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Diversity, Abundance and Distribution Patterns of Epibenthic Echinoderms in Dungonab Bay, Red Sea, Sudan
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作者 Abdelmoneim Karamalla Gaiballa 《Open Journal of Ecology》 2024年第4期366-380,共15页
The abundance, distribution and diversity of epibenthic echinoderm were investigated at Dungonab Bay in the Red Sea coastal water of the Sudan. Four permanent line transects were chosen. Eight (30 × 2) square met... The abundance, distribution and diversity of epibenthic echinoderm were investigated at Dungonab Bay in the Red Sea coastal water of the Sudan. Four permanent line transects were chosen. Eight (30 × 2) square metre belt transects along each permanent line transect at 20 metre intervals were used to collect data. The data were subjected to univariate and multivariate analyses. Spatial variations of epibenthic echinoderm abundance were assessed with one-way analysis of variance. Hierarchical agglomerative clustering was used to identify and illustrate the similarities in echinoderm abundance between line transects and between belt transects. Indices of richness (d), diversity (H'), evenness (J') and dominance (C) were used to explain the diversity of epibenthic echinoderm species. The distribution pattern of each echinoderm species was determined in each permanent line transect. A total of 986 individuals were recorded within sixteen species of epibenthic echinoderms in the four line transects. Holothuriidae was the dominant family (5 species and 342 individuals). The most abundant echinoderms species was Pearsonothuria graeffei (77 individuals, about 7.81%). Abundances intra-transects and intra-families were insignificant (f = 1.67, p = 0.183, df = 3 and f = 3.24, p = 0.083, df = 9, respectively). The highest values of Shannon-Wiener diversity index (H'), Pielou evenness index (J'), Margalef species richness index (d), and Simpson Dominance index (C) were 2.738, 0.9875, 2.791 and 0.07159, respectively. The distribution patterns of all species in the study transects varied between clumped and uniform, with the exception of Asthenosoma varium of the Echinothuridae family, which had clumped distribution patterns in all transects. The study concluded that Dungonab Bay supports rich and diverse communities of epibenthic echinoderms. 展开更多
关键词 SUDAN Red Sea ECHInodeRM DIVERSITY Abundance and distribution
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Distribution of splenic artery lymph nodes and splenic hilar lymph nodes
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作者 Yuya Umebayashi Satoru Muro +5 位作者 Masanori Tokunaga Toshifumi Saito Yuya Sato Toshiro Tanioka Yusuke Kinugasa Keiichi Akita 《World Journal of Gastrointestinal Surgery》 2023年第5期812-824,共13页
BACKGROUND Total gastrectomy with splenectomy is the standard treatment for advanced proximal gastric cancer with greater-curvature invasion.As an alternative to splenectomy,laparoscopic spleen-preserving splenic hila... BACKGROUND Total gastrectomy with splenectomy is the standard treatment for advanced proximal gastric cancer with greater-curvature invasion.As an alternative to splenectomy,laparoscopic spleen-preserving splenic hilar lymph node(LN)dissection(SPSHLD)has been developed.With SPSHLD,the posterior splenic hilar LNs are left behind.AIM To clarify the distribution of splenic hilar(No.10)and splenic artery(No.11p and 11d)LNs and to verify the possibility of omitting posterior LN dissection in laparoscopic SPSHLD from an anatomical standpoint.METHODS Hematoxylin&eosin-stained specimens were prepared from six cadavers,and the distribution of LN No.10,11p,and 11d was evaluated.In addition,heatmaps were constructed and three-dimensional reconstructions were created to visualize the LN distribution for qualitative evaluation.RESULTS There was little difference in the number of No.10 LNs between the anterior and posterior sides.For LN No.11p and 11d,the anterior LNs were more numerous than the posterior LNs in all cases.The number of posterior LNs increased toward the hilar side.Heatmaps and three-dimensional reconstructions showed that LN No.11p was more abundant in the superficial area,while LN No.11d and 10 were more abundant in the deep intervascular area.CONCLUSION The number of posterior LNs increased toward the hilum and was not neglectable.Thus,surgeons should consider that some posterior No.10 and No.11d LNs may remain after SPSHLD. 展开更多
关键词 Gastric cancer Laparoscopic gastrectomy ANATOMY Splenic hilar lymph node Laparoscopic spleen-preserving splenic hilar lymph node dissection
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FPGA-based position reconstruction method for neutron beam flux spatial distribution measurement in BNCT 被引量:1
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作者 Wei Jiang Ping Cao +5 位作者 Yi-Ming Wu Xian-Ke Liu Zhu-Jun Fang Zhi-Yong Zhang Bin Shi Jun Chen 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第3期96-108,共13页
