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A novel method for simulating nuclear explosion with chemical explosion to form an approximate plane wave: Field test and numerical simulation 被引量:1
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作者 Wei Ming Xiaojie Yang +3 位作者 Yadong Mao Xiang Wang Manchao He Zhigang Tao 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第6期2137-2153,共17页
A nuclear explosion in the rock mass medium can produce strong shock waves,seismic shocks,and other destructive effects,which can cause extreme damage to the underground protection infrastructures.With the increase in... A nuclear explosion in the rock mass medium can produce strong shock waves,seismic shocks,and other destructive effects,which can cause extreme damage to the underground protection infrastructures.With the increase in nuclear explosion power,underground protection engineering enabled by explosion-proof impact theory and technology ushered in a new challenge.This paper proposes to simulate nuclear explosion tests with on-site chemical explosion tests in the form of multi-hole explosions.First,the mechanism of using multi-hole simultaneous blasting to simulate a nuclear explosion to generate approximate plane waves was analyzed.The plane pressure curve at the vault of the underground protective tunnel under the action of the multi-hole simultaneous blasting was then obtained using the impact test in the rock mass at the site.According to the peak pressure at the vault plane,it was divided into three regions:the stress superposition region,the superposition region after surface reflection,and the approximate plane stress wave zone.A numerical simulation approach was developed using PFC and FLAC to study the peak particle velocity in the surrounding rock of the underground protective cave under the action of multi-hole blasting.The time-history curves of pressure and peak pressure partition obtained by the on-site multi-hole simultaneous blasting test and numerical simulation were compared and analyzed,to verify the correctness and rationality of the formation of an approximate plane wave in the simulated nuclear explosion.This comparison and analysis also provided a theoretical foundation and some research ideas for the ensuing study on the impact of a nuclear explosion. 展开更多
关键词 Approximate plane wave Multi-hole simultaneous blasting chemical explosion nuclear explosion Pressure sensor inclusion
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Emergency response to nuclear, biological and chemical incidents: challenges and countermeasures 被引量:3
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作者 Hai-Long Li +9 位作者 Wen-Jun Tang Ya-Kun Ma Ji-Min Jia Rong-Li Dang Er-Chen Qiu 《Journal of Medical Colleges of PLA(China)》 CAS 2015年第1期18-20,共3页
Given the multiple terrorist attacks that have occurred in recent years in China, medical rescue teams and specialized incident assessment teams have been established by the government; however, medical rescue after n... Given the multiple terrorist attacks that have occurred in recent years in China, medical rescue teams and specialized incident assessment teams have been established by the government; however, medical rescue after nuclear, biological, and chemical incidents remains challenging and is often inefficient. In the present article, problems were analyzed regarding the assessment of responder countermeasures, training of professionals and the management of emergency medical incidents related to nuclear, biological and chemical attacks. Countermeasures, the establishment of response coordination, public education, practical training and exercise, and a professional consultant team or system should be the focus of emergency medical response facilities. Moreover, the government was offered professionals who are involved in managing nuclear, biological and chemical incidents. 展开更多
关键词 MEDICAL RESCUE nuclear biological and chemical incidents
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Protection of Environment from Damaged Nuclear Station and Transparent Inflatable Blanket for Cities—Protection from Radioactive Dust and Chemical, Biological Weapons 被引量:1
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作者 Alexander Bolonkin 《Journal of Environmental Protection》 2011年第4期327-341,共15页
