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Set-Membership Filtering Approach to Dynamic Event-Triggered Fault Estimation for a Class of Nonlinear Time-Varying Complex Networks
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作者 Xiaoting Du Lei Zou Maiying Zhong 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第3期638-648,共11页
The present study addresses the problem of fault estimation for a specific class of nonlinear time-varying complex networks,utilizing an unknown-input-observer approach within the framework of dynamic event-triggered ... The present study addresses the problem of fault estimation for a specific class of nonlinear time-varying complex networks,utilizing an unknown-input-observer approach within the framework of dynamic event-triggered mechanism(DETM).In order to optimize communication resource utilization,the DETM is employed to determine whether the current measurement data should be transmitted to the estimator or not.To guarantee a satisfactory estimation performance for the fault signal,an unknown-input-observer-based estimator is constructed to decouple the estimation error dynamics from the influence of fault signals.The aim of this paper is to find the suitable estimator parameters under the effects of DETM such that both the state estimates and fault estimates are confined within two sets of closed ellipsoid domains.The techniques of recursive matrix inequality are applied to derive sufficient conditions for the existence of the desired estimator,ensuring that the specified performance requirements are met under certain conditions.Then,the estimator gains are derived by minimizing the ellipsoid domain in the sense of trace and a recursive estimator parameter design algorithm is then provided.Finally,a numerical example is conducted to demonstrate the effectiveness of the designed estimator. 展开更多
关键词 Dynamic event-triggered mechanism(DETM) fault estimation nonlinear time-varying complex networks set-member-ship filtering unknown input observer
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Qualitative Properties and Numerical Solution of the Kolmogorov-Fisher Type Biological Population Task with Double Nonlinear Diffusion
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作者 Dildora Kabulovna Muhamediyeva 《Journal of Applied Mathematics and Physics》 2015年第10期1249-1255,共7页
In the present work we study the global solvability of the Kolmogorov-Fisher type biological population task with double nonlinear diffusion and qualitative properties of the solution of the task based on the self-sim... In the present work we study the global solvability of the Kolmogorov-Fisher type biological population task with double nonlinear diffusion and qualitative properties of the solution of the task based on the self-similar analysis. In additional, in this paper we consider the model of two competing population with dual nonlinear cross-diffusion. 展开更多
关键词 DOUBLE nonlinearity CROSS-DIFFUSION Biological population A Parabolic System of QUASILINEAR Equations CONVECTIVE Heat Transfer Numerical Solution Iterative Process SELF-SIMILAR Solutions
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Adaptive Neural Network-Based Control for a Class of Nonlinear Pure-Feedback Systems With Time-Varying Full State Constraints 被引量:14
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作者 Tingting Gao Yan-Jun Liu +3 位作者 Senior Member IEEE Lei Liu Dapeng Li 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2018年第5期923-933,共11页
Abstract--In this paper, an adaptive neural network (NN) control approach is proposed for nonlinear pure-feedback sys- tems with time-varying full state constraints. The pure-feedback systems of this paper are assum... Abstract--In this paper, an adaptive neural network (NN) control approach is proposed for nonlinear pure-feedback sys- tems with time-varying full state constraints. The pure-feedback systems of this paper are assumed to possess nonlinear function uncertainties. By using the mean value theorem, pure-feedback systems can be transformed into strict feedback forms. For the newly generated systems, NNs are employed to approximate unknown items. Based on the adaptive control scheme and backstepping algorithm, an intelligent controller is designed. At the same time, time-varying Barrier Lyapunov functions (BLFs) with error variables are adopted to avoid violating full state constraints in every step of the backstepping design. All closed- loop signals are uniformly ultimately bounded and the output tracking error converges to the neighborhood of zero, which can be verified by using the Lyapunov stability theorem. Two simulation examples reveal the performance of the adaptive NN control approach. Index TermsmAdaptive control, neural networks (NNs), non- linear pure-feedback systems, time-varying constraints. 展开更多
关键词 Adaptive control neural networks(NNs) nonlinear pure-feedback systems time-varying constraints
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Adaptive Variable Structure Control of MIMO Nonlinear Systems with Time-varying Delays and Unknown Dead-zones 被引量:7
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作者 Tian-Ping Zhang Cai-Ying Zhou Qing Zhu 《International Journal of Automation and computing》 EI 2009年第2期124-136,共13页
In this paper, adaptive variable structure neural control is presented for a class of uncertain multi-input multi-output (MIMO) nonlinear systems with state time-varying delays and unknown nonlinear dead-zones. The ... In this paper, adaptive variable structure neural control is presented for a class of uncertain multi-input multi-output (MIMO) nonlinear systems with state time-varying delays and unknown nonlinear dead-zones. The unknown time-varying delay uncer- tainties are compensated for using appropriate Lyapunov-Krasovskii functionals in the design. The approach removes the assumption of linear function outside the deadband without necessarily constructing a dead-zone inverse as an added contribution. By utilizing the integral-type Lyapunov function and introducing an adaptive compensation term for the upper bound of the residual and optimal approximation error as well as the dead-zone disturbance, the closed-loop control system is proved to be semi-globally uniformly ultimately bounded. In addition, a modified adaptive control algorithm is given in order to avoid the high-frequency chattering phenomenon. Simulation results demonstrate the effectiveness of the approach. 展开更多
关键词 Adaptive control neural networks (NNs) variable structure control DEAD-ZONE nonlinear time-varying delay systems.