A new measurement method for the spatial distribution of neutron beam flux in boron neutron capture therapy(BNCT)is being developed based on the two-dimensional Micromegas detector.To address the issue of long process... A new measurement method for the spatial distribution of neutron beam flux in boron neutron capture therapy(BNCT)is being developed based on the two-dimensional Micromegas detector.To address the issue of long processing times in traditional offline position reconstruction methods,this paper proposes a field programmable gate array based online position reconstruction method utilizing the micro-time projection chamber principle.This method encapsulates key technical aspects:a self-adaptive serial link technique built upon the dynamical adjustment of the delay chain length,fast sorting,a coordinate-matching technique based on the mapping between signal timestamps and random access memory(RAM)addresses,and a precise start point-merging technique utilizing a circular combined RAM.The performance test of the selfadaptive serial link shows that the bit error rate of the link is better than 10-12 at a confidence level of 99%,ensuring reliable data transmission.The experiment utilizing the readout electronics and Micromegas detector shows a spatial resolution of approximately 1.4 mm,surpassing the current method’s resolution level of 5 mm.The beam experiment confirms that the readout electronics system can obtain the flux spatial distribution of neutron beams online,thus validating the feasibility of the position reconstruction method.The online position reconstruction method avoids traditional methods,such as bubble sorting and traversal searching,simplifies the design of the logic firmware,and reduces the time complexity from O(n2)to O(n).This study contributes to the advancement in measuring neutron beam flux for BNCT. 展开更多
关键词 Position reconstruction FPGA Readout electronics Neutron flux spatial distribution
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Federated Learning Model for Auto Insurance Rate Setting Based on Tweedie Distribution 被引量:1
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作者 Tao Yin Changgen Peng +2 位作者 Weijie Tan Dequan Xu Hanlin Tang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第1期827-843,共17页
In the assessment of car insurance claims,the claim rate for car insurance presents a highly skewed probability distribution,which is typically modeled using Tweedie distribution.The traditional approach to obtaining ... In the assessment of car insurance claims,the claim rate for car insurance presents a highly skewed probability distribution,which is typically modeled using Tweedie distribution.The traditional approach to obtaining the Tweedie regression model involves training on a centralized dataset,when the data is provided by multiple parties,training a privacy-preserving Tweedie regression model without exchanging raw data becomes a challenge.To address this issue,this study introduces a novel vertical federated learning-based Tweedie regression algorithm for multi-party auto insurance rate setting in data silos.The algorithm can keep sensitive data locally and uses privacy-preserving techniques to achieve intersection operations between the two parties holding the data.After determining which entities are shared,the participants train the model locally using the shared entity data to obtain the local generalized linear model intermediate parameters.The homomorphic encryption algorithms are introduced to interact with and update the model intermediate parameters to collaboratively complete the joint training of the car insurance rate-setting model.Performance tests on two publicly available datasets show that the proposed federated Tweedie regression algorithm can effectively generate Tweedie regression models that leverage the value of data fromboth partieswithout exchanging data.The assessment results of the scheme approach those of the Tweedie regressionmodel learned fromcentralized data,and outperformthe Tweedie regressionmodel learned independently by a single party. 展开更多
关键词 Rate setting Tweedie distribution generalized linear models federated learning homomorphic encryption
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"Five steps four quadrants" modularized en bloc dissection technique for accessing hepatic hilum lymph nodes in laparoscopic pancreaticoduodenectomy 被引量:1
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作者 Xiao-Si Hu Yong Wang +5 位作者 Hong-Tao Pan Chao Zhu Shi-Lei Chen Hui-Chun Liu Qing Pang Hao Jin 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第2期503-510,共8页
BACKGROUND Although en bloc dissection of hepatic hilum lymph nodes has many advantages in radical tumor treatment,the feasibility and safety of this approach for laparo-scopic pancreaticoduodenectomy(LPD)require furt... BACKGROUND Although en bloc dissection of hepatic hilum lymph nodes has many advantages in radical tumor treatment,the feasibility and safety of this approach for laparo-scopic pancreaticoduodenectomy(LPD)require further clinical evaluation and investigation.AIM To explore the application value of the"five steps four quadrants"modularized en bloc dissection technique for accessing hepatic hilum lymph nodes in LPD patients.METHODS A total of 52 patients who underwent LPD via the"five steps four quadrants"modularized en bloc dissection technique for hepatic hilum lymph nodes from April 2021 to July 2023 in our department were analyzed retrospectively.The patients'body mass index(BMI),preoperative laboratory indices,intraoperative variables and postoperative complications were recorded.The relationships between preoperative data and intraoperative lymph node dissection time and blood loss were also analyzed.RESULTS Among the 52 patients,36 were males and 16 were females,and the average age was 62.2±11.0 years.There were 26 patients with pancreatic head cancer,16 patients with periampullary cancer,and 10 patients with distal bile duct cancer.The BMI was 22.3±3.3 kg/m²,and the median total bilirubin(TBIL)concentration was 57.7(16.0-155.7)µmol/L.All patients successfully underwent the"five steps four quadrants"modularized