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Creation of cytochrome P450 catalysis depending on a non-natural cofactor for fatty acid hydroxylation
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作者 Qing Li Xiaojia Guo +4 位作者 Xueying Wang Junting Wang Li Wan Haizhao Xue Zongbao K.Zhao 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第4期31-36,共6页
Cytochrome P450 enzymes catalyze diverse oxidative transformations at the expense of reduced nicotinamide adenine dinucleotide phosphate(NADPH),however,their applications remain limited largely because NADPH is cost-p... Cytochrome P450 enzymes catalyze diverse oxidative transformations at the expense of reduced nicotinamide adenine dinucleotide phosphate(NADPH),however,their applications remain limited largely because NADPH is cost-prohibitive for biocatalysis at scale yet tightly regulated in host cells.A highly challenging task for P450 catalysis has been to develop an alternative and biocompatible electrondonating system.Here we engineered P450 BM3 to favor reduced nicotinamide cytosine dinucleotide(NCDH)and created non-natural cofactor-dependent P450 catalysis.Two outstanding mutants were identified with over 640-fold NCDH preference improvement and good catalytic efficiencies of over15,000 M^(-1)s^(-1)for the oxidation of the fatty acid probe 12-(para-nitrophenoxy)-dodecanoate.Molecular docking analysis indicated that these mutants bear a compacted cofactor entrance.Upon fusing with an NCD-dependent formate dehydrogenase,fused proteins functioned as NCDH-specific P450catalysts by using formate as the electron donor.Importantly,these mutants and fusions catalyzed NCDH-dependent hydroxylation of fatty acids with similar chain length preference to those by natural P450 BM3 in the presence of NADPH and also similar regioselectivity for subterminal hydroxylation of lauric acid.As P450 BM3 and its variants are catalytically powerful to take diverse substrates and convey different reaction paths,our results offer an exciting opportunity to devise advanced cell factories that convey oxidative biocatalysis with an orthogonal reducing power supply system. 展开更多
关键词 Biocatalysis Cytochrome P450 Directed evolution Fatty acid hydroxylation non-natural cofactor Synthetic biology
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Novel Method for Selective Debenzylation Under Maintenance of Fluoro Atom Substituted on β-Amino Acids
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作者 ZHENG Yi WU Gang +5 位作者 ZHU Xin-rong LI Yue-jie MA Yu-heng ZHAO Xin LU Tao ZHU Yong-qiang 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2011年第2期224-227,共4页
tert-Butyl (R)-3-amino-3-(3-fluorophenyl)propanoate(5) was prepared with conventional debenzylation method. However, the tert-butyl (R)-3-[(S)-1-phenylethyl-amino]-3-(3-fluorophenyl) propanoate(6) and te... tert-Butyl (R)-3-amino-3-(3-fluorophenyl)propanoate(5) was prepared with conventional debenzylation method. However, the tert-butyl (R)-3-[(S)-1-phenylethyl-amino]-3-(3-fluorophenyl) propanoate(6) and tert-butyl (R)-3-amino-3-phenylpropanoate(7) were generated as the byproducts under the general catalytic hydrogenation Pd(OH)2/C-H2 conditions. So a series of experiments was performed to optimize the reaction conditions so that product 5 could be obtained with high purity and yield. Finally an effective catalytic system, Pd/C-HCOOH-CH3OH, was discovered. 展开更多
关键词 β-amino acid DEBENZYLATION DEFLUORINATION Catalytic hydrogenation
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Synthetic Approach for Novel Fluorine Substituted <i>α</i>-Aminophosphonic Acids Containing 1,2,4-Triazin-5-One Moiety as Antioxidant Agents
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作者 Mohammed S. T. Makki Reda M. Abdel-Rahman Abdulrahman S. Alharbi 《International Journal of Organic Chemistry》 2018年第1期1-15,共15页
