AIM: It is controversial whether patients with non-ulcer dyspepsia (NUD) respond differently to Helicobacter pylori(Hpylon) eradication treatment than those with peptic ulcer disease (PUD). To review the evidence for ...AIM: It is controversial whether patients with non-ulcer dyspepsia (NUD) respond differently to Helicobacter pylori(Hpylon) eradication treatment than those with peptic ulcer disease (PUD). To review the evidence for any difference in Hpylorieradication rates between PUD and NUD patients.METHODS: A literature search for full articles and meeting abstracts to July 2004 was conducted. We included studies evaluating the efficacy of a proton pump inhibitor(P) or ranitidine bismuth citrate (RBC) plus two antibiotics of clarithromycin (C), amoxicillin (A), metronidazole (M),or P-based quadruple therapies for eradicating the infection.RESULTS: Twenty-two studies met the criteria. No significant difference in eradication rates was found between PUD and NUD patients when treated with 7-d RBCCA, 10-d PCA or P-based quadruple therapies. When the 7-d PCA was used, the pooled H pylori eradication rate was 82.1% (431/525) and 72.6% (448/617) for PUDand NUD patients, respectively, yielding a RR of 1.15(95%CI 1.01-1.29). However, the statistically significant difference was seen only in meeting abstracts, but not in full publications.CONCLUSION: There is no convincing evidence to suggest that NUD patients respond to Hpylori eradication treatments differently from those with PUD, although a trend exists with the 7-d PCA therapy.展开更多
目的:系统评价非负重运动锻炼在糖尿病足溃疡病人中应用效果,为糖尿病足运动干预提供循证依据。方法:计算机检索PubMed、the Cochrane Library、EMbase、Web of Science、中国知网、万方数据库收录的关于非负重运动锻炼在糖尿病足溃疡...目的:系统评价非负重运动锻炼在糖尿病足溃疡病人中应用效果,为糖尿病足运动干预提供循证依据。方法:计算机检索PubMed、the Cochrane Library、EMbase、Web of Science、中国知网、万方数据库收录的关于非负重运动锻炼在糖尿病足溃疡病人中应用的随机对照试验,检索时限从建库到2022年8月31日。由2名研究人员进行筛选文献、提取资料和评价文献质量,采用RevMan 5.3软件进行Meta分析。结果:共纳入15篇随机对照试验,涉及1296例糖尿病足病人。Meta分析结果显示,非负重运动锻炼可以改善糖尿病足溃疡病人的伤口愈合率[RR=2.76,95%CI(2.00,3.80),P<0.00001],改善病人的踝肱指数(ABI)[RR=0.07,95%CI(0.04,0.10),P<0.0001];两组运动时不良事件发生率比较,差异无统计学意义[RR=0.76,95%CI(0.54,1.09),P=0.14];非负重运动锻炼对血糖相关指标和生活质量的影响尚不明确。结论:现有证据表明,非负重运动锻炼对糖尿病足溃疡病人有较好的临床结局,可以提高病人的伤口愈合率,改善病人的ABI。但纳入的研究在质量和数量上有所限制,需要更多高质量和大样本的研究对此结论进行验证。展开更多
文摘AIM: It is controversial whether patients with non-ulcer dyspepsia (NUD) respond differently to Helicobacter pylori(Hpylon) eradication treatment than those with peptic ulcer disease (PUD). To review the evidence for any difference in Hpylorieradication rates between PUD and NUD patients.METHODS: A literature search for full articles and meeting abstracts to July 2004 was conducted. We included studies evaluating the efficacy of a proton pump inhibitor(P) or ranitidine bismuth citrate (RBC) plus two antibiotics of clarithromycin (C), amoxicillin (A), metronidazole (M),or P-based quadruple therapies for eradicating the infection.RESULTS: Twenty-two studies met the criteria. No significant difference in eradication rates was found between PUD and NUD patients when treated with 7-d RBCCA, 10-d PCA or P-based quadruple therapies. When the 7-d PCA was used, the pooled H pylori eradication rate was 82.1% (431/525) and 72.6% (448/617) for PUDand NUD patients, respectively, yielding a RR of 1.15(95%CI 1.01-1.29). However, the statistically significant difference was seen only in meeting abstracts, but not in full publications.CONCLUSION: There is no convincing evidence to suggest that NUD patients respond to Hpylori eradication treatments differently from those with PUD, although a trend exists with the 7-d PCA therapy.
