To rapidly generate a reentry trajectory for hypersonic vehicle satisfying waypoint and no-fly zone constraints, a novel optimization method, which combines the improved particle swarm optimization (PSO) algorithm w...To rapidly generate a reentry trajectory for hypersonic vehicle satisfying waypoint and no-fly zone constraints, a novel optimization method, which combines the improved particle swarm optimization (PSO) algorithm with the improved Gauss pseudospectral method (GPM), is proposed. The improved PSO algorithm is used to generate a good initial value in a short time, and the mission of the improved GPM is to find the final solution with a high precision. In the improved PSO algorithm, by controlling the entropy of the swarm in each dimension, the typical PSO algorithm's weakness of being easy to fall into a local optimum can be overcome. In the improved GPM, two kinds of breaks are introduced to divide the trajectory into multiple segments, and the distribution of the Legendre-Gauss (LG) nodes can be altered, so that all the constraints can be satisfied strictly. Thereby the advan- tages of both the intelligent optimization algorithm and the direct method are combined. Simulation results demonstrate that the proposed method is insensitive to initial values, and it has more rapid convergence and higher precision than traditional ones.展开更多
Objective The Susong complex zone(SCZ)is a relatively lowgrade metamorphic unit mostly with an epidoteamphibolite facies,located in the southernmost part of the Dabie orogen.However,its rock compositions,ages,
Objective The northern Guangxi region is in the southwestern part of the Southern China continent,which is located at the junction of the southwest section of the Early Paleozoic Yangtze block and Cathaysian block.A s...Objective The northern Guangxi region is in the southwestern part of the Southern China continent,which is located at the junction of the southwest section of the Early Paleozoic Yangtze block and Cathaysian block.A series of NNE-trending ductile shear zones are developed in this region,and these ductile shear zones are mostly previously suggested boundary faults of the Early Paleozoic Yangtze block and Cathaysian block,such as the Shoucheng–Piaoli ductile shear zone in Northern Guangxi (Meng Yuanku et al., 2016; Zhang Xuefeng et al., 2015).展开更多
A No-Fly Zone (NFZ) is a unique mode of humanitarian intervention that is understudied in international relations. This article focuses on the politics of NFZs in international relations, and investigates their nature...A No-Fly Zone (NFZ) is a unique mode of humanitarian intervention that is understudied in international relations. This article focuses on the politics of NFZs in international relations, and investigates their nature by empirically reviewing all three cases of NFZs to date. NFZs represent a middle ground for international intervention which, both legally and legitimately, may be aimed at either protecting populations or promoting regime change in weak states, depending on the circumstances. There may be efforts by intervening states to highlight humanitarian crises among certain targets in order to secure UN authorization for the NFZs;but the implementation of NFZs is also largely driven by the security interests of the enforcing states. As a result, there is the potential for those states implementing NFZs to transcend legal authorization and to at times use excessive force, with the potential for calamitous results for local people, or, in extreme cases, to accomplish regime change by supporting opposition parties in target states.展开更多
A No-Fly Zone(NFZ)is a unique mode of humanitarian intervention which is understudied in international relations.This article focuses on the political dimension of NFZs in international relations and investigates thei...A No-Fly Zone(NFZ)is a unique mode of humanitarian intervention which is understudied in international relations.This article focuses on the political dimension of NFZs in international relations and investigates their implementations by empirically reviewing all three cases of NFZs to date.There may be efforts by intervening states to highlight humanitarian crises among certain targets to secure UN authorization for the NFZs;yet the implementation of NFZs is also driven largely by the security interests of enforcing states.As a result,there is the potential for those states implementing NFZs to transcend legal authorization and sometimes use excessive force,with likely calamitous results for local populations,or in extreme cases,accomplishing regime change by supporting opposition parties in target states.展开更多
Due to the NP-hardness of the two-sided assembly line balancing (TALB) problem, multiple constraints existing in real applications are less studied, especially when one task is involved with several constraints. In ...Due to the NP-hardness of the two-sided assembly line balancing (TALB) problem, multiple constraints existing in real applications are less studied, especially when one task is involved with several constraints. In this paper, an effective hybrid algorithm is proposed to address the TALB problem with multiple constraints (TALB-MC). Considering the discrete attribute of TALB-MC and the continuous attribute of the standard teaching-learning-based optimization (TLBO) algorithm, the random-keys method is hired in task permutation representation, for the purpose of bridging the gap between them. Subsequently, a special mechanism for handling multiple constraints is developed. In the mechanism, the directions constraint