期刊文献+
共找到4,256篇文章
< 1 2 213 >
每页显示 20 50 100
FibroScan-aspartate transaminase:A superior non-invasive model for diagnosing high-risk metabolic dysfunction-associated steatohepatitis 被引量:1
1
作者 Jing-Ya Yin Tian-Yuan Yang +4 位作者 Bing-Qing Yang Chen-Xue Hou Jun-Nan Li Yue Li Qi Wang 《World Journal of Gastroenterology》 SCIE CAS 2024年第18期2440-2453,共14页
BACKGROUND Non-alcoholic fatty liver disease(NAFLD)with hepatic histological NAFLD activity score≥4 and fibrosis stage F≥2 is regarded as“at risk”non-alcoholic steatohepatitis(NASH).Based on an international conse... BACKGROUND Non-alcoholic fatty liver disease(NAFLD)with hepatic histological NAFLD activity score≥4 and fibrosis stage F≥2 is regarded as“at risk”non-alcoholic steatohepatitis(NASH).Based on an international consensus,NAFLD and NASH were renamed as metabolic dysfunction-associated steatotic liver disease(MASLD)and metabolic dysfunction-associated steatohepatitis(MASH),respectively;hence,we introduced the term“high-risk MASH”.Diagnostic values of seven non-invasive models,including FibroScan-aspartate transaminase(FAST),fibrosis-4(FIB-4),aspartate transaminase to platelet ratio index(APRI),etc.for high-risk MASH have rarely been studied and compared in MASLD.AIM To assess the clinical value of seven non-invasive models as alternatives to liver biopsy for diagnosing high-risk MASH.METHODS A retrospective analysis was conducted on 309 patients diagnosed with NAFLD via liver biopsy at Beijing Ditan Hospital,between January 2012 and December 2020.After screening for MASLD and the exclusion criteria,279 patients wereincluded and categorized into high-risk and non-high-risk MASH groups.Utilizing threshold values of each model,sensitivity,specificity,positive predictive value(PPV),and negative predictive values(NPV),were calculated.Receiver operating characteristic curves were constructed to evaluate their diagnostic efficacy based on the area under the curve(AUROC).RESULTS MASLD diagnostic criteria were met by 99.4%patients with NAFLD.The MASLD population was analyzed in two cohorts:Overall population(279 patients)and the subgroup(117 patients)who underwent liver transient elastography(FibroScan).In the overall population,FIB-4 showed better diagnostic efficacy and higher PPV,with sensitivity,specificity,PPV,NPV,and AUROC of 26.9%,95.2%,73.5%,72.2%,and 0.75.APRI,Forns index,and aspartate transaminase to alanine transaminase ratio(ARR)showed moderate diagnostic efficacy,whereas S index and gamma-glutamyl transpeptidase to platelet ratio(GPR)were relatively weaker.In the subgroup,FAST had the highest diagnostic efficacy,its sensitivity,specificity,PPV,NPV,and AUROC were 44.2%,92.3%,82.1%,67.4%,and 0.82.The FIB-4 AUROC was 0.76.S index and GPR exhibited almost no diagnostic value for high-risk MASH.CONCLUSION FAST and FIB-4 could replace liver biopsy as more effectively diagnostic methods for high-risk MASH compared to APRI,Forns index,ARR,S index,and GPR;FAST is superior to FIB-4. 展开更多
关键词 Metabolic dysfunction-associated steatotic liver disease High-risk metabolic dysfunction-associated steatohepatitis non-invasive models Liver biopsy Diagnostic value
下载PDF
Health diagnosis of ultrahigh arch dam performance using heterogeneous spatial panel vector model 被引量:1
2
作者 Er-feng Zhao Xin Li Chong-shi Gu 《Water Science and Engineering》 EI CAS CSCD 2024年第2期177-186,共10页
Currently,more than ten ultrahigh arch dams have been constructed or are being constructed in China.Safety control is essential to long-term operation of these dams.This study employed the flexibility coefficient and ... Currently,more than ten ultrahigh arch dams have been constructed or are being constructed in China.Safety control is essential to long-term operation of these dams.This study employed the flexibility coefficient and plastic complementary energy norm to assess the structural safety of arch dams.A comprehensive analysis was conducted,focusing on differences among conventional methods in characterizing the structural behavior of the Xiaowan arch dam in China.Subsequently,the spatiotemporal characteristics of the measured performance of the Xiaowan dam were explored,including periodicity,convergence,and time-effect characteristics.These findings revealed the governing mechanism of main factors.Furthermore,a heterogeneous spatial panel vector model was developed,considering both common factors and specific factors affecting the safety and performance of arch dams.This model aims to comprehensively illustrate spatial heterogeneity between the entire structure and local regions,introducing a specific effect quantity to characterize local deformation differences.Ultimately,the proposed model was applied to the Xiaowan arch dam,accurately quantifying the spatiotemporal heterogeneity of dam performance.Additionally,the spatiotemporal distri-bution characteristics of environmental load effects on different parts of the dam were reasonably interpreted.Validation of the model prediction enhances its credibility,leading to the formulation of health diagnosis criteria for future long-term operation of the Xiaowan dam.The findings not only enhance the predictive ability and timely control of ultrahigh arch dams'performance but also provide a crucial basis for assessing the effectiveness of engineering treatment measures. 展开更多
