The Impact of Digital Technology on Healthcare Delivery and Patient Outcomes

Digital technology has fundamentally transformed healthcare delivery, exerting profound influence on patient outcomes. This paper delves into the roles played by telemedicine, electronic health records (EHRs), and mobile health applications in augmenting healthcare services. The objective is to scrutinize the ways in which these digital innovations enhance healthcare delivery and patient outcomes, while also identifying the attendant challenges in their adoption. To achieve this, a rigorous literature review encompassing peer-reviewed articles, reports, and case studies that examine the impact of digital technology in healthcare settings was conducted. The findings underscore that digital technology significantly bolsters patient care by enhancing access, operational efficiency, and diagnostic accuracy. Nonetheless, persistent challenges such as safeguarding data privacy, ensuring interoperability across systems, and managing implementation costs continue to pose significant hurdles.

Prospects of 3D Printing Technology in Dental Medicine

With the continuous advancement of technology,the application of 3D printing technology in the field of dental medicine is becoming increasingly widespread.This article aims to explore the current applications and future potential of 3D printing technology in dental medicine and to analyze its benefits and challenges.It first introduces the current state of 3D printing technology in dental implants,crowns,bridges,orthodontics,and maxillofacial surgery.It then discusses the potential applications of 3D printing technology in oral tissue engineering,drug delivery systems,personalized dental prosthetics,and surgical planning.Finally,it analyzes the benefits of 3D printing technology in dental medicine,such as improving treatment accuracy and patient comfort,and shortening treatment times,while also highlighting the challenges faced,such as costs,material choices,and technical limitations.This article aims to provide a reference for professionals in the field of dental medicine and to promote the further application and development of 3D printing technology in this area.

Microwave technology enabled transdermal nanocarrier and drug delivery

Transdermal drug delivery is impeded by the natural barrier of epidermis known as stratum corneum.This limits the route to transport of drugs with a log octanol–water partition coefficient of 1 to 3,molecular weight of less than 500 Da and melting point of less than 200°C.Nanotechnology has received a widespread investigation as the nanocarriers are able to fluidize the stratum corneum as a function of size,shape,surface charges,and hydrophilicity–hydrophobicity balance,while delivering drugs across the skin barrier.

Blood–brain barrier and laser technology for drug brain delivery

Here,we discuss an important problem in medicine as development of efctive strategies for brain drug delivery.This problem is related to the blood-brain barrier(BBB),which is a“customs”controlling the entrance of different molecules from blood into the brain protecting the normal function of central nervous system(CNS).We show three interfaces of anatomical side of BBB and two functional types of BBB一physical and transporter barriers.Although this protective mechanism is essential for health of CNS,it also creates a hindrance to the entry of drugs into the brain.The BBB was discovered over 100 years ago but till now,there is no efective methods for brain drug delivery.There ane more than 70 approaches for overcoming BBB incuding physical,chenical and biological techniques but all of these tools have limitation to be widely used in clinical practice due to invasi venes,challenge in performing,very costly or lim-itation of drug concentration.Photodynamic therapy(PDT)is usual clinical method of surgical navigation for the resection of brain tumor and anti-cancer therapy.Nowadays,the application of PDT is considered as a potential promising tool for brain drug delivery via opening of BBB.Here,we show the first sucoessful experimental results in this field discussing the adventures and disadv antages of PDT-related BBB disruption as well as altematives to overcome these limitations and possi ble mechanisms with new pathways for brain clearance via gly mphatic and lymphatic systems.

The Need for Speed The rapidly growing express delivery service gets even faster with cutting-edge technology

The rapidly growing express delivery service gets even faster with cutting-edge technology.

A Non-Invasive Skin Treatment Combining LED with Pharmacologic and Ultrasonic Technologies for Facial Rejuvenation

Background: Non-invasive facial treatments have the ability to rejuvenate the facial profile when specific pharmacologic agents and modalities are prescribed and used in combination taking into consideration each patient’s unique skin type and condition. RATIONALE Epinova is a non-invasive skin treatment that combines the correct concentrations and combinations of topicals and modalities to elicit facial rejuvenation with no down-time or side effects. Purpose: This paper focuses on facial rejuvenation improvements combining the RATIONALE Essential Six skincare system (RATIONALE, Victoria, Australia) to protect and repair the skin with the RATIONALE Epinova facial treatment every 4-6 weeks—which uses non-invasive technologies and professional strength active ingredients to deliver visible changes to skin tone and texture. Methods: Subjects underwent a RATIONALE consultation, including taking a skin history and skin imaging, followed by a data analysis and diagnosis of skin condition and prescription of a customized RATIONALE treatement (Epinova), including appropriate pharmacologic agents and treatment with personalized photo/sono therapeutic devices. Results: Subjects reported increased skin hydration, tactile improvements, skin firmness and visible radiance following the RATIONALE Epinova treatment. Further investigations will be initiated to explore the potential for longer term improvements, including connenctive tissue deposition, reduction of erythema etc. Treatments should be performed every 4-6 weeks for patients under 40 and every 3-4 weeks for patients over 40, to support cell differentiation, migration and desquamation to achieve non-invasive facial rejuvenation. Conclusion: This study demonstrated that the synergy of pharmacologic, LED light therapy and ultrasonic technologies when prescribed and administered by a trained skin therapist, can lead to a visible improvement in the signs of facial ageing and photodamage, restoring the appearance of healthy, radiant skin. .

