Research on Nourishing Compositions of Fagopyrum tataricum

[Objective] The aim was to identify the nourishing compositions of Fagopyrum tataricum and screen high-quality buckwheat materials.[Method]A total of 10 species of buckwheat including T32,T31,T30,T14,T28,T23,T24,Jiujiang Buckwheat,Weiku 2 and WK-1 were employed as experimental materials,and the contents of the nutritional components（including total sugar,reducing sugar,starch,amylose,amylopectin and protein）,flavonoids content,physical and chemical characteristics（such as expansive force,water holding capacity）of them were respectively measured.[Result]There were significant differences in contents of soluble protein,total sugar,reduced sugar,amylase and expansive force among the cultivars,but the differences in contents of total starch,amylopectin,flavonoids content and water holding capacity were not significant.[Conclusion]The starch content in seeds of buckwheat was relatively high,and amylopectin was the main composition.

Clinical Efficacy and Molecular Mechanism of Nourishing Shen and Supplementing Marrow Principle in Treating β Thalassemia

Objective: To explore the possibility of using traditional Chinese medicine (TCM) in treating β thalassemia, its clinical effect and molecular mechanism of the action.Methods: According to the TCM theory of“Shen producing marrow”, the composite recipe, Yisui Shenxueling Granule (YSSXL), consisting of Chinese drugs for nourishing Shen and supplementing marrow (NS&SM) was given orally to 7 8 patients with β thalassemia (49 of the severe type and 29 of moderate type ), 3 times a day, 10 g each time (for children, the dose would be reduced proper ly), with 3 months as one therapeutic course, and no blood transfusion used in t he course. The clinical therapeutic efficacy and hematologic parameters in patie nts were observed, and systemic gene analysis was conducted with PAGE, PCR, PCR SSCP, RT PCR and DNA sequences analysis and mRNA detection, in order to s tudy the molecular mechanism from the relationships between genetic mutation and clinical efficacy, gene expression and its regulation. Results: YSSXL showed obvious therapeutic effect in treating β thalassemia. Gene analysis revealed that it did not change the genetic mutatio n type, but could obviously increase hemoglobin, fetal hemoglobin (HbF), γ/(β+ γ) globin ratio, γ globin mRNA expression and GM CSF mRNA expression in patients, as well as the GM CSFmRMA in marrow of mice after 60 Co radia tion. Conclusion: YSSXL has a remarkable therapeutic effect on β tha lassemia, and its possible mechanism is its action in unlocking γ gene, in creasing the γ globin expression and enhancing HbF synthesis so as to compe nsate for the gene defect. This study has opened a new path for the treatment of β thalassemia with TCM.

Effects of Nourishing “Yin”-Removing “Fire” Chinese Herb Mixture on the Differential Expression of GABA_AReceptor <i>α</i>Subunits in Hypothalamus of Precocious Puberty Female Rats

GABAergic input to Gonadotropin-releasing hormone (GnRH) neurons is necessary to initiate the onset of puberty and its action mainly depends on GABAA receptor of which the subunit composition, properties and consequently function varies during this period. Nourishing “Yin”-Removing “Fire” Chinese herb mixture, a Chinese herb-based formulation, has been proved that it may retard the initiation of pubertal development in female precocious puberty rats. Our objective is to investigate the effects of Nourishing “Yin”-Removing “Fire” Chinese herb mixture on the expression of GABAA receptor α subunits in hypothalamus. Female Sprague-Dawley rats were divided into normal (N), precocious puberty model (M) induced by danazol, model exposed to saline (MS) and model exposed to Chinese herb mixture (CHM) groups. All rats were administered by the Chinese herb mixture from P15 on. Coefficients of reproductive organs and serum gonadotropins and estradiol levels in M were significantly enhanced while they were significantly decreased in CHM. The hypothalamic GnRH mRNA was also significantly increased in M and in CHM, as well as ERα mRNA. At the mean time, the hypothalamic GABAA receptor α1 and α3 subunits mRNA were more significantly decreased in M than those of N, while they were more significantly enhanced in CHM than those in M (p 0.01), the protein expression of which in hypothalamus had the same trend as the mRNA expression. The evidence suggests that Nourishing “Yin”-Removing “Fire” Chinese herb mixture could significantly retard the sexual development of the precocious rats, and up-regulate the expressions of hypothalamic GABAA receptor α1 and α3 subunits. Our result indicated that GABAA receptor α1 and α3 subunits might involve in the effective treatment of herb mixture on idiopathic precocious puberty.