Novel fluorine substituted α-amino phosphonic acids containing 1,2,4-triazin- 5-one (6a-f) have been obtained from fluoroacylation of 6-(2&prime;-amino-5&prime;-nitrophenyl)-3-thioxo-1,2,4-triazin-5(4H)-one (... Novel fluorine substituted α-amino phosphonic acids containing 1,2,4-triazin- 5-one (6a-f) have been obtained from fluoroacylation of 6-(2&prime;-amino-5&prime;-nitrophenyl)-3-thioxo-1,2,4-triazin-5(4H)-one (1) followed by ammonilysis to give the corresponding 3-amino-derivative 3. Condensation of compound 3 with nitro/halogenated aromatic aldehydes yielded the Schiff bases 4. The simple addition of diethyl phosphonate to compound 4 produced the α-amino phosphonates 5. Acidic hydrolysis of compound 5 produced the fluorine substituted α-amino acids derivatives 6. Structures of the new compounds have been established with the help of elemental analysis and spectral measurements. Also, the products evaluated as antioxidants, where the fluorinated α-amino phosphonic acids 6 are more active than the other synthesized systems. 展开更多
关键词 Synthetic FLUORINE α-amino acids 1 2 4-Triazin-5-One MOIETY ANTIOXIDANTS Activity
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Thermodynamic solvation of a series of homologous α-amino acids in non-aqueous mixture of ethylene-glycol and N,N-dimethyl formamide
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作者 Kalachand Mahali Sanjay Roy Bijoy Krishna Dolui 《Journal of Biophysical Chemistry》 2011年第3期185-193,共9页
Standard free energies (ΔG0t(i) ) and entropies (ΔS0t(i)) of transfer of some homologous α-amino acids viz. glycine (gly), dl-alanine (ala), dl-α-amino butyric acid (aba) and dl-nor-valine (nor-val) from protic et... Standard free energies (ΔG0t(i) ) and entropies (ΔS0t(i)) of transfer of some homologous α-amino acids viz. glycine (gly), dl-alanine (ala), dl-α-amino butyric acid (aba) and dl-nor-valine (nor-val) from protic ethylene glycol (EG) to dipolar aprotic N,N-dimethyl formamide (DMF) have been evaluated from solubility measure-ments at five equidistant temperatures i.e from 15 to 350C. The observed ΔG0t(i) and TΔS0t(i) Vs composition profiles are complicated because of the various interaction effects. The chemical effects of the transfer Gibbs energies (ΔG0t.ch(i)) and entropies of transfer (ΔS0t.ch(i)) have been obtained after elimination of cavity effect, estimated by the scaled particle theory and dipole-dipole interaction effects, estimated by the use of Keesom-orientation expression. The chemical contributions of transfer energetics of homologous α-amino acids are guided by the composite effects of increased dispersion interaction, basicity and decreased acidity, hydrogen bonding effects and solvophobic solvation of ethylene glycol and N, N-dimethyl formamide mixed solvent as compared to that of reference solvent (ethylene glycol). 展开更多
关键词 NON-AQUEOUS Solvent System Transfer Energetic ZWITTERIONS α-amino acids Solvophobic SOLVATION
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Chemical Interaction UO2Cl2 with α-and β-Amino Acids in Aqueous and Organic Solution
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作者 Aibassov Erkin Zhakenovich Kenzhaliev Bagdaulet Kenzhalievich2 +4 位作者 Tussupbaev Nessipbay Kuandykovich Berkinbaeva Ainura Chukmanova Marzhan Iskhakova Renata Bulenbayev Maxat Zhumabaevich 《Journal of Chemistry and Chemical Engineering》 2014年第7期751-756,共6页
This paper presents the results of the search of biologically active uranium compounds such as amino acids. We first received and examined X-ray and IR (infrared radiation) spectroscopy of uranium complexes with α-... This paper presents the results of the search of biologically active uranium compounds such as amino acids. We first received and examined X-ray and IR (infrared radiation) spectroscopy of uranium complexes with α- and β-amino acids in aqueous and organic solution. We proposed a method for direct synthesis of complex organic compounds of uranium chloride UO2Cl2 with α- andβ-amino acids for the synthesis of drugs for the treatment of cancer. 展开更多
关键词 X-ray and IR spectroscopy bioorganic chemistry of uranium synthesis of complex organic compounds of UO2Cl2 with α- and β-amino acids.