The author, in a series of previous articles, designed the “AB Dome” made of transparent thin film supported by a small additional air overpressure for the purpose of covering a city or other important large install... The author, in a series of previous articles, designed the “AB Dome” made of transparent thin film supported by a small additional air overpressure for the purpose of covering a city or other important large installations or sub-regions. In present article the author offers a variation in which a damaged nuclear station can be quickly covered by such a cheap inflatable dome. By containing the radioactive dust from the damaged nuclear station, the danger zone is reduced to about 2 km2 rather than large regions which requires the resettlement of huge masses of people and which stops indus-try in large areas. If there is a big city (as Tokyo) near the nuclear disaster or there is already a dangerous amount of radioactive dust near a city, the city may also be covered by a large inflatable transparent Dome. The building of a gi-gantic inflatable AB Dome over an empty flat surface is not difficult. The cover is spread on a flat surface and a venti-lator (fan system) pumps air under the film cover and lifts the new dome into place but inflation takes many hours. However, to cover a city, garden, forest or other obstacle course in contrast to an empty, mowed field, the thin film cannot be easily deployed over building or trees without risking damage to it by snagging and other complications. This article proposes a new method which solves this problem. The design is a double film blanket filled by light gas such as, methane, hydrogen, or helium - although of these, methane will be the most practical and least likely to leak. Sections of this AB Blanket are lighter than air and will rise in the atmosphere. They can be made on a flat area serving as an as-sembly area and delivered by dirigible or helicopter to station at altitude over the city. Here they connect to the already assembled AB Blanket subassemblies, cover the city in an AB Dome and protect it from bad weather, chemical, bio-logical and radioactive fallout or particulates. After assembly of the dome is completed, the light gas can be replaced by (heavier but cheaper) air. Two projects for Tokyo (Japan) and Moscow (Russia) are used in this paper for sample computation. 展开更多
关键词 Radiation Shield PROTECTION Of Environment From Damaged nuclear STATION Dome For City BLANKET For City PROTECTION Of CITIES From chemical biological and RADIOACTIVE Weapons Encapsulating nuclear Sites
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Chemical and biological flocculation process to treat municipal sewage and analysis of biological function 被引量:6
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作者 XIASi-qing YANGDian-hai XUBin ZHAOJian-fu 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2005年第1期163-167,共5页
The pilot scale experimental apparatus and the procedure of the chemical and biological flocculation process to verify the feasibility in treating Shanghai municipal sewage were introduced in this paper. In addition, ... The pilot scale experimental apparatus and the procedure of the chemical and biological flocculation process to verify the feasibility in treating Shanghai municipal sewage were introduced in this paper. In addition, the biological function of the process was discussed. The results of optimal running showed that in the reaction tank, the concentration of mixed liquor suspended solid(MLSS) was 2 g/L, hydraulic retention time(HRT) was 35 min, dosage of liquid polyaluminium chloride(PAC) was 60 mg/L, and the concentration of polyacrylamide(PAM) was 0 5 mg/L. The effluent average concentrations of COD Cr , TP, SS and BOD 5 were 50 mg/L, 0 62 mg/L, 18 mg/L, and 17 mg/L, respectively. These were better than the designed demand. In addition, the existence of biological degradation in this system was proven by several methods. The removal efficiencies of the chemical and biological flocculation process were 20% higher than that of the chemical flocculation process above at the same coagulant dosage. The treatment process under different situations was evaluated on a pilot scale experiment, and the results provided magnificent parameters and optimal condition for future operation of the plant. 展开更多
关键词 chemical and biological flocculation process municipal water biological function
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Study of Chemical Etching and Chemo-Mechanical Polishing on CdZnTe Nuclear Detectors 被引量:1
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作者 Aaron L. Adams Stephen U. Egarievwe +4 位作者 Ezekiel O. Agbalagba Rubi Gul Anwar Hossain Utpal N. Roy Ralph B. James 《Journal of Materials Science and Chemical Engineering》 2019年第8期33-41,共9页