关键词 Ultrahigh arch dam Structural performance Deformation behavior diagnosis criterion Panel data model
下载PDF
Endoscopic diagnosis and management of gallbladder carcinoma in minimally invasive era:New needs,new models
3
作者 La-Cuo Deqing Jun-Wen Zhang Jian Yang 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第11期4333-4337,共5页
Gallbladder cancer(GBC)is a rare and lethal malignancy;however,it represents the most common type of biliary tract cancer.Patients with GBC are often diagnosed at an advanced stage,thus,unfortunately,losing the opport... Gallbladder cancer(GBC)is a rare and lethal malignancy;however,it represents the most common type of biliary tract cancer.Patients with GBC are often diagnosed at an advanced stage,thus,unfortunately,losing the opportunity for curative surgical intervention.This situation leads to lower quality of life and higher mortality rates.In recent years,the rapid development of endoscopic equipment and techniques has provided new avenues and possibilities for the early and minimally invasive diagnosis and treatment of GBC.This editorial comments on the article by Pavlidis et al.Building upon their work,we explore the new needs and corresponding models for managing GBC from the endoscopic diagnosis and treatment perspective. 展开更多
关键词 ENDOSCOPY diagnosis and treatment Gallbladder carcinoma Minimal invasive New need New model
下载PDF
Key Issues for Modelling, Operation, Management and Diagnosis of Lithium Batteries: Current States and Prospects
4
作者 Bo Yang Yucun Qian +2 位作者 Jianzhong Xu Yaxing Ren Yixuan Chen 《Energy Engineering》 EI 2024年第8期2085-2091,共7页
1 Introduction.With the continuous growth of the global population,the energy demand continues to increase.However,due to the dominance of fossil fuels in global energy and fossil fuels are non-renewable,it has led to... 1 Introduction.With the continuous growth of the global population,the energy demand continues to increase.However,due to the dominance of fossil fuels in global energy and fossil fuels are non-renewable,it has led to the global energy crisis[1].Besides,the use of fossil fuels will generate a mass of air pollutants(e.g.,carbon dioxide,sulfur dioxide,etc.),which will cause serious environmental pollution,climate change[2],etc.To resolve the aforementioned issues,countries around the world have implemented a variety of measures hoping to fundamentally adjust the global energy structure and achieve sustainable development.Thereinto,“Paris Agreement”reached in 2015 under the framework of“United Nations Framework Convention on Climate Change”aims to control the increase in the average temperature of the globe to within 2°C below preindustrial levels,and thereafter to peak global greenhouse gas emissions as soon as possible,continuously decreasing thereafter[3].United Kingdom plans to reduce the average exhaust emissions of“new cars”to approximately 50–70 g/km by 20230,which is roughly half of what it is now[4].In addition,China proposed a plan at“United Nations General Assembly”in 2020 to peak carbon dioxide emissions by 2030 and strive to achieve carbon neutrality by 2060.It is a fact that the whole world is committed to changing the current energy structure,protecting the Earth’s ecology,and achieving global sustainable development[5]. 展开更多
关键词 Lithium batteries optimization operation modelLING state estimation life prediction fault diagnosis
下载PDF
The enlightenment of artificial intelligence large-scale model on the research of intelligent eye diagnosis in traditional Chinese medicine
5
作者 GAO Yuan WU Zixuan +4 位作者 SHENG Boyang ZHANG Fu CHENG Yong YAN Junfeng PENG Qinghua 《Digital Chinese Medicine》 CAS CSCD 2024年第2期101-107,共7页
Eye diagnosis is a method for inspecting systemic diseases and syndromes by observing the eyes.With the development of intelligent diagnosis in traditional Chinese medicine(TCM);artificial intelligence(AI)can improve ... Eye diagnosis is a method for inspecting systemic diseases and syndromes by observing the eyes.With the development of intelligent diagnosis in traditional Chinese medicine(TCM);artificial intelligence(AI)can improve the accuracy and efficiency of eye diagnosis.However;the research on intelligent eye diagnosis still faces many challenges;including the lack of standardized and precisely labeled data;multi-modal information analysis;and artificial in-telligence models for syndrome differentiation.The widespread application of AI models in medicine provides new insights and opportunities for the research of eye diagnosis intelli-gence.This study elaborates on the three key technologies of AI models in the intelligent ap-plication of TCM eye diagnosis;and explores the implications for the research of eye diagno-sis intelligence.First;a database concerning eye diagnosis was established based on self-su-pervised learning so as to solve the issues related to the lack of standardized and precisely la-beled data.Next;the cross-modal understanding and generation of deep neural network models to address the problem of lacking multi-modal information analysis.Last;the build-ing of data-driven models for eye diagnosis to tackle the issue of the absence of syndrome dif-ferentiation models.In summary;research on intelligent eye diagnosis has great potential to be applied the surge of AI model applications. 展开更多