of each task is ensured by the direction check and adjustment. The zoning constraints and the synchronism constraints are satisfied by teasing out the hidden correlations among constraints. The positional constraint is allowed to be violated to some extent in decoding and punished in cost fimction. Finally, with the TLBO seeking for the global optimum, the variable neighborhood search (VNS) is further hybridized to extend the local search space. The experimental results show that the proposed hybrid algorithm outperforms the late acceptance hill-climbing algorithm (LAHC) for TALB-MC in most cases, especially for large-size problems with multiple constraints, and demonstrates well balance between the exploration and the exploitation. This research proposes an effective and efficient algorithm for solving TALB-MC problem by hybridizing the TLBO and VNS.展开更多
Constraint-induced movement therapy after cerebral ischemia stimulates axonal growth by decreasing expression levels of Nogo-A,RhoA,and Rho-associated kinase(ROCK)in the ischemic boundary zone.However,it remains uncle...Constraint-induced movement therapy after cerebral ischemia stimulates axonal growth by decreasing expression levels of Nogo-A,RhoA,and Rho-associated kinase(ROCK)in the ischemic boundary zone.However,it remains unclear if there are any associations between the Nogo-A/RhoA/ROCK pathway and angiogenesis in adult rat brains in pathological processes such as ischemic stroke.In addition,it has not yet been reported whether constraint-induced movement therapy can promote angiogenesis in stroke in adult rats by overcoming Nogo-A/RhoA/ROCK signaling.Here,a stroke model was established by middle cerebral artery occlusion and reperfusion.Seven days after stroke,the following treatments were initiated and continued for 3 weeks:forced limb use in constraint-induced movement therapy rats(constraint-induced movement therapy group),intraperitoneal infusion of fasudil(a ROCK inhibitor)in fasudil rats(fasudil group),or lateral ventricular injection of NEP1-40(a specific antagonist of the Nogo-66 receptor)in NEP1-40 rats(NEP1-40 group).Immunohistochemistry and western blot assay results showed that,at 2 weeks after middle cerebral artery occlusion,expression levels of RhoA and ROCK were lower in the ischemic boundary zone in rats treated with NEP1-40 compared with rats treated with ischemia/reperfusion or constraint-induced movement therapy alone.However,at 4 weeks after middle cerebral artery occlusion,expression levels of RhoA and ROCK in the ischemic boundary zone were markedly decreased in the NEP1-40 and constraint-induced movement therapy groups,but there was no difference between these two groups.Compared with the ischemia/reperfusion group,modified neurological severity scores and foot fault scores were lower and time taken to locate the platform was shorter in the constraint-induced movement therapy and fasudil groups at 4 weeks after middle cerebral artery occlusion,especially in the constraint-induced movement therapy group.Immunofluorescent staining demonstrated that fasudil promoted an immune response of nerve-regeneration-related markers(BrdU in combination with CD31(platelet endothelial cell adhesion molecule),Nestin,doublecortin,NeuN,and glial fibrillary acidic protein)in the subventricular zone and ischemic boundary zone ipsilateral to the infarct.After 3 weeks of constraint-induced movement therapy,the number of regenerated nerve cells was noticeably increased,and was accompanied by an increased immune response of tight junctions(claudin-5),a pericyte marker(a-smooth muscle actin),and vascular endothelial growth factor receptor 2.Taken together,the results demonstrate that,compared with fasudil,constraint-induced movement therapy led to stronger angiogenesis and nerve regeneration ability and better nerve functional recovery at 4 weeks after cerebral ischemia/reperfusion.In addition,constraint-induced movement therapy has the same degree of inhibition of RhoA and ROCK as NEP1-40.Therefore,constraint-induced movement therapy promotes angiogenesis and neurogenesis after cerebral ischemia/reperfusion injury,at least in part by overcoming the Nogo-A/RhoA/ROCK signaling pathway.All protocols were approved by the Institutional Animal Care and Use Committee of China Medical University,China on December 9,2015(approval No.2015 PS326 K).展开更多
基金supported by the National Natural Science Foundation of China(61272011)
文摘To rapidly generate a reentry trajectory for hypersonic vehicle satisfying waypoint and no-fly zone constraints, a novel optimization method, which combines the improved particle swarm optimization (PSO) algorithm with the improved Gauss pseudospectral method (GPM), is proposed. The improved PSO algorithm is used to generate a good initial value in a short time, and the mission of the improved GPM is to find the final solution with a high precision. In the improved PSO algorithm, by controlling the entropy of the swarm in each dimension, the typical PSO algorithm's weakness of being easy to fall into a local optimum can be overcome. In the improved GPM, two kinds of breaks are introduced to divide the trajectory into multiple segments, and the distribution of the Legendre-Gauss (LG) nodes can be altered, so that all the constraints can be satisfied strictly. Thereby the advan- tages of both the intelligent optimization algorithm and the direct method are combined. Simulation results demonstrate that the proposed method is insensitive to initial values, and it has more rapid convergence and higher precision than traditional ones.
