TT viral infection through blood transfusion:retrospective investigation on patients in a prospective study of post-transfusion hepatitis

AIM To investigate the role of bloodtransfusion in TT viral infection(TTV).METHODS We retrospectively studied serumsamples from 192 transfusion recipients whounderwent cardiovascular surgery and bloodtransfusion between July 1991 and June 1992.Allpatients had a follow-up every other week for atleast 6 months after transfusion.Eightyrecipients received blood before screeningdonors for hepatitis C antibody(anti-HCV),and112 recipients received screened blood.Recipients with alanine aminotransferase level】2.5 times the upper normal limit were testedfor serological markers for viral hepatitis A,B,C,G,Epstein-Barr virus and cytomegalovirus.TTV infection was defined by the positivity forserum TTV DNA using the polymerase chainreaction method.RESULTS Eleven and three patients,whoreceived anti-HCV unscreened and screened'blood,respectively,had serum ALT levels】90 IU/L.Five patients(HCV and TTV:1;HCV,HGV,and TTV:1;TTV:2;and CMV and TTV:1)were positive for TTV DNA,and four of them hadsero-conversion of TTV DNA.CONCLUSION TTV can be transmitted viablood transfusion.Two recipients infected byTTV alone may be associated with the hepatitis.However,whether TTV was the causal agentremains unsettled,and further studies arenecessary to define the role of TTV infection inchronic hepatitis.

The prevalence of transfusion transmitted virus infection in blood donors

INIRODUCIIONA newly discovered DNA virus,transfusiontransmitted virus (TTV),was reported as a cause ofpost-transfusion hepatitis of unknown etiology inJapan.In order to investigate TTV prevalence insouthern China,a study was carried out amongblood donors,patients with liver diseases andhemodialysis to determine the epidemiologicalcharateristics.

Occult hepatitis B virus infection and blood transfusion

Transfusion-transmitted infections including hepatitis B virus(HBV) have been a major concern in transfusion medicine. Implementation of HBV nucleic acid testing(NAT) has revealed occult HBV infection(OBI) in blood donors. In the mid-1980 s, hepatitis B core antibody(HBc) testing was introduced to screen blood donors in HBV non-endemic countries to prevent transmission of non-A and non-B hepatitis. That test remains in use for preventing of potential transmission of HBV from hepatitis B surface antigen(HBs Ag)-negative blood donors, even though anti-hepatitis C virus testshave been introduced. Studies of anti-HBc-positive donors have revealed an HBV DNA positivity rate of 0%-15%. As of 2012, 30 countries have implemented HBV NAT. The prevalence of OBI in blood donors was estimated to be 8.55 per 1 million donations, according to a 2008 international survey. OBI is transmissible by blood transfusion. The clinical outcome of occult HBV transmission primarily depends on recipient immune status and the number of HBV DNA copies present in the blood products. The presence of donor anti-HBs reduces the risk of HBV infection by approximately five-fold. The risk of HBV transmission may be lower in endemic areas than in non-endemic areas, because most recipients have already been exposed to HBV. Blood safety for HBV, including OBI, has substantially improved, but the possibility for OBI transmission remains.

Safety of Blood Maintained in Zimbabwe: Low Transfusion Transmissible Infections among Blood Donors

Background: Low level of transfusion transmissible infections (TTIs) is an indicator of a well-performing blood donor program. Aim: The study was designed to estimate the prevalence of TTIs and to evaluate the demographic characteristics of reactive and non-reactive blood donors in Zimbabwe in 2018. Methods: A cross-sectional study was conducted using routinely available data from January to December 2018 in five branches of National Blood Service Zimbabwe (NBSZ). After initial screening for high-risk behavior with a questionnaire, weight, blood pressure and hemoglobin level, eligible donors were invited for blood donation. The following laboratory tests for TTIs were done: antibodies and antigen tests for human immunodeficiency virus 1 and 2 (HIV 1/2), tests for the surface antigen of hepatitis B virus (HBV), testing for hepatitis C virus (HCV) antibody and antibodies for treponema pallidum. Information on age, gender, NBSZ branch, marital status, occupation, donor type (first time/repeat) and TTIs test results were extracted from the NBSZ electronic database (e-Delphyn blood bank software). Results: Out of a sample of 1586 blood donors, thirteen (0.81%) were reactive to at least one TTI marker;five (0.32%) were reactive for human immunodeficiency virus, seven (0.44%) for hepatitis B and one (0.06%) for syphilis. There were no samples with co-infection and hepatitis C virus markers. The prevalence of TTIs was highest in the 31 - 45 years age group (2.3%) and among first-time blood donors (4.7%). The prevalence of all TTI was low with the highest prevalence of 0.44% for the hepatitis B virus. Conclusion: Continued concerted efforts will help to maintain satisfactory blood safety in Zimbabwe.