Next-generation surgicalmeshes for drug delivery and tissue engineering applications:materials,design and emerging manufacturing technologies

Surgical meshes have been employed in the management of a variety of pathological conditions including hernia,pelvic floor dysfunctions,periodontal guided bone regeneration,wound healing and more recently for breast plastic surgery after mastectomy.These common pathologies affect a wide portion of the worldwide population;therefore,an effective and enhanced treatment is crucial to ameliorate patients’living conditions both from medical and aesthetic points of view.At present,non-absorbable synthetic polymers are the most widely used class of biomaterials for the manufacturing of mesh implants for hernia,pelvic floor dysfunctions and guided bone regeneration,with polypropylene and poly tetrafluoroethylene being the most common.Biological prostheses,such as surgical grafts,have been employed mainly for breast plastic surgery and wound healing applications.Despite the advantages of mesh implants to the treatment of these conditions,there are still many drawbacks,mainly related to the arising of a huge number of post-operative complications,among which infections are the most common.Developing a mesh that could appropriately integrate with the native tissue,promote its healing and constructive remodelling,is the key aim of ongoing research in the area of surgical mesh implants.To this end,the adoption of new biomaterials including absorbable and natural polymers,the use of drugs and advanced manufacturing technologies,such as 3D printing and electrospinning,are under investigation to address the previously mentioned challenges and improve the outcomes of future clinical practice.The aim of this work is to review the key advantages and disadvantages related to the use of surgical meshes,the main issues characterizing each clinical procedure and the future directions in terms of both novel manufacturing technologies and latest regulatory considerations.

Design of a Submarine Pipeline Inspection Robot System Based on CT Technology

With the rapid development of submarine oil and gas,the security issues of submarine oil and gas pipeline become increasingly prominent,and regular inspection of submarine pipeline is particularly important.Therefore,a submarine pipeline inspection robot system based on CT technology to solve the problems such as low traditional manual inspection efficiency,high labor cost,low security and backward inspection methods.Based on the platform of ROV robot,carrying CT scanner as an external detection device,the system is used for non-invasive inspection of submarine pipeline,which is safe and harmless,with good economy,high mobility,and strong environmental adaptability.Compared with traditional technology,CT scanner’s external inspection technology used in the system avoids the damage to the external protective layer of the pipeline in the measurement of pipeline wall thickness.Meantime,it can provide the tomography of the pipe wall and the composition of the sediment material on the inside wall,which fills the gap in this technical field in China.According to the test,the robot has the characteristics of stable adsorption,flexible movement,and clear pipeline CT scanning image,and can realize the intelligent inspection of submarine pipeline.

Periodontal Diseases and Recently Applied Nano-Technology: A Review Article

Nowadays, nano-technology is a promising option for scientists to enhance dental conditions and provide new techniques to offer a more reliable and comfortable therapeutic pickups. In this regard, there are different methods to manufacture novel nano-structured dental materials, and also modern drug delivery techniques. In this review article, all our efforts are based on the recently nano-dental approaches closely linked to treat or prevent some common dental diseases including tooth erosion, tooth sensitivity, periodontal disease, oral cancer, and so on. All the data and articles putted in this survey are gathered from Google Scholar, PubMed, and some dental databases.

