Recently, many new features of Sobolev spaces W k,p ？RN ？ were studied in [4-6, 32]. This paper is devoted to giving a brief review of some known characterizations of Sobolev spaces in Euclidean spaces and describin...Recently, many new features of Sobolev spaces W k,p ？RN ？ were studied in [4-6, 32]. This paper is devoted to giving a brief review of some known characterizations of Sobolev spaces in Euclidean spaces and describing our recent study of new characterizations of Sobolev spaces on both Heisenberg groups and Euclidean spaces obtained in [12] and [13] and outlining their proofs. Our results extend those characterizations of first order Sobolev spaces in [32] to the Heisenberg group setting. Moreover, our theorems also provide diff erent characterizations for the second order Sobolev spaces in Euclidean spaces from those in [4, 5].展开更多
The present note is concerned with two connected and highly important fundamental questions of physics and cosmology, namely if E8E8 Lie symmetry group describes the universe and where cosmic dark energy comes from. F...The present note is concerned with two connected and highly important fundamental questions of physics and cosmology, namely if E8E8 Lie symmetry group describes the universe and where cosmic dark energy comes from. Furthermore, we reason following Wheeler, Hartle and Hawking that since the boundary of a boundary is an empty set which models the quantum wave of the cosmos, then it follows that dark energy is a fundamental physical phenomenon associated with the boundary of the holographic boundary. This leads directly to a clopen universe which is its own Penrose tiling-like multiverse with energy density in full agreement with COBE, WMAP and Type 1a supernova cosmic measurements.展开更多
AIM： To figure out the contributed factors of the hospitalization expenses of senile cataract patients（HECP） and build up an area-specified senile cataract diagnosis related group（DRG） of Shanghai thereby formula...AIM： To figure out the contributed factors of the hospitalization expenses of senile cataract patients（HECP） and build up an area-specified senile cataract diagnosis related group（DRG） of Shanghai thereby formulating the reference range of HECP and providing scientific basis for the fair use and supervision of the health care insurance fund.METHODS： The data was collected from the first page of the medical records of 22 097 hospitalized patients from tertiary hospitals in Shanghai from 2010 to 2012 whose major diagnosis were senile cataract. Firstly, we analyzed the influence factors of HECP using univariate and multivariate analysis. DRG grouping was conducted according to the exhaustive Chi-squared automatic interaction detector（E-CHAID） model, using HECP as target variable. Finally we evaluated the grouping results using non-parametric test such as Kruskal-Wallis H test, RIV, CV, etc.RESULTS： The 6 DRGs were established as well as criterion of HECP, using age, sex, type of surgery and whether complications/comorbidities occurred as the key variables of classification node of senile cataract cases.CONCLUSION： The grouping of senile cataract cases based on E-CHAID algorithm is reasonable. And the criterion of HECP based on DRG can provide a feasible way of management in the fair use and supervision of medical insurance fund.展开更多
Objective:To investigate the impact of the endogamous marriage culture on the prevalence of the hemoglobin E(HbE) recessive variant.Methods:The prevalence of the hemoglobin E(HbE)recessive variant was determined by do...Objective:To investigate the impact of the endogamous marriage culture on the prevalence of the hemoglobin E(HbE) recessive variant.Methods:The prevalence of the hemoglobin E(HbE)recessive variant was determined by dot-blot hybridization in 4 endogamous villages(1 Mlabri and 3 Htin ethnic groups) in comparison with 9 other nearby non-endogamous populations.Results:Although the overall HbE prevalence in the population studied(8.44%,33/391)was not significantly different from that of the general southeast Asian population,a high prevalence and individuals with homozygous HbE were observed in two villages,the Mlabri from Wiang Sa district and the Htin from Thung Chang district of Nan province(26.3%and26.9%,respectively).The low HbE allelic frequency noticed in some endogamous populations suggests that not only endogamy but also other evolutionary forces,such as founder effect and HbE/β-thalassemia negative selection may have an effect on the distribution of the HbE trait.Conclusion:Our study strongly documents that cultural impact has to be considered in the extensive prevalence studies for genetic disorders in the ethnic groups of northern Thailand.展开更多
The Ca. LSU intron flanking a 129 bp cxon upstream and a fOO bp exondownstream was inserted into the lacZ gene on pRS426 to transform E. coli. Northern blot analysisand RT-PCR showed that splicing of Ca. LSU in E. col...The Ca. LSU intron flanking a 129 bp cxon upstream and a fOO bp exondownstream was inserted into the lacZ gene on pRS426 to transform E. coli. Northern blot analysisand RT-PCR showed that splicing of Ca. LSU in E. coli is efficient upon inducible expression of theprecursor RNA, In contrast, co-lranscriptional self-splicing of the intron in vitro is much lessactive. Therefore, this E. coli splicing system can be used as a better model to investigate theeffect of the ribozyme inhibitors on Ca. LSUsplicing in living cell. We examined (he effects ofneomycin sulfatc and pentamidine on Ca. LSU splicing in E. coli, and found that these drugsdoes-dependently inhibit the intron splicing. However, heomycin is more potent than pentamidine inthis action.展开更多
