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Damage evolution of rock-encased-backfill structure under stepwise cyclic triaxial loading 被引量:1
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作者 Xin Yu Yuye Tan +4 位作者 Weidong Song John Kemeny Shengwen Qi Bowen Zheng Songfeng Guo 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第2期597-615,共19页
Rock-encased-backfill(RB)structures are common in underground mining,for example in the cut-andfill and stoping methods.To understand the effects of cyclic excavation and blasting activities on the damage of these RB ... Rock-encased-backfill(RB)structures are common in underground mining,for example in the cut-andfill and stoping methods.To understand the effects of cyclic excavation and blasting activities on the damage of these RB structures,a series of triaxial stepwise-increasing-amplitude cyclic loading experiments was conducted with cylindrical RB specimens(rock on outside,backfill on inside)with different volume fractions of rock(VF=0.48,0.61,0.73,and 0.84),confining pressures(0,6,9,and 12 MPa),and cyclic loading rates(200,300,400,and 500 N/s).The damage evolution and meso-crack formation during the cyclic tests were analyzed with results from stress-strain hysteresis loops,acoustic emission events,and post-failure X-ray 3D fracture morphology.The results showed significant differences between cyclic and monotonic loadings of RB specimens,particularly with regard to the generation of shear microcracks,the development of stress memory and strain hardening,and the contact forces and associated friction that develops along the rock-backfill interface.One important finding is that as a function of the number of cycles,the elastic strain increases linearly and the dissipated energy increases exponentially.Also,compared with monotonic loading,the cyclic strain hardening characteristics are more sensitive to rising confining pressures during the initial compaction stage.Another finding is that compared with monotonic loading,more shear microcracks are generated during every reloading stage,but these microcracks tend to be dispersed and lessen the likelihood of large shear fracture formation.The transition from elastic to plastic behavior varies depending on the parameters of each test(confinement,volume fraction,and cyclic rate),and an interesting finding was that the transformation to plastic behavior is significantly lower under the conditions of 0.73 rock volume fraction,400 N/s cyclic loading rate,and 9 MPa confinement.All the findings have important practical implications on the ability of backfill to support underground excavations. 展开更多
关键词 Rock and backfill Triaxial cyclic loading Volume fraction Damage evolution 3D visualization
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Liquefaction susceptibility and deformation characteristics of saturated coral sandy soils subjected to cyclic loadings-a critical review 被引量:1
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作者 Chen Guoxing Qin You +3 位作者 Ma Weijia Liang Ke Wu Qi C.Hsein Juang 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2024年第1期261-296,共36页
Coral sandy soils widely exist in coral island reefs and seashores in tropical and subtropical regions.Due to the unique marine depositional environment of coral sandy soils,the engineering characteristics and respons... Coral sandy soils widely exist in coral island reefs and seashores in tropical and subtropical regions.Due to the unique marine depositional environment of coral sandy soils,the engineering characteristics and responses of these soils subjected to monotonic and cyclic loadings have been a subject of intense interest among the geotechnical and earthquake engineering communities.This paper critically reviews the progress of experimental investigations on the undrained behavior of coral sandy soils under monotonic and cyclic loadings over the last three decades.The focus of coverage includes the contractive-dilative behavior,the pattern of excess pore-water pressure(EPWP)generation and the liquefaction mechanism and liquefaction resistance,the small-strain shear modulus and strain-dependent shear modulus and damping,the cyclic softening feature,and the anisotropic characteristics of undrained responses of saturated coral sandy soils.In particular,the advances made in the past decades are reviewed from the following aspects:(1)the characterization of factors that impact the mechanism and patterns of EPWP build-up;(2)the identification of liquefaction triggering in terms of the apparent viscosity and the average flow coefficient;(3)the establishment of the invariable form of strain-based,stress-based,or energy-based EPWP ratio formulas and the unique relationship between the new proxy of liquefaction resistance and the number of cycles required to reach liquefaction;(4)the establishment of the invariable form of the predictive formulas of small strain modulus and strain-dependent shear modulus;and(5)the investigation on the effects of stress-induced anisotropy on liquefaction susceptibility and dynamic deformation characteristics.Insights gained through the critical review of these advances in the past decades offer a perspective for future research to further resolve the fundamental issues concerning the liquefaction mechanism and responses of coral sandy sites subjected to cyclic loadings associated with seismic events in marine environments. 展开更多
