AIM To report on a more accurate diagnostic possibility offered by endoscopic ultrasound-guided cutting of holes and deep biopsy (EUS-CHDB) for pathologic diagnosis of gastric infiltrative tumors and gastrointestinal ...AIM To report on a more accurate diagnostic possibility offered by endoscopic ultrasound-guided cutting of holes and deep biopsy (EUS-CHDB) for pathologic diagnosis of gastric infiltrative tumors and gastrointestinal submucosal tumors. METHODS Ten consecutive patients who were suspected of having gastric invasive tumors or gastrointestinal submucosal tumors underwent EUS-CHDB with a novel vertical diathermic loop. We reviewed their medical data and analysed the effectiveness and safety of this new method. The final diagnosis was based on the surgical pathology or clinical/imaging follow-up. RESULTS EUS-CHDB was performed successfully in all the ten patients. Neither severe haemorrhage nor perforation occurred in any patient. Among the ten patients, there were three cases of gastric linitis plastica, one case of gastric lymphoma, five cases of gastrointestinal stromal tumors (GISTs), and only one case of chronic non-atrophic gastritis. That is, nine (90%) of the cases CONCLUSION EUS-CHDB may be a technically feasible and safe option for patients with gastric infiltrative tumors or gastrointestinal submucosal tumors. EUS-CHDB may be used as a remedial or even preferred biopsy method for submucosal lesions.展开更多
A multi-hole vertical-cavity surface-emitting laser （VCSEL） operating in stable single mode with a low threshold current was produced by introducing multi-leaf scallop holes on the top distributed Bragg-refleetor of...A multi-hole vertical-cavity surface-emitting laser （VCSEL） operating in stable single mode with a low threshold current was produced by introducing multi-leaf scallop holes on the top distributed Bragg-refleetor of an oxidation- confined 850 nm VCSEL. The single-mode output power of 2.6 mW, threshold current of 0.6 mA, full width of half maximum lasing spectrum of less than 0.1 nm, side mode suppression ratio of 28.4 dB, and far-field divergence angle of about 10% are obtained. The effects of different hole depths on the optical characteristics are simulated and analysed, including far-field divergence, spectrum and lateral cavity mode. The single-mode performance of this multi-hole device is attributed to the large radiation loss from the inter hole spacing and the scattering loss at the bottom of the holes, particularly for higher order modes.展开更多
The polarization of traditional photonic crystal（PC） vertical cavity surface emitting laser（VCSEL） is uncontrollable,resulting in the bit error increasing easily.Elliptical hole photonic crystal can control the tr...The polarization of traditional photonic crystal（PC） vertical cavity surface emitting laser（VCSEL） is uncontrollable,resulting in the bit error increasing easily.Elliptical hole photonic crystal can control the transverse mode and polarization of VCSEL efficiently.We analyze the far field divergence angle,and birefringence of elliptical hole PC VCSEL.When the ratio of minor axis to major axis b/a = 0.7,the PC VCSEL can obtain single mode and polarization.According to the simulation results,we fabricate the device successfully.The output power is 1.7 mW,the far field divergence angle is less than 10°,and the side mode suppression ratio is over 30 dB.The output power in the Y direction is 20 times that in the X direction.展开更多
With the advantages of wide distribution,fast growth,and broad metabolic spectrum to organic carbon compounds,Vibrio may play an important role in organic carbon cycling.However,the ecological roles of Vibrio in many ...With the advantages of wide distribution,fast growth,and broad metabolic spectrum to organic carbon compounds,Vibrio may play an important role in organic carbon cycling.However,the ecological roles of Vibrio in many marine environments have not been explored.Here,the world's deepest'blue hole',the Sansha Yongle Blue Hole(SYBH)in the South China Sea,which is a geographically semi-enclosed environment featuring unique chemical characters,was investigated.The abundance,diversity and carbon source utilization capability of Vibrio were studied by quantification and high-throughput sequencing of Vibrio specific 16S rRNA genes and cultivation methods.The abundance of Vibrio in water column of the SYBH ranged from 3.78×10^4 to 7.35×10^616S rRNA gene copies L_1.Free-living Vibrio was more abundant than particle-associated Vibrio(~1.20×10^6 versus-2.68×10^5 gene copies L_1),indicating that Vibrio prefers a free-living life style.The Vibrio assemblages showed clear vertical stratification and could be divided into three groups:aerobic-transition,middle anaerobic and bottom anaerobic zones.Dissolved oxygen(DO),temperature,pH and salinity were the main environmental factors affecting the abundance and community composition.Cultivated Vibrio demonstrated a degrading capability to various macromolecular substrates,including starch,Tween 20/40/80,DNA,gelatin,alginate,casein,chitin,lecithin,K-carrageenan,mannan,xylan and hyaluronic acid.This suggests that Vibrio could produce a variety of highly active extracellular enzymes.Our study provides new insights into the distribution pattern and possible role in carbon cycle of Vibrio in the unique environment of a"blue hole'.展开更多
文摘AIM To report on a more accurate diagnostic possibility offered by endoscopic ultrasound-guided cutting of holes and deep biopsy (EUS-CHDB) for pathologic diagnosis of gastric infiltrative tumors and gastrointestinal submucosal tumors. METHODS Ten consecutive patients who were suspected of having gastric invasive tumors or gastrointestinal submucosal tumors underwent EUS-CHDB with a novel vertical diathermic loop. We reviewed their medical data and analysed the effectiveness and safety of this new method. The final diagnosis was based on the surgical pathology or clinical/imaging follow-up. RESULTS EUS-CHDB was performed successfully in all the ten patients. Neither severe haemorrhage nor perforation occurred in any patient. Among the ten patients, there were three cases of gastric linitis plastica, one case of gastric lymphoma, five cases of gastrointestinal stromal tumors (GISTs), and only one case of chronic non-atrophic gastritis. That is, nine (90%) of the cases CONCLUSION EUS-CHDB may be a technically feasible and safe option for patients with gastric infiltrative tumors or gastrointestinal submucosal tumors. EUS-CHDB may be used as a remedial or even preferred biopsy method for submucosal lesions.
