Background: Breast-conserving surgery (BCS) followed by whole breast irradiation (WBI) has become the standard of care for treating patients with early-stage breast cancer. Recently, various radiation techniques follo...Background: Breast-conserving surgery (BCS) followed by whole breast irradiation (WBI) has become the standard of care for treating patients with early-stage breast cancer. Recently, various radiation techniques followed by BCS have been reported. We have been investigating “personalized radiotherapy after BCS” ranging from accelerated partial breast irradiation (APBI) to WBI with regional nodal irradiation (RNI) based on the axillary node status. In this study, we compared different cohorts that received personalized radiotherapy. Method: Of 317 consecutive patients who underwent BCS followed by radiotherapy since November 2007, 187 who received APBI and 122 who received WBI were analyzed. Results: The local-only recurrence rate was 1.1% in the APBI group and 3.3% in the WBI group, and the regional-only recurrence rate was 1.1% for APBI and 0.8% for WBI. Conclusions: The clinical efficacy of APBI for local control after BCS was comparable to that of WBI ± RNI. Although this study was based on a small number of patients with a short follow-up period, the feasibility of breast-conserving therapy using multicatheter brachytherapy to achieve acceptable clinical outcomes was demonstrated.展开更多
As is well known, Greece has a significant number of earthquakes each year. Ιn recent years, several earthquakes have occurred in Greece. For this scope, a methodology was used to determine the source parameters. Thi...As is well known, Greece has a significant number of earthquakes each year. Ιn recent years, several earthquakes have occurred in Greece. For this scope, a methodology was used to determine the source parameters. This methodology is based on minimizing the difference between the observed and the synthetic waveforms, using the method Source Parameters Calculation—SPCa <a href="#ref1" target="_blank">[1]</a>. The source parameters, using the proposed methodology, are calculated by comparing observed seismograms and synthetic by inverting data. The synthetics are calculated using the reflectivity method (Kennett, 1983) as implemented by Randall et al. (1994) for a given earth structure. This study includes inversion results for the strongest events that occurred in Greece from 2008 to 2014. For the same events calculated the main fault plane, using the method of Hypocenter Centroid-plot (HC-plot) <a href="#ref2" target="_blank">[2]</a> <a href="#ref3" target="_blank">[3]</a>. This methodology is a simple geometrical method based on the combination between the hypocentral position and the two possible fault planes.展开更多
文摘Background: Breast-conserving surgery (BCS) followed by whole breast irradiation (WBI) has become the standard of care for treating patients with early-stage breast cancer. Recently, various radiation techniques followed by BCS have been reported. We have been investigating “personalized radiotherapy after BCS” ranging from accelerated partial breast irradiation (APBI) to WBI with regional nodal irradiation (RNI) based on the axillary node status. In this study, we compared different cohorts that received personalized radiotherapy. Method: Of 317 consecutive patients who underwent BCS followed by radiotherapy since November 2007, 187 who received APBI and 122 who received WBI were analyzed. Results: The local-only recurrence rate was 1.1% in the APBI group and 3.3% in the WBI group, and the regional-only recurrence rate was 1.1% for APBI and 0.8% for WBI. Conclusions: The clinical efficacy of APBI for local control after BCS was comparable to that of WBI ± RNI. Although this study was based on a small number of patients with a short follow-up period, the feasibility of breast-conserving therapy using multicatheter brachytherapy to achieve acceptable clinical outcomes was demonstrated.
文摘As is well known, Greece has a significant number of earthquakes each year. Ιn recent years, several earthquakes have occurred in Greece. For this scope, a methodology was used to determine the source parameters. This methodology is based on minimizing the difference between the observed and the synthetic waveforms, using the method Source Parameters Calculation—SPCa <a href="#ref1" target="_blank">[1]</a>. The source parameters, using the proposed methodology, are calculated by comparing observed seismograms and synthetic by inverting data. The synthetics are calculated using the reflectivity method (Kennett, 1983) as implemented by Randall et al. (1994) for a given earth structure. This study includes inversion results for the strongest events that occurred in Greece from 2008 to 2014. For the same events calculated the main fault plane, using the method of Hypocenter Centroid-plot (HC-plot) <a href="#ref2" target="_blank">[2]</a> <a href="#ref3" target="_blank">[3]</a>. This methodology is a simple geometrical method based on the combination between the hypocentral position and the two possible fault planes.