关键词 liquefaction susceptibility dynamic deformation characteristics coral sandy soil cyclic loading review and prospect
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Enhancing capacitive deionization performance and cyclic stability of nitrogen-doped activated carbon by the electro-oxidation of anode materials
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作者 Xiaona Liu Baohua Zhao +6 位作者 Yanyun Hu Luyue Huang Jingxiang Ma Shuqiao Xu Zhonglin Xia Xiaoying Ma Shuangchen Ma 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第5期23-33,共11页
Electrode materials with high desalination capacity and long-term cyclic stability are the focus of capacitive deionization(CDI) community. Understanding the causes of performance decay in traditional carbons is cruci... Electrode materials with high desalination capacity and long-term cyclic stability are the focus of capacitive deionization(CDI) community. Understanding the causes of performance decay in traditional carbons is crucial to design a high-performance material. Based on this, here, nitrogen-doped activated carbon(NAC) was prepared by pyrolyzing the blend of activated carbon powder(ACP) and melamine for the positive electrode of asymmetric CDI. By comparing the indicators changes such as conductivity, salt adsorption capacity, pH, and charge efficiency of the symmetrical ACP-ACP device to the asymmetric ACP-NAC device under different CDI cycles, as well as the changes of the electrochemical properties of anode and cathode materials after long-term operation, the reasons for the decline of the stability of the CDI performance were revealed. It was found that the carboxyl functional groups generated by the electro-oxidation of anode carbon materials make the anode zero-charge potential(E_(pzc)) shift positively,which results in the uneven distribution of potential windows of CDI units and affects the adsorption capacity. Furthermore, by understanding the electron density on C atoms surrounding the N atoms, we attribute the increased cyclic stability to the enhanced negativity of the charge of carbon atoms adjacent to quaternary-N and pyridinic-oxide-N. 展开更多
关键词 Anodic oxidation Capacitive deionization cyclic stability N-DOPING
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Experimental study of the damage characteristics of rocks containing non-penetrating cracks under cyclic loading
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作者 Jun Xu Xiaochun Xiao +3 位作者 Lu Ma Sen Luo Jiaxu Jin Baijian Wu 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第2期197-210,共14页
The damage evolution process of non-penetrating cracks often causes some unexpected engineering disasters.Gypsum specimens containing non-penetrating crack(s)are used to study the damage evolution and characteristics ... The damage evolution process of non-penetrating cracks often causes some unexpected engineering disasters.Gypsum specimens containing non-penetrating crack(s)are used to study the damage evolution and characteristics under cyclic loading.The results show that under cyclic loading,the relationship between the number of non-penetrating crack(s)and the characteristic parameters(cyclic number,peak stress,peak strain,failure stress,and failure strain)of the pre-cracked specimens can be represented by a decreasing linear function.The damage evolution equation is fitted by calibrating the accumulative plastic strain for each cycle,and the damage constitutive equation is proposed by the concept of effective stress.Additionally,non-penetrating cracks are more likely to cause uneven stress distribution,damage accumulation,and local failure of specimen.The local failure can change the stress distribution and relieve the inhibition of non-penetrating crack extension and eventually cause a dramatic destruction of the specimen.Therefore,the evolution process caused by non-penetrating cracks can be regarded as one of the important reasons for inducing rockburst.These results are expected to improve the understanding of the process of spalling formation and rockburst and can be used to analyze the stability of rocks or rock structures. 展开更多
关键词 Damage characteristics Constitutive model Fissured rocks Non-penetrating crack cyclic loading
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Mechanical responses of anchoring structure under triaxial cyclic loading
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作者 Peng Wang Nong Zhang +5 位作者 Qun Wei Xingliang Xu Guangzhen Cui Aoran Li Sen Yang Jiaguang Kan 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第2期545-560,共16页