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Effects of β-Amino Butyric Acid Induced Rice Blast Resistance on Reactive Oxygen Metabolism 被引量:5
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作者 李莉 郭晓丽 +5 位作者 刘晓梅 温嘉伟 张秀容 孙辉 赵宇 任金平 《Agricultural Science & Technology》 CAS 2009年第3期112-114,共3页
[Objective] This study was to understand the effects of β-Amino butyric acid(abbreviated as BABA) induced rice blast resistance on reactive oxygen metabolism. [Method] Using the cultivar Chaochan 2 that is highly sus... [Objective] This study was to understand the effects of β-Amino butyric acid(abbreviated as BABA) induced rice blast resistance on reactive oxygen metabolism. [Method] Using the cultivar Chaochan 2 that is highly susceptible to disease as experimental material, the changes of catalase(CAT), and superoxide dismutase(SOD) and MDA activities in rice treated by BABA were investigated. [Result] In rice plants treated by BABA, the activities of CAT and SOD increased, meanwhile the MDA content also rose to some extent, resulting in the disease resistance to rice blast. [Conclusion] By influencing reactive oxygen metabolism, BABA endows rice plants with resistance to rice blast. BABA is safe to environment and has highly resistance-inducing capacity, it could be generalized in production. 展开更多
关键词 β-amino butyric acid Rice blast Induced resistance
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Different characteristics of 40 kinds of free amino acids and 5-amino levulinic acid between wines and sakes(Japanese rice wines)
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作者 Tohru Kimura 《Journal of Future Foods》 2024年第4期361-368,共8页
Based on a systemic analysis for the globa1 burden of disease study from 1990 to 2016,the Global Burden of Diseases(GBD)2016 Alcohol Collaborators reported that alcohol use was a 1eading nisk factor for globa1 disease... Based on a systemic analysis for the globa1 burden of disease study from 1990 to 2016,the Global Burden of Diseases(GBD)2016 Alcohol Collaborators reported that alcohol use was a 1eading nisk factor for globa1 disease burden and caused substantial health loss.However,alcoholic dnink(wines and sakes)contains abundant nutrients,particularly fermentable amino acids denived from grapes and rice.Amino acid nutrition and metabolism is strongly associated with health and preventiom against various diseases.The purpose of this study was to elucidate 40 kinds of free amino acid(FAA)profles in wines and sakes.In addition,the present study also provided the contents of 5-aminolevulinic acid(5-AI A)involved in the vital functionality of mitochondria.FAAs were detected and analyzed by use of an automatic amino acid analyzer.Aromatic amino acid,branched chain amino acid and Fischer ratio were calculated for each beverage.Individua1 FAAs showed significant differences between wines and sakes.Sakes abundantly contained almost all FAAs whereas wines had just a lttle content in some FAAs.Sakse were rich in arginine,glycine,alanine,valine,glutamic acid and leucine,while wines were remarkably nich in proline(Pro).Wines showed increased FAA levels in 6 kinds of variables(4-hydroxyproline,3-methy1 histidine,B-alanine,a-aminobutyric acid,Pro and a.