Advances in research on influencing factors of hepatitis B virus infection caused by blood transfusions

As one of the main factors affecting safe blood transfusion, hepatitis B virus(HBV) infection through blood transfer seriously endangers human health. Therefore, studies should focus on both reducing infection rate of HBV and accurately evaluating the risk of infection. This study discusses the main factors affecting HBV infection that results from blood transfusions, with the aim of gaining insights into reducing HBV infection.

A 10 Years Comparative Study to Assess Trends in Seroprevalence of Transfusion Transmitted Infections among Blood Donors at Gwalior, India

Introduction: Transfusion Transmitted Infections (TTIs) threaten safety of the recipients and the community as a whole and are the subject of real concern worldwide. Aims and Objectives: To know the prevalence of transfusion transmitted infections amongst the blood donors, to evaluate the changing trends of TTIs and to compare these observations within the study as well as with the other relevant studies. Place and Duration of Study: This study was carried out at Blood Bank, Department of Pathology, Gajra Raja Medical College, Gwalior, India, from January 2004 to December 2013 (ten years). Materials and Methods: In this study 122,006 voluntary and replacement donations were screened for TTIs;HIV, HBV, HCV, Syphilis, Malaria and their seroprevalence was calculated. Further study was divided in Group “A” (from 2004 to 2008) and Group “B” (from 2009 to 2013) to compare the results. Results: Out of total 122,006 blood units collected, 79,750 (65.3%) were voluntary and 42,256 (34.7%) were replacement donors. The seropositivity of TTIs in the entire study, in group “A” and in Group “B” was 3.26% (3985/122,006) (p = 0.000005), 2.25% (1238/54,874) (p = 0.000005) and 4.09% (2747/67,123) (p = 0.000005) respectively. In Group “A” and “B” seroprevalence of HIV, HBV, HCV, Syphilis and Malaria was 0.29%, 1.16%, 0.61%, 0.06%, 0.11% and 0.13%, 3.15%, 0.24%, 0.17%, 0.03% respectively. Conclusion: Our study concluded that there was significant increase in seroprevalence of HBV and syphilis whereas decreasing pattern in HIV, HCV and Malaria was observed in last five years as compared to previous five years among the blood donors.

TT virus and hepatitis G virus infections in Korean blood donors and patients with chronic liver disease

AIM:To determine the prevalences of TTV and HGV infections among blood donors and patients with chronic liver disease in Korea,to investigate the association of TTV and HGV infections with blood transfusion,and to assess the correlation between TTV and HGV viremia and hepatic damage. METHODS:A total of 391 serum samples were examined in this study.Samples were obtained from healthy blood donors(n=110),hepatitis B surface antigen(HBsAg)-positive donors(n=112),anti-hepatitis C virus(anti-HCV)-positive donors(n=69),patients with type B chronic liver disease (n=81),and patients with type C chronic liver disease(n=19). Trv DNA was detected using the hemi-nested PCR.HGV RNA was tested using RT-PCR.A history of blood transfusion and serum levels of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)were also determined. RESULTS:TTV DNA was detected in 8.2%of healthy blood donors,16.1%of HBsAg-positive donors,20.3%of anti- HCV-positive donors,21.0%of patients with type B chronic liver disease,and 21.1%of patients with type C chronic liver disease.HGV RNA was detected in 1.8%of healthy blood donors,1.8%of HBsAg-positive donors,17.4%of anti-HCV-positive donors,13.6%of patients with type B chronic liver disease,and 10.5%of patients with type C chronic liver disease.The prevalence of TTV and HGV infections in HBV- or HCV-positive donors and patients was significantly higher than in healthy blood donors(P<0.05), except for the detection rate of HGV in HBsAg-positive donors which was the same as for healthy donors.There was a history of transfusion in 66.7%of TTV DNA-positive patients and 76.9%of HGV RNA-positive patients(P<0.05).No significant increase in serum ALT and AST was detected in the TTV or HGV-positive donors and patients. CONCLUSION:TTV and HGV infections are more frequently found in donors and patients infected with HBV or HCV than in healthy blood donors.However,there is no significant association between TTV or HGV infections and liver injury.

