Treatment of denudatine 1 with 10% HCl soln. at 45-50℃ for 3 days leads to a pair of epimers 4A and 4B, Structures of 4A and 4B have been elucidated on the basis of chemical and spectral methods.
Enantiomerically pure a-substituted bamino esters were prepared from natural L-a-amino acids through Arndt-Eistert homologation and diastereoselective aalkylation.
文摘Treatment of denudatine 1 with 10% HCl soln. at 45-50℃ for 3 days leads to a pair of epimers 4A and 4B, Structures of 4A and 4B have been elucidated on the basis of chemical and spectral methods.
基金The project is generously supported by the National Natural Science Foundation of China (Grant No. 29972002 20172002)+1 种基金 the Trans-Century Training Programme Foundation for the Talents by Ministry of Education and Bayer Co. Ltd (Germany). We thank Dr
文摘Enantiomerically pure a-substituted bamino esters were prepared from natural L-a-amino acids through Arndt-Eistert homologation and diastereoselective aalkylation.