-aminoadipic acid).In functionally characteristic FAAs,both wines and sakes were considerably abundant in y aminobutynic acid and 5-AI A The total amount of aromatic amino acid and branched chain amino acid were markedly higher in sakes than in wines.These results revealed that there were the apparent different characteristics in FAA profiles between wines and sakes.This difference resulted from fermentation process in wines(single fermentation)and sakes(paralle1 double fermentation).Forty kinds of FAA profiles are more usefu1 in investigating characteristics of the taste of wines and sakes.In future,detailed FAA analysis has the potential to find functional nutrients such as 5-AI A,whereas other foods generally contain ittle amount of these FAAs. 展开更多
关键词 FERMENTATION 5-amino levulinic acid Free anino acids γ-aminobutyric acid Sake WINE
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Content and Partial Characterization of Unknown N in Humic Acids 被引量:1
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作者 YEWEI WENQI-XIAO 《Pedosphere》 SCIE CAS CSCD 1991年第3期283-287,共5页
INTRODUCTION Nitrogen is a key component of soil organic matter. Only when we have succeeded in characterizing the major part of organic N-containing compounds will we be able to understand fully the transformation re... INTRODUCTION Nitrogen is a key component of soil organic matter. Only when we have succeeded in characterizing the major part of organic N-containing compounds will we be able to understand fully the transformation reactions in the soil and to use soil-N more efficiently. However, only about 1/ 4——1/ 2 of the total N in humic acid (HA), one of the major constituents of soil organic matter, can be accounted for as amino acids and amino sugars, and most of the remainder has still to be accounted for. It has been 展开更多
关键词 humic acid non-α-amino acid N-phenyl amino acid real amide unknown N
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Syntheses and Structural Characterization of Dimethyltin Complexs of N-(3-Methoxysalicylidene)-α-amino Acid 被引量:3
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作者 党艳秋 杨红军 田来进 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2012年第4期479-484,共6页
Three new dimethyltin complexes of N-(3-methoxysalicylidene)-α-amino acid,(CH3)2Sn(3-CH3O-2-OC6H3CH=NCHRCOO)(R = H,1;CH3,2;(CH3)2CH,3),have been synthe-sized by treating dimethyltin dichloride with the pota... Three new dimethyltin complexes of N-(3-methoxysalicylidene)-α-amino acid,(CH3)2Sn(3-CH3O-2-OC6H3CH=NCHRCOO)(R = H,1;CH3,2;(CH3)2CH,3),have been synthe-sized by treating dimethyltin dichloride with the potassium salt of the ligand and characterized by elemental analysis,IR and 1H NMR spectra.The crystal structure of [(CH3)2Sn(3-CH3O-2-OC6H3CH=NCH2COO)(CH3OH)]2 H2O(1a),formed from methanol solution of 1,has been deter-mined.The crystal belongs to the monoclinic system,space group C/2c with a = 20.636(3),b = 7.8854(9),c = 20.668(2) ,β= 113.265(2)°,V = 3089.7(6) 3,Z = 4,Dc = 1.707 g/cm3,= 1.675 mm-1,F(000) = 1592,R = 0.0301 and wR = 0.0841.In complex 1a,the tin atom is six-coordinate and possesses a distorted [SnC2NO3] octahedral geometry with the two methyl groups occupying the trans positions.The weak Sn O interactions and intermolecular hydrogen bonds connected the molecules into an infinite chain. 展开更多
关键词 organotin complex N-(3-methoxysalicyliden)-α-amino acid crystal structure
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A practical synthesis of trifluorophenyl R-amino acid:The key precursor for the new anti-diabetic drug sitagliptin 被引量:1