Cadmium zinc telluride (CdZnTe) semiconductor has applications in the detection of X-rays and gamma-rays at room temperature without having to use a cooling system. Chemical etching and chemo-mechanical polishing are ... Cadmium zinc telluride (CdZnTe) semiconductor has applications in the detection of X-rays and gamma-rays at room temperature without having to use a cooling system. Chemical etching and chemo-mechanical polishing are processes used to smoothen CdZnTe wafer during detector device fabrication. These processes reduce surface damages left after polishing the wafers. In this paper, we compare the effects of etching and chemo-mechanical polishing on CdZnTe nuclear detectors, using a solution of hydrogen bromide in hydrogen peroxide and ethylene glycol mixture. X-ray photoelectron spectroscopy (XPS) was used to monitor TeO2 on the wafer surfaces. Current-voltage and detector-response measurements were made to study the electrical properties and energy resolution. XPS results showed that the chemical etching process resulted in the formation of more TeO2 on the detector surfaces compared to chemo-mechanical polishing. The electrical resistivity of the detector is of the order of 1010 &#937;-cm. The chemo-mechanical polishing process increased the leakage current more that chemical etching. For freshly treated surfaces, the etching process is more detrimental to the energy resolution compared to chemo-mechanically polishing. 展开更多
关键词 CDZNTE chemical ETCHING Chemo-Mechanical POLISHING Gamma RAYS nuclear Detectors X-Ray PHOTOELECTRON Spectroscopy
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Biological effect of expression of exogenous human nuclear receptor hLRH-1 in SW480 cells and its molecular mechanism 被引量:1
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作者 Shuiliang Wang Yingmeng Zheng Fenghua Lan 《The Chinese-German Journal of Clinical Oncology》 CAS 2007年第3期228-231,共4页
Objective: To explore the possible biological function of human nuclear receptor hLRH-1 in tumorigenesis and progress of colon cancer. Methods: Plasmids pcDNA3-hLRH-1 were introduced into SW480 cells via lipofectami... Objective: To explore the possible biological function of human nuclear receptor hLRH-1 in tumorigenesis and progress of colon cancer. Methods: Plasmids pcDNA3-hLRH-1 were introduced into SW480 cells via lipofectamine. The expression of mRNA and protein of exogenous hLRH-1 were detected by RT-PCR and western blotting, respectively. MTT assay was carried out to survey the proliferation of SW480 cells with overexpression of hLRH-1. Meanwhile, the expression of proliferation-related genes cyclin E1 and cyclin D1, and apoptosis-related genes PTEN and Rbl, were analyzed by realtime RT-PCR. Results: The proliferation of SW480 cells was promoted under the condition of overexpression of hLRH-1. The expression of cyclin E1 was up-regulated significantly, while that of PTEN and Rbl were down-regulated in SW480 cells with overexpressed hLRH-1. Conclusion: The expression of exogenous hLRH-1 in SW480 cells induced the proliferation resulting form up-regulation of cyclin E1, as well as participated in the regulation of apoptosis via influencing the expression of PTEN and Rb1. 展开更多
关键词 nuclear receptor hLRH-1 colon cancer expression of exogenous gene biological effect
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Explanation of Cold Nuclear Fusion and Biotransmutations
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作者 Auguste Meessen 《Journal of Modern Physics》 2023年第7期1087-1116,共30页
Low energy nuclear reactions are possible in condensed matter because of image forces. They result from induced charges at the surface of metals or very polarizable media. The height and width of the Coulomb barrier i... Low energy nuclear reactions are possible in condensed matter because of image forces. They result from induced charges at the surface of metals or very polarizable media. The height and width of the Coulomb barrier in free space can thus be reduced. Nuclear fusion requires also the formation of a compound nucleus in one of its excited states, but two deuterons yield an α particle that has 2 excited states. They are respectively accessible at high or low energies. Since the reduction of the Coulomb barrier depends on the local curvature of the interface, cold fusion becomes autocatalytic, but heat production is controllable. Even microbes, plants and animals can produce transmutations. They are also due to image forces. This solves a basic problem in nuclear physics and there are possible applications: facilitated synthesis of superheavy elements and development of a new type of energy sources. They are moderate, but safe. 展开更多