基金Project supported by the National High Technology Research and Development Program of China (Grant No. 2008AA03Z402)the National Natural Science Foundation of China (Grant No. 61076044)the Natural Science Foundation of Beijing,China(Grant Nos. 4092007 and 4102003)
文摘A multi-hole vertical-cavity surface-emitting laser （VCSEL） operating in stable single mode with a low threshold current was produced by introducing multi-leaf scallop holes on the top distributed Bragg-refleetor of an oxidation- confined 850 nm VCSEL. The single-mode output power of 2.6 mW, threshold current of 0.6 mA, full width of half maximum lasing spectrum of less than 0.1 nm, side mode suppression ratio of 28.4 dB, and far-field divergence angle of about 10% are obtained. The effects of different hole depths on the optical characteristics are simulated and analysed, including far-field divergence, spectrum and lateral cavity mode. The single-mode performance of this multi-hole device is attributed to the large radiation loss from the inter hole spacing and the scattering loss at the bottom of the holes, particularly for higher order modes.
基金Project supported by the National High Technology Research and Development Program of China (Grant No. 2008AA03Z402)the Beijing Municipal Natural Science Foundation,China (Grant Nos. 4092007,4112006,4102003,and 4132006)+1 种基金the National Natural Science Foundation of China (Grant Nos. 61076044,61036002,61036009,and 60978067)the Doctoral Fund of the Ministry of Education of China (Grant No. 20121103110018)
文摘The polarization of traditional photonic crystal（PC） vertical cavity surface emitting laser（VCSEL） is uncontrollable,resulting in the bit error increasing easily.Elliptical hole photonic crystal can control the transverse mode and polarization of VCSEL efficiently.We analyze the far field divergence angle,and birefringence of elliptical hole PC VCSEL.When the ratio of minor axis to major axis b/a = 0.7,the PC VCSEL can obtain single mode and polarization.According to the simulation results,we fabricate the device successfully.The output power is 1.7 mW,the far field divergence angle is less than 10°,and the side mode suppression ratio is over 30 dB.The output power in the Y direction is 20 times that in the X direction.
基金This work was supported by the National Natural Science Foundation of China(Grants nos.41730530,91751202 and 41476112).
文摘With the advantages of wide distribution,fast growth,and broad metabolic spectrum to organic carbon compounds,Vibrio may play an important role in organic carbon cycling.However,the ecological roles of Vibrio in many marine environments have not been explored.Here,the world's deepest'blue hole',the Sansha Yongle Blue Hole(SYBH)in the South China Sea,which is a geographically semi-enclosed environment featuring unique chemical characters,was investigated.The abundance,diversity and carbon source utilization capability of Vibrio were studied by quantification and high-throughput sequencing of Vibrio specific 16S rRNA genes and cultivation methods.The abundance of Vibrio in water column of the SYBH ranged from 3.78×10^4 to 7.35×10^616S rRNA gene copies L_1.Free-living Vibrio was more abundant than particle-associated Vibrio(~1.20×10^6 versus-2.68×10^5 gene copies L_1),indicating that Vibrio prefers a free-living life style.The Vibrio assemblages showed clear vertical stratification and could be divided into three groups:aerobic-transition,middle anaerobic and bottom anaerobic zones.Dissolved oxygen(DO),temperature,pH and salinity were the main environmental factors affecting the abundance and community composition.Cultivated Vibrio demonstrated a degrading capability to various macromolecular substrates,including starch,Tween 20/40/80,DNA,gelatin,alginate,casein,chitin,lecithin,K-carrageenan,mannan,xylan and hyaluronic acid.This suggests that Vibrio could produce a variety of highly active extracellular enzymes.Our study provides new insights into the distribution pattern and possible role in carbon cycle of Vibrio in the unique environment of a"blue hole'.