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ABSOLUTE STABILITY OF TIME-VARYING NONLINEAR CONTROL SYSTEM 被引量:1
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作者 肖冬梅 邓宗琦 《Acta Mathematica Scientia》 SCIE CSCD 1999年第4期442-448,共7页
In this paper the authors study two classes of time-varying nonlinear control systems. A few sufficient conditions of absolute stability of these systems were obtained by means of classical analysis and the analogue o... In this paper the authors study two classes of time-varying nonlinear control systems. A few sufficient conditions of absolute stability of these systems were obtained by means of classical analysis and the analogue of the variation of constants formula of nonlinear systems. Moreover, they gave some sufficient conditions of absolute stability in Hurwitz angle for these systems. 展开更多
关键词 absolute stability two classes time-varying nonlinear control system
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Exponential stability for networked control systems based on the model of nonlinear discrete-time system with time-varying delay 被引量:1
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作者 HUANGJian GUANZhihong WANGZhongdong 《Journal of Chongqing University》 CAS 2004年第1期30-33,共4页
An uncertain nonlinear discrete-time system model with time-varying input delays for networked control systems (NCSs) is presented. The problem of exponential stability for the system is considered and some new criter... An uncertain nonlinear discrete-time system model with time-varying input delays for networked control systems (NCSs) is presented. The problem of exponential stability for the system is considered and some new criteria of exponential stability are obtained based on norm inequality methods. A numerical example is given todemonstrate that those criteria are useful to analyzing the stability of nonlinear NCSs. 展开更多
关键词 networked control systems nonlinear discrete-time system time-varying delay exponential stability
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Time-varying nonlinear dynamics of a deploying piezoelectric laminated composite plate under aerodynamic force 被引量:1
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作者 S.F.Lu W.Zhang X.J.Song 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2018年第2期303-314,共12页
Using Reddy’s high-order shear theory for laminated plates and Hamilton’s principle, a nonlinear partial differential equation for the dynamics of a deploying cantilevered piezoelectric laminated composite plate, un... Using Reddy’s high-order shear theory for laminated plates and Hamilton’s principle, a nonlinear partial differential equation for the dynamics of a deploying cantilevered piezoelectric laminated composite plate, under the combined action of aerodynamic load and piezoelectric excitation, is introduced. Two-degree of freedom(DOF)nonlinear dynamic models for the time-varying coefficients describing the transverse vibration of the deploying laminate under the combined actions of a first-order aerodynamic force and piezoelectric excitation were obtained by selecting a suitable time-dependent modal function satisfying the displacement boundary conditions and applying second-order discretization using the Galerkin method. Using a numerical method, the time history curves of the deploying laminate were obtained, and its nonlinear dynamic characteristics,including extension speed and different piezoelectric excitations, were studied. The results suggest that the piezoelectric excitation has a clear effect on the change of the nonlinear dynamic characteristics of such piezoelectric laminated composite plates. The nonlinear vibration of the deploying cantilevered laminate can be effectively suppressed by choosing a suitable voltage and polarity. 展开更多
关键词 Deploying piezoelectric laminated composite plate time-varying nonlinear dynamics Third-order shear deformation plate theory Time-dependent modal function Aerodynamic force
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Nonlinear System Identification with Unknown Piecewise Time-Varying Delay 被引量:1
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作者 陈磊 丁永生 +1 位作者 郝矿荣 任立红 《Journal of Donghua University(English Edition)》 EI CAS 2016年第3期505-509,共5页
Identification of nonlinear systems with unknown piecewise time-varying delay is concerned in this paper.Multiple auto regressive exogenous(ARX) models are identified at different process operating points,and the comp... Identification of nonlinear systems with unknown piecewise time-varying delay is concerned in this paper.Multiple auto regressive exogenous(ARX) models are identified at different process operating points,and the complete dynamics of the nonlinear system is represented by using a combination of a normalized exponential function as the probability density function with each of the local models.The parameters of the local ARX models and the exponential functions as well as the unknown piecewise time-varying delays are estimated simultaneously under the framework of the expectation maximization(EM) algorithm.A simulation example is applied to demonstrating the proposed identification method. 展开更多