关键词 Cold Fusion nuclear Reactions biological Transmutations Coulomb Barrier Image Force Superheavy Elements New Energy Source
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Computer Handling of Chemical and Biological Data of Traditional Chinese Medicines 被引量:1
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作者 CHE Chun-tao Paul R.Carlierand Ophelia C.W.Lee 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 1997年第2期77-81,共5页
A specialty database has been established at The Hong Kong University of Science and Technology to handle the chemical and biological data of medicinal plants and other natural products from scientific literatures. De... A specialty database has been established at The Hong Kong University of Science and Technology to handle the chemical and biological data of medicinal plants and other natural products from scientific literatures. Designed as a relational system capable of analyzing, comparing, and correlating data, the system can retrieve information in assimilated tabular formats. The database can provide information supports to researchers in the fields of medicinal chemistry, biochemistry, pharmacology, botany and other disciplines of natural products research. 展开更多
关键词 Computer handling chemical data biological data Traditional Chinese medicine
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Physico-Chemical and Biological Characteristics of the Nklobisson Artificial Lake in Yaounde, Cameroon
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作者 Josephine Ndjama Gideon Aghaindum Ajeagah +7 位作者 Ndondo Gustave Raoul Nkoue Wirmvem Mengnjo Jude Ngon Eric Belmond Birama Gloria Eneke Takem Eyong Andrew Ako Ako Mohamadou Bello Tchouya Romaric Victorien Ntchantcho Joseph Victor Hell 《Journal of Water Resource and Protection》 2017年第12期1547-1563,共17页
The deterioration of water quality in lakes constitutes an environmental problem faced by humanity. The Nkolbisson artificial lake which is located downstream of the Abiergue and Mintotomo streams in Yaounde is under ... The deterioration of water quality in lakes constitutes an environmental problem faced by humanity. The Nkolbisson artificial lake which is located downstream of the Abiergue and Mintotomo streams in Yaounde is under the influence of various forms of pollution, mostly resulting from human activities. There is proliferation of algae on the lake surface that consumes the available oxygen in the lake. The main objective of the current study is to evaluate the different forms of pollutants in the lake, in order to propose efficient solutions for a suitable management strategy, basing on the physico-chemical and biological analysis. The lake retains an average of 2535.49 tons/year of suspended solids in the rainy season and 1438.05 tons/year in the dry season. The range of dissolved oxygen (5.2 - 3.8 mg/l);pH (7.8 - 6.8);temperature (23.9°C - 23.1°C);electrical conductivity (266.1 - 87.3 μS/cm);turbidity (22.3 - 10 UNT);suspended solid (240 - 40 mg/l);BOD (55 - 8 mg/l);COD (76 - 87.3 mg/l). Biologically, faecal coliforms fluctuates between (42 × 102 - 425 × 103 FCU/100 ml), faecal streptococci (8 × 103 - 158 × 103 FCU/100 ml) and total Coliform (15 × 103 - 78 × 106 FCU/100 ml) evidence that, the studied lake is highly polluted. Consequently the lake retains an average of 2888.7 tons/year of suspended matter. 展开更多
关键词 biological PHYSICO-chemical POLLUTION Artificial LAKE Cameroon
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Does nuclear energy reduce carbon emissions despite using fuels and chemicals?Transition to clean energy and finance for green solutions
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作者 Muhammad Imran Khalid Zaman +3 位作者 Abdelmohsen A.Nassani Gheorghița Dinca˘ Haroon ur Rashid Khan Mohamed Haffar 《Geoscience Frontiers》 SCIE CAS CSCD 2024年第4期359-371,共13页