Dynamic load on anchoring structures(AS)within deep roadways can result in cumulative damage and failure.This study develops an experimental device designed to test AS under triaxial loads.The device enables the inves... Dynamic load on anchoring structures(AS)within deep roadways can result in cumulative damage and failure.This study develops an experimental device designed to test AS under triaxial loads.The device enables the investigation of the mechanical response,failure mode,instability assessment criteria,and anchorage effect of AS subjected to combined cyclic dynamic-static triaxial stress paths.The results show that the peak bearing strength is positively correlated with the anchoring matrix strength,anchorage length,and edgewise compressive strength.The bearing capacity decreases significantly when the anchorage direction is severely inclined.The free face failure modes are typically transverse cracking,concave fracturing,V-shaped slipping and detachment,and spallation detachment.Besides,when the anchoring matrix strength and the anchorage length decrease while the edgewise compressive strength,loading rate,and anchorage inclination angle increase,the failure intensity rises.Instability is determined by a negative tangent modulus of the displacement-strength curve or the continued deformation increase against the general downward trend.Under cyclic loads,the driving force that breaks the rock mass along the normal vector and the rigidity of the AS are the two factors that determine roadway stability.Finally,a control measure for surrounding rock stability is proposed to reduce the internal driving force via a pressure relief method and improve the rigidity of the AS by full-length anchorage and grouting modification. 展开更多
关键词 Triaxial stress Dynamic-static combination load cyclic loading Anchoring structure(AS) Cumulative damage
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Theoretical investigation on axial cyclic performance of monopile in sands using interface constitutive models
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作者 Pan Zhou Jingpei Li +2 位作者 Kaoshan Dai Stefan Vogt Seyedmohsen Miraei 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第7期2645-2662,共18页
Cyclic loads generated by environmental factors,such as winds,waves,and trains,will likely lead to performance degradation in pile foundations,resulting in issues like permanent displacement accumulation and bearing c... Cyclic loads generated by environmental factors,such as winds,waves,and trains,will likely lead to performance degradation in pile foundations,resulting in issues like permanent displacement accumulation and bearing capacity attenuation.This paper presents a semi-analytical solution for predicting the axial cyclic behavior of piles in sands.The solution relies on two enhanced nonlinear load-transfer models considering stress-strain hysteresis and cyclic degradation in the pile-soil interaction.Model parameters are calibrated through cyclic shear tests of the sand-steel interface and laboratory geotechnical testing of sands.A novel aspect involves the meticulous formulation of the shaft loadtransfer function using an interface constitutive model,which inherently inherits the interface model’s advantages,such as capturing hysteresis,hardening,degradation,and particle breakage.The semi-analytical solution is computed numerically using the matrix displacement method,and the calculated values are validated through model tests performed on non-displacement and displacement piles in sands.The results demonstrate that the predicted values show excellent agreement with the measured values for both the static and cyclic responses of piles in sands.The displacement pile response,including factors such as bearing capacity,mobilized shaft resistance,and convergence rate of permanent settlement,exhibit improvements compared to non-displacement piles attributed to the soil squeezing effect.This methodology presents an innovative analytical framework,allowing for integrating cyclic interface models into the theoretical investigation of pile responses. 展开更多
关键词 PILES cyclic degradation Load-transfer models Interface constitutive model Semi-analytical solution Model tests
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Effect of NaCl Concentration on the Cumulative Strain and Pore Distribution of Clay under Cyclic Loading
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作者 Xinshan Zhuang Shunlei Xia Ruijie Pan 《Fluid Dynamics & Materials Processing》 EI 2024年第2期447-461,共15页