The Beijing Diesel Engine Group Corporation I/E Co. is a subsidiary company under the Beijing Diesel Engine Group Corporation (BDEGC), a foreign window for the enterprise. The BDEGC is the nation’s largest specialize...The Beijing Diesel Engine Group Corporation I/E Co. is a subsidiary company under the Beijing Diesel Engine Group Corporation (BDEGC), a foreign window for the enterprise. The BDEGC is the nation’s largest specialized diesel engine production factory, a super large enterprise at state level. Its main products include six series of motors and the 1040 series light trucks, 6400 and 6401 wagon cars, agricultural self-discharging semitrailers, and light-duty pilothouses and covers. The power of annual diesel engine output has reached 40 million KW, with the products’ coverage rate on the market ranking in a leading position among the same trade nationwide. Since the 1980s, the BDEGC has exported indefinite quantities of展开更多
Dysregulation of polycomb group protein Bmi-1 expression has been linked with an invasive phenotype of certain human cancers and poor prognosis of patients; however, the underlying mechanisms are
The trust plays an extremely important role in online shopping. In order to make online shopping trusty, this paper puts foreword a new trust model in e-commerce environment GIR-TM (Groups’ Internal Recommendation Tr...The trust plays an extremely important role in online shopping. In order to make online shopping trusty, this paper puts foreword a new trust model in e-commerce environment GIR-TM (Groups’ Internal Recommendation Trust Model). First, it regarded the network as a combination of groups, and then did the internal recommendation based on these groups. The GIR-TM, in the process of recommendation, distinguished clearly between the trust degrees of recommen-dation node and the trust degrees of recommended node, and then calculated the integrated credibility value of the recommended node according to the weight of recommendation node in the group, the partial trust degree and the de-gree of recommendation when the recommendation node recommends the recommended node, and the overall credibil-ity value of recommended node as well. Lastly through listing the experimental data and comparing with the HHRB-TM (History and Honest Recommendation Based Trust Model) on the same condition, it is verified that GIR-TM is feasible and effective.展开更多
Realizing the physical reality of ‘tHooft’s self similar and dimensionaly regularized fractal-like spacetime as well as being inspired by a note worthy anecdote involving the great mathematician of Alexandria, Pytha...Realizing the physical reality of ‘tHooft’s self similar and dimensionaly regularized fractal-like spacetime as well as being inspired by a note worthy anecdote involving the great mathematician of Alexandria, Pythagoras and the larger than life man of theoretical physics Einstein, we utilize some deep mathematical connections between equivalence classes of equivalence relations and E-infinity theory quotient space. We started from the basic principles of self similarity which came to prominence in science with the advent of the modern theory of nonlinear dynamical systems, deterministic chaos and fractals. This fundamental logico-mathematical thread related to partially ordered sets is then applied to show how the classical Newton’s kinetic energy E = 1/2mv<sup>2</sup> leads to Einstein’s celebrated maximal energy equation E = mc<sup>2</sup> and how in turn this can be dissected into the ordinary energy density E(O) = mc<sup>2</sup>/22 and the dark energy density E(D) = mc<sup>2</sup>(21/22) of the cosmos where m is the mass;v is the velocity and c is the speed of light. The important role of the exceptional Lie symmetry groups and ‘tHooft-Veltman-Wilson dimensional regularization in fractal spacetime played in the above is also highlighted. The author hopes that the unusual character of the analysis and presentation of the present work may be taken in a positive vein as seriously attempting to propose a different and new way of doing theoretical physics by treating number theory, set theory, group theory, experimental physics as well as conventional theoretical physics on the same footing and letting all these diverse tools lead us to the answer of fundamental questions without fear of being labelled in one way or another.展开更多
目的:探讨高迁移率簇蛋白B1(High mobility group box-1,HMGB1)和上皮型钙黏素(E-cadherin)在卵巢癌组织中的表达及临床意义。方法:选取我院妇产科2008年5月至2011年1月75例确诊为卵巢癌的患者为研究对象,采用免疫组化SP法染色,比较HMGB...目的:探讨高迁移率簇蛋白B1(High mobility group box-1,HMGB1)和上皮型钙黏素(E-cadherin)在卵巢癌组织中的表达及临床意义。方法:选取我院妇产科2008年5月至2011年1月75例确诊为卵巢癌的患者为研究对象,采用免疫组化SP法染色,比较HMGB1和E-cadherin在卵巢癌组织及正常卵巢组织的表达差异,并分析不同临床病理参数下卵巢癌组织中HMGB1和E-cadherin的表达意义。结果:卵巢癌组织E-cadherin表达阳性率低于正常卵巢组织(χ2=12.62,P<0.01);卵巢癌组中HMGB1阳性表达率为(58/75)高于正常卵巢组织中表达(4/40)(χ2=47.60,P<0.01)。HMGB1和E-cadherin的表达与卵巢癌病理类型和病理分级无关(P>0.05),与临床分期和有无淋巴结转移有关(P<0.05)。卵巢癌组织中HMGB1和E-cadherin的异常表达呈显著负相关(r=-0.299,P<0.01)。结论:HMGB1和E-cadherin在卵巢癌发生、浸润、转移过程中起重要作用。展开更多
文摘Recently, many new features of Sobolev spaces W k,p ？RN ？ were studied in [4-6, 32]. This paper is devoted to giving a brief review of some known characterizations of Sobolev spaces in Euclidean spaces and describing our recent study of new characterizations of Sobolev spaces on both Heisenberg groups and Euclidean spaces obtained in [12] and [13] and outlining their proofs. Our results extend those characterizations of first order Sobolev spaces in [32] to the Heisenberg group setting. Moreover, our theorems also provide diff erent characterizations for the second order Sobolev spaces in Euclidean spaces from those in [4, 5].