关键词 nonlinear system identification piecewise time-varying delay multiple model approach expectation maximization(EM) algorithm
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Nonlinear parametrically excited vibration and active control of gear pair system with time-varying characteristic
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作者 刘爽 王进进 +1 位作者 刘金杰 李雅倩 《Chinese Physics B》 SCIE EI CAS CSCD 2015年第10期303-311,共9页
In the present work, we investigate the nonlinear parametrically excited vibration and active control of a gear pair system involving backlash, time-varying meshing stiffness and static transmission error. Firstly, a ... In the present work, we investigate the nonlinear parametrically excited vibration and active control of a gear pair system involving backlash, time-varying meshing stiffness and static transmission error. Firstly, a gear pair model is established in a strongly nonlinear form, and its nonlinear vibration characteristics are systematically investigated through different approaches. Several complicated phenomena such as period doubling bifurcation, anti period doubling bifurcation and chaos can be observed under the internal parametric excitation. Then, an active compensation controller is designed to suppress the vibration, including the chaos. Finally, the effectiveness of the proposed controller is verified numerically. 展开更多
关键词 nonlinear parametrically excited vibration time-varying meshing stiffness static transmission er-ror CHAOS
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TECHNICAL STABILITY OF NONLINEAR TIME-VARYING SYSTEMS WITH SMALL PARAMETERS
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作者 楚天广 王照林 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2000年第11期1264-1271,共8页
Technical stability:allowing quantitative estimation of trajectory behavior of a dynamical system over a given time interval was considered. Based on a differential comparison principle and a basic monotonicity condit... Technical stability:allowing quantitative estimation of trajectory behavior of a dynamical system over a given time interval was considered. Based on a differential comparison principle and a basic monotonicity condition, technical stability relative to certain prescribed state constraint sets of a class of nonlinear time-varying systems with small parameters was analyzed by means of vector Liapunov function method. Explicit criteria of technical stability are established in terms of coefficients of the system under consideration. Conditions under which the technical stability of the system can be derived from its reduced linear time-varying (LTV) system were further examined, as well as a condition for linearization approach to technical stability of general nonlinear systems. Also, a simple algebraic condition of exponential asymptotic stability of LTV systems is presented. Two illustrative examples are given to demonstrate the availability of the presently proposed method. 展开更多
关键词 nonlinear time-varying system small parameter technical stability vector comparison principle reduced system linearization technique exponential asymptotic stability
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Robust Stability Criteria for Neutral Systems with Interval Time-Varying Delays and Nonlinear Perturbations
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作者 Mao Wang Yan-Ling Wei +1 位作者 Zhao-Lan He Le Xiao 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2014年第2期68-74,共7页
This paper investigates the problem of delay-dependent robust stability analysis for a class of neutral systems with interval time-varying delays and nonlinear perturbations. Such nonlinear perturbations are with time... This paper investigates the problem of delay-dependent robust stability analysis for a class of neutral systems with interval time-varying delays and nonlinear perturbations. Such nonlinear perturbations are with time-varying but norm-bounded characteristics. Based on a new Lyapunov-Krasovskii functional, together ,sith a free-weighting matrices technique, improved delay-dependent stability criteria are established. It is shown that less conservative results can be obtained in terms of linear matrix inequalities (LMIs). Numerical examples are provided to demonstrate the effectiveness and less conservatism of the proposed approach. 展开更多
关键词 neutral systems interval time-varying delays nonlinear perturbations robust matrix inequality
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Dynamics of a Nonautonomous Plant Disease Model with General Nonlinear Incidence Rate and Time-Varying Impulse
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作者 Jianping Wang Xue Zhang +1 位作者 Juanjuan Wang Quanben Sun 《Journal of Applied Mathematics and Physics》 2019年第10期2518-2530,共13页