Clay,as the most common soil used for foundationfill,is widely used in various infrastructure projects.The phy-sical and mechanical properties of clay are influenced by the pore solution environment.This study uses a GD... Clay,as the most common soil used for foundationfill,is widely used in various infrastructure projects.The phy-sical and mechanical properties of clay are influenced by the pore solution environment.This study uses a GDS static/dynamic triaxial apparatus and nuclear magnetic resonance experiments to investigate the effects of cyclic loading on clay foundations.Moreover,the development of cumulative strain in clay is analyzed,and afitting model for cumulative plastic strain is introduced by considering factors such as NaCl solution concentration,con-solidation stress ratio,and cycle number.In particular,the effects of the NaCl solution concentration and con-solidation stress ratio on the pore distribution of the test samples before and after cyclic loading are examined,and the relationship between microscopic pore size and macroscopic cumulative strain is obtained accordingly.Our results show that as the consolidation stress ratio grows,an increasing number of large pores in the soil samples are transformed into small pores.As the NaCl solution concentration becomes higher,the number of small pores gradually decreases,while the number of large pores remains unchanged.Cyclic loading causes the disappearance of the large pores in the samples,and the average pore size before cyclic loading is posi-tively correlated with the axial cumulative strain after cyclic loading.The cumulative strain produced by the soil under cyclic loading is inversely proportional to the NaCl solution concentration and consolidation stress ratio. 展开更多
关键词 Geotechnical engineering CLAY cyclic loading nuclear magnetic resonance NaCl solution consolidation ratio accumulative strain
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Numerical Analysis of Fiber Reinforced Polymer-Confined Concrete under Cyclic Compression Using Cohesive Zone Models
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作者 Mingxu Zhang Mingliang Wang Wei Zhang 《Structural Durability & Health Monitoring》 EI 2024年第5期599-622,共24页
This paper examines the mechanical behavior offiber reinforced polymer(FRP)-confined concrete under cyclic compression using the 3D cohesive zone model(CZM).A numerical modeling method was developed,employing zero-thick... This paper examines the mechanical behavior offiber reinforced polymer(FRP)-confined concrete under cyclic compression using the 3D cohesive zone model(CZM).A numerical modeling method was developed,employing zero-thickness cohesive elements to represent the stress-displacement relationship of concrete potential fracture surfaces and FRP-concrete interfaces.Additionally,mixed-mode damage plastic constitutive models were pro-posed for the concrete potential fracture surfaces and FRP-concrete interface,considering interfacial friction.Furthermore,an anisotropic plastic constitutive model was developed for the FRP composite jacket.The CZM model proposed in this study was validated using experimental data from plain concrete and large rupture strain(LRS)FRP-confined concrete subjected to cyclic compression.The simulation results demonstrate that the pro-posed model accurately predicts the mechanical response of both concrete and FRP-confined concrete under cyc-lic compression.Lastly,various parametric studies were conducted to investigate the internal failure mechanism of FRP-confined concrete under cyclic loading to analyze the influence of the inner friction plasticity of different components. 展开更多
关键词 cyclic compression CZM FRP wrapped concrete constitutive model fracture behavior
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The Effect of Preloading on the Cyclic Liquefaction Strength Measured in the Laboratory
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作者 Konstantinos Stamatopoulos 《Journal of Civil Engineering and Architecture》 2024年第6期269-275,共7页
The effect of preloading on the liquefaction cyclic strength was investigated by cyclic shear tests where horizontal shear stress oscillated about a zero mean value on sands with varying fines content and at varying p... The effect of preloading on the liquefaction cyclic strength was investigated by cyclic shear tests where horizontal shear stress oscillated about a zero mean value on sands with varying fines content and at varying prestress ratios, densities and verticalstresses. Test results showed a marked increase of the cyclic soil strength with the prestress ratio. The effect is more pronounced for the looser specimens. An empirical expression predicting this effect is proposed. This expression is validated from results of a field test. 展开更多
关键词 cyclic liquefaction shear stress field test
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The Performance of Small Diameter Aluminum Light Support Structures Containing Handholes under Cyclic Fatigue
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作者 Cameron R. Rusnak Aya Al-Hamami Craig C. Menzemer 《Open Journal of Civil Engineering》 2024年第2期196-213,共18页
