The mixed ligand coordination compound of copper with norfloxacin (NFLX) and 1, 10-phen has been synthesized and characterized by means of X-ray single crystal diffraction. The structure features of the coordination ...The mixed ligand coordination compound of copper with norfloxacin (NFLX) and 1, 10-phen has been synthesized and characterized by means of X-ray single crystal diffraction. The structure features of the coordination compound are described. Antibacterial activities of the coordination compound have been tested against different microorganisms. The antitumor activities of the coordination compound on leukemia HL-60 cell line and liver cancer BEL-7402 cell line have been measured, respectively. The results indicated that the coordination compound has strong inhibitory effect on HL-60 and BEL-7402 cell lines.展开更多
In this study, an approach was proposed to employ new target branched compounds(TBCs) including multiple antibiotic norfloxacin frameworks for intensified adsorption films to achieve super protection of mild steel in ...In this study, an approach was proposed to employ new target branched compounds(TBCs) including multiple antibiotic norfloxacin frameworks for intensified adsorption films to achieve super protection of mild steel in HCl medium. Thus, the TBCs containing bis/tri norfloxacin skeletons were synthesized by multi-step preparation route. In addition, the reference linear compound(RLC) including a single norfloxacin part was also synthesized. The chemical structures of these compounds were confirmed by various means. It was demonstrated that the TBCs could form the tough adsorption films on the surface of mild steel, which could be processed mainly through chemisorption effect. The electrochemical analysis suggested that the TBCs displayed superior corrosion inhibition performance for low carbon steel in1.0 mol·L^(-1) HCl solution over the RLC(RLC, 87.80%;TBC1, 97.63%;TBC2, 98.35%), which was further understood by the molecular modelling. The isotherm adsorption plots were employed to analyze the spontaneous adsorption process of the TBCs on low carbon steel surface, and a prominent chemisorption could be inferred by the standard Gibbs free energy changes of the adsorption.展开更多
Norfloxacin sorption and the factors （soil organic matter （SOM）, pH, and exogenous copper （Cu） influencing the sorption were investigated in a black soil （soil B）, a fluvo-aquic soil （soil F）, and a red soil ...Norfloxacin sorption and the factors （soil organic matter （SOM）, pH, and exogenous copper （Cu） influencing the sorption were investigated in a black soil （soil B）, a fluvo-aquic soil （soil F）, and a red soil （soil R）. With increasing norfloxacin concentrations, sorption amount of norfloxacin increased in both the bulk soils and their SOM-removed soils, but the sorption capacity of SOM-removed soils was higher than that of their corresponding bulk soils, indicating that the process of norfloxacin sorption in soil was influenced by the soil properties including SOM. The sorption data in all bulk soils and SOM-removed soils were fitted to Freundlich and Langmuir models. The correlation coefficients suggested that the experimental data fitted better to Freundlich equation than to Langmuir equation. Furthermore, the data from soil F and SOM-removed F could not be described by Langmuir equation. The norfloxacin sorption amount decreased in soil B and soil F, whereas it increased in soil R as solution pH increased. The maximum KD and Koc were achieved in soil R when the equilibrium solution pH was 6. The norfloxacin sorption was also influenced by the exogenous Cu^2＋, which depended on the soil types and Cu^2＋ concentrations. With increasing Cu^2＋ concentrations in solution, generally, sorption amount, KD and Koc for norfloxacin in soils increased and were up to a peak at 100 mg/L Cu^2＋, and then the sorption amount decreased regardless of norfloxacin levels.展开更多
Semiconductor photocatalysis can be operated over a narrow pH range for wastewater treatment. In this study, a simulated solar-light-mediated bismuth tungstate (SSL/Bi2WO6) process is found to be effective for norflox...Semiconductor photocatalysis can be operated over a narrow pH range for wastewater treatment. In this study, a simulated solar-light-mediated bismuth tungstate (SSL/Bi2WO6) process is found to be effective for norfloxacin degradation over a narrow pH range. To broaden the operating pH range of the SSL/Bi2WO6 process, an NH4+ buffer system and an Fe3+ salt were introduced under extremely basic and acidic pH conditions, respectively. The NH4+ buffer system continuously supplied hydroxyl ions to generate ·OH radicals and prevented acidification of the solution, resulting in improved norfloxacin removal and mineralization removal under alkaline conditions. In contrast, the Fe3+ salt offered an additional homogeneous photo-sensitization pathway. The former treatment assisted in norfloxacin decay and the latter increased the collision frequency between the photo-generated hole and hydroxyl ions. Moreover, the effect of parameters such as pH and Fe3+ dosage was optimized.展开更多
The objectives of the study were to investigate the effects of β-cyclodextrin(βCD) and hydroxypropyl-β-cyclodextrin(HPβCD) on the solubility and dissolution rate of norfloxacin prepared using three different metho...The objectives of the study were to investigate the effects of β-cyclodextrin(βCD) and hydroxypropyl-β-cyclodextrin(HPβCD) on the solubility and dissolution rate of norfloxacin prepared using three different methods, at drug to cyclodextrin weight ratios of 1:1, 1:2, 1:4 and 1:8. All the methods increased the solubility and dissolution rate of norfloxacin via inclusion complexation with βCD and HPβCD. Norfloxacin was converted from crystalline to amorphous form through inclusion complexation. Solvent evaporation method was the most effective method in terms of norfloxacin solubilisation, while inclusion complex of HPβCD has higher solubility than βCD complex when prepared using the same procedure.展开更多
基金funded by the National Natural Science Foundation of China(No.50073019)
文摘The mixed ligand coordination compound of copper with norfloxacin (NFLX) and 1, 10-phen has been synthesized and characterized by means of X-ray single crystal diffraction. The structure features of the coordination compound are described. Antibacterial activities of the coordination compound have been tested against different microorganisms. The antitumor activities of the coordination compound on leukemia HL-60 cell line and liver cancer BEL-7402 cell line have been measured, respectively. The results indicated that the coordination compound has strong inhibitory effect on HL-60 and BEL-7402 cell lines.
