Mesopelagic fish,the most important daily vertically migrating community in the oceans,are characterized by high lipid content which may obscure the interpretation of stable isotopes analysis.Demersal fish,which are i...Mesopelagic fish,the most important daily vertically migrating community in the oceans,are characterized by high lipid content which may obscure the interpretation of stable isotopes analysis.Demersal fish,which are important consumers in the food web dominated by mesopelagic fish,also have a high lipid content.Here we collected 127 fish samples from the South China Sea and evaluated the effect of lipid contents on△δ^(13)C of mesopelagic and demersal fish.In lipid-extracted mesopelagic fish,the C/N content ratio(<5.5)shows a clear correlation withΔδ^(13)C(the offset of bulk and lipid-extractedδ^(13)C values),especially in non-migratory and semi-migratory species;these values were less correlation in demersal fish.Based on our results,we suggest that mesopelagic and demersal fish in different regions of the South China Sea should be studied separately using appropriate correction models and less fit for the traditional model.Moreover,the C/N content ratio should be used cautiously for establishing the lipid normalization model,especially for the fish in migratory mesopelagic fish and demersal fish.Our results also reveal that mesopelagic fish across nearby regions could be analyzed together.The new models described here can be applied in future studies of mesopelagic and demersal fish in the South China Sea.展开更多
<strong>Background:</strong> Aberrant lipid metabolism presumed to have important relationship with gestational diabetes mellitus (GDM), though previous studies revealed inconsistent results on this area.&...<strong>Background:</strong> Aberrant lipid metabolism presumed to have important relationship with gestational diabetes mellitus (GDM), though previous studies revealed inconsistent results on this area.<strong> Objectives:</strong> To identify the difference of serum lipid profile between gestational diabetes mellitus (GDM) and pregnant woman with normal glucose tolerance (NGT). <strong>Methods:</strong> This cross sectional study was conducted from January 2017 to December 2017 at Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh with 31 GDM and equal number of NGT pregnant women diagnosed on the basis of WHO criteria-2013, during 24 - 40 weeks of gestation. Glucose was measured by glucose oxidase method and fasting serum lipid profile [Total cholesterol (TC), High Density Lipoprotein-cholesterol (HDL-C) and Triglyceride (TG)] was measured by enzymatic-colorimetric method. Data were analyzed and compared by statistical tests. <strong>Results: </strong>Among total sixty-two (62) study subjects, 31 were GDM (age: 27.52 ± 4.8 years, body mass index (BMI): 27.17 ± 3.3 kg/m<sup>2</sup>) and 31 were pregnant women with NGT (age: 24.94 ± 4.2 years, BMI: 25.43 ± 6.5 kg/m<sup>2</sup>). Mean age of GDM group was significantly higher than that of NGT group (p = 0.028). Women with GDM showed relatively higher BMI than NGT women but that was not statistically significant (p = 0.194). Fasting lipid profiles between GDM and NGT (GDM vs. NGT;total cholesterol: 194.21 ± 42.18 vs. 208.52 ± 42.18 mg/dl, p = 0.187;HDL-C: 47.50 ± 16.17 vs. 47.18 ± 11.71 mg/dl, p = 0.928;LDL-C: 109.25 ± 28.80 vs. 119.30 ± 34.76 mg/dl, p = 0.220 and triglyceride 204.78 ± 58.50 vs. 202.34 ± 79.18 mg/dl, p = 0.891) were not significantly different. The variations in all lipid fraction values were not statistically significant among GDM women when analyzed between BMI groups holding BMI cut-off at 23 kg/m<sup>2</sup>. No significant differences of any values of lipid profile were found in GDM women according to various age categories (Age < 25 years vs. ≥25 years). <strong>Conclusions: </strong>Lipid profile does not differ between women with GDM and pregnant woman with NGT.展开更多