关键词 Traditional Chinese medicine(TCM) Eye diagnosis Artificial intelligence(AI) Large-scale model Self-supervised learning Deep neural network
下载PDF
A hybrid CNN-LSTM model for diagnosing rice nutrient levels at the rice panicle initiation stage
6
作者 Fubing Liao Xiangqian Feng +6 位作者 Ziqiu Li Danying Wang Chunmei Xu Guang Chu Hengyu Ma Qing Yao Song Chen 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第2期711-723,共13页
Nitrogen(N)and potassium(K)are two key mineral nutrient elements involved in rice growth.Accurate diagnosis of N and K status is very important for the rational application of fertilizers at a specific rice growth sta... Nitrogen(N)and potassium(K)are two key mineral nutrient elements involved in rice growth.Accurate diagnosis of N and K status is very important for the rational application of fertilizers at a specific rice growth stage.Therefore,we propose a hybrid model for diagnosing rice nutrient levels at the early panicle initiation stage(EPIS),which combines a convolutional neural network(CNN)with an attention mechanism and a long short-term memory network(LSTM).The model was validated on a large set of sequential images collected by an unmanned aerial vehicle(UAV)from rice canopies at different growth stages during a two-year experiment.Compared with VGG16,AlexNet,GoogleNet,DenseNet,and inceptionV3,ResNet101 combined with LSTM obtained the highest average accuracy of 83.81%on the dataset of Huanghuazhan(HHZ,an indica cultivar).When tested on the datasets of HHZ and Xiushui 134(XS134,a japonica rice variety)in 2021,the ResNet101-LSTM model enhanced with the squeeze-and-excitation(SE)block achieved the highest accuracies of 85.38 and 88.38%,respectively.Through the cross-dataset method,the average accuracies on the HHZ and XS134 datasets tested in 2022 were 81.25 and 82.50%,respectively,showing a good generalization.Our proposed model works with the dynamic information of different rice growth stages and can efficiently diagnose different rice nutrient status levels at EPIS,which are helpful for making practical decisions regarding rational fertilization treatments at the panicle initiation stage. 展开更多
关键词 dynamic model of deep learning UAV rice panicle initiation nutrient level diagnosis image classification
下载PDF
Impact of cancer diagnosis on life expectancy by area-level socioeconomic groups in New South Wales, Australia: a population-based study
7
作者 Md Mijanur Rahman Michael David +5 位作者 David Goldsbury Karen Canfell Kou Kou Paramita Dasgupta Peter Baade Xue Qin Yu 《Cancer Biology & Medicine》 SCIE CAS CSCD 2024年第8期692-702,共11页
Objective: Improvement in cancer survival over recent decades has not been accompanied by a narrowing of socioeconomic disparities. This study aimed to quantify the loss of life expectancy(LOLE) resulting from a cance... Objective: Improvement in cancer survival over recent decades has not been accompanied by a narrowing of socioeconomic disparities. This study aimed to quantify the loss of life expectancy(LOLE) resulting from a cancer diagnosis and examine disparities in LOLE based on area-level socioeconomic status(SES).Methods: Data were collected for all people between 50 and 89 years of age who were diagnosed with cancer, registered in the NSW Cancer Registry between 2001 and 2019, and underwent mortality follow-up evaluations until December 2020. Flexible parametric survival models were fitted to estimate the LOLE by gender and area-level SES for 12 common cancers.Results: Of 422,680 people with cancer, 24% and 18% lived in the most and least disadvantaged areas, respectively. Patients from the most disadvantaged areas had a significantly greater average LOLE than patients from the least disadvantaged areas for cancers with high survival rates, including prostate [2.9 years(95% CI: 2.5±3.2 years) vs. 1.6 years(95% CI: 1.3±1.9 years)] and breast cancer [1.6 years(95% CI: 1.4±1.8 years) vs. 1.2 years(95% CI: 1.0±1.4 years)]. The highest average LOLE occurred in males residing in the most disadvantaged areas with pancreatic [16.5 years(95% CI: 16.1±16.8 years) vs. 16.2 years(95% CI: 15.7±16.7 years)] and liver cancer [15.5 years(95% CI: 15.0±16.0 years) vs. 14.7 years(95% CI: 14.0±15.5 years)]. Females residing in the least disadvantaged areas with thyroid cancer [0.9 years(95% CI: 0.4±1.4 years) vs. 0.6 years(95% CI: 0.2±1.0 years)] or melanoma [0.9 years(95% CI: 0.8±1.1 years) vs. 0.7 years(95% CI: 0.5±0.8 years)] had the lowest average LOLE.Conclusions: Patients from the most disadvantaged areas had the highest LOLE with SES-based differences greatest for patients diagnosed with cancer at an early stage or cancers with higher survival rates, suggesting the need to prioritise early detection and reduce treatment-related barriers and survivorship challenges to improve life expectancy. 展开更多
关键词 Cancer diagnosis life expectancy loss of life expectancy area-level socioeconomic status flexible parametric model
下载PDF
Non-invasively differentiate non-alcoholic steatohepatitis by visualizing hepatic integrinαvβ3 expression with a targeted molecular imaging modality