文摘The present note is concerned with two connected and highly important fundamental questions of physics and cosmology, namely if E8E8 Lie symmetry group describes the universe and where cosmic dark energy comes from. Furthermore, we reason following Wheeler, Hartle and Hawking that since the boundary of a boundary is an empty set which models the quantum wave of the cosmos, then it follows that dark energy is a fundamental physical phenomenon associated with the boundary of the holographic boundary. This leads directly to a clopen universe which is its own Penrose tiling-like multiverse with energy density in full agreement with COBE, WMAP and Type 1a supernova cosmic measurements.
基金Supported by the Key Research and Development Program of Hunan Province(No.2017SK2011)
文摘AIM： To figure out the contributed factors of the hospitalization expenses of senile cataract patients（HECP） and build up an area-specified senile cataract diagnosis related group（DRG） of Shanghai thereby formulating the reference range of HECP and providing scientific basis for the fair use and supervision of the health care insurance fund.METHODS： The data was collected from the first page of the medical records of 22 097 hospitalized patients from tertiary hospitals in Shanghai from 2010 to 2012 whose major diagnosis were senile cataract. Firstly, we analyzed the influence factors of HECP using univariate and multivariate analysis. DRG grouping was conducted according to the exhaustive Chi-squared automatic interaction detector（E-CHAID） model, using HECP as target variable. Finally we evaluated the grouping results using non-parametric test such as Kruskal-Wallis H test, RIV, CV, etc.RESULTS： The 6 DRGs were established as well as criterion of HECP, using age, sex, type of surgery and whether complications/comorbidities occurred as the key variables of classification node of senile cataract cases.CONCLUSION： The grouping of senile cataract cases based on E-CHAID algorithm is reasonable. And the criterion of HECP based on DRG can provide a feasible way of management in the fair use and supervision of medical insurance fund.
基金supported by CMU Short Term Research Fellowships in Overseasfunded by a Junior Researcher Fellowship 2013,Faculty of Science,Chiang Mai University, Thailand
文摘Objective:To investigate the impact of the endogamous marriage culture on the prevalence of the hemoglobin E(HbE) recessive variant.Methods:The prevalence of the hemoglobin E(HbE)recessive variant was determined by dot-blot hybridization in 4 endogamous villages(1 Mlabri and 3 Htin ethnic groups) in comparison with 9 other nearby non-endogamous populations.Results:Although the overall HbE prevalence in the population studied(8.44%,33/391)was not significantly different from that of the general southeast Asian population,a high prevalence and individuals with homozygous HbE were observed in two villages,the Mlabri from Wiang Sa district and the Htin from Thung Chang district of Nan province(26.3%and26.9%,respectively).The low HbE allelic frequency noticed in some endogamous populations suggests that not only endogamy but also other evolutionary forces,such as founder effect and HbE/β-thalassemia negative selection may have an effect on the distribution of the HbE trait.Conclusion:Our study strongly documents that cultural impact has to be considered in the extensive prevalence studies for genetic disorders in the ethnic groups of northern Thailand.