纳米粒子在骨组织工程化基因修饰治疗中的应用

背景:传统的骨组织工程技术治疗临界骨缺损存在成骨效率低、安全性差等问题。而以非病毒纳米粒子为基因载体构建的基因强化型骨组织工程移植物,具有更高的成骨效率和安全性,引起了国内外学者的广泛关注和研究。目的:对当前国内外有关纳米粒子在组织工程成骨基因治疗研究中取得的新技术、新方法以及面临的挑战等进行综述,旨在为纳米粒子介导的骨组织工程基因治疗研究提供参考。方法:第一作者在Pub Med、Web of Science和中国知网数据库上进行文献检索,并以“Bone defect repair,Bone tissue engineering,Gene delivery,Nanoparticles,Non-viral gene vector,Sustained release technology,Sequential release,Targeted delivery”作为英文检索词,以“骨缺损修复,骨组织工程,基因递送,纳米粒子,非病毒基因载体,缓释技术,序贯释放,靶向递送”作为中文检索词,最终纳入84篇文献进行总结。结果与结论:(1)在骨缺损愈合的各个生理阶段进行针对性的基因递送可以显著增强骨修复效果。在早期炎症阶段,通过纳米粒子递送抗炎基因来调节炎症反应,可以为后续骨愈合奠定基础;在血管新生期,向局部递送促血管化基因有助于形成高度组织化、可灌注的血管系统,加快骨愈合速度;随着血管化的进行,骨骼的神经再支配也开始发生,此时递送促神经再生的功能性基因有利于促进神经化骨再生;在成骨阶段,通过构建纳米粒子-成骨基因复合物,可以直接提升支架及体内新骨形成的效率。(2)各种有机、无机纳米颗粒、金属有机框架和外泌体等非病毒纳米载体,在骨组织工程基因治疗中具有巨大的潜力,这些纳米基因载体各有其独特的优势和不足,因此在实际应用时,需要根据基因转染效率、生物安全性和成骨特性等因素选择最合适的类型。(3)为了全面提升递送基因的效果,目前主要通过对纳米载体进行各种功能设计来增强基因转染效率,包括增强缓释性和多基因递送序贯性等时间调控能力、增强对骨组织和成骨相关细胞的空间靶向能力、增强跨膜运输效率和细胞核靶向能力等全过程调控手段。(4)未来要进一步推动纳米粒子介导的骨组织工程基因治疗在临床上的应用,还需要克服诸多技术挑战,包括提高有机纳米基因载体的基因转染效率、降低无机纳米载体的生物安全性风险、优化新型纳米载体的生产工艺以及促进其它生理过程与成骨交互作用等,这些问题也是未来骨组织工程基因治疗的研究热点和潮流。

Challenges and trends in apomorphine drug delivery systems for the treatment of Parkinson's disease

Parkinson's disease(PD) is a chronic debilitating disease affecting approximately 1% of the population over the age of 60. The severity of PD is correlated to the degree of dopaminergic neuronal loss. Apomorphine has a similar chemical structure as the neurotransmitter dopamine and has been used for the treatment of advanced PD patients. In PD patients,apomorphine is normally administered subcutaneously with frequent injections because of the compound's extensive hepatic first-pass metabolism. There is, hence, a large unmet need for alternative administrative routes for apomorphine to improve patient compliance.The present review focuses on the research and development of alternative delivery of apomorphine, aiming to highlight the potential of non-invasive apomorphine therapy in PD,such as sublingual delivery and transdermal delivery.

Learning Management System for Improved Service Delivery in Tertiary Institution

Learning Management System (LMS) provides educators, administrators and learners with a single robust, secure and integrated system to create personalized learning environments. This paper was motivated by the lag in technological evolution and traditional learning system in the Educational system in most of the Universities. Hence, a call for a change in the way service is delivered in our tertiary institutions. The work proposed the use of Moodle Learning Management System (LMS) as a tool to improve service delivery in tertiary institution. The methodology used was SSADM while the programming used was PHP, HTML, CSS and Ajax. MySQL was for the database design. The expected result was an e-learning site for Computer Science Imo State University Owerri, a platform that increases the possibility of interaction between students and lecturers.

水凝胶微针在经皮给药系统中的研究进展

微针是一种微凸起阵列组成的微创装置,穿过皮肤角质层形成暂时性微通道,可实现对药物的经皮递送。对微针在经皮给药应用中的优缺点进行了简单阐述,重点介绍了水凝胶微针。综述了水凝胶微针的形成机制、基质材料及制备方法,并对水凝胶微针在疾病诊断和治疗方面的应用进行了介绍,指出了水凝胶微针在生物安全性、制定载药量标准等方面存在的问题,对未来的研究方向进行了展望。智能化、便携化是未来的微针发展趋势,若可以实现根据患者需求在给药时间、给药部位、给药剂量等方面的精准调控,水凝胶微针将在疾病诊断与治疗方面发挥更大的潜力。

基于5G技术的校园无人车配送系统设计与实施研究

文章以青岛职业技术学院为案例,基于5G技术设计了校园无人车配送系统。通过勘察和数据采集确定了配送需求和路径,并设计了无人车控制系统,实现自主行驶和环境感知。采用基于5G的通信模块实现与服务器的实时通信,通过仿真和优化,建立了系统原型,并进行了实地测试。结果表明,该系统能高效、安全地提高校园内配送效率和服务质量,对未来校园无人车配送系统具有重要参考价值。