In this paper, for controlling the spread of plant diseases, a nonautonomous SEIS (Susceptible → Exposed → Infectious → Susceptible) epidemic model with a general nonlinear incidence rate and time-varying impulsive... In this paper, for controlling the spread of plant diseases, a nonautonomous SEIS (Susceptible → Exposed → Infectious → Susceptible) epidemic model with a general nonlinear incidence rate and time-varying impulsive control strategy is proposed and investigated. This novel model could result in an objective criterion on how to control plant disease transmission by replanting of healthy plants and removal of infected plants. Using the method of small amplitude perturbation, the sufficient conditions under which guarantee the globally attractive of the disease-free periodic solution and the permanence of the disease are obtained, that is, the disease dies out if R12>1. 展开更多
关键词 PLANT Disease NONAUTONOMOUS Model time-varying IMPULSE General nonlinear INCIDENCE PERMANENCE
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Properties of Solutions of Kolmogorov-Fisher Type Biological Population Task with Variable Density
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作者 Muhamediyeva Dildora 《Journal of Applied Mathematics and Physics》 2016年第5期903-913,共11页
In this paper, we discussed population model of two competing populations with non-linear double diffusion and variable density which described by nonlinear system of competing individuals. We identify new properties,... In this paper, we discussed population model of two competing populations with non-linear double diffusion and variable density which described by nonlinear system of competing individuals. We identify new properties, such as finite speed of propagation, and localization of the outbreaks in a specific area. 展开更多
关键词 Model of Biological population REACTION-DIFFUSION Double nonlinearity Self-Similar Solution Variable Density Fast Diffusion Low Diffusion
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A Comparative Study of Nonlinear Time-Varying Process Modeling Techniques: Application to Chemical Reactor
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作者 Errachdi Ayachi Saad Ihsen Benrejeb Mohamed 《Journal of Intelligent Learning Systems and Applications》 2012年第1期20-28,共9页
This paper proposes the design and a comparative study of two nonlinear systems modeling techniques. These two approaches are developed to address a class of nonlinear systems with time-varying parameter. The first is... This paper proposes the design and a comparative study of two nonlinear systems modeling techniques. These two approaches are developed to address a class of nonlinear systems with time-varying parameter. The first is a Radial Basis Function (RBF) neural networks and the second is a Multi Layer Perceptron (MLP). The MLP model consists of an input layer, an output layer and usually one or more hidden layers. However, training MLP network based on back propagation learning is computationally expensive. In this paper, an RBF network is called. The parameters of the RBF model are optimized by two methods: the Gradient Descent (GD) method and Genetic Algorithms (GA). However, the MLP model is optimized by the Gradient Descent method. The performance of both models are evaluated first by using a numerical simulation and second by handling a chemical process known as the Continuous Stirred Tank Reactor CSTR. It has been shown that in both validation operations the results were successful. The optimized RBF model by Genetic Algorithms gave the best results. 展开更多
关键词 nonlinear SYSTEMS time-varying SYSTEMS Multi Layer PERCEPTRON RADIAL Basis Function Gradient DESCENT GENETIC Algorithms Optimization
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Optimal Control of Nonlinear Systems Using Experience Inference Human-Behavior Learning
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作者 Adolfo Perrusquía Weisi Guo 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2023年第1期90-102,共13页
Safety critical control is often trained in a simulated environment to mitigate risk.Subsequent migration of the biased controller requires further adjustments.In this paper,an experience inference human-behavior lear... Safety critical control is often trained in a simulated environment to mitigate risk.Subsequent migration of the biased controller requires further adjustments.In this paper,an experience inference human-behavior learning is proposed to solve the migration problem of optimal controllers applied to real-world nonlinear systems.The approach is inspired in the complementary properties that exhibits the hippocampus,the neocortex,and the striatum learning systems located in the brain.The hippocampus defines a physics informed reference model of the realworld nonlinear system for experience inference and the neocortex is the adaptive dynamic programming(ADP)or reinforcement learning(RL)algorithm that ensures optimal performance of the reference model.This optimal performance is inferred to the real-world nonlinear system by means of an adaptive neocortex/striatum control policy that forces the nonlinear system to behave as the reference model.Stability and convergence of the proposed approach is analyzed using Lyapunov stability theory.Simulation studies are carried out to verify the approach. 展开更多