基金Supported by the National Natural Science Foundation of China (30170213) and the Foundation of Wuhan University(0000028)
文摘The Ca. LSU intron flanking a 129 bp cxon upstream and a fOO bp exondownstream was inserted into the lacZ gene on pRS426 to transform E. coli. Northern blot analysisand RT-PCR showed that splicing of Ca. LSU in E. coli is efficient upon inducible expression of theprecursor RNA, In contrast, co-lranscriptional self-splicing of the intron in vitro is much lessactive. Therefore, this E. coli splicing system can be used as a better model to investigate theeffect of the ribozyme inhibitors on Ca. LSUsplicing in living cell. We examined (he effects ofneomycin sulfatc and pentamidine on Ca. LSU splicing in E. coli, and found that these drugsdoes-dependently inhibit the intron splicing. However, heomycin is more potent than pentamidine inthis action.
文摘The Beijing Diesel Engine Group Corporation I/E Co. is a subsidiary company under the Beijing Diesel Engine Group Corporation (BDEGC), a foreign window for the enterprise. The BDEGC is the nation’s largest specialized diesel engine production factory, a super large enterprise at state level. Its main products include six series of motors and the 1040 series light trucks, 6400 and 6401 wagon cars, agricultural self-discharging semitrailers, and light-duty pilothouses and covers. The power of annual diesel engine output has reached 40 million KW, with the products’ coverage rate on the market ranking in a leading position among the same trade nationwide. Since the 1980s, the BDEGC has exported indefinite quantities of
文摘Dysregulation of polycomb group protein Bmi-1 expression has been linked with an invasive phenotype of certain human cancers and poor prognosis of patients; however, the underlying mechanisms are
文摘The trust plays an extremely important role in online shopping. In order to make online shopping trusty, this paper puts foreword a new trust model in e-commerce environment GIR-TM (Groups’ Internal Recommendation Trust Model). First, it regarded the network as a combination of groups, and then did the internal recommendation based on these groups. The GIR-TM, in the process of recommendation, distinguished clearly between the trust degrees of recommen-dation node and the trust degrees of recommended node, and then calculated the integrated credibility value of the recommended node according to the weight of recommendation node in the group, the partial trust degree and the de-gree of recommendation when the recommendation node recommends the recommended node, and the overall credibil-ity value of recommended node as well. Lastly through listing the experimental data and comparing with the HHRB-TM (History and Honest Recommendation Based Trust Model) on the same condition, it is verified that GIR-TM is feasible and effective.
文摘Realizing the physical reality of ‘tHooft’s self similar and dimensionaly regularized fractal-like spacetime as well as being inspired by a note worthy anecdote involving the great mathematician of Alexandria, Pythagoras and the larger than life man of theoretical physics Einstein, we utilize some deep mathematical connections between equivalence classes of equivalence relations and E-infinity theory quotient space. We started from the basic principles of self similarity which came to prominence in science with the advent of the modern theory of nonlinear dynamical systems, deterministic chaos and fractals. This fundamental logico-mathematical thread related to partially ordered sets is then applied to show how the classical Newton’s kinetic energy E = 1/2mv<sup>2</sup> leads to Einstein’s celebrated maximal energy equation E = mc<sup>2</sup> and how in turn this can be dissected into the ordinary energy density E(O) = mc<sup>2</sup>/22 and the dark energy density E(D) = mc<sup>2</sup>(21/22) of the cosmos where m is the mass;v is the velocity and c is the speed of light. The important role of the exceptional Lie symmetry groups and ‘tHooft-Veltman-Wilson dimensional regularization in fractal spacetime played in the above is also highlighted. The author hopes that the unusual character of the analysis and presentation of the present work may be taken in a positive vein as seriously attempting to propose a different and new way of doing theoretical physics by treating number theory, set theory, group theory, experimental physics as well as conventional theoretical physics on the same footing and letting all these diverse tools lead us to the answer of fundamental questions without fear of being labelled in one way or another.
文摘目的:探讨高迁移率簇蛋白B1(High mobility group box-1,HMGB1)和上皮型钙黏素(E-cadherin)在卵巢癌组织中的表达及临床意义。方法:选取我院妇产科2008年5月至2011年1月75例确诊为卵巢癌的患者为研究对象,采用免疫组化SP法染色,比较HMGB1和E-cadherin在卵巢癌组织及正常卵巢组织的表达差异,并分析不同临床病理参数下卵巢癌组织中HMGB1和E-cadherin的表达意义。结果:卵巢癌组织E-cadherin表达阳性率低于正常卵巢组织(χ2=12.62,P<0.01);卵巢癌组中HMGB1阳性表达率为(58/75)高于正常卵巢组织中表达(4/40)(χ2=47.60,P<0.01)。HMGB1和E-cadherin的表达与卵巢癌病理类型和病理分级无关(P>0.05),与临床分期和有无淋巴结转移有关(P<0.05)。卵巢癌组织中HMGB1和E-cadherin的异常表达呈显著负相关(r=-0.299,P<0.01)。结论:HMGB1和E-cadherin在卵巢癌发生、浸润、转移过程中起重要作用。