Green power conversion is the shift away from traditional fuels towards clean energy sources such as nuclear power plants,hydroelectric dams,wind farms,and solar panels.This research examines the impact of clean energ... Green power conversion is the shift away from traditional fuels towards clean energy sources such as nuclear power plants,hydroelectric dams,wind farms,and solar panels.This research examines the impact of clean energy demand and green financing on reducing carbon emissions in 29 economies in Europe and Asia from 2007 to 2020.The study used a two-step differenced GMM estimator for the available data set spanning 2007 to 2020.The study found that rising demand for nuclear power helps to achieve a carbon-neutral agenda,but insufficient funding for renewable energy leads to higher carbon emissions.The research suggests increasing investment in nuclear energy and green financing can improve regional environmental quality.The study found a causal link between fuel imports,nuclear power and regional growth.It also determined that fuel imports,chemical use,green financing and the need for nuclear energy will likely impact regional environmental quality.The research recommends allocating more resources toward innovation to boost energy efficiency and expanding investment in renewable and nuclear energy production industries via green finance.The study also highlights the need to encourage the development of renewable energy sources to cut carbon emissions and establish a sustainable society. 展开更多
关键词 nuclear energy Renewable energy Green financing Fuel imports chemical use Differenced GMM estimator
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Research and applications of nuclear tracks: Developments in Pakistan and global comparison 被引量:1
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作者 Mukhtar Ahmed Rana 《Natural Science》 2012年第11期950-967,共18页
The present paper describes the development and applications of nuclear track detection technique in Pakistan. Pakistan entered in the field of nuclear tracks in early 1970s when it was still quite new. Highlights of ... The present paper describes the development and applications of nuclear track detection technique in Pakistan. Pakistan entered in the field of nuclear tracks in early 1970s when it was still quite new. Highlights of successes of different Pakistani laboratories, working on nuclear tracks, achieved on their own or in collaboration with similar centers in the world are described briefly. The robust features of this investigation are the comprehensive investigation of the addressed research, analysis and review of results, and discussions with the perspectives of applications and new research directions. Further analysis of the published results by the present author and some new results are also presented. This paper portrays a comprehensive picture of the nuclear track detection research and technology in Pakistan and can be useful for a similar development in any country around the globe. 展开更多
关键词 nuclear TRACKS LATENT TRACKS ANNEALING chemical ETCHING Radionuclides NANOTECHNOLOGY Formatting
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Analysis of Te and TeO<sub>2</sub>on CdZnTe Nuclear Detectors Treated with Hydrogen Bromide and Ammonium-Based Solutions
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作者 Mebougna L. Drabo Stephen U. Egarievwe +3 位作者 Ifechukwude O. Okwechime Dominique E. Jones Anwar Hossain Ralph B. James 《Journal of Materials Science and Chemical Engineering》 2017年第4期9-18,共10页
Surface defects caused during cutting and polishing in the fabrication of cadmium zinc telluride (CdZnTe) nuclear detectors limit their spectral performance. Chemical treatments are often used to remove surface damage... Surface defects caused during cutting and polishing in the fabrication of cadmium zinc telluride (CdZnTe) nuclear detectors limit their spectral performance. Chemical treatments are often used to remove surface damages and defects. In this paper, we present the analysis of Te and TeO2 species on the surfaces of CdZnTe nuclear detectors treated with hydrogen bromide and ammonium-based solutions. The CdZnTe wafers were chemo-mechanically polished in a mixture of hydrogen bromide in hydrogen peroxide and ethylene glycol, followed by a chemical passivation in a mixture of ammonium fluoride and hydrogen peroxide solution. X-ray photoelectron spectroscopy showed significant conversion of Te to TeO2, thus producing a more chemically stable surface. The resistivity of the CdZnTe samples is in the order of 1010 ohms-cm. The current for a given applied voltage increased following the passivation and decreased after a 3-hour period. Results from spectral response measurements showed that the 59.5-keV gamma-peak of Am-241 was stable under the same channel for the surface treatment processes. 展开更多
关键词 CDZNTE chemical Treatment nuclear Detectors Surface PASSIVATION XPS
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Research on Monitoring and Earlywarning System of Marine Organisms for the Intake of Nuclear PowerPlants