基金financially supported by the National Basic Research Program of China(grant No.2015CB856104)the National Natural Science Foundation of China(grant No.41773020)
文摘Objective The Susong complex zone(SCZ)is a relatively lowgrade metamorphic unit mostly with an epidoteamphibolite facies,located in the southernmost part of the Dabie orogen.However,its rock compositions,ages,
基金funded by the National Natural Science Foundation of China(grants No.41572191 and 41702211)the Natural Science Foundation of Guangxi(grant No.2017GXNSFBA198166)
文摘Objective The northern Guangxi region is in the southwestern part of the Southern China continent,which is located at the junction of the southwest section of the Early Paleozoic Yangtze block and Cathaysian block.A series of NNE-trending ductile shear zones are developed in this region,and these ductile shear zones are mostly previously suggested boundary faults of the Early Paleozoic Yangtze block and Cathaysian block,such as the Shoucheng–Piaoli ductile shear zone in Northern Guangxi (Meng Yuanku et al., 2016; Zhang Xuefeng et al., 2015).
基金sponsored by the Key Research Base Project “The Comparative Study of the States outside the NPT Regime”(project number: 11JZ004)from the Education Department of Shaanxi Provincial Government
文摘A No-Fly Zone (NFZ) is a unique mode of humanitarian intervention that is understudied in international relations. This article focuses on the politics of NFZs in international relations, and investigates their nature by empirically reviewing all three cases of NFZs to date. NFZs represent a middle ground for international intervention which, both legally and legitimately, may be aimed at either protecting populations or promoting regime change in weak states, depending on the circumstances. There may be efforts by intervening states to highlight humanitarian crises among certain targets in order to secure UN authorization for the NFZs;but the implementation of NFZs is also largely driven by the security interests of the enforcing states. As a result, there is the potential for those states implementing NFZs to transcend legal authorization and to at times use excessive force, with the potential for calamitous results for local people, or, in extreme cases, to accomplish regime change by supporting opposition parties in target states.
基金This article has been sponsored by the Core Research Base Project“The Comparative Study of the States outside the NPT Regime”(project number:11jz004)from Education Department of Shaanxi Provincial Government and two-class General Financial Grant for the China Postdoctoral Science Foundation(Grant No.:2012M521660).
文摘A No-Fly Zone(NFZ)is a unique mode of humanitarian intervention which is understudied in international relations.This article focuses on the political dimension of NFZs in international relations and investigates their implementations by empirically reviewing all three cases of NFZs to date.There may be efforts by intervening states to highlight humanitarian crises among certain targets to secure UN authorization for the NFZs;yet the implementation of NFZs is also driven largely by the security interests of enforcing states.As a result,there is the potential for those states implementing NFZs to transcend legal authorization and sometimes use excessive force,with likely calamitous results for local populations,or in extreme cases,accomplishing regime change by supporting opposition parties in target states.