8
作者 Xiao-Quan Huang Ling Wu +7 位作者 Chun-Yan Xue Chen-Yi Rao Qing-Qing Fang Ying Chen Cao Xie Sheng-Xiang Rao Shi-Yao Chen Feng Li 《World Journal of Hepatology》 2024年第11期1290-1305,共16页
BACKGROUND Non-invasive methods to diagnose non-alcoholic steatohepatitis(NASH),an inflammatory subtype of non-alcoholic fatty liver disease(NAFLD),are currently unavailable.AIM To develop an integrinαvβ3-targeted m... BACKGROUND Non-invasive methods to diagnose non-alcoholic steatohepatitis(NASH),an inflammatory subtype of non-alcoholic fatty liver disease(NAFLD),are currently unavailable.AIM To develop an integrinαvβ3-targeted molecular imaging modality to differentiate NASH.METHODS Integrinαvβ3 expression was assessed in Human LO2 hepatocytes Scultured with palmitic and oleic acids(FFA).Hepatic integrinαvβ3 expression was analyzed in rabbits fed a high-fat diet(HFD)and in rats fed a high-fat,high-carbohydrate diet(HFCD).After synthesis,cyclic arginine-glycine-aspartic acid peptide(cRGD)was labeled with gadolinium(Gd)and used as a contrast agent in magnetic resonance imaging(MRI)performed on mice fed with HFCD.RESULTS Integrinαvβ3 was markedly expressed on FFA-cultured hepatocytes,unlike the control hepatocytes.Hepatic integrinαvβ3 expression significantly increased in both HFD-fed rabbits and HFCD-fed rats as simple fatty liver(FL)progressed to steatohepatitis.The distribution of integrinαvβ3 in the liver of NASH cases largely overlapped with albumin-positive staining areas.In comparison to mice with simple FL,the relative liver MRI-T1 signal value at 60 minutes post-injection of Gd-labeled cRGD was significantly increased in mice with steatohepatitis(P<0.05),showing a positive correlation with the NAFLD activity score(r=0.945;P<0.01).Hepatic integrinαvβ3 expression was significantly upregulated during NASH development,with hepatocytes being the primary cells expressing integrinαvβ3.CONCLUSION After using Gd-labeled cRGD as a tracer,NASH was successfully distinguished by visualizing hepatic integrinαvβ3 expression with MRI. 展开更多
关键词 Non-alcoholic steatohepatitis Cyclic peptides Magnetic resonance imaging non-invasive diagnosis Hepatic integrinαvβ3
下载PDF
Fault Diagnosis Method of Rolling Bearing Based on ESGMD-CC and AFSA-ELM
9
作者 Jiajie He Fuzheng Liu +3 位作者 Xiangyi Geng Xifeng Liang Faye Zhang Mingshun Jiang 《Structural Durability & Health Monitoring》 EI 2024年第1期37-54,共18页
Incomplete fault signal characteristics and ease of noise contamination are issues with the current rolling bearing early fault diagnostic methods,making it challenging to ensure the fault diagnosis accuracy and relia... Incomplete fault signal characteristics and ease of noise contamination are issues with the current rolling bearing early fault diagnostic methods,making it challenging to ensure the fault diagnosis accuracy and reliability.A novel approach integrating enhanced Symplectic geometry mode decomposition with cosine difference limitation and calculus operator(ESGMD-CC)and artificial fish swarm algorithm(AFSA)optimized extreme learning machine(ELM)is proposed in this paper to enhance the extraction capability of fault features and thus improve the accuracy of fault diagnosis.Firstly,SGMD decomposes the raw vibration signal into multiple Symplectic geometry components(SGCs).Secondly,the iterations are reset by the cosine difference limitation to effectively separate the redundant components from the representative components.Additionally,the calculus operator is performed to strengthen weak fault features and make them easier to extract,and the singular value decomposition(SVD)weighted by power spectrum entropy(PSE)can be utilized as the sample feature representation.Finally,AFSA iteratively optimized ELM is adopted as the optimized classifier for fault identification.The superior performance of the proposed method has been validated by various experiments. 展开更多
关键词 Symplectic geometry mode decomposition calculus operator cosine difference limitation fault diagnosis AFSAELM model
下载PDF
Non-invasive model for predicting high-risk esophageal varices based on liver and spleen stiffness 被引量:1
10
作者 Long-Bao Yang Xin Gao +7 位作者 Hong Li Xin-Xing Tantai Fen-Rong Chen Lei Dong Xu-Sheng Dang Zhong-Cao Wei Chen-Yu Liu Yan Wang 《World Journal of Gastroenterology》 SCIE CAS 2023年第25期4072-4084,共13页
BACKGROUND Acute bleeding due to esophageal varices(EVs)is a life-threatening complication in patients with cirrhosis.The diagnosis of EVs is mainly through upper gastrointestinal endoscopy,but the discomfort,contrain... BACKGROUND Acute bleeding due to esophageal varices(EVs)is a life-threatening complication in patients with cirrhosis.The diagnosis of EVs is mainly through upper gastrointestinal endoscopy,but the discomfort,contraindications and complications of gastrointestinal endoscopic screening reduce patient compliance.According to the bleeding risk of EVs,the Baveno VI consensus divides varices into high bleeding risk EVs(HEVs)and low bleeding risk EVs(LEVs).We sought to identify a non-invasive prediction model based on spleen stiffness measurement(SSM)and liver stiffness measurement(LSM)as an alternative to EVs screening.AIM To develop a safe,simple and non-invasive model to predict HEVs in