关键词 Experience inference hippocampus learning system linear time-variant(LTV)systems neocortex/striatum learning systems nonlinear systems optimal control
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基于不同群体药动学分析工具建立真实世界丙戊酸群体药代动力学模型
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作者 万盼婷 王翠蓉 邱广富 《医药前沿》 2024年第14期17-20,共4页
目的:基于NONMEM和MONOLIX 2种不同群体药动学分析工具建立真实世界丙戊酸群体药动学模型(PPK),探索可能影响丙戊酸血药浓度的潜在协变量,为癫痫患者使用丙戊酸提供科学依据。方法:回顾性收集2021年1月—2022年12月南京医科大学第二附... 目的:基于NONMEM和MONOLIX 2种不同群体药动学分析工具建立真实世界丙戊酸群体药动学模型(PPK),探索可能影响丙戊酸血药浓度的潜在协变量,为癫痫患者使用丙戊酸提供科学依据。方法:回顾性收集2021年1月—2022年12月南京医科大学第二附属医院收治的167例癫痫患者239个丙戊酸稳态血药浓度数据资料,按随机数字表法将其分为模型组(n=111)与验证组(n=56)。2种群体药动学分析工具同时建立适合真实世界的群体药动学模型,采用拟合度优度诊断、可视化预测检验对所得的模型进行内部验证和外部验证,评估模型的预测能力。结果:该群体药动学为一室模型,在使用NONMEM软件建立的最终模型中纳入了联合用药(DDI)-美罗培南和给药方式(ROUTE)作为协变量;而在使用MONOLIX软件建立的最终模型中纳入了联合用药(DDI)-美罗培南和体质量(BW)作为协变量。与此同时,与NONMEM相比较,MONOLIX软件所得到的最终模型具有更好的精密度和准确度。结论:本研究初步构建了适用于癫痫患者给予丙戊酸剂量指导的群体药动学模型。 展开更多
关键词 非线性混合效应模型法 血药浓度 丙戊酸 群体药动学模型
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Asymmetric time-varying integral barrier Lyapunov function based adaptive optimal control for nonlinear systems with dynamic state constraints
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作者 Yan WEI Mingshuang HAO +1 位作者 Xinyi YU Linlin OU 《Frontiers of Information Technology & Electronic Engineering》 SCIE EI CSCD 2024年第6期887-902,共16页
This paper investigates the issue of adaptive optimal tracking control for nonlinear systems with dynamic state constraints.An asymmetric time-varying integral barrier Lyapunov function(ATIBLF)based integral reinforce... This paper investigates the issue of adaptive optimal tracking control for nonlinear systems with dynamic state constraints.An asymmetric time-varying integral barrier Lyapunov function(ATIBLF)based integral reinforcement learning(IRL)control algorithm with an actor–critic structure is first proposed.The ATIBLF items are appropriately arranged in every step of the optimized backstepping control design to ensure that the dynamic full-state constraints are never violated.Thus,optimal virtual/actual control in every backstepping subsystem is decomposed with ATIBLF items and also with an adaptive optimized item.Meanwhile,neural networks are used to approximate the gradient value functions.According to the Lyapunov stability theorem,the boundedness of all signals of the closed-loop system is proved,and the proposed control scheme ensures that the system states are within predefined compact sets.Finally,the effectiveness of the proposed control approach is validated by simulations. 展开更多
关键词 State constraints Asymmetric time-varying integral barrier Lyapunov function(ATIBLF) Adaptive optimal control nonlinear systems
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Command filtered integrated estimation guidance and control for strapdown missiles with circular field of view
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作者 Wei Wang Jiaqi Liu +2 位作者 Shiyao Lin Baokui Geng Zhongjiao Shi 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第5期211-221,共11页
In this paper,an integrated estimation guidance and control(IEGC)system is designed based on the command filtered backstepping approach for circular field-of-view(FOV)strapdown missiles.The threedimensional integrated... In this paper,an integrated estimation guidance and control(IEGC)system is designed based on the command filtered backstepping approach for circular field-of-view(FOV)strapdown missiles.The threedimensional integrated estimation guidance and control nonlinear model with limited actuator deflection angle is established considering the seeker's FOV constraint.The boundary time-varying integral barrier Lyapunov function(IBLF)is employed in backstepping design to constrain the body line-of-sight(BLOS)in IEGC system to fit a circular FOV.Then,the nonlinear adaptive controller is designed to estimate the changing aerodynamic parameters.The generalized extended state observer(GESO)is designed to estimate the acceleration of the maneuvering targets and the unmatched time-varying disturbances for improving tracking accuracy.Furthermore,the command filters are used to solve the"differential expansion"problem during the backstepping design.The Lyapunov theory is used to prove the stability of the overall closed-loop IEGC system.Finally,the simulation results validate the integrated system's effectiveness,achieving high accuracy strikes against maneuvering targets. 展开更多
关键词 Integrated estimation guidance and control Circular field-of-view time-varying integral barrier Lyapunov function Command filtered backstepping control nonlinear adaptive control Extended state observer
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农村人口老龄化与农业绿色发展:促进或抑制?
