Background Non-high-density lipoprotein cholesterol(non-HDL-C) and Apolipoprotein B(apo B) increase cardiovascular disease(CVD) risk, but few studies have explored the correlations of non-HDL-C and apo B with coronary...Background Non-high-density lipoprotein cholesterol(non-HDL-C) and Apolipoprotein B(apo B) increase cardiovascular disease(CVD) risk, but few studies have explored the correlations of non-HDL-C and apo B with coronary atherosclerosis in non-diabetes acute coronary syndrome(ACS). Methods The study enrolled 443 subjects with non-diabetic ACS, and all subject check coronary angiography, and coronary atherosclerosis were evaluated using Gensini Score(GS) scale including small(GS1-15), middle(GS16-43), and severe(GS≥44). All subjects were classified into 4 groups: High apo B(≥90 mg/d L) and High non-HDL-C(≥130 mg/d L), High non-HDL-C alone, High apo B alone, and normal apo B and non-HDL-C. Results After adjusted for risk factors, non-HDL-C and apo B were positively correlated with GS( r = 0.075, P = 0.002 and r = 0.092, P < 0.001). In the GS 0-15,high non-HDL-C + high apo B group 29.3% and high apo B alone group 28.2% were significantly lower than normal non-HDL-C+ normal apo B group 48%(p = 0.010). In the GS 16-43, high non-HDL-C alone group 50.4%and high apo B alone group 47.6% were significantly more than high non-HDL-C+ high apo B group 34.1%(P =0.036). In the GS ≥44, high non-HDL-C+ high apo B group 36.6% was significantly higher than high non-HDLC alone group 16% and normal non-HDL-C+ normal apo B 14.2%(P < 0.001). Conclusions The high non-HDLC and apo B are the risk factors for coronary artery atherosclerosis in non-diabetic ACS.展开更多
基金supported by the Natural Science Foundation of China(No.81070182)the Natural Science Foundation of Guangdong Province(No.10151008901000224)
文摘Background Non-high-density lipoprotein cholesterol(non-HDL-C) and Apolipoprotein B(apo B) increase cardiovascular disease(CVD) risk, but few studies have explored the correlations of non-HDL-C and apo B with coronary atherosclerosis in non-diabetes acute coronary syndrome(ACS). Methods The study enrolled 443 subjects with non-diabetic ACS, and all subject check coronary angiography, and coronary atherosclerosis were evaluated using Gensini Score(GS) scale including small(GS1-15), middle(GS16-43), and severe(GS≥44). All subjects were classified into 4 groups: High apo B(≥90 mg/d L) and High non-HDL-C(≥130 mg/d L), High non-HDL-C alone, High apo B alone, and normal apo B and non-HDL-C. Results After adjusted for risk factors, non-HDL-C and apo B were positively correlated with GS( r = 0.075, P = 0.002 and r = 0.092, P < 0.001). In the GS 0-15,high non-HDL-C + high apo B group 29.3% and high apo B alone group 28.2% were significantly lower than normal non-HDL-C+ normal apo B group 48%(p = 0.010). In the GS 16-43, high non-HDL-C alone group 50.4%and high apo B alone group 47.6% were significantly more than high non-HDL-C+ high apo B group 34.1%(P =0.036). In the GS ≥44, high non-HDL-C+ high apo B group 36.6% was significantly higher than high non-HDLC alone group 16% and normal non-HDL-C+ normal apo B 14.2%(P < 0.001). Conclusions The high non-HDLC and apo B are the risk factors for coronary artery atherosclerosis in non-diabetic ACS.