Aluminum light poles play a pivotal role in modern infrastructure, ensuring proper illumination along highways and in populated areas during nighttime. These poles typically feature handholes near their bases, providi... Aluminum light poles play a pivotal role in modern infrastructure, ensuring proper illumination along highways and in populated areas during nighttime. These poles typically feature handholes near their bases, providing access to electrical wiring for installation and maintenance. While essential for functionality, these handholes introduce a vulnerability to the overall structure, making them a potential failure point. Although prior research and analyses on aluminum light poles have been conducted, the behavior of smaller diameter poles containing handholes remains unexplored. Recognizing this need, a research team at the University of Akron undertook a comprehensive experimental program involving aluminum light poles with handholes containing welded inserts in order to gain a better understanding of their fatigue life, mechanical behavior, and failure mechanisms. The research involved testing seven large-scale aluminum light poles each 8-inch diameter, with two separate handholes. These handholes included a reinforcement that was welded to the poles. Finite Element Analysis (FEA), statistical analysis, and comparison analysis with their large counterparts (10-inch diameter) were used to augment the experimental results. The results revealed two distinct failure modes: progressive crack propagation leading to ultimate failure, and rupture of the pole near the weld initiation/termination site around the handhole. The comparison analysis indicated that the 8-inch diameter specimens exhibited an average fatigue life exceeding that of their 10-inch counterparts by an average of 30.7%. The experimental results were plotted alongside the fatigue detail classifications outlined in the Aluminum Design Manual (ADM), enhancing understanding of the fatigue detail category of the respective poles/handholes. 展开更多
关键词 Light Pole Handhole cyclic Fatigue Fatigue Analysis Finite Element Analysis Statistical Analysis
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Investigation of the Micro-Mechanics of an Extruded Precipitation-Strengthened Magnesium Alloy under Cyclic Loading
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作者 Chuhao Liu Xiaodan Zhang +1 位作者 Huamiao Wang Yinghong Peng 《Journal of Materials Science and Chemical Engineering》 2024年第7期40-52,共13页
Precipitation strengthening is a crucial microscopic mechanism for enhancing the strength of magnesium alloys. In order to elucidate the influence of precipitation on the microscopic deformation mechanisms and macrosc... Precipitation strengthening is a crucial microscopic mechanism for enhancing the strength of magnesium alloys. In order to elucidate the influence of precipitation on the microscopic deformation mechanisms and macroscopic mechanical response of magnesium alloys under cyclic loading conditions, we employed a crystal plasticity model to analyze the stress-strain curves, specific crystal plane diffraction intensities, and the temporal evolution of various microscopic deformation mechanisms and twinning volume fractions for an extruded magnesium alloy, AXM10304, containing coherent precipitates. The research findings indicate that precipitation does not fundamentally alter the microscopic mechanisms of this alloy. However, it hinders twinning during the compression stage, mildly promotes detwinning during the tension stage, and enhances tension secondary hardening by elevating the difficulty of activation of the prismatic slip. 展开更多
关键词 cyclic Deformation Magnesium Alloy In-Situ Neutron Diffraction Precipitation Strengthening Crystal Plasticity Lattice Strain Mechanism Evolution
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Mechanical response and microscopic damage mechanism of pre-flawed sandstone subjected to monotonic and multilevel cyclic loading:A laboratory-scale investigation 被引量:3
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作者 Kesheng Li Shengqi Yang +3 位作者 Chuanxiao Liu Yun Chen Guanglei Zhang Qing Ma 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2023年第12期1487-1510,共24页
This study aims to investigate the mechanical response and acoustic emission(AE)characteristic of pre-flawed sandstone under both monotonic and multilevel constant-amplitude cyclic loads.Specifically,we explored how c... This study aims to investigate the mechanical response and acoustic emission(AE)characteristic of pre-flawed sandstone under both monotonic and multilevel constant-amplitude cyclic loads.Specifically,we explored how coplanar flaw angle and load type impact the strength and deformation behavior and microscopic damage mechanism.Results indicated that being fluctuated before rising with increasing fissure angle under monotonic loading,the peak strength of the specimen first increased slowly and then steeply under cyclic loading.The effect of multilevel cyclic loading on the mechanical parameters was more significant.For a single fatigue stage,the specimen underwent greater deformation in early cycles,which subsequently stabilized.Similar variation pattern was also reflected by AE count/energy/b-value.Crack behaviors were dominated by the fissure angle and load type and medium-scale crack accounted for 74.83%–86.44%of total crack.Compared with monotonic loading,crack distribution of specimen under cyclic loading was more complicated.Meanwhile,a simple model was proposed to describe the damage evolution of sandstone under cyclic loading.Finally,SEM images revealed that the microstructures at the fracture were mainly composed of intergranular fracture,and percentage of transgranular fracture jumped under cyclic loading due to the rapid release of elastic energy caused by high loading rate. 展开更多