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作者 lu hairong meng yahui +1 位作者 zhang xiaochen duan yongbo 《Animal Husbandry and Feed Science》 CAS 2018年第4期236-240,共5页
An monitoring and earlywarning system is proposed for marine organisms and the cause of water intake blockage is analyzed. Based onthe intelligent sensing technology, computer software and hardware technology and digi... An monitoring and earlywarning system is proposed for marine organisms and the cause of water intake blockage is analyzed. Based onthe intelligent sensing technology, computer software and hardware technology and digital signal processing technology, the buoy monitoring platformsystem is developed by internet of things technology, cloud computing and the application of large data. Remote realtime monitoring of aquatic organisms and foreign bodies is realized based on underwater acoustic detection and low light imaging technology. Data processing center is established to store, analyze and process monitoring information and display it in real time, and provide emergency decision support. Through development and test of relevant key equipments, the reliability of cold source system of nuclear power plants is improved, which effectively reduces theinfluence of marine biological invasion on security and economic operation of the units. 展开更多
关键词 Water intake of nuclear power plants Marine biological invasion Monitoring and early warning
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High-Level Nuclear Wastes and the Environment: Analyses of Challenges and Engineering Strategies
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作者 Mukhtar Ahmed Rana 《World Journal of Nuclear Science and Technology》 2012年第3期89-105,共17页
The main objective of this paper is to analyze the current status of high-level nuclear waste disposal along with presentation of practical perspectives about the environmental issues involved. Present disposal design... The main objective of this paper is to analyze the current status of high-level nuclear waste disposal along with presentation of practical perspectives about the environmental issues involved. Present disposal designs and concepts are analyzed on a scientific basis and modifications to existing designs are proposed from the perspective of environmental safety. A new concept of a chemical heat sink is introduced for the removal of heat emitted due to radioactive decay in the spent nuclear fuel or high-level radioactive waste, and thermal spikes produced by radiation in containment materials. Mainly, UO2 and metallic U are used as fuels in nuclear reactors. Spent nuclear fuel contains fission products and transuranium elements which would remain radioactive for 104 to 108years. Essential concepts and engineering strategies for spent nuclear fuel disposal are described. Conceptual designs are described and discussed considering the long-term radiation and thermal activity of spent nuclear fuel. Notions of physical and chemical barriers to contain nuclear waste are highlighted. A timeframe for nuclear waste disposal is proposed and time-line nuclear waste disposal plan or policy is described and discussed. 展开更多
关键词 HIGH-LEVEL nuclear WASTE nuclear WASTE CONTAINMENT and Disposal Environment Conceptual Model Designs RADIOACTIVITY Damage chemical Heat SINK
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Nuclear Planetology:Especially Concerning the Moon and Mars
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作者 Kyeong Ja Kim Nobuyuki Hasebe 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2012年第10期1313-1380,共68页
To approach basic scientific questions on the origin and evolution of plan- etary bodies such as planets, their satellites and asteroids, one needs data on their chemical composition. The measurements of gamma-rays, X... To approach basic scientific questions on the origin and evolution of plan- etary bodies such as planets, their satellites and asteroids, one needs data on their chemical composition. The measurements of gamma-rays, X-rays and neutrons emit- ted from their surface materials provide information on abundances of major elements and naturally radioactive gamma-ray emitters. Neutron spectroscopy can provide sen- sitive maps of hydrogen- and carbon-containing compounds, even if buried, and can uniquely identify layers of carbon-dioxide frost. Nuclear spectroscopy, as a means of compositional analysis, has been applied via orbital and lander spacecraft to extrater- restrial planetary bodies: the Moon, Venus, Mars, Mercury and asteroids. The knowl- edge of their chemical abundances, especially concerning the Moon and Mars, has greatly increased in recent years. This paper describes the principle of nuclear spec- troscopy, nuclear planetary instruments carried on planetary missions so far, and the nature of observational results and findings of the Moon and Mars, recently obtained by nuclear spectroscopy. 展开更多