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作者 余永琦 池泽新 +1 位作者 黄微 彭柳林 《中国生态农业学报(中英文)》 CAS CSCD 北大核心 2024年第11期1968-1980,共13页
为明晰农村人口老龄化对农业绿色发展的影响及其机理,本研究基于2003—2020年中国31个省份(不包括中国香港、澳门地区和台湾地区)的面板数据,利用固定效应模型和调节效应模型,实证分析了农村人口老龄化对农业绿色发展的影响机理。研究发... 为明晰农村人口老龄化对农业绿色发展的影响及其机理,本研究基于2003—2020年中国31个省份(不包括中国香港、澳门地区和台湾地区)的面板数据,利用固定效应模型和调节效应模型,实证分析了农村人口老龄化对农业绿色发展的影响机理。研究发现:1)我国农业绿色发展水平逐步提升,但呈现非均衡的发展特征。2)农村人口老龄化会显著抑制农业绿色发展,其抑制效应在低老龄化区域更为突出;分维度异质性检验发现,农村人口老龄化会抑制资源节约和经济效应,而对环境友好具有显著的促进作用,对生态保育不具有影响。3)农村人口老龄化对农业绿色发展的影响存在U型的非线性关系,且样本量主要分布在转折点左侧,边际影响以负向为主。4)农业社会化服务能够有效缓解农村人口老龄化对农业绿色发展的抑制效应。为加快推进农业绿色发展,建议因地施策推进农业绿色发展,不断缩小各地发展差异;着力提升老龄农户的人力资本积累效应,大力培育新型职业农民;支持和鼓励各类新型经营主体加快农业社会化服务供给,积极引导老龄农户有序融入社会化服务体系;实现老龄农户与现代农业有机衔接,推进农业绿色生产。 展开更多
关键词 农业绿色发展 农村人口老龄化 非线性关系 农业社会化服务
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基于群体药代动力学研究的奥氮平PK参数分析
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作者 李思民 孙红梅 +2 位作者 吴丹 聂彩霞 陈路琼 《广州医药》 2024年第6期608-615,共8页
目的通过分析奥氮平的群体药代动力学研究,探讨影响奥氮平药动学参数的因素,为临床制定个体化给药方案提供依据。方法在中国知网、万方、维普、迈特思创、PubMed和Embase等中英文数据库,以“奥氮平”“群体药代动力学”“模型”“非线... 目的通过分析奥氮平的群体药代动力学研究,探讨影响奥氮平药动学参数的因素,为临床制定个体化给药方案提供依据。方法在中国知网、万方、维普、迈特思创、PubMed和Embase等中英文数据库,以“奥氮平”“群体药代动力学”“模型”“非线性混合效应模型”及“olanzapine pamoate”“olanzapine”“population pharmacokinetic”“pharmacokinetic model”“nonlinear mixed effect”“NONMEM”为检索策略,检索建库至2023年5月所有关于奥氮平群体药代动力学的研究。结果共纳入14篇奥氮平的群体药代动力学研究,大多数研究将奥氮平的药代动力学描述为一个单室模型。成人群体药代动力学模型群体典型值吸收速率常数:(0.3~2.85)/h;表观分布清除率:(10.4~25.4)L/h;表观分布容积:(223~2390)L。儿童青少年模型群体典型值吸收速率常数:(0.142~0.758)/h;表观分布清除率:(13.6~16.8)L/h;表观分布容积:(322~899)L。年龄、体质量、性别、种族、吸烟状况、合并用药是影响奥氮平药动学参数的显著协变量。结论奥氮平药动学参数估计值存在差异且有不同程度的个体间变异,未来应侧重于对特殊人群的研究。有必要对先前发表的模型进行外部验证,以便更准地的描述模型的适用性。 展开更多
关键词 奥氮平 群体药代动力学 非线性混合效应模型 个体化给药
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