关键词 SANDSTONE Pre-existing coplanar flaws Multilevel constant-amplitude cyclic loading Mechanical behavior Microscopic damage mechanism
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Mechanical and hydraulic properties of fault rocks under multi‑stage cyclic loading and unloading
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作者 Wentao Hou Dan Ma +3 位作者 Qiang Li Jixiong Zhang Yong Liu Chenyao Zhou 《International Journal of Coal Science & Technology》 EI CAS CSCD 2023年第4期151-170,共20页
The rock mass in fault zones is frequently subjected to cyclic loading and unloading during deep resource exploitation and tunnel excavation.Research on the mechanical and hydraulic characteristics of fault rock durin... The rock mass in fault zones is frequently subjected to cyclic loading and unloading during deep resource exploitation and tunnel excavation.Research on the mechanical and hydraulic characteristics of fault rock during the cyclic loading and unloading is of great signifcance for revealing the formation mechanism of water-conducting pathways in fault and preventing water inrush disasters.In this study,the mechanical and seepage tests of fault rock under the multi-stage cyclic loading and unloading of axial compression were carried out by using the fuid–solid coupling triaxial experimental device.The hysteresis loop of the stress–strain curve,peak strain rate,secant Young's modulus,and permeability of fault rock were obtained,and the evolution law of the dissipated energy of fault rock with the cyclic number of load and unloading was discussed.The experimental results show that with an increase in the cyclic number of loading and unloading,several changes occur.The hysteresis loop of the stress–strain curve of the fault rock shifts towards higher levels of strain.Additionally,both the peak strain rate and the secant Young's modulus of the fault rock increase,resulting in an increase in the secant Young's modulus of the fault rock mass.However,the growth rate of the secant Young's modulus gradually slows down with the increase of cyclic number of loading and unloading.The permeability evolution of fault rock under the multi-stage cyclic loading and unloading of axial compression can be divided into three stages:steady increase stage,cyclic decrease stage,and rapid increase stage.Besides,the calculation model of dissipated energy of fault rock considering the efective stress was established.The calculation results show that the relationship between the dissipated energy of fault rock and the cyclic number of loading and unloading conforms to an exponential function. 展开更多
关键词 Multi-stage cyclic loading and unloading Fault rocks Mechanical properties Hydraulic properties Energy dissipation
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Mechanical responses and acoustic emission behaviors of coal under compressive differential cyclic loading(DCL):a numerical study via 3D heterogeneous particle model
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作者 Zhengyang Song Yunfeng Wu +2 位作者 Yong Zhang Yi Yang Zhen Yang 《International Journal of Coal Science & Technology》 EI CAS CSCD 2023年第3期136-154,共19页
The stability of coal walls(pillars)can be seriously undermined by diverse in-situ dynamic disturbances.Based on a 3D par-ticle model,this work strives to numerically replicate the major mechanical responses and acous... The stability of coal walls(pillars)can be seriously undermined by diverse in-situ dynamic disturbances.Based on a 3D par-ticle model,this work strives to numerically replicate the major mechanical responses and acoustic emission(AE)behaviors of coal samples under multi-stage compressive cyclic loading with different loading and unloading rates,which is termed differential cyclic loading(DCL).A Weibull-distribution-based model with heterogeneous bond strengths is constructed by both considering the stress-strain relations and AE parameters.Six previously loaded samples were respectively grouped to indicate two DCL regimes,the damage mechanisms for the two groups are explicitly characterized via the time-stress-dependent variation of bond size multiplier,and it is found the two regimes correlate with distinct damage patterns,which involves the competition between stiffness hardening and softening.The numerical b-value is calculated based on the mag-nitudes of AE energy,the results show that both stress level and bond radius multiplier can impact the numerical b-value.The proposed numerical model succeeds in replicating the stress-strain relations of lab data as well as the elastic-after effect in DCL tests.The effect of damping on energy dissipation and phase shift in numerical model is summarized. 展开更多