Genetic diversity and occult hepatitis B infection in Africa: A comprehensive review

BACKGROUND Occult hepatitis B infection(OBI)is a globally prevalent infection,with its frequency being influenced by the prevalence of hepatitis B virus(HBV)infection in a particular geographic region,including Africa.OBI can be transmitted th-rough blood transfusions and organ transplants and has been linked to the development of hepatocellular carcinoma(HCC).The associated HBV genotype influences the infection.AIM To highlight the genetic diversity and prevalence of OBI in Africa.METHODS This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and involved a comprehensive search on PubMed,Google Scholar,Science Direct,and African Journals Online for published studies on the prevalence and genetic diversity of OBI in Africa.RESULTS The synthesis included 83 articles,revealing that the prevalence of OBI varied between countries and population groups,with the highest prevalence being 90.9%in patients with hepatitis C virus infection and 38%in blood donors,indicating an increased risk of HBV transmission through blood transfusions.Cases of OBI reactivation have been reported following chemotherapy.Genotype D is the predominant,followed by genotypes A and E.CONCLUSION This review highlights the prevalence of OBI in Africa,which varies across countries and population groups.The study also demonstrates that genotype D is the most prevalent.

High frequencies of HGV and TTV infections in blood donors in Hangzhou

AIM: To determine the frequencies of HGV and TTV infections in blood donors in Hangzhou. METHODS: RT-nested PCR for HGV RNA detection and semi-nested PCR for TTV DNA detection in the sera from 203 blood donors, and nucleotide sequence analysis were performed. RESULTS: Thirty-two (15.8%) and 30 (14.8%) of the 203 serum samples were positive for HGV RNA and TTV DNA, respectively. And 5 (2.5%) of the 203 serum samples were detectable for both HGV RNA and TTV DNA. Homology of the nucleotide sequences of HGV RT-nested PCR products and TTV semi-nested PCR products from 3 serum samples compared with the reported HGV and TTV sequences was 89.36%, 87.94%, 88.65% and 63.51%, 65.77% and 67.12%, respectively. CONCLUSION: The infection rates of HGV and/or TTV in blood donors are relatively high, and to establish HGV and TTV examinations to screen blood donors is needed for transfusion security. The genomic heterogeneity of TTV or HGV is present in the isolates from different areas.

Prevalence of transfusion transmissible infections among various donor groups:A comparative analysis

BACKGROUND Transfusion transmissible infections(TTIs)are illnesses spread through contaminated blood or blood products.In India,screening for TTIs such as hepatitis B virus(HBV),hepatitis C virus(HCV),human immunodeficiency virus(HIV)-I/II,malaria,and syphilis is mandatory before blood transfusions.Worldwide,HCV,HBV,and HIV are the leading viruses causing mortality,affecting millions of people globally,including those with co-infections of HIV/HCV and HIV/HBV.Studies highlight the impact of TTIs on life expectancy and health risks,such as liver cirrhosis,cancer,and other diseases in individuals with chronic HBV.Globally,millions of blood donations take place annually,emphasizing the importance of maintaining blood safety.AIM To study the prevalence of TTIs,viz.,HBV,HCV,HIV I/II,syphilis,and malaria parasite(MP),among different blood donor groups.METHODS The study assessed the prevalence of TTIs among different blood donor groups in Delhi,India.Groups included total donors,in-house donors,total camp donors,institutional camp donors,and community camp donors.Tests for HIV,HBV,and HCV were done using enzyme-linked immunosorbent assay,while syphilis was tested with rapid plasma reagins and MP rapid card methods.The prevalence of HBV,HCV,HIV,and syphilis,expressed as percentages.Differences in infection rates between the groups were analyzed usingχ²tests and P-values(less than 0.05).RESULTS The study evaluated TTIs among 42158 blood donors in Delhi.The overall cumulative frequency of TTIs in total blood donors was 2.071%,and the frequencies of HBV,HCV,HIV-I/II,venereal disease research laboratory,and MP were 1.048%,0.425%,0.221%,0.377%,and 0.0024%,respectively.In-house donors,representing 37656 donors,had the highest transfusion transmissible infection(TTI)prevalence at 2.167%.Among total camp donors(4502 donors),TTIs were identified in 1.266%of donors,while community camp donors(2439 donors)exhibited a prevalence of 1.558%.Institutional camp donors(2063 donors)had the lowest TTI prevalence at 0.921%.Statistical analysis revealed significant differences in overall TTI prevalence,with total and in-house donors exhibiting higher rates compared to camp donors.CONCLUSION Ongoing monitoring and effective screening programs are essential for minimizing TTIs.Customizing blood safety measures for different donor groups and studying socio-economic-health factors is essential to improving blood safety.