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作者 Li Li Zeng Ying Jie Ding +2 位作者 Gui Cheng Zhang Hong Rui Song Wen Hui Hu 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第12期1397-1399,共3页
Sitagliptin is the first new anti-diabetic drug in DPP-Ⅳ inhibitor class. The general synthesis of sitagliptin is by coupling of the β-amino acid fragment with the heterocycle fragment. Though the specific β-amino ... Sitagliptin is the first new anti-diabetic drug in DPP-Ⅳ inhibitor class. The general synthesis of sitagliptin is by coupling of the β-amino acid fragment with the heterocycle fragment. Though the specific β-amino acid can be easily made from the corresponding R-amino acid by Arndt-Eistert hornologation, the optically pure precursor R-amino acid is difficult to prepare. We herein reported a practical protocol to make the trifluorophenyl substituted R-amino acid 4 in 〉99.9% ee and 40.3% yield by the enzymatic resolution employing enantioselective hydrolysis and a general separation procedure. This protocol requires only cheap starting materials and friendly reaction condition. The procedure not only allows people to prepare the drug substance, but also provides an alternative method for prepareing the rare α-amino acid and the subsequent β-amino acid. 展开更多
关键词 SITAGLIPTIN β-amino acid DPP-Ⅳ inhibitor Practical synthesis
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The design and synthesis of a novel organophosphorus compound containing the structure of both β-amino acid and β-aminophosphonate
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作者 Han Bing Teng 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第7期810-812,共3页
A novel organophosphorus compound containing the structure of bothβ-amino acid andβ-aminophosphonate is designed and synthesized.Arbuzov reaction with P(OEt)_3,the N-Boc protected iodide 3 cannot provide the desir... A novel organophosphorus compound containing the structure of bothβ-amino acid andβ-aminophosphonate is designed and synthesized.Arbuzov reaction with P(OEt)_3,the N-Boc protected iodide 3 cannot provide the desired product but 2-oxazolidinone 4 because of the neighboring-group participation of the Boc moiety.To avoid the intramolecular participation of the carbamates,the Ts protecting group is employed and the Ts-protected iodide 5 affords the target product successfully. 展开更多
关键词 β-amino acid β-aminophosphonate Neighboring-group participation Arbuzov reaction Amino-protecting group
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Synthesis and Structural Characterization of Some Diorganotin Complexes of N-(3,5-Dibromosalicylidene)-α-amino Acid and their Diphenyltin Dichloride Adducts
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作者 LaiJinTIAN ZhiCaiSHANG +1 位作者 XiJieLIU QingSenYU 《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第2期193-196,共4页
The title complexes, R′2Sn(3,5-Br2-2-OC6H2CH=NCHRCOO), and their diphenyltindichloride adduct, R′2Sn(3,5-Br2-2-OC6H2CH=NCHRCOO)?SnPh2Cl2, were synthesized and char-acterized by elemental analysis, IR, H and C NMR an... The title complexes, R′2Sn(3,5-Br2-2-OC6H2CH=NCHRCOO), and their diphenyltindichloride adduct, R′2Sn(3,5-Br2-2-OC6H2CH=NCHRCOO)?SnPh2Cl2, were synthesized and char-acterized by elemental analysis, IR, H and C NMR and X-ray single crystal diffraction. The 1 13structural features of the compounds were described. 展开更多
关键词 Diorganotin complexes molecular adduct crystal structure α-amino acid Schiff base.