基金the National Natural Science Foundation of China (21376282, 21676035, 21878029)Chongqing Science and Technology Commission (2022NSCQ-MSX1298)+1 种基金China Postdoctoral Science Foundation (22012T50762 & 2011M501388)Graduate Student Research Innovation Project, Chongqing University (CYB18046)。
文摘In this study, an approach was proposed to employ new target branched compounds(TBCs) including multiple antibiotic norfloxacin frameworks for intensified adsorption films to achieve super protection of mild steel in HCl medium. Thus, the TBCs containing bis/tri norfloxacin skeletons were synthesized by multi-step preparation route. In addition, the reference linear compound(RLC) including a single norfloxacin part was also synthesized. The chemical structures of these compounds were confirmed by various means. It was demonstrated that the TBCs could form the tough adsorption films on the surface of mild steel, which could be processed mainly through chemisorption effect. The electrochemical analysis suggested that the TBCs displayed superior corrosion inhibition performance for low carbon steel in1.0 mol·L^(-1) HCl solution over the RLC(RLC, 87.80%;TBC1, 97.63%;TBC2, 98.35%), which was further understood by the molecular modelling. The isotherm adsorption plots were employed to analyze the spontaneous adsorption process of the TBCs on low carbon steel surface, and a prominent chemisorption could be inferred by the standard Gibbs free energy changes of the adsorption.
基金supported by the National Key Basic Research Support Foundation of China (No.2005CB121105), the Ministry of Science and Technology of China (No. 2006BAD05B05)the International Foundation for Science (No. C/4076).
文摘Norfloxacin sorption and the factors （soil organic matter （SOM）, pH, and exogenous copper （Cu） influencing the sorption were investigated in a black soil （soil B）, a fluvo-aquic soil （soil F）, and a red soil （soil R）. With increasing norfloxacin concentrations, sorption amount of norfloxacin increased in both the bulk soils and their SOM-removed soils, but the sorption capacity of SOM-removed soils was higher than that of their corresponding bulk soils, indicating that the process of norfloxacin sorption in soil was influenced by the soil properties including SOM. The sorption data in all bulk soils and SOM-removed soils were fitted to Freundlich and Langmuir models. The correlation coefficients suggested that the experimental data fitted better to Freundlich equation than to Langmuir equation. Furthermore, the data from soil F and SOM-removed F could not be described by Langmuir equation. The norfloxacin sorption amount decreased in soil B and soil F, whereas it increased in soil R as solution pH increased. The maximum KD and Koc were achieved in soil R when the equilibrium solution pH was 6. The norfloxacin sorption was also influenced by the exogenous Cu^2＋, which depended on the soil types and Cu^2＋ concentrations. With increasing Cu^2＋ concentrations in solution, generally, sorption amount, KD and Koc for norfloxacin in soils increased and were up to a peak at 100 mg/L Cu^2＋, and then the sorption amount decreased regardless of norfloxacin levels.
基金supported by the National Science Foundation of China(41877481,41503102)the open project of the State Key Laboratory of Loess and Quaternary Geology,Institute of Earth Environment,Chinese Academy of Science(SKLLQG1729)+2 种基金the China Postdoctoral Science Foundation(2018M643669)the Fundamental Research Funds for the Central Universities(2018249)the "Hundred Talent Program" of the Chinese Academy of Sciences~~
文摘Semiconductor photocatalysis can be operated over a narrow pH range for wastewater treatment. In this study, a simulated solar-light-mediated bismuth tungstate (SSL/Bi2WO6) process is found to be effective for norfloxacin degradation over a narrow pH range. To broaden the operating pH range of the SSL/Bi2WO6 process, an NH4+ buffer system and an Fe3+ salt were introduced under extremely basic and acidic pH conditions, respectively. The NH4+ buffer system continuously supplied hydroxyl ions to generate ·OH radicals and prevented acidification of the solution, resulting in improved norfloxacin removal and mineralization removal under alkaline conditions. In contrast, the Fe3+ salt offered an additional homogeneous photo-sensitization pathway. The former treatment assisted in norfloxacin decay and the latter increased the collision frequency between the photo-generated hole and hydroxyl ions. Moreover, the effect of parameters such as pH and Fe3+ dosage was optimized.
文摘The objectives of the study were to investigate the effects of β-cyclodextrin(βCD) and hydroxypropyl-β-cyclodextrin(HPβCD) on the solubility and dissolution rate of norfloxacin prepared using three different methods, at drug to cyclodextrin weight ratios of 1:1, 1:2, 1:4 and 1:8. All the methods increased the solubility and dissolution rate of norfloxacin via inclusion complexation with βCD and HPβCD. Norfloxacin was converted from crystalline to amorphous form through inclusion complexation. Solvent evaporation method was the most effective method in terms of norfloxacin solubilisation, while inclusion complex of HPβCD has higher solubility than βCD complex when prepared using the same procedure.