patients with viral cirrhosis and identify patients who can be exempted from upper gastrointestinal endoscopy.METHODS Data from 200 patients with viral cirrhosis were included in this study,with 140 patients as the modelling group and 60 patients as the external validation group,and the EVs types of patients were determined by upper gastrointestinal endoscopy and the Baveno Ⅵ consensus.Those patients were divided into the HEVs group(66 patients)and the LEVs group(74 patients).The effect of each parameter on HEVs was analyzed by univariate and multivariate analyses,and a noninvasive prediction model was established.Finally,the discrimination ability,calibration ability and clinical efficacy of the new model were verified in the modelling group and the external validation group.RESULTS Univariate and multivariate analyses showed that SSM and LSM were associated with the occurrence of HEVs in patients with viral cirrhosis.On this basis,logistic regression analysis was used to construct a prediction model:Ln[P/(1-P)]=-8.184-0.228×SSM+0.642×LSM.The area under the curve of the new model was 0.965.When the cut-off value was 0.27,the sensitivity,specificity,positive predictive value and negative predictive value of the model for predicting HEVs were 100.00%,82.43%,83.52%,and 100%,respectively.Compared with the four prediction models of liver stiffness-spleen diameter to platelet ratio score,variceal risk index,aspartate aminotransferase to alanine aminotransferase ratio,and Baveno VI,the established model can better predict HEVs in patients with viral cirrhosis.CONCLUSION Based on the SSM and LSM measured by transient elastography,we established a non-invasive prediction model for HEVs.The new model is reliable in predicting HEVs and can be used as an alternative to routine upper gastrointestinal endoscopy screening,which is helpful for clinical decision making. 展开更多
关键词 CIRRHOSIS High-risk esophageal varices non-invasive prediction model Spleen stiffness measurement Liver stiffness measurement Upper gastrointestinal endoscopy
下载PDF
Relationship Between Gene-Phenotype and Clinical Manifestations of Chromosomal Copy Number Variations Indicated by Non-Invasive Prenatal Testing
11
作者 Zixin Pi Xiaoyan Duan +1 位作者 Jing Peng Yanhui Liu 《Journal of Clinical and Nursing Research》 2024年第1期88-95,共8页
Objective:To analyze the clinical value of non-invasive prenatal testing(NIPT)in detecting chromosomal copy number variations(CNVs)and to explore the relationship between gene expression and clinical manifestations of... Objective:To analyze the clinical value of non-invasive prenatal testing(NIPT)in detecting chromosomal copy number variations(CNVs)and to explore the relationship between gene expression and clinical manifestations of chromosomal copy number variations.Methods:3551 naturally conceived singleton pregnant women who underwent NIPT were included in this study.The NIPT revealed abnormalities other than sex chromosome abnormalities and trisomy 13,18,and 21.Pregnant women with chromosome copy number variations underwent genetic counseling and prenatal ultrasound examination.Interventional prenatal diagnosis and chromosome microarray analysis(CMA)were performed.The clinical phenotypes and pregnancy outcomes of different prenatal diagnoses were analyzed.Additionally,a follow-up was conducted by telephone to track fetal development after birth,at six months,and one year post-birth.Results:A total of 53 cases among 3551 cases showed chromosomal copy number variation.Interventional prenatal diagnosis was performed in 36 cases:27 cases were negative and 8 were consistent with the NIPT test results.This indicates that NIPT’s positive predictive value(PPV)in CNVs is 22.22%.Conclusion:NIPT has certain clinical significance in screening chromosome copy number variations and is expected to become a routine screening for chromosomal microdeletions and microduplications.However,further interventional prenatal diagnosis is still needed to identify fetal CNVs. 展开更多
关键词 non-invasive prenatal testing Chromosomal copy number variation Chromosomes 1 and 3 Chromosome 4 Chromosome 7 Chromosome 15 Prenatal diagnosis
下载PDF
Letter to editor‘Non-invasive model for predicting high-risk esophageal varices based on liver and spleen stiffness’
12
作者 Xin Gao Xiao-Yan Guo +6 位作者 Long-Bao Yang Zhong-Cao Wei Pan Zhang Ya-Tao Wang Chen-Yu Liu Dan-Yang Zhang Yan Wang 《World Journal of Hepatology》 2023年第11期1250-1252,共3页
predicting high-risk esophageal varices based on liver and spleen stiffness".Acute bleeding caused by esophageal varices is a life-threatening complication in patients with liver cirrhosis.Due to the discomfort,c... predicting high-risk esophageal varices based on liver and spleen stiffness".Acute bleeding caused by esophageal varices is a life-threatening complication in patients with liver cirrhosis.Due to the discomfort,contraindications,and associated complications of upper gastrointestinal endoscopy screening,it is crucial to identify an imaging-based non-invasive model for predicting high-risk esophageal varices in patients with cirrhosis. 展开更多
关键词 CIRRHOSIS High-risk esophageal varices non-invasive prediction model Spleen stiffness measurement Liver stiffness measurement Upper gastrointestinal endoscopy
