The mixed ligand coordination compound of copper with norfloxacin (NFLX) and 1, 10-phen has been synthesized and characterized by means of X-ray single crystal diffraction. The structure features of the coordination ...The mixed ligand coordination compound of copper with norfloxacin (NFLX) and 1, 10-phen has been synthesized and characterized by means of X-ray single crystal diffraction. The structure features of the coordination compound are described. Antibacterial activities of the coordination compound have been tested against different microorganisms. The antitumor activities of the coordination compound on leukemia HL-60 cell line and liver cancer BEL-7402 cell line have been measured, respectively. The results indicated that the coordination compound has strong inhibitory effect on HL-60 and BEL-7402 cell lines.展开更多
A novel drug agent named norfloxacin biomonomer was developed in order to solve the problem of low drug content,uneven drug distribution,low molecular weight,and wide molecular weight distribution of polymer drug,base...A novel drug agent named norfloxacin biomonomer was developed in order to solve the problem of low drug content,uneven drug distribution,low molecular weight,and wide molecular weight distribution of polymer drug,based on polyurethane,which was used as an antibacterial agent to control the bacterial infection associated with biofilm formation on polymeric materials used in biologic environments.In this research,norfloxacin biomonomer was synthesized by esterifying the compound of norfloxacin.High-performance liquid chromatography system was used to analyze the purity of the final product and intermediate products,and Fourier transform infrared spectrometer and mass spectrum were used to verify the final product and intermediate products.The results showed that the objective product was developed successfully.The final product of norfloxacin biomonomer could be incorporated into the polyurethane as chain extender.展开更多
以苄氯和诺氟沙星为原料,无水碳酸钾和碘化钾为催化剂,采用微波辐射技术合成了诺氟沙星衍生物,产品结构经IR和1HNMR分析证明与预期结构相符;同时运用正交试验对影响收率的因素进行考察,确定了最佳反应条件:微波辐射功率700W,辐射时间15 ...以苄氯和诺氟沙星为原料,无水碳酸钾和碘化钾为催化剂,采用微波辐射技术合成了诺氟沙星衍生物,产品结构经IR和1HNMR分析证明与预期结构相符;同时运用正交试验对影响收率的因素进行考察,确定了最佳反应条件:微波辐射功率700W,辐射时间15 m in,反应温度80℃,苄氯、诺氟沙星和碳酸钾的物质的量比为1.3∶1∶1,碘化钾用量0.3 g;反应收率也从常规加热法的29.3%提高到90.2%.与常规加热法对比,微波法缩短了反应时间,提高了反应收率.展开更多
基金funded by the National Natural Science Foundation of China(No.50073019)
文摘The mixed ligand coordination compound of copper with norfloxacin (NFLX) and 1, 10-phen has been synthesized and characterized by means of X-ray single crystal diffraction. The structure features of the coordination compound are described. Antibacterial activities of the coordination compound have been tested against different microorganisms. The antitumor activities of the coordination compound on leukemia HL-60 cell line and liver cancer BEL-7402 cell line have been measured, respectively. The results indicated that the coordination compound has strong inhibitory effect on HL-60 and BEL-7402 cell lines.
基金supported by the program of the Fujian Provincial Department of Science&Technology(No.2006I0019)supported by the Science and Technology Department of Fujian Province Subsidization Provincial University Projects(2008F50502)the Fujian Provincial Key Laboratory of Polymer Materials.
文摘A novel drug agent named norfloxacin biomonomer was developed in order to solve the problem of low drug content,uneven drug distribution,low molecular weight,and wide molecular weight distribution of polymer drug,based on polyurethane,which was used as an antibacterial agent to control the bacterial infection associated with biofilm formation on polymeric materials used in biologic environments.In this research,norfloxacin biomonomer was synthesized by esterifying the compound of norfloxacin.High-performance liquid chromatography system was used to analyze the purity of the final product and intermediate products,and Fourier transform infrared spectrometer and mass spectrum were used to verify the final product and intermediate products.The results showed that the objective product was developed successfully.The final product of norfloxacin biomonomer could be incorporated into the polyurethane as chain extender.
文摘以苄氯和诺氟沙星为原料,无水碳酸钾和碘化钾为催化剂,采用微波辐射技术合成了诺氟沙星衍生物,产品结构经IR和1HNMR分析证明与预期结构相符;同时运用正交试验对影响收率的因素进行考察,确定了最佳反应条件:微波辐射功率700W,辐射时间15 m in,反应温度80℃,苄氯、诺氟沙星和碳酸钾的物质的量比为1.3∶1∶1,碘化钾用量0.3 g;反应收率也从常规加热法的29.3%提高到90.2%.与常规加热法对比,微波法缩短了反应时间,提高了反应收率.