关键词 nuclear planetology: planetary remote sensing -- elemental mapping --nuclear science payloads -- chemical abundance
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Characterization of CdZnTeSe Nuclear Detector Chemically Etched in Bromine Methanol
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作者 Ezekiel O. Agbalagba Mebougna L. Drabo +5 位作者 Stephen U. Egarievwe Utpal N. Roy Amir H. Davis Mordecai B. Israel Parion L. Alexander Ralph B. James 《Materials Sciences and Applications》 2021年第8期363-373,共11页
Semiconductor nuclear radiation detectors made from tertiary and quaternary compounds of cadmium telluride (CdTe) can operate at room temperature without cryogenic cooling. One of such materials that have become of gr... Semiconductor nuclear radiation detectors made from tertiary and quaternary compounds of cadmium telluride (CdTe) can operate at room temperature without cryogenic cooling. One of such materials that have become of great interest is cadmium zinc telluride selenide (CdZnTeSe). Compared to other CdTe-based materials, such as cadmium zinc telluride (CdZnTe), CdZnTeSe can be grown with much less Te inclusions and sub-grain boundary networks. Chemical etching is often used to smoothen wafer surfaces during detector fabrication. This paper presents the characterization of CdZnTeSe that is chemically etched using bromine methanol solution. Infrared imaging shows that the wafer has no sub-grain boundary networks that often limit detector performance. The current-voltage (I-V) characterization experiment gave a resistivity of 4.6 × 10<sup>10</sup> Ω-cm for the sample. The I-V curve was linear in the ±10 to ±50 volts range. An energy resolution of 7.2% was recorded at 100 V for the 59.6-keV gamma line of <sup>241</sup>Am. 展开更多
关键词 CdZnTeSe chemical Etching Energy Resolution Gamma-Ray Spectroscopy Infrared Imaging nuclear Detectors
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Chemical composition and biological activity of Houttuynia cordata
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作者 Yibo Wang Yunpeng Yang +3 位作者 Xinyao Wang Wenhan Wang Luming Pan Yu Chen 《Asian Journal of Traditional Medicines》 2024年第4期223-234,共12页
Houttuynia cordata is an important traditional Chinese medicine.It is widely used for clearing heat and detoxification,reducing swelling and treating sores,diuresis and dehumidification.It is also used to treat lung c... Houttuynia cordata is an important traditional Chinese medicine.It is widely used for clearing heat and detoxification,reducing swelling and treating sores,diuresis and dehumidification.It is also used to treat lung carbuncles,ulcers,hemorrhoids,rectal bleeding,spleen and stomach heat,which are caused by excess heat,heat toxicity,dampness,and disease heat.Modern pharmacological experiments have shown that H.cordata has antibacterial,antiviral,immune enhancing,diuretic and other effects.This article reviews the chemical components and biological activities of H.cordata to provide reference for clinical application. 展开更多
关键词 Houttuynia cordata chemical composition biological activity
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Proliferating cell nuclear antigen clamp associated factor,a potential proto-oncogene with increased expression in malignant gastrointestinal tumors 被引量:1
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作者 Li-Juan Liu Jian-Ming Liao Fan Zhu 《World Journal of Gastrointestinal Oncology》 SCIE 2021年第10期1425-1439,共15页
Gastrointestinal(GI)cancers,including malignancies in the gastrointestinal tract and accessory organs of digestion,represent the leading cause of death worldwide due to the poor prognosis of most GI cancers.An investi... Gastrointestinal(GI)cancers,including malignancies in the gastrointestinal tract and accessory organs of digestion,represent the leading cause of death worldwide due to the poor prognosis of most GI cancers.An investigation into the potential molecular targets of prediction,diagnosis,prognosis,and therapy in GI cancers is urgently required.Proliferating cell nuclear antigen(PCNA)clamp associated factor(PCLAF),which plays an essential role in cell proliferation,apoptosis,and cell cycle