下载PDF
Covid-19 Diagnosis Using a Deep Learning Ensemble Model with Chest X-Ray Images
13
作者 Fuat Türk 《Computer Systems Science & Engineering》 SCIE EI 2023年第5期1357-1373,共17页
Covid-19 is a deadly virus that is rapidly spread around the world towards the end of the 2020.The consequences of this virus are quite frightening,especially when accompanied by an underlying disease.The novelty of t... Covid-19 is a deadly virus that is rapidly spread around the world towards the end of the 2020.The consequences of this virus are quite frightening,especially when accompanied by an underlying disease.The novelty of the virus,the constant emergence of different variants and its rapid spread have a negative impact on the control and treatment process.Although the new test kits provide almost certain results,chest X-rays are extremely important to detect the progression and degree of the disease.In addition to the Covid-19 virus,pneumonia and harmless opacity of the lungs also complicate the diagnosis.Considering the negative results caused by the virus and the treatment costs,the importance of fast and accurate diagnosis is clearly seen.In this context,deep learning methods appear as an extremely popular approach.In this study,a hybrid model design with superior properties of convolutional neural networks is presented to correctly classify the Covid-19 disease.In addition,in order to contribute to the literature,a suitable dataset with balanced case numbers that can be used in all artificial intelligence classification studies is presented.With this ensemble model design,quite remarkable results are obtained for the diagnosis of three and four-class Covid-19.The proposed model can classify normal,pneumonia,and Covid-19 with 92.6%accuracy and 82.6%for normal,pneumonia,Covid-19,and lung opacity. 展开更多
关键词 Deep learning multi class diagnosis Covid-19 Covid-19 ensemble model medical image analysis
下载PDF
Non-invasive diagnosis of gastric mucosal atrophy in an asymptomatic population with high prevalence of gastric cancer 被引量:14
14
作者 Antonio Rollan Catterina Ferreccio +3 位作者 Alessandra Gederlini Carolina Serrano Javiera Torres Paul Harris 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第44期7172-7178,共7页
AIM: To validate a non-invasive method to detect gastric mucosal atrophy in a Chilean population with high prevalence of gastric cancer and a poor survival rate. METHODS: We first determined the optimal cut-off level ... AIM: To validate a non-invasive method to detect gastric mucosal atrophy in a Chilean population with high prevalence of gastric cancer and a poor survival rate. METHODS: We first determined the optimal cut-off level of serum pepsinogen (PG)-1, PG-1/PG-2 ratio and 17-gastrin in 31 voluntary symptomatic patients (mean age: 66.1 years), of them 61% had histologically confirmed gastric atrophy. Then, in a population-based sample of 536 healthy individuals (209 residents in counties with higher relative risk and 327 residents in counties with lower relative risk for gastric cancer), we measured serum anti-H pylori antibodies, PG and 17-gastrin and estimated their risk of gastric cancer. RESULTS: We found that serum PG-1 < 61.5 μg/L, PG-1/PG-2 ratio < 2.2 and 17-gastrin > 13.3 pmol/L had a high specificity (91%-100%) and a fair sensitivity (56%-78%) to detect corpus-predominant atrophy. Based on low serum PG-1 and PG-1/PG-2 ratio together as diagnostic criteria, 12.5% of the asymptomatic subjects had corpus-predominant atrophy (0% of those under 25 years and 20.2% over 65 years old). The frequency of gastric atrophy was similar (12% vs 13%) but H pylori infection rate was slightly higher (77% vs 71%) in the high-risk compared to the low-risk counties. Based on their estimated gastric cancer risk, individuals were classified as: low-risk group (no H pylori infection and no atrophy; n = 115; 21.4%); moderate-risk group(H pylori infection but no atrophy; n = 354, 66.0%); and high-risk group (gastric atrophy, with or without H pylori infection; n = 67, 12.5%). The high-risk group was significantly older (mean age: 61.9 ± 13.3 years), more frequently men and less educated as compared with the low-risk group. CONCLUSION: We propose to concentrate on an upper gastrointestinal endoscopy for detection of early gastric cancer in the high-risk group. This intervention model could improve the poor prognosis of gastric cancer in Chile. 展开更多
关键词 Gastric cancer H pylori Gastric atrophy non-invasive diagnosis PEPSINOGEN GASTRIN
下载PDF
A Novel Deep Model with Meta-Learning for Rolling Bearing Few-Shot Fault Diagnosis
15
作者 Xiaoxia Liang Ming Zhang +3 位作者 Guojin Feng Yuchun Xu Dong Zhen Fengshou Gu 《Journal of Dynamics, Monitoring and Diagnostics》 2023年第2期102-114,共13页