Follow-up study of hepatitis C virus infection in uremic patients on maintenance hemodialysis for 30 months

INTRODUCTIONA high prevalence of antibodies to hepatitis C virus(HCV)(range from 3.3%-80%)has beenreported in hemodialysis(HD)patients,andworrisome as it often becomes chronic and induceschronic liver disease,therefore thenephrologists face a major challenge of how toprevent it.The main route of HCV transmission

Seroprevalence of Hepatitis B Virus (HBV) among Voluntary Healthy Blood Donors at Tellewonyan Memorial Hospital Voinjama, Lofa County, Liberia

Background: The prevalence of transfusion associated hepatitis B virus (HBV) infection differs across different population geographically. Ascertaining the seroprevalence of HBV infection is vital to informing the way of precautionary and control strategies. This study sought to establish the seroprevalence of hepatitis B surface antigen (HBVsAg) among blood donors in Yelewonyan Memorial Hospital Lofa, Liberia. Methods: This was a retrospective study which involved reviewing of blood donation records for the year 2020 at Telewonyan Memorial Hospital in Lofa County. The data obtained from the records were analyzed. Data analysis was done using SPSS version 12 for windows. Results: A total of 584 voluntary blood donors were screened for donation in 2020. Out of 584, 554 (95.9%) were males while the rest were females. Prevalence of 3.3% was observed among blood donors in Telewonyan Memorial Hospital. There is a significant difference between gender and age with HBV seropositivity among blood donors. Conclusion: The findings of this study suggest that the study site is of low endemicity with HBV infection. Usually, males are more probably to be HBVsAg seropositive than their female’s counterpart. Planning more extensive study and educational programs would help minimize the spread of HBV infection among the general population.

外科手术患者术后切口感染的危险因素分析

目的分析外科手术患者术后切口感染的危险因素。方法回顾性分析2022年1月至2022年12月于九江市第一人民医院进行外科手术治疗的256例患者的临床资料,所有入选者均进行相应的手术治疗,根据术后切口感染发生情况分组,比较两组相关资料,分析外科发生切口感染的相关因素。结果256例患者中,有20例发生切口感染,术后切口感染发生率为7.81%(20/256)。单因素分析结果显示,感染组年龄>60岁、合并糖尿病、术前贫血、手术时间≥3 h、急诊手术、围手术期输血占比均高于未感染组,差异有统计学意义(P<0.05)。logistic回归分析结果显示,年龄>60岁(OR=6.316,95%CI=2.214~18.018,P=0.001)、合并糖尿病(OR=4.787,95%CI=1.877~12.209,P=0.001)、术前贫血(OR=4.756,95%CI=1.860~12.163,P=0.001)、手术时间≥3 h(OR=6.367,95%CI=2.458~16.491,P<0.001)、急诊手术(OR=6.574,95%CI=2.547~16.968,P<0.001)、围手术期输血(OR=5.441,95%CI=2.111~14.024,P<0.001)是外科手术患者术后切口感染的独立危险因素(P<0.05,OR>1)。结论手术为重要的治疗方法,但因本身具有创伤性,术后切口感染发生率较高,对于年龄>60岁、合并糖尿病、术前贫血、手术时间≥3 h、急诊手术、围手术期输血的患者,需重点管理,尽可能降低切口感染发生率。

