Objective:To evaluate the pain degree of the patients with chronic non-cancer pain by using the evaluation model constituted by heart rate variability,anxiety and depression scale and quality of life rating scale.This...Objective:To evaluate the pain degree of the patients with chronic non-cancer pain by using the evaluation model constituted by heart rate variability,anxiety and depression scale and quality of life rating scale.This study also aims toevaluate the efficacy after treatment and nursing intervention.Methods:100 patients with chronic non-cancer pain treated in the hospital from February 2016 to April 2017 were selected to compare their heart rate variability,score of anxiety and depression,score of quality of life and NRS score before and after treatment and nursing intervention.Results:After treatment and nursing intervention,the heart rate variability time domain SDNN significantly increased(P<0.05).The score of anxiety and depression was lower than that before intervention(P<0.05)while the scores of various dimensions of quality of life were higher than those before intervention(P<0.05).The results also showed that NRS score was lower than that before intervention(P<0.05).Conclusion:These findings suggest that the measurement combination of heart rate variability,anxiety and depression scale and quality of life rating scale can be used as an evaluation model to evaluate the pain degree of the patients with chronic non-cancer pain the efficacy after treatment and nursing intervention,which is worthy of clinic application.展开更多
Flexible polymeric patches find widespread applications in biomedicine because of their biological and tunable features including excellent patient compliance,superior biocompatibility and biodegradation,as well as hi...Flexible polymeric patches find widespread applications in biomedicine because of their biological and tunable features including excellent patient compliance,superior biocompatibility and biodegradation,as well as high loading capability and permeability of drug.Such polymeric patches are classified into microneedles(MNs),hydrogel,microcapsule,microsphere and fiber depending on the formed morphology.The combination of nanomaterials with polymeric patches allows for improved advantages of increased curative efficacy and lowered systemic toxicity,promoting on-demand and regulated drug administration,thus providing the great potential to their clinic translation.In this review,the category of flexible polymeric patches that are utilized to integrate with nanomaterials is briefly presented and their advantages in bioapplications are further discussed.The applications of nanomaterials embedded polymeric patches in non-cancerous diseases were also systematically reviewed,including diabetes therapy,wound healing,dermatological disease therapy,bone regeneration,cardiac repair,hair repair,obesity therapy and some immune disease therapy.Alternatively,the limitations,latest challenges and future perspectives of such biomedical therapeutic devices are addressed.展开更多
Liver transplantation (LT) is recognized as best treatment option in patients with early hepatocellular cancer (HCC) in underlying liver cirrhosis. Apart from tumor size and number implemented in the Milan criteria, w...Liver transplantation (LT) is recognized as best treatment option in patients with early hepatocellular cancer (HCC) in underlying liver cirrhosis. Apart from tumor size and number implemented in the Milan criteria, which are current worldwide standards for patient selection, several biological tumor factors have been identified to affect cancer-specific outcome. In particular, grading and vascular tumor invasions were shown to correlate with aggressive biological tumor behavior and poor survival following LT. Identifying tumors with favorable biology is one important approach for expanding the pool of eligible liver recipients beyond the Milan burden limits. Improving the immunological state and condition for appropriate defense against circulating cancer cell attack may be another important prognostic aspect. Therefore, there is increasing interest in non-cancer factors related to the peritransplant period that may influence the oncological outcome by providing negative immunomodulatory actions. Considering and modulation of these non-HCC factors of prognosis might contribute in safely expanding the HCC LT selection criteria.展开更多
1文献来源Planchard D,Jänne PA,Cheng Y,et al.Osimertinib with or without chemotherapy in EGFR⁃mutated advanced NSCLC[J].N Engl J Med,2023,389(21):1935-1948.2证据水平1b。
文摘Objective:To evaluate the pain degree of the patients with chronic non-cancer pain by using the evaluation model constituted by heart rate variability,anxiety and depression scale and quality of life rating scale.This study also aims toevaluate the efficacy after treatment and nursing intervention.Methods:100 patients with chronic non-cancer pain treated in the hospital from February 2016 to April 2017 were selected to compare their heart rate variability,score of anxiety and depression,score of quality of life and NRS score before and after treatment and nursing intervention.Results:After treatment and nursing intervention,the heart rate variability time domain SDNN significantly increased(P<0.05).The score of anxiety and depression was lower than that before intervention(P<0.05)while the scores of various dimensions of quality of life were higher than those before intervention(P<0.05).The results also showed that NRS score was lower than that before intervention(P<0.05).Conclusion:These findings suggest that the measurement combination of heart rate variability,anxiety and depression scale and quality of life rating scale can be used as an evaluation model to evaluate the pain degree of the patients with chronic non-cancer pain the efficacy after treatment and nursing intervention,which is worthy of clinic application.
基金the Young Individual Research Grants(YIRG)(Grant No.A2084c0168)Singapore and A*STAR Central Funds(Grant No.C211718004),Singapore.
文摘Flexible polymeric patches find widespread applications in biomedicine because of their biological and tunable features including excellent patient compliance,superior biocompatibility and biodegradation,as well as high loading capability and permeability of drug.Such polymeric patches are classified into microneedles(MNs),hydrogel,microcapsule,microsphere and fiber depending on the formed morphology.The combination of nanomaterials with polymeric patches allows for improved advantages of increased curative efficacy and lowered systemic toxicity,promoting on-demand and regulated drug administration,thus providing the great potential to their clinic translation.In this review,the category of flexible polymeric patches that are utilized to integrate with nanomaterials is briefly presented and their advantages in bioapplications are further discussed.The applications of nanomaterials embedded polymeric patches in non-cancerous diseases were also systematically reviewed,including diabetes therapy,wound healing,dermatological disease therapy,bone regeneration,cardiac repair,hair repair,obesity therapy and some immune disease therapy.Alternatively,the limitations,latest challenges and future perspectives of such biomedical therapeutic devices are addressed.
文摘Liver transplantation (LT) is recognized as best treatment option in patients with early hepatocellular cancer (HCC) in underlying liver cirrhosis. Apart from tumor size and number implemented in the Milan criteria, which are current worldwide standards for patient selection, several biological tumor factors have been identified to affect cancer-specific outcome. In particular, grading and vascular tumor invasions were shown to correlate with aggressive biological tumor behavior and poor survival following LT. Identifying tumors with favorable biology is one important approach for expanding the pool of eligible liver recipients beyond the Milan burden limits. Improving the immunological state and condition for appropriate defense against circulating cancer cell attack may be another important prognostic aspect. Therefore, there is increasing interest in non-cancer factors related to the peritransplant period that may influence the oncological outcome by providing negative immunomodulatory actions. Considering and modulation of these non-HCC factors of prognosis might contribute in safely expanding the HCC LT selection criteria.
文摘1文献来源Planchard D,Jänne PA,Cheng Y,et al.Osimertinib with or without chemotherapy in EGFR⁃mutated advanced NSCLC[J].N Engl J Med,2023,389(21):1935-1948.2证据水平1b。
