Alzheimer’s disease(AD)is a progressive neurodegenerative disorder that affects both cognition and non-cognition functions.The disease follows a continuum,starting with preclinical stages,progressing to mild cognitiv...Alzheimer’s disease(AD)is a progressive neurodegenerative disorder that affects both cognition and non-cognition functions.The disease follows a continuum,starting with preclinical stages,progressing to mild cognitive and behavioral impairment,ultimately leading to dementia.Early detection of AD is crucial for better diagnosis and more effective treatment.However,the current AD diagnostic tests of biomarkers using cerebrospinal fluid and/or brain imaging are invasive or expensive,and mostly are still not able to detect early disease state.Consequently,there is an urgent need to develop new diagnostic techniques with higher sensitivity and specificity during the preclinical stages of AD.Various non-cognitive manifestations,including behavioral abnormalities,sleep disturbances,sensory dysfunctions,and physical changes,have been observed in the preclinical AD stage before occurrence of notable cognitive decline.Recent research advances have identified several biofluid biomarkers as early indicators of AD.This review focuses on these non-cognitive changes and newly discovered biomarkers in AD,specifically addressing the preclinical stages of the disease.Furthermore,it is of importance to explore the potential for developing a predictive system or network to forecast disease onset and progression at the early stage of AD.展开更多
We assess how implicit selections based on non-cognitive abilities may have changed in the context of the great higher education expansion in China,applying the classic supply-demand framework and utilizing the Big Fi...We assess how implicit selections based on non-cognitive abilities may have changed in the context of the great higher education expansion in China,applying the classic supply-demand framework and utilizing the Big Five personality model.Using the Chinese General Social Survey(CGSS)data from 2012,difference-in-difference(DID),difference-in-difference-in-difference(DDD)and descriptive analyses establish the following three major findings.First,from the generation entering college before the expansion-post-70s-to the generation entering college after the expansion-post-80s and post-90s-implicit selections in higher education based on personality have weakened with the increased supply of higher education opportunities.Second,selections have significantly weakened in terms of the openness dimension of personality,yet there is some evidence that selections have strengthened in terms of conscientiousness.This reflects that open-mindedness has become a relatively higher supply trait and conscientiousness has become a relatively lower supply trait among members of the post-90s generation.Third,selections have weakened only on the openness dimension for males,but on multiple dimensions beginning with agreeableness for females,reflecting a greatly increased supply of higher education opportunities for females with this dominant trait.The finding on strengthened selections based on conscientiousness has important implications for what and how to educate today’s college students.展开更多
Policymakers in developing countries have prioritized the mass expansion of vocational education and training(VET).This study examines whether the quality of VET in developing countries increases by investing greater ...Policymakers in developing countries have prioritized the mass expansion of vocational education and training(VET).This study examines whether the quality of VET in developing countries increases by investing greater resources per student.To achieve this goal,we examine the impacts of attending model schools(which have far more resources per student)on a range of student cognitive,non-cognitive,and behavioral outcomes.Using representative data from a survey of approximately 12,000 VET students from China,multivariate regression and propensity score matching analyses show that attending model vocational high schools do not benefit student outcomes,despite their substantially greater resources.展开更多
基金supported by funding from the National Natural Science Foundation of China(Nos.32220103006 and 82271524)the Intramural Research Program of NIH,National Institute on Aging(Nos.ZIA AG000944 and AG000928).
文摘Alzheimer’s disease(AD)is a progressive neurodegenerative disorder that affects both cognition and non-cognition functions.The disease follows a continuum,starting with preclinical stages,progressing to mild cognitive and behavioral impairment,ultimately leading to dementia.Early detection of AD is crucial for better diagnosis and more effective treatment.However,the current AD diagnostic tests of biomarkers using cerebrospinal fluid and/or brain imaging are invasive or expensive,and mostly are still not able to detect early disease state.Consequently,there is an urgent need to develop new diagnostic techniques with higher sensitivity and specificity during the preclinical stages of AD.Various non-cognitive manifestations,including behavioral abnormalities,sleep disturbances,sensory dysfunctions,and physical changes,have been observed in the preclinical AD stage before occurrence of notable cognitive decline.Recent research advances have identified several biofluid biomarkers as early indicators of AD.This review focuses on these non-cognitive changes and newly discovered biomarkers in AD,specifically addressing the preclinical stages of the disease.Furthermore,it is of importance to explore the potential for developing a predictive system or network to forecast disease onset and progression at the early stage of AD.
文摘We assess how implicit selections based on non-cognitive abilities may have changed in the context of the great higher education expansion in China,applying the classic supply-demand framework and utilizing the Big Five personality model.Using the Chinese General Social Survey(CGSS)data from 2012,difference-in-difference(DID),difference-in-difference-in-difference(DDD)and descriptive analyses establish the following three major findings.First,from the generation entering college before the expansion-post-70s-to the generation entering college after the expansion-post-80s and post-90s-implicit selections in higher education based on personality have weakened with the increased supply of higher education opportunities.Second,selections have significantly weakened in terms of the openness dimension of personality,yet there is some evidence that selections have strengthened in terms of conscientiousness.This reflects that open-mindedness has become a relatively higher supply trait and conscientiousness has become a relatively lower supply trait among members of the post-90s generation.Third,selections have weakened only on the openness dimension for males,but on multiple dimensions beginning with agreeableness for females,reflecting a greatly increased supply of higher education opportunities for females with this dominant trait.The finding on strengthened selections based on conscientiousness has important implications for what and how to educate today’s college students.
基金the financial assistance of the National Natural Science Foundation of China(Nos.71110107028,71333012,and 71033003).
文摘Policymakers in developing countries have prioritized the mass expansion of vocational education and training(VET).This study examines whether the quality of VET in developing countries increases by investing greater resources per student.To achieve this goal,we examine the impacts of attending model schools(which have far more resources per student)on a range of student cognitive,non-cognitive,and behavioral outcomes.Using representative data from a survey of approximately 12,000 VET students from China,multivariate regression and propensity score matching analyses show that attending model vocational high schools do not benefit student outcomes,despite their substantially greater resources.
