Structural and Biological Insights into the Hot-Spot Marine Natural Products Reported from 2012 to 2021

Comprehensive Summary The vast marine ecosystem contains a sea of natural products,which are potential model molecules for new drug development.With more than one thousand new structures been discovered each year,the past decade has become the golden time for marine natural product discovery,leading to a valuable but extra-large chemical database.Serving as an epitome of the most promising compounds,which take the ultra-new skeletons and/or excellent bioactivities,this review covers 243 hot-spot marine natural products reported from 2012 to 2021,to abstract some important chemical and/or biological inspirations for marine natural product study and marine drug development in the future.In addition,some general rules regarding to the source organism,structure-specialty,organism-structure specificity,and organism-bioactivity relationship of these outstanding compounds will also be presented.

High-Temperature and Low-Frequency Acoustic Energy Absorption by a Novel Porous Metamaterial Structure

In this paper,we propose a novel porous metamaterial structure with an improved acoustic energy absorption performance at high-temperature and in the low-frequency range.In the proposed novel porous metamaterial structure,a porous material matrix containing periodically perforated cylindrical holes arranged in a triangular lattice pattern is applied,and additional interlayers of another porous material are introduced around these perforations.The theoretical model is established by adopting the double porosity theory for the interlayer and the cylindrical hole which form an equivalent inclusion and then applying the homogenization method to the porous metamaterial structure formed by the equivalent inclusion and the porous matrix.The temperature-dependent air and material parameters are considered in the extended theoretical model,which is validated by the finite element results obtained by COMSOL Multiphysics.The acoustic or sound energy absorption performance can be improved remarkably at very low frequencies and high temperature.Furthermore,the underlying acoustic energy absorption mechanism inside the unit-cell is investigated by analyzing the distribution of the time-averaged acoustic power dissipation density and the energy dissipation ratio of each constituent porous material.The results reveal that regardless of the temperature,the acoustic energy is mostly dissipated in the porous material with a lower airflow resistivity,while the acoustic energy dissipated in the porous material with a higher airflow resistivity also becomes considerable in the high-frequency range.The novel porous metamaterial structure proposed in this paper can be efficiently utilized to improve the acoustic energy absorption performance at high temperature.

Crystal structure of full-length human glucagon receptor reveals novel receptor activation mechanisms

Subject Code:C05With the support by the National Natural Science Foundation of China,a team of scientists let by Profs.Wu Beili(吴蓓丽),Wang Mingwei and Jiang Hualiang from Shanghai Institute of Materia Medica,Chinese Academy of Sciences has determined the high-resolution atomic structure of a full-length class B

Hierarchical coupling effect in hollow Ni/NiFe2O4-CNTs microsphere via spray-drying for enhanced oxygen evolution electrocatalysis

Design and fabrication of cost-effective transition metal and their oxides-based nanocomposites are of paramount significance for metal-air batteries and water-splitting.However,the traditional optimized designs for nanostructure are complicated,low-efficient and underperform for wide-scale applications.Herein,a novel hierarchical framework of hollow Ni/NiFe2O4-CNTs compositemicrosphere forcibly-assembled by zero-dimensional(OD)Ni/NiFo204 nanoparticle(<16 nm)and one-dimensional(1D)self-supporting CNTs was fabricated successfully.Benefitted from the unique nanostructure,such monohybrids can achieve remarkable oxygen evolution reaction(OER)performance in alkaline media with a low overpotential and superior durability,which exceeds most of the commercial catalysts based on IrO/RuO2 or other non-noble metal nanomaterials.The enhanced OER performance of Ni/NiFe2OA-CNTs composite is mainly ascribed to the increased catalytic activity and the optimized conductivity induced by the effects of strong hierarchical coupling and charge transfers between CNTs and Ni/NiFe204 nanoparticles.These effects are greatly boosted by the polarized heterojunction interfaces confirmed by electron holography.The density functional theory(DFT)calculation indicates the epitaxial Ni further enriches the intrinsic electrons contents of NiFe204 and thus accelerates absorption/desorption kinetics of OER intermediates.This work hereby paves a facile route to construct the hollow composite microsphere with excellent OER electrocatalytic activity based on non-noble metal oxide/CNTs.