创伤输血后感染患者血清T淋巴细胞表达情况及危险因素分析

目的 分析创伤输血后感染患者血清T淋巴细胞变化情况及其是否与患者发生感染有关,并分析患者感染的危险因素,以期为患者感染预防及是否需要进行免疫监测提供参考。方法 纳入2019年1月至2023年5月青海省第五人民医院收治的创伤输血病例126例,检测患者输血前后血清T淋巴细胞水平,根据患者是否发生感染分组为感染组(43例)、未感染组(83例),比较两组血清T淋巴细胞水平,并收集患者年龄、性别、创伤类型、是否使用免疫抑制剂、红细胞保存时间等一般资料进行单因素分析,将其中有统计学意义的资料纳入多因素Logistic回归分析模型完成创伤输血后感染的危险因素分析。结果 输血后患者CD3^(+)T淋巴细胞、CD4^(+)T淋巴细胞、CD4^(+)/CD8^(+)水平显著降低,CD8^(+)T淋巴细胞显著升高(P<0.05);感染组患者CD3^(+)T淋巴细胞、CD4^(+)T淋巴细胞、CD4^(+)/CD8^(+)水平显著低于未感染组,CD8^(+)T淋巴细胞水平显著高于未感染组(P<0.05);一般资料的单因素分析中感染组患者多发伤、使用免疫抑制剂、接受消化道脱污染治疗、平均红细胞保存时间≥14d、红细胞输入总单位数≥7个占比显著高于未感染组(P< 0.05),其余吸烟、酗酒、年龄、性别、平均血小板保存时间、是否合并糖尿病、血小板输入总单位数等资料无显著差异(P>0.05);多因素Logistic回归分析提示CD8^(+)T淋巴细胞升高、多发伤、使用免疫抑制剂、接受消化道脱污染治疗、平均红细胞保存时间≥14d、红细胞输入总单位数≥7个是创伤输血患者感染的独立危险因素,CD3^(+)T淋巴细胞、CD4^(+)T淋巴细胞、CD4^(+)/CD8^(+)增加为保护因素。结论 创伤输血后易对患者免疫功能产生影响,创伤输血后感染患者较未感染患者T淋巴细胞亚群紊乱现象更明显,创伤输血患者需重视其免疫监测,预防感染。

血sIL-2R、CRP、WBC与围术期输血患者感染的相关性研究

目的探讨血可溶性白介素-2受体(sIL-2R)、白细胞计数(WBC)、C反应蛋白(CRP)与围术期输血患者感染的相关性。方法选取2020年8月至2023年2月该院围术期输血后感染者37例设为研究组,根据1∶1原则选取同期在该院接受输血但无感染的37例为对照组。抽取所有受检者空腹静脉血,经酶联免疫吸附试验测定sIL-2R、CRP表达,用血细胞分析仪测定WBC,并对研究组实施抗感染治疗。统计研究组与对照组不同感染情况(感染位置、感染程度)及不同感染控制情况者血sIL-2R、WBC、CRP表达,分析血sIL-2R、WBC、CRP表达与感染情况的相关性。结果研究组血sIL-2R、WBC、CRP高于对照组,差异有统计学意义(P<0.05)。深部感染者、重度感染者血sIL-2R、WBC、CRP高于浅表感染者、轻中度感染者(P<0.05)。经Spearman检验证实,血sIL-2R、WBC、CRP与感染位置、感染程度呈显著正相关关系(P<0.05)。研究组感染控制31例、感染未控制6例,感染控制者血sIL-2R、WBC、CRP低于未控制者,差异有统计学意义(P<0.05)。结论围术期输血后感染患者sIL-2R、WBC、CRP异常增高,增高幅度与感染位置、感染程度存在正相关关系,且通过监测上述指标还可评估感染控制情况。

受血者输血前检测感染性疾病指标的结果及临床意义分析

目的:分析受血者输血前检测感染性疾病指标的结果与临床意义。方法:选取2020年1月—2023年6月在永州市第三人民医院接受输血治疗的受血者1379例为研究对象。所有受血者输血前检测乙肝表面抗原(HBSAg)、人类免疫缺陷病毒抗体(抗-HIV)、丙型肝炎病毒抗体(抗-HCV)、梅毒螺旋体特异性抗体(抗-TP)、丙氨酸氨基转移酶(ALT)水平。分析感染性疾病指标结果并探讨其临床意义。结果:1379例受血者中,感染性指标检测结果阳性者共101例,阳性检出率为7.32%,其中HBSAg阳性检出率最高,为4.57%。784例男性受血者中,感染性指标检测结果阳性者共57例,阳性检出率为7.27%;595例女性受血者中,感染性指标检测结果阳性者共44例,阳性检出率为7.39%。不同性别受血者HBSAg、抗-HIV、抗-HCV、抗-TP、ALT阳性检出率比较,差异无统计学意义(P>0.05)。1272例无输血史受血者中,感染性指标检测结果阳性者共78例,阳性检出率为6.13%;107例有输血史受血者中,感染性指标检测结果阳性者共23例,阳性检出率为21.50%。有输血史受血者HBSAg、抗-HIV、抗-TP、ALT阳性检出率高于无输血史者(P<0.05)。1379例受血者中,多重感染患者27例,总阳性率为1.96%,抗-HIV+HBSAg混合感染率最高,为0.58%。结论:部分受血者患感染性疾病,其中有输血史的受血者阳性检出率高于无输血史者,且存在多重感染情况,输血前进行感染性疾病指标检测有助于为临床加强输血安全监控提供指导。