Art of Nourishing Life According to the Kidney Meridian in Zhenjiu Dacheng(The Great Compendium of Acupuncture and Moxibustion)

“Daoyin Benjing”(Art of Nourishing Life)discusses the kidney meridian in depth.It is a dense and heterogeneous text that is heavily influenced by Daoism.The text proposes rules for the maintenance of life using language that is often cryptic and under-standable only to the initiated.This language is closely interwoven with the classical terms of traditional Chinese medicine.The kidney is the home of vital energy,which is a type of sexual energy and the root of life.Engagement in moderate sexual activity nourishes life and leads to a long life.This is the goal of every Daoist follower and the goal of every doctor.

Kanglu Brand Pilose Antler Nourishing Cream

Kanglu Brand Pilose Antler Nourishing Cream, developed by the Navy Anti-aging Research Institute and the Hainan Fengmu Deer Breeding Farm, is a kind of high-tech nourishing cream. The cream is produced from the fresh pilose antler of younger deer, and contains the quintessence of pilose antlers——the total fat and SOD. The SOD is regarded as the best anti-aging agent

Study on COVID-19 based on nourishing yin and resolving phlegm

To explore the theoretical basis of nourishing yin and resolving phlegm method and the characteristics of stage drug use.Inquire literature and seek the internal relationship between phlegm,dampness,water,drink and body fluid,blood and yin essence,and to expound the theoretical basis and characteristics of nourishing yin and resolving phlegm method.We put forward that expectorant is the key to the diagnosis and treatment of corona virus disease 2019(COVID-19)in traditional Chinese medicine.Phlegm,drinking,dampness,body fluid,blood,and yin essence belong to the category of yin.Clinical syndrome can be evaluated based on the degree of yin injury and phlegm dampness.

The effect of Supplementing Qi and Nourishing Yin combined with chemotherapy for lung cancer： a meta-analysis

Objective： To evaluate whether herbs of supplementing Qi and nourishing Yin combined with chemotherapy （versus chemotherapy alone） improve survival, increase tumor response, improve performance status or reduce chemotherapy toxicity in patients with lung cancer. Methods： Searching the randomized controlled trials （RCT） studies from the databases （China HowNet database, Wan Fang database, VIP database, Master Thesis and Pubmed） between January 2013 and January 2017. RevMan 5.3 software was used to evaluate the quality of these collected papers. Results： Of 48 potentially relevant publications, 10 randomized studies representing 691 patients met inclusion criteria with 369 cases in the supplementing Qi and nourishing Yin plus Chemotherapy group （Herbs ＋ Chem group） and 322 cases in Chemotherapy group （Chem only group）. There were significant differences between Herbs ＋ Chem group and Chem only group in improving the treatment efficacy and reducing the side effects of chemotherapy （P 〈 0.001 for all）. There were also significant differences between the two groups in tumor response and quality of life （P 〈 0.001 for all）. Conclusion： Herbs of supplementing Qi and nourishing Yin may increase chemotherapy effectiveness, reduce chemotherapy toxicity and improve the quality of life of patients with lung cancer when combined with chemotherapy.

Zhu Zhenheng, Founder of the School of Yin Nourishing

Zhu Zhenheng (courtesy name:Zhu Yanxiu,1281-1358) was from Yiwu County,Zhejiang Province.His family lived near a river named Dan Xi for many generations,hence his sobriquet Old Man Dan Xi,or Mr Dan Xi.Since he was intelligent,diligent and eager to learn,he traveled around to visit literary celebrities with the expectation to pass the imperial examination and seek an official position.When he was 36 years old,he heard that Xu Qian,a famous scholar of the Neo-Confucianism came to give lectures in Dongyang County,Zhejiang Province,he soon rushed there to learn from him.1 He kept on study for years and made great progress.But he suffered a reversal of fortune and failed the imperial examinations.At this moment,Xu Qian was badly ill and completely bedridden.One day,when Zhu went to visit him,he said:'I have been ill for a long time,and only those who are skillful in medicine can save me.