en bloc dissection technique without lymph node clearance-related complications such as postoperative bleeding or lymphatic leakage.Correlation analysis revealed significant associations between preoperative BMI(r=0.3581,P=0.0091),TBIL level(r=0.2988,P=0.0341),prothrombin time(r=0.3018,P=0.0297)and lymph node dissection time.Moreover,dissection time was significantly correlated with intraoperative blood loss(r=0.7744,P<0.0001).Further stratified analysis demonstrated that patients with a preoperative BMI≥21.9 kg/m²and a TIBL concentration≥57.7μmol/L had significantly longer lymph node dissection times(both P<0.05).CONCLUSION The"five steps four quadrants"modularized en bloc dissection technique for accessing the hepatic hilum lymph node is safe and feasible for LPD.This technique is expected to improve the efficiency of hepatic hilum lymph node dissection and shorten the learning curve;thus,it is worthy of further clinical promotion and application. 展开更多
关键词 Five steps four quadrants Hepatic hilum lymph node Modularized en bloc clearance Laparoscopic pancreaticoduodenectomy
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Synergetic optimization operation method for distribution network based on SOP and PV 被引量:1
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作者 Lei Chen Ning Zhang +4 位作者 Xingfang Yang Wei Pei Zhenxing Zhao Yinan Zhu Hao Xiao 《Global Energy Interconnection》 EI CSCD 2024年第2期130-141,共12页
The integration of distributed generation brings in new challenges for the operation of distribution networks,including out-of-limit voltage and power flow control.Soft open points(SOP)are new power electronic devices... The integration of distributed generation brings in new challenges for the operation of distribution networks,including out-of-limit voltage and power flow control.Soft open points(SOP)are new power electronic devices that can flexibly control active and reactive power flows.With the exception of active power output,photovoltaic(PV)devices can provide reactive power compensation through an inverter.Thus,a synergetic optimization operation method for SOP and PV in a distribution network is proposed.A synergetic optimization model was developed.The voltage deviation,network loss,and ratio of photovoltaic abandonment were selected as the objective functions.The PV model was improved by considering the three reactive power output modes of the PV inverter.Both the load fluctuation and loss of the SOP were considered.Three multi-objective optimization algorithms were used,and a compromise optimal solution was calculated.Case studies were conducted using an IEEE 33-node system.The simulation results indicated that the SOP and PVs complemented each other in terms of active power transmission and reactive power compensation.Synergetic optimization improves power control capability and flexibility,providing better power quality and PV consumption rate. 展开更多
关键词 Synergetic optimization Soft open point(SOP) Photovoltaic(PV) distribution network
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Coseismic deformation and fault slip distribution of the 2023 M_(W)7.8 and M_(W)7.6 earthquakes in Türkiye 被引量:1
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作者 Weikang Li Lijiang Zhao +4 位作者 Kai Tan Xiaofei Lu Caihong Zhang Chengtao Li Shuaishuai Han 《Earthquake Science》 2024年第3期263-276,共14页
On February 6,2023,a devastating earthquake with a moment magnitude of M_(W)7.8 struck the town of Pazarcik in south-central Türkiye,followed by another powerful earthquake with a moment magnitude of M_(W)7.6 tha... On February 6,2023,a devastating earthquake with a moment magnitude of M_(W)7.8 struck the town of Pazarcik in south-central Türkiye,followed by another powerful earthquake with a moment magnitude of M_(W)7.6 that struck the nearby city of Elbistan 9 h later.To study the characteristics of surface deformation caused by this event and the influence of fault rupture,this study calculated the static coseismic deformation of 56 stations and dynamic displacement waveforms of 15 stations using data from the Turkish national fixed global navigation satellite system(GNSS)network.A maximum static coseismic displacement of 0.38 m for the M_(W)7.8 Kahramanmaras earthquake was observed at station ANTE,36 km from the epicenter,and a maximum dynamic coseismic displacement of 4.4 m for the M_(W)7.6 Elbistan earthquake was observed at station EKZ1,5 km from the epicenter.The rupture-slip distributions of the two earthquakes were inverted using GNSS coseismic deformation as a constraint.The results showed that the Kahramanmaras earthquake rupture segment was distinct and exposed on the ground,resulting in significant rupture slip along the Amanos and Pazarcik fault segments of the East Anatolian Fault.The maximum slip in the Pazarcik fault segment was 10.7 m,and rupture occurred at depths of 0–15 km.In the Cardak fault region,the Elbistan earthquake caused significant ruptures at depths of 0–12 km,with the largest amount of slip reaching 11.6 m.The Coulomb stress change caused by the Kahramanmaras earthquake rupture along the Cardak fault segment was approximately 2 bars,and the area of increased Coulomb stress corresponded to the subsequent rupture region of the M_(W)7.6 earthquake.Thus,it is likely that the M_(W)7.8 earthquake triggered or promoted the M_(W)7.6 earthquake.Based on the cumulative stress impact of the M_(W)7.8 and M_(W)7.6 events,the southwestern segment of the East Anatolian Fault,specifically the Amanos fault segment,experienced a Coulomb rupture stress change exceeding 2 bars,warranting further attention to assess its future seismic hazard risk. 展开更多
