Exercise is recommended for the treatment of type 2 diabetes because of its benefits on body weight and glycemic control. Our recent work using the db/db mouse, a model that mimics the phenotype of type 2 diabetes, de...Exercise is recommended for the treatment of type 2 diabetes because of its benefits on body weight and glycemic control. Our recent work using the db/db mouse, a model that mimics the phenotype of type 2 diabetes, demonstrated that forced treadmill training exerted detrimental effects on obesity, hyperglycemia and insulin resistance. We investigated whether this response is explained by increased corticosterone and norepinephrine secretion, measured as urinary byproducts, since these hormones are known to alter glucose homeostasis. Male db/db mice and lean littermates serving as controls, were assigned to sedentary, voluntary wheel, and forced treadmill training groups for a period of 5 weeks. After 5 weeks of treadmill running, db/db mice remained hyperglycemic compared to sedentary db/db mice and were hyperinsulinemic compared to db/db voluntary runners. Urine glucose and corticosterone levels were also highest in db/db treadmill runners compared to all groups. Urine normetanephrine levels, although lower in db/db mice compared to control mice, were increased after treadmill running. Our results indicate that treadmill running leads to perturbations in plasma levels of hormones associated with glucose homeostasis. A greater stress response may be invoked by treadmill training, worsening glycemic control in this model of type 2 diabetes.展开更多
本文对国产复合材料SDMSD、OMO、NMN进行了模拟线圈、TGA、挂漆量、相容性等试验。结果表明。用作低压电机槽绝缘、相绝缘的SDMSD、OMO、NMN复合材料都能满足 F 级耐温要求。在挂漆量、相容性、价格等方面,SDMSD较 OMO、NMN占优势。从...本文对国产复合材料SDMSD、OMO、NMN进行了模拟线圈、TGA、挂漆量、相容性等试验。结果表明。用作低压电机槽绝缘、相绝缘的SDMSD、OMO、NMN复合材料都能满足 F 级耐温要求。在挂漆量、相容性、价格等方面,SDMSD较 OMO、NMN占优势。从下线效果还说明。SDMSD的槽满率也能达到通用的DMD、NMN水平。展开更多
文摘Exercise is recommended for the treatment of type 2 diabetes because of its benefits on body weight and glycemic control. Our recent work using the db/db mouse, a model that mimics the phenotype of type 2 diabetes, demonstrated that forced treadmill training exerted detrimental effects on obesity, hyperglycemia and insulin resistance. We investigated whether this response is explained by increased corticosterone and norepinephrine secretion, measured as urinary byproducts, since these hormones are known to alter glucose homeostasis. Male db/db mice and lean littermates serving as controls, were assigned to sedentary, voluntary wheel, and forced treadmill training groups for a period of 5 weeks. After 5 weeks of treadmill running, db/db mice remained hyperglycemic compared to sedentary db/db mice and were hyperinsulinemic compared to db/db voluntary runners. Urine glucose and corticosterone levels were also highest in db/db treadmill runners compared to all groups. Urine normetanephrine levels, although lower in db/db mice compared to control mice, were increased after treadmill running. Our results indicate that treadmill running leads to perturbations in plasma levels of hormones associated with glucose homeostasis. A greater stress response may be invoked by treadmill training, worsening glycemic control in this model of type 2 diabetes.
文摘本文对国产复合材料SDMSD、OMO、NMN进行了模拟线圈、TGA、挂漆量、相容性等试验。结果表明。用作低压电机槽绝缘、相绝缘的SDMSD、OMO、NMN复合材料都能满足 F 级耐温要求。在挂漆量、相容性、价格等方面,SDMSD较 OMO、NMN占优势。从下线效果还说明。SDMSD的槽满率也能达到通用的DMD、NMN水平。