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Dietary <i>γ</i>-Aminobutyric Acid Shortens the Life Span of Stroke-Prone Spontaneously Hypertensive Rats
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作者 Nakamichi Watanabe Naomi Washio 《Food and Nutrition Sciences》 2011年第4期301-303,共3页
Dietary γ-amino butyric acid (GABA) has been suggested to decrease systolic blood pressure. This study aimed to ex-amine the effects of dietary GABA on the life span of stroke-prone spontaneously hypertensive rats (S... Dietary γ-amino butyric acid (GABA) has been suggested to decrease systolic blood pressure. This study aimed to ex-amine the effects of dietary GABA on the life span of stroke-prone spontaneously hypertensive rats (SHRSPs). In this study, life span was determined for SHRSPs provided 1% NaCl solution or 0.01% GABA in 1% NaCl solution as drinking water. The life span of the GABA-fed group (76.3 ± 1.65 days) was significantly shorter than that of the control group (81.6 ± 0.88 days). The results of this study may not be applicable to humans. Future studies will be necessary to elucidate the mechanism underlying this phenomenon. 展开更多
关键词 γ-amino Butyric acid Stroke-Prone Spontaneously HYPERTENSIVE Rat Life Span
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A Theoretical Study of <i>β</i>-Amino Acid Conformational Energies and Solvent Effect
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作者 Victor F. Waingeh Felix N. Ngassa Jie Song 《Open Journal of Physical Chemistry》 2015年第4期122-131,共10页
The conformations of four β-amino acids in a model peptide environment were investigated using Hartree-Fock (HF) and density functional theory (DFT) methods in gas phase and with solvation. Initial structures were ob... The conformations of four β-amino acids in a model peptide environment were investigated using Hartree-Fock (HF) and density functional theory (DFT) methods in gas phase and with solvation. Initial structures were obtained by varying dihedral angles in increments of 45° in the range 0° - 360°. Stable geometries were optimized at both levels of theory with the correlation consistent double-zeta basis set with polarization functions (cc-pVDZ). The results suggest that solvation generally stabilizes the conformations relative to the gas phase and that intramolecular hydrogen bonding may play an important role in the stability of the conformations. The β3 structures, in which the R-group of the amino acid is located on the carbon atom next to the N-terminus, are somewhat more stable relative to each other than the β2 structures which have the R-group on the carbon next to the carbonyl. 展开更多
关键词 Density Functional Theory β-amino acids Conformational SEARCH
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Development of <i>α</i>-Amino Acid Detection with Peroxyoxalate Chemiluminescence by Using Water-Acetonitrile-Ethyl Acetate Mixed Solution
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作者 Hyo Kan Ryo Mizutani Kazuhiko Tsukagoshi 《American Journal of Analytical Chemistry》 2020年第1期15-24,共10页
Peroxyoxalate chemiluminescence was, for the first time, examined by using ternary mixed solutions of water-hydrophilic/hydrophobic organic solvent. Eosin Y as a model fluorescence compound was dissolved with the tern... Peroxyoxalate chemiluminescence was, for the first time, examined by using ternary mixed solutions of water-hydrophilic/hydrophobic organic solvent. Eosin Y as a model fluorescence compound was dissolved with the ternary solutions of water (1.0 mM carbonate buffer, pH 9.0)-acetonitrile-ethyl acetate, water-rich of 15:3:2 volume ratio and organic solvent-rich of 3:8:4 volume ratio, to which bis(2,4,6-trichlorophenyl) oxalate and hydrogen peroxide chemiluminescence reagent were added. The chemiluminescence observed with the ternary solutions, especially the organic solvent-rich solution, showed a larger signal than that observed with the water only solution or water-acetonitrile mixed solution. Chemiluminescence in the presence of twenty types of α-amino acid was similarly examined by using the ternary organic solvent-rich solution. The chemiluminescence of three α-amino acids with fluorescence properties was enhanced with the ternary solution. The data reported here may contribute to development of a new, sensitive peroxyoxalate chemiluminescence detection system. 展开更多
关键词 PEROXYOXALATE chemiluminescence α-amino acids Water-Acetonitrile-Ethyl Acetate Bis(2 4 6-Trichlorophenyl) OXALATE
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Emergence of taurine as a therapeutic agent for neurological disorders