Machine learning,especially deep learning,has been highly successful in data-intensive applications;however,the performance of these models will drop significantly when the amount of the training data amount does not ... Machine learning,especially deep learning,has been highly successful in data-intensive applications;however,the performance of these models will drop significantly when the amount of the training data amount does not meet the requirement.This leads to the so-called few-shot learning(FSL)problem,which requires the model rapidly generalize to new tasks that containing only a few labeled samples.In this paper,we proposed a new deep model,called deep convolutional meta-learning networks,to address the low performance of generalization under limited data for bearing fault diagnosis.The essential of our approach is to learn a base model from the multiple learning tasks using a support dataset and finetune the learnt parameters using few-shot tasks before it can adapt to the new learning task based on limited training data.The proposed method was compared to several FSL methods,including methods with and without pre-training the embedding mapping,and methods with finetuning the classifier or the whole model by utilizing the few-shot data from the target domain.The comparisons are carried out on 1-shot and 10-shot tasks using the Case Western Reserve University bearing dataset and a cylindrical roller bearing dataset.The experimental result illustrates that our method has good performance on the bearing fault diagnosis across various few-shot conditions.In addition,we found that the pretraining process does not always improve the prediction accuracy. 展开更多
关键词 BEARING deep model fault diagnosis few-shot learning META-LEARNING
下载PDF
Non-invasive Prenatal Diagnosis of Trisomy 21 by Dosage Ratio of Fetal Chromosome-specific Epigenetic Markers in Maternal Plasma 被引量:4
16
作者 张铭 李涛 +5 位作者 陈静怡 李莉 周春 王燕 刘文惠 张元珍 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2011年第5期687-692,共6页
This study examined the methylation difference in AIRE and RASSF1A between maternal and placental DNA, and the implication of this difference in the identification of free fetal DNA in maternal plasma and in prenatal ... This study examined the methylation difference in AIRE and RASSF1A between maternal and placental DNA, and the implication of this difference in the identification of free fetal DNA in maternal plasma and in prenatal diagnosis of trisomy 21. Maternal plasma samples were collected from 388 singleton pregnancies, and placental or chorionic villus tissues from 112 of them. Methylation-specific PCR (MSP) and methylation-sensitive restriction enzyme digestion followed by fluorescent quantitative PCR (MSRE + PCR) were employed to detect the maternal-fetal methylation difference in AIRE and RASSF1A. Diagnosis of trisomy 21 was established according to the ratio of fetal-specific AIRE to RASSF1A in maternal plasma. Both methods confirmed that AIRE and RASSF1A were hypomethylated in maternal blood cells but hypermethylated in placental or chorionic villus tissues. Moreover, the differential methylation for each locus could be seen during the whole pregnant period. The positive rates of fetal AIRE and RASSF1A in maternal plasma were found to be 78.1% and 82.1% by MSP and 94.8% and 96.9% by MSRE + PCR. MSRE + PCR was superior to MSP in the identification of fetal-specific hypermethylated sequences (P〈0.05). Based on the data from 266 euploidy pregnancies, the 95% reference interval of the fetal AIRE/RASSF1A ratio in maternal plasma was 0.33-1.77, which was taken as the reference value for determining the numbers of fetal chromosome 21 in 102 pregnancies. The accu-racy rate in 98 euploidy pregnancies was 96.9% (95/98). Three of the four trisomy 21 pregnancies were confirmed with this method. It was concluded that hypermethylated AIRE and RASSF1A may serve as fetal-specific markers for the identification of fetal DNA in maternal plasma and may be used for noninvasive prenatal diagnosis of trisomy 21. 展开更多
关键词 fetal DNA differential methylation AIRE RASSF1A non-invasive prenatal diagnosis
下载PDF
Acetone sensors for non-invasive diagnosis of diabetes based on metal-oxide-semiconductor materials 被引量:3
17
作者 Yujie Li Min Zhang Haiming Zhang 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第9期156-163,共8页
In recent years, clinical studies have found that acetone concentration in exhaled breath can be taken as a characteristic marker of diabetes. Metal-oxide-semiconductor (MOS) materials are widely used in acetone gas s... In recent years, clinical studies have found that acetone concentration in exhaled breath can be taken as a characteristic marker of diabetes. Metal-oxide-semiconductor (MOS) materials are widely used in acetone gas sensors due to their low cost, high sensitivity, fast response/recovery time, and easy integration. This paper reviews recent progress in acetone sensors based on MOS materials for diabetes diagnosis. The methods of improving the performance of acetone sensor have been explored for comparison, especially in high humidity conditions. We summarize the current excellent methods of preparations of sensors based on MOSs and hope to provide some help for the progress of acetone sensors in the diagnosis of diabetes. 展开更多
关键词 non-invasive diabetes diagnosis acetone sensor SELECTIVE high humidity
下载PDF
Enrichment of Fetal Nucleated Red Blood Cells by Multi-core Magnetic Composite Particles for Non-invasive Prenatal Diagnosis 被引量:1
18
作者 PAN Ying WANG Qing +7 位作者 HUANG Wen-jun QIAO Feng-1i LIU Yu-ping ZHANG Yu-cheng HAI De-yang DU Ying,ting WANG Wen-yue ZHANG Ai-chen 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2012年第3期443-448,共6页