关键词 2023 Türkiye earthquake GNSS observation coseismic deformation field slip distribution
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Integrative biogeography: Validating hypotheses of species distribution 被引量:1
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作者 Zhong-E Hou Shu-Qiang Li 《Zoological Research(Diversity and Conservation)》 2024年第1期86-88,共3页
DEAR EDITOR,Biogeography is a scientific field dedicated to the investigation of the origins and distribution patterns of organisms,as well as predicting future alterations in their geographical distributions(Cox&... DEAR EDITOR,Biogeography is a scientific field dedicated to the investigation of the origins and distribution patterns of organisms,as well as predicting future alterations in their geographical distributions(Cox&Moore,2005).However,the majority of conclusions drawn within the field of biogeography are hypothetical.Rigorous testing of these biogeographic hypotheses remains a considerable challenge.This paper presents the concept of“integrative biogeography”,which emphasizes the experimental testing of biogeographic hypotheses through studies on geological history,as well as biotic and abiotic factors(Figure 1). 展开更多
关键词 BIOGEOGRAPHY distribution DATING
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Extended wet sieving method for determination of complete particle size distribution of general soils 被引量:1
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作者 Shengnan Ma Yi Song +2 位作者 Jiawei Liu Xingyu Kang Zhongqi Quentin Yue 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第1期242-257,共16页
The traditional standard wet sieving method uses steel sieves with aperture?0.063 mm and can only determine the particle size distribution(PSD)of gravel and sand in general soil.This paper extends the traditional meth... The traditional standard wet sieving method uses steel sieves with aperture?0.063 mm and can only determine the particle size distribution(PSD)of gravel and sand in general soil.This paper extends the traditional method and presents an extended wet sieving method.The extended method uses both the steel sieves and the nylon filter cloth sieves.The apertures of the cloth sieves are smaller than 0.063 mm and equal 0.048 mm,0.038 mm,0.014 mm,0.012 mm,0.0063 mm,0.004 mm,0.003 mm,0.002 mm,and 0.001 mm,respectively.The extended method uses five steps to separate the general soil into many material sub-groups of gravel,sand,silt and clay with known particle size ranges.The complete PSD of the general soil is then calculated from the dry masses of the individual material sub-groups.The extended method is demonstrated with a general soil of completely decomposed granite(CDG)in Hong Kong,China.The silt and clay materials with different particle size ranges are further examined,checked and verified using stereomicroscopic observation,physical and chemical property tests.The results further confirm the correctness of the extended wet sieving method. 展开更多
关键词 Particle size distribution(PSD) General soil SILT CLAY Wet sieving Physical and chemical properties
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Hydrocarbon accumulation and orderly distribution of whole petroleum system in marine carbonate rocks of Sichuan Basin,SW China 被引量:1
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作者 GUO Xusheng HUANG Renchun +3 位作者 ZHANG Dianwei LI Shuangjian SHEN Baojian LIU Tianjia 《Petroleum Exploration and Development》 SCIE 2024年第4期852-869,共18页
Based on the situation and progress of marine oil/gas exploration in the Sichuan Basin,SW China,the whole petroleum system is divided for marine carbonate rocks of the basin according to the combinations of hydrocarbo... Based on the situation and progress of marine oil/gas exploration in the Sichuan Basin,SW China,the whole petroleum system is divided for marine carbonate rocks of the basin according to the combinations of hydrocarbon accumulation elements,especially the source rock.The hydrocarbon accumulation characteristics of each whole petroleum system are analyzed,the patterns of integrated conventional and unconventional hydrocarbon accumulation are summarized,and the favorable exploration targets are proposed.Under the control of multiple extensional-convergent tectonic cycles,the marine carbonate rocks of the Sichuan Basin contain three sets of regional source rocks and three sets of regional cap rocks,and can be divided into the Cambrian,Silurian and Permian whole petroleum systems.These whole petroleum systems present mainly independent hydrocarbon accumulation,containing natural gas of affinity individually.Locally,large fault zones run through multiple whole petroleum systems,forming a fault-controlled complex whole petroleum system.The hydrocarbon accumulation sequence of continental shelf facies shale gas accumulation,marginal platform facies-controlled gas reservoirs,and intra-platform fault-and facies-controlled gas reservoirs is common in the whole petroleum system,with a stereoscopic accumulation and orderly distribution pattern.High-quality source rock is fundamental to the formation of large gas fields,and natural gas in a whole petroleum system is generally enriched near and within the source rocks.The development and maintenance of large-scale reservoirs are essential for natural gas enrichment,multiple sources,oil and gas transformation,and dynamic adjustment are the characteristics of marine petroleum accumulation,and good preservation conditions are critical to natural gas accumulation.Large-scale marginal-platform reef-bank facies zones,deep shale gas,and large-scale lithological complexes related to source-connected faults are future marine hydrocarbon exploration targets in the Sichuan Basin. 展开更多