Dyslipidemia the major cause of atherosclerosis are suggested to act synergistically with non-lipid risk factors to increase atherogenesis.Low-density lipoprotein cholesterol(LDL-C) is the main therapeutic target in t...Dyslipidemia the major cause of atherosclerosis are suggested to act synergistically with non-lipid risk factors to increase atherogenesis.Low-density lipoprotein cholesterol(LDL-C) is the main therapeutic target in the prevention of CVD.Increased triglycerides(TG) and decreased high-density lipoprotein(LDL-C) are considered to be a major risk factor for the development of insulin resistant and metabolic syndrome.Although the TG/ HDL-C ratio has been used in recent studies as a clinical indicator for insulin resistance,results were inconsistent. The TG/HDL-C ratio is also widely used to assess the lipid atherogenesis.How ever the utility of this rate for predicting coronary heart disease(CHD) risk is not clear.We encountered myocardial infarct patients with normal serum lipid concentration so this study was undertaken to evaluate the usefulness of these lipid ratios in predicting CHD risk in normolipidemic AMI patients and to compare the results with healthy subjects.The aim of the present study was to evaluate serum TC/HDL-C,TG/HDL-C and LDL-C/HDL-C in myocardial infarct subjects with normal lipid profile.To study this,lipid profile was determined in 165 normolipidemic acute myocardial infarction patients and 165 age/sex-matched controls.Total cholesterol,triglycerides,and HDL-cholesterol were analyzed enzymatically using kits obtained from Randox Laboratories Limited,Crumlin,UK. Plasma LDL-cholesterol was determined from the values of total cholesterol and HDL- cholesterol using the friedwalds formula.The values were expressed as means±standard deviation(SD) and data from patients and controls was compared using students t-test.The results and conclusion of the study were:Total cholesterol, TC:HDL-C ratio,triglycerides,LDL-cholesterol,LDL:HDL-C ratio were higher in MI patients(p【0. 001).HDL-C concentration was significantly lower in MI patients than controls(p【0.001).Higher ratio of TC/HDL-C,TG/HDL-C and LDL-C/HDL-C was observed in AMI patients compared to controls.展开更多
目的 探讨正常妊娠女性血脂的动态变化特点。方法回顾性分析2015年1月1日至12月31日本院收治的771例正常妊娠孕妇的临床资料,同时选取同期本院妇科住院患者100例作为对照。收集产妇的年龄、身高、非孕期体重、孕晚期体重,孕早期(12^(+6...目的 探讨正常妊娠女性血脂的动态变化特点。方法回顾性分析2015年1月1日至12月31日本院收治的771例正常妊娠孕妇的临床资料,同时选取同期本院妇科住院患者100例作为对照。收集产妇的年龄、身高、非孕期体重、孕晚期体重,孕早期(12^(+6)周前)、孕中期(13～27^(+6)周)、孕晚期(≥28周)的血脂(总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、载脂蛋白A、载脂蛋白B、脂蛋白a)测定结果。对血脂与体重、体重指数(body mass index,BMI)等因素的关系进行分析。结果①与正常非孕期女性相比,妊娠女性的血脂在孕早期即发生明显改变,表现为总胆固醇、低密度脂蛋白、载脂蛋白B下降(P均<0.05),甘油三脂、高密度脂蛋白、载脂蛋白A明显升高(P均<0.05),而脂蛋白a无明显变化(P>0.05)。②正常妊娠女性孕早、中、晚期血脂指标除脂蛋白a外(P=0.1399),其余均明显升高(各组指标经方差分析比较,P均<0.001),其中甘油三酯增加最为明显,孕晚期甘油三酯较孕早期增加3倍,而具有保护作用的载脂蛋白A/载脂蛋白B在孕晚期明显下降。③在孕早期,总胆固醇、甘油三酯、低密度脂蛋白、载脂蛋白B均与体重、体重指数及孕周呈正性相关(P<0.01),而除甘油三酯与年龄相关外,其余血脂指标与年龄、身高无相关性。在孕晚期,血脂仍受非孕期体重、BMI以及孕周影响,且大多数血脂增长程度(除高密度脂蛋白与载脂蛋白A)与早孕期体重、BMI均呈负性相关。体重增长的程度对血脂变化影响不大。结论正常妊娠女性自孕早期出现明显血脂变化,随孕周增加血脂呈不同程度上升,其中以甘油三酯升高最为明显。血脂受非孕期体重、BMI、孕周影响较大,但其增长与孕期体重增长无明显相关。展开更多
基金the National Natural Science Foundation of China under contract Nos 42090043 and 41876074the National Basic Research Program(973 Program)of China under contract No.2014CB441502.
