings reveal that six slopes exhibit stability,while two are considered partially unstable.Notably,the proposed method demonstrates a closer match with the actual conditions and is more time-efficient compared with the BQ and SSPC methods.However,due to the limited research on disintegrated dolomite slopes,the results of the SMRDDS method tend to be conservative as a safety precaution.In conclusion,the SMRDDS method can quickly evaluate the current situation of disintegrated dolomite slopes in the field.This contributes significantly to disaster risk reduction for disintegrated dolomite slopes.
文摘Ahn To develop a high resolution HPLC method for the determination of ondansetron in human plasma and to study the pharmacokinetics of ondansetron in orally disintegrating tablets. Methods HPLC determination involved liquid-liquid extraction, separation on a CN column and ultraviolet detection at 310 ran with granisetron as an internal standard. Pharmacokinetics and bioequivalence of ondansetron in orally disintegrating tablets by direct compression and conventional 8 mg tablets were evaluated and compared in 20 healthy human male volunteers after a single oral dose in a randomized cross-over study. Results The limit of quantification was 0.25 ng· mL^-1. The recovery was about 85 % or over for ondan setron and about 90% for internal standard. Linearity was good within the concentration range of 0.5 - 50 ng·mL^-1 with r^2 ranging from 0.997 1 to 0.999 9. Intra- and inter-assay coefficients of variation ranged from 1.78% to 2.38% and 3.88% -5.19%, respectively. Accuracies for spiked concentrations of 2.0, 10.0, and 30.0 ng·mL^-1 were 104.7% ±4.4%, 102.2% ± 1.1%, and99.51% ±2.34%, respectively. Pharmacokinetic parameters of AUCo-t, AUCo-∞ , Cmax, Tmax, and T1/2 were 230.2 ± 78.0 ng·h·L^-1 , 265.2± 101.5 ng·h·mL^-1, 35.67 ± 8.94 ng·mL^-l, 1.51 ±0.79 h, and 5.00± 1.41 h for orally disintegrating tablets, respectively. The analysis of variance did not show any significant difference between orally disintegrating tablets and conventional tablets, and 90% confidence intervals fell within the acceptable range for bioequivalence. Conclusion High resolution HPLC method has been set up and applied in pharmacokinetic evaluation of ondansetron in orally disintegrating tablets.