关键词 Sichuan Basin margin oil/gas whole petroleum system carbonate hydrocarbon accumulation hydrocarbon distribution law hydrocarbon exploration target
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Clinical Study of Double Contrast-Enhanced Ultrasound Combined with Dye Method and Marker Placement to Identify and Locate Sentinel Lymph Nodes in Patients with Breast Cancer
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作者 Dayan Yang Lini Gao 《Advances in Breast Cancer Research》 CAS 2024年第3期49-58,共10页
Objective: To explore the value of percutaneous ultrasonography combined with transvenous ultrasonography for accurate localization of sentinel lymph nodes and diagnosis of metastatic lymph nodes in patients with brea... Objective: To explore the value of percutaneous ultrasonography combined with transvenous ultrasonography for accurate localization of sentinel lymph nodes and diagnosis of metastatic lymph nodes in patients with breast cancer. Methods: 18 cases of patients with breast cancer attending the Hainan General Hospital from May 2022 to June 2024 who were proposed to undergo axillary lymph node dissection were selected, and the ultrasonographic agent was injected subcutaneously through the areola on the 1st day before the operation, and the marker localization of the manifestation of the Sentinel lymph nodes and draw the lymphatic vessel alignment for drainage on the body surface, and record the manifestation of SLN by conventional ultrasound and dual ultrasonography. At the time of surgery, intraoperative melphalan localization was used to identify the SLN, the difference between the number of ultrasound and melphalan localization was observed, and resection was performed for pathological examination to determine whether they were metastatic or not. Results: There were 8 metastatic lymph nodes and 18 non-metastatic lymph nodes among 31 SLN. A total of 62 SLN were localized by intraoperative melphalan, of which 31 were consistent with ultrasound localization and 31 were not identified by ultrasound. The diagnostic sensitivity of SLN metastasis diagnosed by transcutaneous ultrasonography was 62.50%, specificity was 91.30%, positive predictive value was 71.43%, negative predictive value 87.50%, accuracy was 83.87%, and the AUC was 0.769;the diagnostic sensitivityof transvenous ultrasonography diagnosed was 75.00%, specificity was 75.00%, and the accuracy was 83.87%, 75.00%, specificity 91.30%, positive predictive value 75.00%, negative predictive value 91.30%, accuracy 87.10%, AUC 0.832;dual ultrasonography diagnostic sensitivity 87.50%, specificity 91.30%, positive predictive value 77.78%, negative predictive value 95.45%, accuracy 90.32%. The AUC was 0.894. Conclusion: Transcutaneous ultrasonography combined with transvenous ultrasonography can accurately localize sentinel lymph nodes and improve the sensitivity and accuracy of the diagnosis of metastatic SLN. 展开更多
关键词 Sentinel Lymph nodes Breast Cancer ULTRASOUND ULTRASONOGRAPHY Axillary Lymph nodes
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Influence of Topography on the Distribution and Structure of Woody Plants in the Senegalese Sahel (Sandy Ferlo)
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作者 Moustapha Bassimbe Sagna Aïssatou Ndong Thiam +5 位作者 Khoudia Niang Oumar Sarr Aly Diallo Sekouna Diatta Daouda Ngom Aliou Guissé 《American Journal of Plant Sciences》 CAS 2024年第1期14-28,共15页
This study describes the floristic composition and structure of a woody stand in the Senegalese Sahel, paying particular attention to the edaphic factors of its floristic composition. A stratified inventory considerin... This study describes the floristic composition and structure of a woody stand in the Senegalese Sahel, paying particular attention to the edaphic factors of its floristic composition. A stratified inventory considering the different relief units was adopted. Woody vegetation was surveyed using a dendrometric approach. The results obtained show that the flora is dominated by a few species adapted to drought, such as Balanites aegyptiaca (L.) Del., Calotropis procera Ait. and Boscia senegalensis (Pers.). The distribution of this flora and the structure of the ligneous plants are linked to the topography. In the lowlands, the flora is more diversified and the ligneous plants reach their optimum level of development compared with the higher relief areas. In the lowlands, there are a few woody species which, in the past, were indicative of better climatic conditions. These are Anogeissus leiocarpus (DC.), Commiphora africana (A. Rich.), Feretia apodanthera Del., Loeseneriella africana (A. Smith), Mitragyna inermis (Willd.) and Sclerocarya birrea (A. Rich). It is important that their reintroduction into reforestation projects takes account of their edaphic preference. 展开更多
关键词 Woody Plants distribution TOPOGRAPHY Ferlo Senegal
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Neural stem cell-derived exosomes promote mitochondrial biogenesis and restore abnormal protein distribution in a mouse model of Alzheimer's disease 被引量:1
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作者 Bo Li Yujie Chen +10 位作者 Yan Zhou Xuanran Feng Guojun Gu Shuang Han Nianhao Cheng Yawen Sun Yiming Zhang Jiahui Cheng Qi Zhang Wei Zhang Jianhui Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1593-1601,共9页
Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheime... Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheimer’s disease affects the entire brain,further research is needed to elucidate alterations in mitochondrial metabolism in the brain as a whole.Here,we investigated the expression of several important mitochondrial biogenesis-related cytokines in multiple brain regions after treatment with neural stem cell-derived exosomes and used a combination of whole brain clearing,immunostaining,and lightsheet imaging to clarify their spatial distribution.Additionally,to clarify whether the sirtuin 1(SIRT1)-related pathway plays a regulatory role in neural stem cell-de rived exosomes interfering with mitochondrial functional changes,we generated a novel nervous system-SIRT1 conditional knoc kout AP P/PS1mouse model.Our findings demonstrate that neural stem cell-de rived exosomes significantly increase SIRT1 levels,enhance the production of mitochondrial biogenesis-related fa ctors,and inhibit astrocyte activation,but do not suppress amyloid-βproduction.Thus,neural stem cell-derived exosomes may be a useful therapeutic strategy for Alzheimer’s disease that activates the SIRT1-PGC1αsignaling pathway and increases NRF1 and COXIV synthesis to improve mitochondrial biogenesis.In addition,we showed that the spatial distribution of mitochondrial biogenesis-related factors is disrupted in Alzheimer’s disease,and that neural stem cell-derived exosome treatment can reverse this effect,indicating that neural stem cell-derived exosomes promote mitochondrial biogenesis. 展开更多
关键词 Alzheimer’s disease mitochondrial biogenesis neural stem cell-derived exosome SIRT1-PGC1α regional brain distribution whole brain clearing and imaging
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Diversity of Orchids in Terms of Their Distribution, Uses and Conservation in Annapurna Conservation Area of Nepal
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作者 Babu Lal Tiruwa Basu Dev Neupane +2 位作者 Rabin Kadariya Chiranjibi Prasad Pokheral Bijaya Pant 《American Journal of Plant Sciences》 CAS 2024年第6期422-440,共19页
The Annapurna Conservation Area (ACA), the first conservation area and the largest protected area (PA) in Nepal, is incredibly rich in biodiversity. Notwithstanding this, orchids in the ACA have not been explored enou... The Annapurna Conservation Area (ACA), the first conservation area and the largest protected area (PA) in Nepal, is incredibly rich in biodiversity. Notwithstanding this, orchids in the ACA have not been explored enough yet thus making the need for ambitious research to be carried out. Previous study only included 81 species of orchids within ACA. This study aims to update the record of species and genera richness in the ACA. In total 198 species of orchids, belonging to 67 genera (40% and 62% of the total recorded orchid species and genera in Nepal) has been recorded in ACA. This represents an increase of 144% in species and 56% in genera over the previous data. Out of the 198 species, 99 were epiphytes, 6 were holomycotrophic and 93 were terrestrial. Among the 67 genera, Bulbophyllum (17) species were dominant, followed by Dendrobium (16), Herminium (10), Coelogyne, Plantanthera (9 each), Eria, Habenaria, Oberonia (8 each), Calanthe (7), and Liparis (6). Fifty-six species were found to be ornamentally significant and 85 species medicinally significant. 展开更多
关键词 ORCHIDS Annapurna Conservation Area DIVERSITY distribution USES
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Boosting Adversarial Training with Learnable Distribution
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作者 Kai Chen Jinwei Wang +2 位作者 James Msughter Adeke Guangjie Liu Yuewei Dai 《Computers, Materials & Continua》 SCIE EI 2024年第3期3247-3265,共19页
In recent years,various adversarial defense methods have been proposed to improve the robustness of deep neural networks.Adversarial training is one of the most potent methods to defend against adversarial attacks.How... In recent years,various adversarial defense methods have been proposed to improve the robustness of deep neural networks.Adversarial training is one of the most potent methods to defend against adversarial attacks.However,the difference in the feature space between natural and adversarial examples hinders the accuracy and robustness of the model in adversarial training.This paper proposes a learnable distribution adversarial training method,aiming to construct the same distribution for training data utilizing the Gaussian mixture model.The distribution centroid is built to classify samples and constrain the distribution of the sample features.The natural and adversarial examples are pushed to the same distribution centroid to improve the accuracy and robustness of the model.The proposed method generates adversarial examples to close the distribution gap between the natural and adversarial examples through an attack algorithm explicitly designed for adversarial training.This algorithm gradually increases the accuracy and robustness of the model by scaling perturbation.Finally,the proposed method outputs the predicted labels and the distance between the sample and the distribution centroid.The distribution characteristics of the samples can be utilized to detect adversarial cases that can potentially evade the model defense.The effectiveness of the proposed method is demonstrated through comprehensive experiments. 展开更多
关键词 Adversarial training feature space learnable distribution distribution centroid
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Adaptive Update Distribution Estimation under Probability Byzantine Attack