A novel kind of multi-core magnetic composite particles, the surfaces of which were respectively mo- dified with goat-anti-mouse IgG and antitransferrin receptor(anti-CD71), was prepared. The fetal nucleated red blo... A novel kind of multi-core magnetic composite particles, the surfaces of which were respectively mo- dified with goat-anti-mouse IgG and antitransferrin receptor(anti-CD71), was prepared. The fetal nucleated red blood cells(FNRBCs) in the peripheral blood of a gravida were rapidly and effectively enriched and separated by the mo- dified multi-core magnetic composite particles in an external magnetic field. The obtained FNRBCs were used for the identification of the fetal sex by means of fluorescence in situ hybridization(FISH) technique. The results demonstrate that the multi-core magnetic composite particles meet the requirements for the enrichment and speration of FNRBCs with a low concentration and the accuracy of detetion for the diagnosis of fetal sex reached to 95%. Moreover, the obtained FNRBCs were applied to the non-invasive diagnosis of Down syndrome and chromosome 3p21 was de- tected. The above facts indicate that the novel multi-core magnetic composite particles-based method is simple, relia- ble and cost-effective and has opened up vast vistas for the potential application in clinic non-invasive prenatal diag- nosis. 展开更多
关键词 Fetal nucleated red blood cell(FNRBC) Prenatal diagnosis non-invasive Multi-core magnetic compositeparticle
下载PDF
Non-Invasive Evaluation and Differential Diagnosis for Pediatric Leukoderma in a Single Institute 被引量:1
19
作者 Madoka Takafuji Atsushi Tanemura +4 位作者 Yuma Hanaoka Noriko Arase Eiji Kiyohara Ichiro Katayama Manabu Fujimoto 《Journal of Cosmetics, Dermatological Sciences and Applications》 2019年第4期313-320,共8页
Background: Although vitiligo shows a similar clinical picture to other disorders in which patients exhibit depigmented spots, there are few reports on the differentiation of these conditions from each other. Purpose:... Background: Although vitiligo shows a similar clinical picture to other disorders in which patients exhibit depigmented spots, there are few reports on the differentiation of these conditions from each other. Purpose: We aimed to investigate the differences and similarities between vitiligo and nevus depigmentosus in children based on the clinical course and characteristics. Materials and Methods: We conducted an examination of the disease type, treatment, progress, and differentiation of 85 cases of vitiligo and nevus depigmentosus that developed before 15 years of age among patients who visited the Osaka University Department of Dermatology with a chief complaint of white patches from January 2010 to March 2017. Results: The median age at the onset of symptoms of 79 patients with vitiligo was 4.5 years and while that of 6 patients with nevus depigmentosus was 0.8 years, indicating that the onset of nevus depigmentosus occurred earlier. While vitiligo often developed in the head and neck regions, with a tendency for depigmented spots in multiple regions, nevus depigmentosus did not show this tendency in these regions. Upon performing Wood’s lamp observation in 38 cases of vitiligo, 35 cases were found to be fluorescent chalky white and in 3 cases histologically diagnosed as vitiligo, no clear fluorescent color was observed. All 6 patients diagnosed with nevus depigmentosus exhibited a non-fluorescent off-white color under a Wood’s lamp. Conclusions: This study indicates that non-invasive observation using a Wood’s lamp is useful in the differential diagnosis of pediatric leukoderma, in addition to the subsequent clinical course, such as the presence or absence of lesional repigmentation and/or enlargement. 展开更多
关键词 PEDIATRIC Leukoderma VITILIGO NEVUS Depigmentosus non-invasive diagnosis Wood’s Lamp
下载PDF
Non-invasive Prenatal Gene Diagnosis: Progress through Cell-free Fetal DNA and RNA in Maternal Plasma and Urine
20
作者 GUO Xun-yang, GUO Yi-bin ( Department of Medical Genetics, Zhongshan School of Medicine, SUN Yat-Sen University, Guangzhou 510080, China ) 《中山大学学报(医学科学版)》 CAS CSCD 北大核心 2008年第S2期140-142,共3页
Non-invasive prenatal gene diagnosis has been developed rapidly in the recent years, and numerous medical researchers are focusing on it. Such techniques could not only achieve prenatal diagnosis accurately, but also ... Non-invasive prenatal gene diagnosis has been developed rapidly in the recent years, and numerous medical researchers are focusing on it. Such techniques could not only achieve prenatal diagnosis accurately, but also prevent tangential illness in fetuses and thus, reduce the incidence of diseases. Moreover, it is non-invasive prenatal gene diagnosis that prevents potential threaten and danger to both mothers and fetuses. Therefore, it is welcomed by clinical gynecologist and obstetrian, researchers of medical genetics, and especially, pregnancies. This review article touches briefly on the advanced development of using cell-free DNA, RNA in maternal plasma and urine for non-invasive prenatal gene diagnosis. 展开更多
关键词 non-invasive prenatal gene diagnosis CELL-FREE fetal DNA and RNA DNA and RNA detection MATERNAL URINE MATERNAL plasma
下载PDF
上一页 1 2 213 下一页 到第
使用帮助 返回顶部