regulation by binding to PCNA,is a potential molecular target of GI cancers as it contributes to a series of malignant properties,including tumorigenesis,epithelial-mesenchymal transition,migration,and invasion.Furthermore,PCLAF is an underlying plasma prediction target in colorectal cancer and liver cancer.In addition to GI cancers,PCLAF is also involved in other types of cancers and autoimmune diseases.Several pivotal pathways,including the Rb/E2F pathway,NF-κB pathway,and p53-p21 cascade,are implicated in PCLAF-mediated diseases.PCLAF also contributes to some diseases through dysregulation of the p53 pathway,WNT signal pathway,MEK/ERK pathway,and PI3K/AKT/mTOR signal cascade.This review mainly describes in detail the role of PCLAF in physiological status and GI cancers.The signaling pathways involved in PCLAF are also summarized.Suppression of the interaction of PCLAF/PCNA or the expression of PCLAF might be potential biological therapeutic strategies for GI cancers. 展开更多
关键词 Proliferating cell nuclear antigen Proliferating cell nuclear antigen clamp associated factor Transcript variant Gastrointestinal cancers Signal pathway biological therapeutic
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Nuclear geyser model of the origin of life:Driving force to promote the synthesis of building blocks of life 被引量:2
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作者 Toshikazu Ebisuzaki Shigenori Maruyama 《Geoscience Frontiers》 SCIE CAS CSCD 2017年第2期275-298,共24页
We propose the nuclear geyser model to elucidate an optimal site to bear the first life.Our model overcomes the difficulties that previously proposed models have encountered.Nuclear geyser is a geyser driven by a natu... We propose the nuclear geyser model to elucidate an optimal site to bear the first life.Our model overcomes the difficulties that previously proposed models have encountered.Nuclear geyser is a geyser driven by a natural nuclear reactor,which was likely common in the Hadean Earth,because of a much higher abundance of 235U as nuclear fuel.The nuclear geyser supplies the following:(1)high-density ionizing radiation to promote chemical chain reactions that even tar can be used for intermediate material to restart chemical reactions,(2)a system to maintain the circulation of material and energy,which includes cyclic environmental conditions(warm/cool,dry/wet,etc.)to enable to produce complex organic compounds,(3)a lower temperature than 100℃ as not to break down macromolecular organic compounds,(4)a locally reductive environment depending on rock types exposed along the geyser wall,and(5)a container to confine and accumulate volatile chemicals.These five factors are the necessary conditions that the birth place of life must satisfy.Only the nuclear geyser can meet all five,in contrast to the previously proposed birth sites,such as tidal flat,submarine hydrothermal vent,and outer space.The nuclear reactor and associated geyser,which maintain the circulations of material and energy with its surrounding environment,are regarded as the nuclear geyser system that enables numerous kinds of chemical reactions to synthesize complex organic compounds,and where the most primitive metabolism could be generated. 展开更多
关键词 Origin of life chemical evolution Natural nuclear reactor Aqueous electron Radiation chemistry
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Chemical compositions and biological activities of Flos lonicerae 被引量:1
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作者 Yi’an Shi Luming Pan +3 位作者 Luyan Yang Jing Sun Meng Zhang Yu Chen 《Asian Journal of Traditional Medicines》 CAS 2023年第2期60-68,共9页
Flos lonicerae is the dry flower bud of Lonicera japonica Thunb,and it is a very important Chinese herbal medicine in China.In ancient times,it was widely used to treat the exopathogenic wind-heat,epidemic febrile dis... Flos lonicerae is the dry flower bud of Lonicera japonica Thunb,and it is a very important Chinese herbal medicine in China.In ancient times,it was widely used to treat the exopathogenic wind-heat,epidemic febrile diseases,sores,carbuncles and some infectious diseases.Modern pharmacological research has indicated that it has anti-inflammatory,anti-bacterial,anti-viral and anti-oxidation activities.This paper reviews the chemical compositions and biological activities of Flos lonicerae in order to provide reference for its application in clinical practice in the future. 展开更多
关键词 Flos lonicerae chemical composition biological activity
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