基金Supported by National Natural Science Foundation of China(Grant Nos.51275366,50875190,51305311)Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20134219110002)
文摘Due to the NP-hardness of the two-sided assembly line balancing (TALB) problem, multiple constraints existing in real applications are less studied, especially when one task is involved with several constraints. In this paper, an effective hybrid algorithm is proposed to address the TALB problem with multiple constraints (TALB-MC). Considering the discrete attribute of TALB-MC and the continuous attribute of the standard teaching-learning-based optimization (TLBO) algorithm, the random-keys method is hired in task permutation representation, for the purpose of bridging the gap between them. Subsequently, a special mechanism for handling multiple constraints is developed. In the mechanism, the directions constraint of each task is ensured by the direction check and adjustment. The zoning constraints and the synchronism constraints are satisfied by teasing out the hidden correlations among constraints. The positional constraint is allowed to be violated to some extent in decoding and punished in cost fimction. Finally, with the TLBO seeking for the global optimum, the variable neighborhood search (VNS) is further hybridized to extend the local search space. The experimental results show that the proposed hybrid algorithm outperforms the late acceptance hill-climbing algorithm (LAHC) for TALB-MC in most cases, especially for large-size problems with multiple constraints, and demonstrates well balance between the exploration and the exploitation. This research proposes an effective and efficient algorithm for solving TALB-MC problem by hybridizing the TLBO and VNS.
基金supported by the National Natural Science Foundation of China(General Program),No.81771271(to JF)
文摘Constraint-induced movement therapy after cerebral ischemia stimulates axonal growth by decreasing expression levels of Nogo-A,RhoA,and Rho-associated kinase(ROCK)in the ischemic boundary zone.However,it remains unclear if there are any associations between the Nogo-A/RhoA/ROCK pathway and angiogenesis in adult rat brains in pathological processes such as ischemic stroke.In addition,it has not yet been reported whether constraint-induced movement therapy can promote angiogenesis in stroke in adult rats by overcoming Nogo-A/RhoA/ROCK signaling.Here,a stroke model was established by middle cerebral artery occlusion and reperfusion.Seven days after stroke,the following treatments were initiated and continued for 3 weeks:forced limb use in constraint-induced movement therapy rats(constraint-induced movement therapy group),intraperitoneal infusion of fasudil(a ROCK inhibitor)in fasudil rats(fasudil group),or lateral ventricular injection of NEP1-40(a specific antagonist of the Nogo-66 receptor)in NEP1-40 rats(NEP1-40 group).Immunohistochemistry and western blot assay results showed that,at 2 weeks after middle cerebral artery occlusion,expression levels of RhoA and ROCK were lower in the ischemic boundary zone in rats treated with NEP1-40 compared with rats treated with ischemia/reperfusion or constraint-induced movement therapy alone.However,at 4 weeks after middle cerebral artery occlusion,expression levels of RhoA and ROCK in the ischemic boundary zone were markedly decreased in the NEP1-40 and constraint-induced movement therapy groups,but there was no difference between these two groups.Compared with the ischemia/reperfusion group,modified neurological severity scores and foot fault scores were lower and time taken to locate the platform was shorter in the constraint-induced movement therapy and fasudil groups at 4 weeks after middle cerebral artery occlusion,especially in the constraint-induced movement therapy group.Immunofluorescent staining demonstrated that fasudil promoted an immune response of nerve-regeneration-related markers(BrdU in combination with CD31(platelet endothelial cell adhesion molecule),Nestin,doublecortin,NeuN,and glial fibrillary acidic protein)in the subventricular zone and ischemic boundary zone ipsilateral to the infarct.After 3 weeks of constraint-induced movement therapy,the number of regenerated nerve cells was noticeably increased,and was accompanied by an increased immune response of tight junctions(claudin-5),a pericyte marker(a-smooth muscle actin),and vascular endothelial growth factor receptor 2.Taken together,the results demonstrate that,compared with fasudil,constraint-induced movement therapy led to stronger angiogenesis and nerve regeneration ability and better nerve functional recovery at 4 weeks after cerebral ischemia/reperfusion.In addition,constraint-induced movement therapy has the same degree of inhibition of RhoA and ROCK as NEP1-40.Therefore,constraint-induced movement therapy promotes angiogenesis and neurogenesis after cerebral ischemia/reperfusion injury,at least in part by overcoming the Nogo-A/RhoA/ROCK signaling pathway.All protocols were approved by the Institutional Animal Care and Use Committee of China Medical University,China on December 9,2015(approval No.2015 PS326 K).