被遮蔽的从属性:“互联网+劳动关系”的关键内核及其协调策略--以外卖骑手作为观察对象

围绕外卖骑手与互联网平台之间能否形成劳动法意义上的劳动关系,存在着否定性意见、肯定性意见、观望性意见三种差异化观点。从实然状态来看,在表象上,互联网平台与专送骑手和众包骑手之间均不存在或难以存在从属性。从应然状态来看,一方面,外卖骑手不仅仅在现实世界中的流通环节提供送餐行为,更在与之平行的虚拟世界或数字世界的生产环节中生产具有价值的数据,另一方面,人的逻辑和算法逻辑的冲突,背后的“从属性”实像被互联网及技术所遮蔽和掩盖,由此亟待揭开互联网平台与外卖骑手之间的“隐蔽从属性”并适用劳动法调整。但即使立法层面采纳“隐蔽从属性”的观点和理由,确认互联网平台与外卖骑手之间存在劳动关系,也依旧需要对劳动法进行一个相当程度甚至颠覆性的改造和重塑。同时,辅之严禁“最严算法”、适用“算法取中”、实现“算法透明”、发挥“算法伦理”,以充分塑造“新”的劳动秩序。

面向云计算技术的云边协同和无人配送路径研究

近年来,智能物联网(Artificial Internet of Things,AIoT)不断推动物流行业的智慧化发展。为了提高物流配送效率,降低物流配送成本,文章提出了一种面向云计算技术的云边协同无人配送路径规划技术,通过云服务器、边缘服务器和终端设备的有效协调,实现无人配送过程中的用户交互、功能应用、资源管理等功能,为推动智慧物流的发展提供有效参考。利用无人机作为无人配送装置,搭建相应的软硬件架构,在某小区内进行实验,发现无人机能按照最优路径将相关装置有效配送至收货人处,证明该研究具有良好的应用价值。

siRNA纳米递送系统在类风湿性关节炎治疗中的研究进展

类风湿性关节炎是一种自身免疫性疾病,其病因复杂,目前尚未有很好的治疗方法,长期服用抗风湿药物也带来诸多副作用。RNA干扰技术是指通过外源性或内源性的双链RNA在体内诱导靶基因m RNA产生特异性降解,进而引起不同水平的基因沉默,具有高效、高特异性、低毒等优点,在生物医药领域有着巨大潜力。小干扰RNA(si RNA)作为RNA干扰技术的重要效应分子,在治疗类风湿关节炎方面具有巨大潜力。本文综述了siRNA递送系统用于治疗类风湿关节炎的最新研究进展,阐明了基于siRNA纳米给药系统治疗类风湿关节炎的优势,并展望了未来siRNA递送的发展方向。

基于微纳米技术的细胞内递送的物理方法

随着生物医药学的发展,向细胞内递送外源性大分子在基础生物学和临床应用中至关重要,但基于病毒载体的传统生物方法存在通量低、毒性大、递送性能低以及耗时长等问题。文章综述了电穿孔、声穿孔、微注射和细胞挤压等基于细胞膜破坏实现胞内物质递送的技术,这些通过微纳米技术完成的高通量胞内物质递送的物理方法,可以弥补传统生物方法的很多缺陷,实验证明了其在保证细胞活性的基础上具有可观的转染效率。文章重点描述了基于细胞挤压实现细胞内递送的微流控操作平台及其机理,并讨论各种通过膜破坏技术完成细胞药物或分子递送技术的优势、局限性和发展前景。

会阴无保护接生技术护理干预对新生儿Apgar评分的影响

目的探讨会阴无保护接生技术护理干预对新生儿Apgar评分的影响。方法应用医学实验观察法,选取2022年6月至2023年6月在福建医科大学附属泉州第一医院行经阴道试产的80例产妇,均分为两组,一组应用会阴无保护接生技术组作为观察组(n=40),另一组采用传统接生技术和方法组作为对照组(n=40),观察和统计两组产妇不同接生方法应用后,对护理满意度、新生儿Apgar评分、新生儿预后的影响。结果观察组临床护理满意度高于对照组(P<0.05);观察组在出生1 min后Apgar评分、出生5 min后Apgar评分上均高于对照组(均P<0.05);观察组在新生儿肺炎发生评分、新生儿肢体损伤评分、新生儿感染评分上均低于对照组(均P<0.05)。结论应用会阴无保护接生技术经阴道试产的应用,在保障新生儿安全,提高临床护理满意度,改善新生儿Apgar评分上作用突出。