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作者 Gang Long Zhaoxin Zhang 《Computers, Materials & Continua》 SCIE EI 2024年第10期1667-1685,共19页
The secure and normal operation of distributed networks is crucial for accurate parameter estimation.However,distributed networks are frequently susceptible to Byzantine attacks.Considering real-life scenarios,this pa... The secure and normal operation of distributed networks is crucial for accurate parameter estimation.However,distributed networks are frequently susceptible to Byzantine attacks.Considering real-life scenarios,this paper investigates a probability Byzantine(PB)attack,utilizing a Bernoulli distribution to simulate the attack probability.Historically,additional detection mechanisms are used to mitigate such attacks,leading to increased energy consumption and burdens on distributed nodes,consequently diminishing operational efficiency.Differing from these approaches,an adaptive updating distributed estimation algorithm is proposed to mitigate the impact of PB attacks.In the proposed algorithm,a penalty strategy is initially incorporated during data updates to weaken the influence of the attack.Subsequently,an adaptive fusion weight is employed during data fusion to merge the estimations.Additionally,the reason why this penalty term weakens the attack has been analyzed,and the performance of the proposed algorithm is validated through simulation experiments. 展开更多
关键词 distribution estimation network security least-mean-square binomial distribution probability Byzantine attack
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Target Controllability of Multi-Layer Networks With High-Dimensional Nodes
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作者 Lifu Wang Zhaofei Li +1 位作者 Ge Guo Zhi Kong 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第9期1999-2010,共12页
This paper studies the target controllability of multilayer complex networked systems,in which the nodes are highdimensional linear time invariant(LTI)dynamical systems,and the network topology is directed and weighte... This paper studies the target controllability of multilayer complex networked systems,in which the nodes are highdimensional linear time invariant(LTI)dynamical systems,and the network topology is directed and weighted.The influence of inter-layer couplings on the target controllability of multi-layer networks is discussed.It is found that even if there exists a layer which is not target controllable,the entire multi-layer network can still be target controllable due to the inter-layer couplings.For the multi-layer networks with general structure,a necessary and sufficient condition for target controllability is given by establishing the relationship between uncontrollable subspace and output matrix.By the derived condition,it can be found that the system may be target controllable even if it is not state controllable.On this basis,two corollaries are derived,which clarify the relationship between target controllability,state controllability and output controllability.For the multi-layer networks where the inter-layer couplings are directed chains and directed stars,sufficient conditions for target controllability of networked systems are given,respectively.These conditions are easier to verify than the classic criterion. 展开更多
关键词 High-dimensional nodes inter-layer couplings multi-layer networks target controllability
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The Effect of Key Nodes on theMalware Dynamics in the Industrial Control Network
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作者 Qiang Fu JunWang +1 位作者 Changfu Si Jiawei Liu 《Computers, Materials & Continua》 SCIE EI 2024年第4期329-349,共21页
As industrialization and informatization becomemore deeply intertwined,industrial control networks have entered an era of intelligence.The connection between industrial control networks and the external internet is be... As industrialization and informatization becomemore deeply intertwined,industrial control networks have entered an era of intelligence.The connection between industrial control networks and the external internet is becoming increasingly close,which leads to frequent security accidents.This paper proposes a model for the industrial control network.It includes a malware containment strategy that integrates intrusion detection,quarantine,and monitoring.Basedonthismodel,the role of keynodes in the spreadofmalware is studied,a comparisonexperiment is conducted to validate the impact of the containment strategy.In addition,the dynamic behavior of the model is analyzed,the basic reproduction number is computed,and the disease-free and endemic equilibrium of the model is also obtained by the basic reproduction number.Moreover,through simulation experiments,the effectiveness of the containment strategy is validated,the influence of the relevant parameters is analyzed,and the containment strategy is optimized.In otherwords,selective immunity to key nodes can effectively suppress the spread ofmalware andmaintain the stability of industrial control systems.The earlier the immunization of key nodes,the better.Once the time exceeds the threshold,immunizing key nodes is almost ineffective.The analysis provides a better way to contain the malware in the industrial control network. 展开更多
关键词 Key nodes dynamic model industrial control network SIMULATION
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Management of lateral pelvic lymph nodes in rectal cancer:Is it time to reach an Agreement?