关键词 Differential cyclic loading(DCL) Particle model Acoustic emission(AE) Discrete element method(DEM)Damage mechanism
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Dopamine and cyclic adenosine monophosphate-regulated phosphoprotein with an apparent Mr of 32000 promotes colorectal cancer growth
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作者 Kuan He Chao-Zheng Xie +6 位作者 Ya Li Zhen-Zhou Chen Shi-Hao Xu Si-Qi Huang Jian-Guo Yang Zheng-QiangWei Xu-Dong Peng 《World Journal of Gastrointestinal Oncology》 SCIE 2023年第11期1936-1950,共15页
BACKGROUND Dopamine and cyclic adenosine monophosphate(cAMP)-regulated phosphop-rotein with an apparent Mr of 32000(DARPP-32)is a protein that is involved in regulating dopamine and cAMP signaling pathways in the brai... BACKGROUND Dopamine and cyclic adenosine monophosphate(cAMP)-regulated phosphop-rotein with an apparent Mr of 32000(DARPP-32)is a protein that is involved in regulating dopamine and cAMP signaling pathways in the brain.However,recent studies have shown that DARPP-32 is also expressed in other tissues,including colorectal cancer(CRC),where its function is not well understood.AIM To explore the effect of DARPP-32 on CRC progression.METHODS The expression levels of DARPP-32 were assessed in CRC tissues using both quantitative polymerase chain reaction and immunohistochemistry assays.The proliferative capacity of CRC cell lines was evaluated with Cell Counting Kit-8 and 5-ethynyl-2’-deoxyuridine assays,while apoptosis was measured by flow cytometry.The migratory and invasive potential of CRC cell lines were deter-mined using wound healing and transwell chamber assays.In vivo studies involved monitoring the growth rate of xenograft tumors.Finally,the underlying molecular mechanism of DARPP-32 was investigated through RNA-sequencing and western blot analyses.RESULTS DARPP-32 was frequently upregulated in CRC and associated with abnormal clinicopathological features in CRC.Overexpression of DARPP-32 was shown to promote cancer cell proliferation,migration,and invasion and reduce apoptosis.DARPP-32 knockdown resulted in the opposite functional effects.Mechanistically,DARPP-32 may regulate the phosphoinositide 3-kinase(PI3K)/AKT signaling pathway in order to carry out its biological function.CONCLUSION DARPP-32 promotes CRC progression via the PI3K/AKT signaling pathway. 展开更多
关键词 Colorectal cancer Dopamine and cyclic adenosine monophosphate-regulated phosphoprotein with an apparent Mr of 32000 Proliferation Migration Phosphoinositide 3-kinase Akt
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Hydraulic and volume change behaviors of compacted highly expansive soil under cyclic wetting and drying 被引量:3
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作者 Mohamed Farid Abbas Abdullah Ali Shaker Mosleh A.Al-Shamrani 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2023年第2期486-499,共14页
The wide engineered application of compacted expansive soils necessitates understanding their behavior under field conditions.The results of this study demonstrate how seasonal climatic variation and stress and bounda... The wide engineered application of compacted expansive soils necessitates understanding their behavior under field conditions.The results of this study demonstrate how seasonal climatic variation and stress and boundary conditions individually or collectively influence the hydraulic and volume change behavior of compacted highly expansive soils.The cyclic wetting and drying(CWD)process was applied for two boundary conditions,i.e.constant stress(CS)and constant volume(CV),and for a wide range of axial stress states.The adopted CWD process affected the hydraulic and volume change behaviors of expansive soils,with the first cycle of wetting and drying being the most effective.The CWD process under CS conditions resulted in shrinkage accumulation and reduction in saturated hydraulic conductivity(k sat).On the other hand,CWD under CV conditions caused a reduction of swell pressure while has almost no impact on k sat.An elastic response to CWD was achieved after the third cycle for saturated hydraulic conductivity(k sat),the third to fourth cycle for the volume change potential under the CV conditions,and the fourth to fifth cycle for the volume change potential under the CS conditions.Finally,both swell pressure(s s)and saturated hydraulic conductivity(k sat)are not fundamental parameters of the expansive soil but rather depend on stress,boundary and wetting conditions. 展开更多
关键词 Expansive soils Hydraulic conductivity Volume change potential cyclic wetting and drying(CWD) Swell pressure
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Liquefaction proneness of stratified sand-silt layers based on cyclic triaxial tests 被引量:1