文摘Mesopelagic fish,the most important daily vertically migrating community in the oceans,are characterized by high lipid content which may obscure the interpretation of stable isotopes analysis.Demersal fish,which are important consumers in the food web dominated by mesopelagic fish,also have a high lipid content.Here we collected 127 fish samples from the South China Sea and evaluated the effect of lipid contents on△δ^(13)C of mesopelagic and demersal fish.In lipid-extracted mesopelagic fish,the C/N content ratio(<5.5)shows a clear correlation withΔδ^(13)C(the offset of bulk and lipid-extractedδ^(13)C values),especially in non-migratory and semi-migratory species;these values were less correlation in demersal fish.Based on our results,we suggest that mesopelagic and demersal fish in different regions of the South China Sea should be studied separately using appropriate correction models and less fit for the traditional model.Moreover,the C/N content ratio should be used cautiously for establishing the lipid normalization model,especially for the fish in migratory mesopelagic fish and demersal fish.Our results also reveal that mesopelagic fish across nearby regions could be analyzed together.The new models described here can be applied in future studies of mesopelagic and demersal fish in the South China Sea.
文摘<strong>Background:</strong> Aberrant lipid metabolism presumed to have important relationship with gestational diabetes mellitus (GDM), though previous studies revealed inconsistent results on this area.<strong> Objectives:</strong> To identify the difference of serum lipid profile between gestational diabetes mellitus (GDM) and pregnant woman with normal glucose tolerance (NGT). <strong>Methods:</strong> This cross sectional study was conducted from January 2017 to December 2017 at Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh with 31 GDM and equal number of NGT pregnant women diagnosed on the basis of WHO criteria-2013, during 24 - 40 weeks of gestation. Glucose was measured by glucose oxidase method and fasting serum lipid profile [Total cholesterol (TC), High Density Lipoprotein-cholesterol (HDL-C) and Triglyceride (TG)] was measured by enzymatic-colorimetric method. Data were analyzed and compared by statistical tests. <strong>Results: </strong>Among total sixty-two (62) study subjects, 31 were GDM (age: 27.52 ± 4.8 years, body mass index (BMI): 27.17 ± 3.3 kg/m<sup>2</sup>) and 31 were pregnant women with NGT (age: 24.94 ± 4.2 years, BMI: 25.43 ± 6.5 kg/m<sup>2</sup>). Mean age of GDM group was significantly higher than that of NGT group (p = 0.028). Women with GDM showed relatively higher BMI than NGT women but that was not statistically significant (p = 0.194). Fasting lipid profiles between GDM and NGT (GDM vs. NGT;total cholesterol: 194.21 ± 42.18 vs. 208.52 ± 42.18 mg/dl, p = 0.187;HDL-C: 47.50 ± 16.17 vs. 47.18 ± 11.71 mg/dl, p = 0.928;LDL-C: 109.25 ± 28.80 vs. 119.30 ± 34.76 mg/dl, p = 0.220 and triglyceride 204.78 ± 58.50 vs. 202.34 ± 79.18 mg/dl, p = 0.891) were not significantly different. The variations in all lipid fraction values were not statistically significant among GDM women when analyzed between BMI groups holding BMI cut-off at 23 kg/m<sup>2</sup>. No significant differences of any values of lipid profile were found in GDM women according to various age categories (Age < 25 years vs. ≥25 years). <strong>Conclusions: </strong>Lipid profile does not differ between women with GDM and pregnant woman with NGT.