Efficacy and safety of the decoction of nourishing marrow and raising energy in terms of Traditional Chinese Medicine in patients with vascular dementia:a randomized controlled trial

OBJECTIVE: To explore the efficacy and safety of the decoction of nourishing marrow and raising energy in terms of Traditional Chinese Medicine(TCM) in patients with vascular dementia.METHODS: Totally 86 patients with vascular dementia patients hospitalized from September 2010 to January 2015 were recruited and randomly divided into two groups: control group and observation group. Patients in control group received the conventional treatment, whereas patients in another group were treated with the therapy of nourishing marrow and raising energy according to the theory of TCM. Blesse dementia scale scores were measured before and after the treatment for both groups and adverse effect was documented as well.RESULTS: After treatment, Blesse dementia scale scores reduced in both groups, and the difference in score reduction between the two groups was significant(P<0.05). The rate of adverse events was significantly lower in observation group than in control group(P<0.05).CONCLUSION: Our results demonstrate that the decoction of nourishing marrow and raising energy was an effective and safe alternative to vascular dementia in human subjects.

Experience in the Treatment of Tumors by Replenishing Qi and Nourishing Blood,Detoxicating and Resolving Masses

The pathogenesis of malignant tumors is the deficiency of vital Qi and the excess of pathogenic Qi.Its basic treating principle is to strengthen vital Qi to eliminate pathogenic factor.The paper is to summarize the clinical experiences in tumor treatment of Dr.Chen Shizhou,a well-known traditional Chinese medicine expert in Weifang City,Shandong Province.He put forward the treatment method of"replenishing Qi and nourishing blood,detoxicating and resolving masses",paying attention to protecting stomach qi and advocating survival with tumor,with remarkable clinical effects.

舒神汤联合穴位拔罐治疗慢性顽固性失眠50例

目的观察舒神汤联合神门、三阴交穴位拔罐治疗慢性顽固性失眠的临床效果。方法选择100例病程6个月以上的慢性顽固性失眠患者。双盲随机分成治疗组与对照组。对照组行常规治疗,采用安眠类西药;治疗组应用舒神汤,联合神门、三阴交穴位拔罐。两组治疗4周,观察治疗效果。结果治疗组治愈率64.0%(32/50)高于对照组的8.0%(4/50),总有效率100.0%(50/50)高于对照组的66.0%(33/50),差异均有统计学意义(P<0.05)。治疗后,治疗组汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)评分较治疗前明显降低,且治疗组低于对照组,差异有统计学意义(P<0.05);治疗组匹兹堡睡眠质量指数(PSQI)评分较治疗前明显降低,且治疗组低于对照组,差异有统计学意义(P<0.05);治疗组健康状况调查问卷(SF-36)评分较治疗前明显升高,差异有统计学意义(P<0.05),且治疗组高于对照组,差异有统计学意义(P<0.05)。对照组不良反应总发生率为46.0%(23/50),高于治疗组的2.0%(1/50),差异有统计学意义(P<0.05)。结论舒神汤联合神门、三阴交穴位拔罐治疗慢性顽固性失眠安全性高、有显著效果。

基于血浊理论辨治脑病研究进展

脑病种类众多,临床对其辨治面临诸多难题,需要新的诊疗思路。国医大师王新陆教授提出了血浊理论,并将其运用于脑病辨治,认为脑病发病与七情内伤、饮食失节及环境污染等相关,主要病机为浊血伤髓、脑窍失养,并提出清化血浊、益脑填髓的治则,同时强调未病先防、活用援药。目前,在该理论指导下,采用中药内服、针药结合治疗脑病已取得较为显著的疗效,相关机制研究也正在展开。本文梳理血浊相关文献,对基于血浊理论辨治缺血性脑卒中、血管性痴呆、脑小血管病、偏头痛和癫痫等脑病的近况作一综述,以期为中医诊治脑病提供参考。参考文献46篇。