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作者 Sigfredo E Romero-Zoghbi Fernando López-Campos Felipe Couñago 《World Journal of Clinical Oncology》 2024年第4期472-477,共6页
In this editorial,we proceed to comment on the article by Chua et al,addressing the management of metastatic lateral pelvic lymph nodes(mLLN)in stage II/III rectal cancer patients below the peritoneal reflection.The t... In this editorial,we proceed to comment on the article by Chua et al,addressing the management of metastatic lateral pelvic lymph nodes(mLLN)in stage II/III rectal cancer patients below the peritoneal reflection.The treatment of this nodal area sparks significant controversy due to the strategic differences followed by Eastern and Western physicians,albeit with a higher degree of convergence in recent years.The dissection of lateral pelvic lymph nodes without neoadjuvant therapy is a standard practice in Eastern countries.In contrast,in the West,preference leans towards opting for neoadjuvant therapy with chemoradiotherapy or radiotherapy,that would cover the treatment of this area without the need to add the dissection of these nodes to the total mesorectal excision.In the presence of high-risk nodal characteristics for mLLN related to radiological imaging and lack of response to neoadjuvant therapy,the risk of lateral local recurrence increases,suggesting the appropriate selection of strategies to reduce the risk of recurrence in each patient profile.Despite the heterogeneous and retrospective nature of studies addressing this area,an international consensus is necessary to approach this clinical scenario uniformly. 展开更多
关键词 Rectal cancer Lateral pelvic lymph node metastases Pelvic lymph node dissection Total neoadjuvant therapy Selective management of the lateral pelvic nodes Prophylactic management of the lateral pelvic nodes CHEMORADIOTHERAPY Total mesorectal excision
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Simulation of Haloxylon Ammodendron Stand Basic Diameter Structure Based on Fuzzy Distribution Function
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作者 Shaohua Wang Chuanqiang Liu Ting Yang 《Agricultural Sciences》 2024年第1期132-145,共14页
Based on the investigation data of 12 Haloxylon ammodendron plots in the south edge of Gurbantunggut Desert, Fuzzy distribution was introduced into the study of Haloxylon ammodendron base diameter structure fitting ac... Based on the investigation data of 12 Haloxylon ammodendron plots in the south edge of Gurbantunggut Desert, Fuzzy distribution was introduced into the study of Haloxylon ammodendron base diameter structure fitting according to the consistency between the characteristics of Fuzzy distribution function and the distribution series of cumulative percentage of stand base diameter, and the fitting precision and effect of Fuzzy distribution function were discussed. The root mean square error RMSE and determination coefficient R<sup>2</sup> values showed that Fuzzy-Γ<sub>1</sub>, Fuzzy-Γ<sub>2</sub>, Fuzzy-Γ<sub>3</sub>, Fuzzy-Γ<sub>4</sub> had good fitting performance, among which Fuzzy-Γ<sub>1</sub> had relatively high fitting precision, and its parameters were closely related to stand age and density, Fuzzy-Γ<sub>2</sub> distribution function was the second, and Fuzzy-Γ<sub>4</sub> distribution function had the worst fitting effect. By introducing a parameter c from the similarity of four distribution function formulas, a generalized Fuzzy distribution function Fuzzy-Γ<sub>5</sub> is obtained. This function shows the highest fitting accuracy. Most of the values of parameter c are near 1 or 2, which shows that the diameter distribution is mainly approximate to Fuzzy-Γ<sub>1</sub> and Fuzzy-Γ<sub>2</sub>. 展开更多
关键词 Fuzzy distribution Function Haloxylon Ammodendron Base Diameter distribution Stand Factor
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