大面积烧伤患者烧伤初期输血治疗的效果

目的分析大面积烧伤患者烧伤初期输血治疗的可行性,为烧伤患者的治疗提供参考。方法选取2018年2月—2023年2月本院烧伤科收治的60例患者为研究对象,所有患者均为大面积烧伤患者。采用随机数字表法将其分为对照组和观察组,每组30例。对照组采取常规治疗法,观察组则采取烧伤初期输血治疗,以验证烧伤初期输血治疗的效果。对比指标包括临床治疗效果、住院时间、合并感染发生率以及血常规指标等。结果观察组治疗总有效率高于对照组(P<0.05);相较于对照组,观察组住院时间更短(P<0.05),合并感染发生率更低(P<0.05)。入院时,两组在红细胞计数、血红蛋白(Hb)、红细胞比容(HCT)及血小板计数的对比中无显著差异(P>0.05);烧伤后第1d,观察组上述指标显著上升(P<0.05);输血治疗后(7d、14d),观察组红细胞、Hb、HCT虽有所下降但仍高于输血前,且高于同期的对照组(P<0.05);烧伤后7d,观察组血小板计数低于对照组(P<0.05)。结论输血治疗有助于控制合并感染发生风险,改善患者的贫血情况,并进一步加速患者康复,提升患者的整体治疗效果。

血液透析患者丙型肝炎病毒感染的预防

目的 调查血透患者丙肝病毒 (HCV)感染情况及影响因素 ,探讨预防HCV感染的措施。方法 在未采取HCV感染预防措施的 1990～ 1992年间、采取HCV感染预防措施的 1997～ 1999年间及使用一次性透析器后的2 0 0 1～ 2 0 0 2年间 ,采用日本Kuraray公司提供的抗HCV 14试剂盒 ,以间接酶免疫测定法检测长期维持性血透患者抗体。结果 HCV的 1年阳转率 1991～ 1992年为 42 .2 %,1998～ 1999年为 2 2 .8%,2 0 0 1年～ 2 0 0 2年为 9%;输血量越多 ,透析时间越长 ,丙肝的感染率越高。结论 多次输血是血透患者高丙肝病毒感染的主要原因 ,透析过程中的医院感染也是不容忽视的重要因素。减少输血量 ,加强对血透患者HCV感染者的管理 ,严格消毒隔离 ,透析器一次使用等可有效控制血液透析 (HD)患者高HCV感染状态。

围术期输血对患者术后感染的影响

本研究通过对中国人民解放军总医院术后感染病例的回顾性分析,探讨患者围术期的输血状况是否会加重术后感染程度。应用中国人民解放军总医院输血科开发软件"临床输血数据库"进行检索,选取150例外科手术后感染病例,按感染部位分为深部感染组和浅部感染组,对两组患者的年龄、住院时间、红细胞输注量、非红细胞输注量、输血次数和平均每次输血量进行对比分析。结果表明,发生浅部感染患者的中位红细胞输注量和非红细胞输注量分别为4.50(0-59)U和2.95(0-119.6)U,深部感染组中位红细胞输注量和非红细胞输注量分别为9.00(0-153)U和8.05(0-136.6)U,两组患者存在明显差异(P<0.05)。两组患者最显著的差异是输血次数的不同,发生浅部感染的患者中位输血次数为2(1-31)次,远远低于发生深部感染患者的输血次数4(1-49)次(P<0.001)。两组患者的平均每次输注量没有明显差异。结论:手术患者围术期的输血量及输血次数同患者术后感染的严重程度似乎呈正相关。