基于络病学说探讨动脉粥样硬化辨治规律

动脉粥样硬化属中医脉络病范畴,发生与发展与络病学说密切相关。基于络病学说,总结本病病机为本虚标实,其中本虚为脏腑功能受损,络虚不荣,标实为痰、瘀、毒互结,络阻不通,络道亢变、络道绌急、络久成积是本病病情进展的重要因素,治疗采用攻补兼施的原则,具体治法有益气养阴荣络、活血化痰通络和平衡阴阳宁络,以使气血充和,阴阳平衡,络脉条达。

秦国政教授运用“益火补土”法治疗小儿隐睾症的经验

小儿隐睾症病机繁杂,迁延难愈,不仅影响患儿成年后的生育能力,还能增加睾丸癌变的发生。中医药基于整体观念、辨证论治两大特点,对治疗该病具有相对优势。秦国政教授立足于中医理论体系,认为小儿隐睾症的病变脏腑在肾与脾,脾肾阳虚为发病病机,提出以“益火补土”为治法,采用还少丹加减治疗小儿隐睾症的效果颇佳。本文总结秦教授治疗小儿隐睾症的临证经验,另附医案1则供阅,以期为临床治疗该病提供新的参考和借鉴。

纳支法配合常规取穴法针刺治疗脾气虚弱型上胞下垂探析

脾气虚弱型上胞下垂的基本病因病机为脾虚中气不足,筋肉失养,睑肌无力。本研究运用子午流注纳支法按时循经选取脾经和胃经腧穴针刺,同时配合选取眼周穴位常规针刺,治疗脾气虚弱型上胞下垂,可发挥健脾胃、补气血、通经络、升清阳、举下陷之功,并列举验案,疗效显著。按时循经取穴法为子午流注纳支法的针灸取穴方法之一,结合常规取穴法针刺,可为治疗脾气虚弱型及其他证型的上胞下垂提供新的思路和方法。

针刺治疗干眼症作用机制研究概述

近年来,有关针刺治疗干眼症的报道日益增多,针刺治疗干眼症的作用机制也逐渐成为研究热点。文章从西医和中医角度总结针刺治疗干眼症的作用机制。从西医角度看,针刺治疗干眼症的作用机制可能与降低炎症反应、抑制信号传导通路、调节激素水平、调节神经功能、促进泪液中黏蛋白表达、抑制泪腺组织中细胞凋亡、增加乳铁蛋白含量等有关;从中医角度看,针刺主要通过疏肝泻火、益肾调肝、滋补肺阴、益气养阴等途径发挥疏通眼部经络、调节眼部气血的作用,从而缓解干眼症的临床症状。参考文献48篇。

扶正补土针灸联合经颅磁刺激治疗脑卒中后手功能障碍临床研究

目的:观察扶正补土针灸联合经颅磁刺激治疗脑卒中后手功能障碍的临床疗效。方法:选取2022年6月—2023年7月濮阳市中医医院收治的82例脑卒中后手功能障碍患者,根据治疗方式不同分为研究组和对照组,各41例。对照组采用经颅磁刺激治疗,研究组在对照组基础上采用扶正补土针灸治疗。2组均治疗4周。比较2组中医证候评分、Fugl-Meyer量表评分、手指总主动活动度、腕背伸肌群及腕掌屈肌群积分肌电值、临床疗效及不良反应。结果:治疗后,研究组总有效率为95.12%(39/41),对照组为80.94%(33/41),2组比较,差异有统计学意义(P<0.05)。治疗后,2组肢体困重、五心烦热、纳差、腹胀、倦乏等中医证候评分均较治疗前下降(P<0.05),且研究组各项评分均低于对照组(P<0.05)。治疗后,2组Fugl-Meyer、手指总主动活动度评分均较治疗前升高(P<0.05),且研究组Fugl-Meyer、手指总主动活动度评分均高于对照组(P<0.05)。治疗后,2组腕背伸肌群及腕掌屈肌群积分肌电值均较治疗前升高(P<0.05),且研究组上述2项指标均高于对照组(P<0.05)。研究组不良反应发生率为9.76%(4/41),对照组为12.20%(5/41),2组比较,差异无统计学意义(P>0.05)。结论:扶正补土针灸联合经颅磁刺激治疗脑卒中后手功能障碍,可提高治疗效率,有效缓解患者临床症状,改善手指功能,提升腕背伸肌群、腕掌屈肌群力量,且不良反应相对较少。