文摘Dyslipidemia the major cause of atherosclerosis are suggested to act synergistically with non-lipid risk factors to increase atherogenesis.Low-density lipoprotein cholesterol(LDL-C) is the main therapeutic target in the prevention of CVD.Increased triglycerides(TG) and decreased high-density lipoprotein(LDL-C) are considered to be a major risk factor for the development of insulin resistant and metabolic syndrome.Although the TG/ HDL-C ratio has been used in recent studies as a clinical indicator for insulin resistance,results were inconsistent. The TG/HDL-C ratio is also widely used to assess the lipid atherogenesis.How ever the utility of this rate for predicting coronary heart disease(CHD) risk is not clear.We encountered myocardial infarct patients with normal serum lipid concentration so this study was undertaken to evaluate the usefulness of these lipid ratios in predicting CHD risk in normolipidemic AMI patients and to compare the results with healthy subjects.The aim of the present study was to evaluate serum TC/HDL-C,TG/HDL-C and LDL-C/HDL-C in myocardial infarct subjects with normal lipid profile.To study this,lipid profile was determined in 165 normolipidemic acute myocardial infarction patients and 165 age/sex-matched controls.Total cholesterol,triglycerides,and HDL-cholesterol were analyzed enzymatically using kits obtained from Randox Laboratories Limited,Crumlin,UK. Plasma LDL-cholesterol was determined from the values of total cholesterol and HDL- cholesterol using the friedwalds formula.The values were expressed as means±standard deviation(SD) and data from patients and controls was compared using students t-test.The results and conclusion of the study were:Total cholesterol, TC:HDL-C ratio,triglycerides,LDL-cholesterol,LDL:HDL-C ratio were higher in MI patients(p【0. 001).HDL-C concentration was significantly lower in MI patients than controls(p【0.001).Higher ratio of TC/HDL-C,TG/HDL-C and LDL-C/HDL-C was observed in AMI patients compared to controls.
文摘目的 探讨正常妊娠女性血脂的动态变化特点。方法回顾性分析2015年1月1日至12月31日本院收治的771例正常妊娠孕妇的临床资料,同时选取同期本院妇科住院患者100例作为对照。收集产妇的年龄、身高、非孕期体重、孕晚期体重,孕早期(12^(+6)周前)、孕中期(13～27^(+6)周)、孕晚期(≥28周)的血脂(总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、载脂蛋白A、载脂蛋白B、脂蛋白a)测定结果。对血脂与体重、体重指数(body mass index,BMI)等因素的关系进行分析。结果①与正常非孕期女性相比,妊娠女性的血脂在孕早期即发生明显改变,表现为总胆固醇、低密度脂蛋白、载脂蛋白B下降(P均<0.05),甘油三脂、高密度脂蛋白、载脂蛋白A明显升高(P均<0.05),而脂蛋白a无明显变化(P>0.05)。②正常妊娠女性孕早、中、晚期血脂指标除脂蛋白a外(P=0.1399),其余均明显升高(各组指标经方差分析比较,P均<0.001),其中甘油三酯增加最为明显,孕晚期甘油三酯较孕早期增加3倍,而具有保护作用的载脂蛋白A/载脂蛋白B在孕晚期明显下降。③在孕早期,总胆固醇、甘油三酯、低密度脂蛋白、载脂蛋白B均与体重、体重指数及孕周呈正性相关(P<0.01),而除甘油三酯与年龄相关外,其余血脂指标与年龄、身高无相关性。在孕晚期,血脂仍受非孕期体重、BMI以及孕周影响,且大多数血脂增长程度(除高密度脂蛋白与载脂蛋白A)与早孕期体重、BMI均呈负性相关。体重增长的程度对血脂变化影响不大。结论正常妊娠女性自孕早期出现明显血脂变化,随孕周增加血脂呈不同程度上升,其中以甘油三酯升高最为明显。血脂受非孕期体重、BMI、孕周影响较大,但其增长与孕期体重增长无明显相关。