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作者 Ashok Jangra Priyanka Gola +13 位作者 Jiten Singh Pooja Gond Swarnabha Ghosh Mahesh Rachamalla Abhijit Dey Danish Iqbal Mehnaz Kamal Punya Sachdeva Saurabh Kumar Jha Shreesh Ojha Dinesh Kumar Niraj Kumar Jha Hitesh Chopra Shing Cheng Tan 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第1期62-68,共7页
Taurine is a sulfur-containing,semi-essential amino acid that occurs naturally in the body.It alternates between inflammation and oxidative stress-mediated injury in various disease models.As part of its limiting func... Taurine is a sulfur-containing,semi-essential amino acid that occurs naturally in the body.It alternates between inflammation and oxidative stress-mediated injury in various disease models.As part of its limiting functions,taurine also modulates endoplasmic reticulum stress,Ca^(2+)homeostasis,and neuronal activity at the molecular level.Taurine effectively protects against a number of neurological disorders,including stro ke,epilepsy,cerebral ischemia,memory dysfunction,and spinal cord injury.Although various therapies are available,effective management of these disorders remains a global challenge.Approximately 30 million people are affected worldwide.The design of taurine fo rmation co uld lead to potential drugs/supplements for the health maintenance and treatment of central nervous system disorders.The general neuroprotective effects of taurine and the various possible underlying mechanisms are discussed in this review.This article is a good resource for understanding the general effects of taurine on various diseases.Given the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms,it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics,with emphasis on mechanism and clinical studies to determine efficacy. 展开更多
关键词 antioxidant EPILEPSY γ-amino butyric acid neurodegenerative disorders NEUROPROTECTION oxidative stress spinal cord injury TAURINE
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CeCl_3·7H_2O as an efficient catalyst for one-pot synthesis of β-amino ketones by three-component Mannich reaction 被引量:10
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作者 Yan Dai Chun Xu Lü 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第1期31-34,共4页
Cerium trichloride heptahydrate(CeCl_3·7H_2O) was found to be an efficient and recyclable catalyst for the three-component direct Mannich reaction of anilines and benzaldehydes with acetophenone.This protocol has... Cerium trichloride heptahydrate(CeCl_3·7H_2O) was found to be an efficient and recyclable catalyst for the three-component direct Mannich reaction of anilines and benzaldehydes with acetophenone.This protocol has advantages of high yield,no environmental pollution,mild condition,and simple work-up procedure. 展开更多
关键词 Cerium trichloride heptahydrate Mannich reaction β-amino ketones Lewis acid
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Highly efficient synthesis of β-amino esters via Mannich-type reaction under solvent-free conditions using ZnCl_2 catalyst 被引量:8
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作者 Albert S.C.Chan 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第4期407-410,共4页
β-Amino esters were synthesized via ZnCl2-catalyzed Mannich-type reaction of imines and malonate esters under solvent-free conditions in 6 min. The β-amino ester was converted into the corresponding aspartic acid de... β-Amino esters were synthesized via ZnCl2-catalyzed Mannich-type reaction of imines and malonate esters under solvent-free conditions in 6 min. The β-amino ester was converted into the corresponding aspartic acid derivatives. 展开更多
关键词 β-amino esters Aspartic acid derivativates Mannich-type reaction SOLVENT-FREE Krapcho decarboxylation reaction Zinc chloride
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Synthesis of Optically Active trans-2-Aminocyclopropane-carboxylic Esters
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作者 Jiang Chun ZHON Shang Zhong LIU Qing Hua BIAN Ming Ming YIN Min WANG 《Chinese Chemical Letters》 SCIE CAS CSCD 2006年第5期584-586,共3页
Two new optically active trans-2-atrfinocyclopropanecarboxylic esters (β-ACCs) of optical purity 91%-96% were concisely synthesized via ozonization, oxidation, Curtius rearrangement from commercial available optica... Two new optically active trans-2-atrfinocyclopropanecarboxylic esters (β-ACCs) of optical purity 91%-96% were concisely synthesized via ozonization, oxidation, Curtius rearrangement from commercial available optically active trans-chrysanthemate in total yield 36%. 展开更多
关键词 CYCLOPROPANE chrysanthemate β-amino acid.
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Synthesis of β–Amino Acid Derivatives
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作者 Zhao Yonghua Ma Zhihua +1 位作者 Jiang Nan Wang Jianbo 《合成化学》 CAS CSCD 2004年第z1期46-46,共1页
关键词 SYNTHESIS STEREOSELECTIVE β-amino acids.
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