从六经辨证探析腰椎退行性疾病的诊治思路

腰椎退行性疾病(LDD)病机变化大致符合六经传变规律,通过梳理《黄帝内经》《伤寒杂病论》有关腰痹疾病的相关认识,认为LDD初期多以外感邪气为主要病因,病位在太阳,以汗而发之为主;LDD后期,以肾气亏虚为主要病因,病位多在少阴,以虚而补之为要。除太阳、少阴病外,LDD还可累及他经产生合病,根据具体病情大致可分为太阳阳明合病、太阳少阳合病、太阳少阴合病、太阴少阴合病、少阴厥阴合病。治疗方面,病在阳者,多祛邪通络、调和营卫,方用桂枝汤加葛根汤、芍药桂枝知母汤、柴胡桂枝汤等;病在阴者,多温经养血、强筋健骨,方用附子汤、甘姜苓术汤、当归四逆汤等。

Shoreline Change Modeling on Emergency Beach Nourishment Project on West Beach of Beidaihe,China

By use of a shorehne-change numerical model （GENESIS） based on one-line theory, a preliminary modeling study on shoreline changes caused by a beach nourishment project in Beidaihe, China, is presented in this paper. Firstly, the GENESIS model is verified and model sensitivity to the major parameter changes is discussed by simulating a hydraulic model test. The beach nourishment project, after that the shoreline change is kept being monitored, is a small-scale emergency one carried out to use two bathing places on the west beach in the summer, 2008. In this paper the shoreline changes caused by the beach nourishment project are modeled by the GENESIS model, and the computed results fit well with the measured shorelines. With the same model and parameters, a long-term performance of the project is predicted, and the result shows that the bathing places only can be suitable for bathing in 2 to 3 years without subsequence nourishment project. Therefore, it is proposed to nourish the beaches in time to keep the service life of the beach in recent years and carry out the beach nourishment project for the whole west beach as soon as possible.

温阳益髓方联合富血小板血浆治疗早中期膝骨关节炎的疗效及对血清S100B、CTX-Ⅱ水平的影响

目的 分析温阳益髓方联合富血小板血浆(PRP)治疗早中期膝骨关节炎(KOA)的疗效及对血清S100B、Ⅱ型胶原C端肽(CTX-Ⅱ)水平的影响。方法 选取2021年4月至2023年1月该院收治的150例早中期KOA患者作为研究对象,根据随机数字表法将其分为观察组和对照组,各75例。对照组给予PRP治疗,观察组在对照组基础上联合温阳益髓方治疗。对比两组临床疗效、不良反应总发生率、复发率,治疗前、治疗1个月后Lysholm膝关节功能量表(LKS)评分,血清S100B、CTX-Ⅱ水平,以及治疗前、治疗1周、1个月后视觉模拟评分法(VAS)评分。结果 观察组总有效率高于对照组,复发率低于对照组,差异均有统计学意义(P<0.05)。治疗1个月后两组LKS评分高于治疗前,且观察组LKS评分高于对照组,差异均有统计学意义(P<0.05)。重复测量方差分析显示,两组治疗期间VAS评分变化有交互效应(F=20.132,P=0.030),故进一步做单独交应分析,对照组和观察组治疗1周、1个月后的VAS评分均低于治疗前,且治疗1个月后的VAS评分低于治疗1周后,差异均有统计学意义(P<0.05)。多变量方差分析结果显示,治疗1周、1个月后观察组VAS评分低于对照组,差异均有统计学意义(P<0.05)。治疗1个月后两组血清S100B、CTX-Ⅱ水平低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 温阳益髓方联合PRP治疗早中期KOA患者的临床效果显著,可有效缓解疼痛症状,改善血清S100B、CTX-Ⅱ水平,促进膝关节功能康复,降低疾病复发率,值得临床推广。