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作者 Arpit Jain Satyendra Mittal Sanjay Kumar Shukla 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2023年第7期1826-1845,共20页
Most studies on liquefaction have addressed homogeneous soil strata using sand or sand with fine content without considering soil stratification.In this study,cyclic triaxial tests were conducted on the stratified san... Most studies on liquefaction have addressed homogeneous soil strata using sand or sand with fine content without considering soil stratification.In this study,cyclic triaxial tests were conducted on the stratified sand specimens embedded with the silt layers to investigate the liquefaction failures and void-redistribution at confining stress of 100 kPa under stress-controlled mode.The loosening of underlying sand mass and hindrance to pore-water flow caused localized bulging at the sand-silt interface.It is observed that at a silt thickness of 0.2H(H is the height of the specimen),nearly 187 load cycles were required to attain liquefaction,which was the highest among all the silt thicknesses with a single silt layer.Therefore,0.2H is assumed as the optimum silt thickness(t_(opt)).The silt was placed at the top,middle and bottom of the specimen to understand the effect of silt layer location.Due to the increase in depth of the silt layer from the top position(capped soil state)to the bottom,the cycles to reach liquefaction(N_(cyc,L))increased 2.18 times.Also,when the number of silt layers increased from single to triple,there was an increase of about 880%in N_(cyc,L).The micro-characterization analysis of the soil specimens indicated silty materials transported in upper sections of the specimen due to the dissipated pore pressure.The main parameters,including thickness(t),location(z),cyclic stress ratio(CSR),number of silt layers(n)and modified relative density(D_(r,m)),performed significantly in governing the lique-faction resistance.For this,a multilinear regression model is developed based on critical parameters for prediction of N_(cyc,L).Furthermore,the developed constitutive model has been validated using the data from the present study and earlier findings. 展开更多
关键词 cyclic triaxial tests Soil stratification Soil liquefaction Regression model
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Enhance liquid nitrogen fracturing performance on hot dry rock by cyclic injection 被引量:1
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作者 Chun-Yang Hong Rui-Yue Yang +3 位作者 Zhong-Wei Huang Xiao-Ying Zhuang Hai-Tao Wen Xiao-Li Hu 《Petroleum Science》 SCIE EI CAS CSCD 2023年第2期951-972,共22页
Producing complex fracture networks in a safe way plays a critical role in the hot dry rock (HDR) geothermal energy exploitation. However, conventional hydraulic fracturing (HF) generally produces high breakdown press... Producing complex fracture networks in a safe way plays a critical role in the hot dry rock (HDR) geothermal energy exploitation. However, conventional hydraulic fracturing (HF) generally produces high breakdown pressure and results only in single main fracture morphology. Furthermore, HF has also other problems such as the increased risk of seismic events and consuption of large amount of water. In this work, a new stimulation method based on cyclic soft stimulation (CSS) and liquid nitrogen (LN2) fracturing, known as cyclic LN2 fracturing is explored, which we believe has the potential to solve the above issues related to HF. The fracturing performances including breakdown pressure and fracture morphology on granites under true-triaxial stresses are investigated and compared with cyclic water fracturing. Cryo-scanning electron microscopy (Cryo-SEM) tests and X-ray computed tomography (CT) scanning tests were used for quantitative characterization of fracture parameters and to evaluate the cyclic LN2 fracturing performances. The results demonstrate that the cyclic LN2 fracturing results in reduced breakdown pressure, with between 21% and 67% lower pressure compared with using cyclic water fracturing. Cyclic LN2 fracturing tends to produce more complex and branched fractures, whereas cyclic water fracturing usually produces a single main fracture under a low number of cycles and pressure levels. Thermally-induced fractures mostly occur around the interfaces of different particles. This study shows the potential benefits of cyclic LN2 fracturing on HDR. It is expected to provide theoretical guidance for the cyclic LN2 fracturing application in HDR reservoirs. 展开更多
关键词 Hot dry rock Liquid nitrogen fracturing cyclic injection Thermal stress Fatigue damage
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Influence of volume compression on the unloading deformation behavior of red sandstone under damage-controlled cyclic triaxial loading 被引量:1
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作者 Huaizhong Liu Jianliang Pei +3 位作者 Jianfeng Liu Mingli Xiao Li Zhuo Hongqiang Xie 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2023年第5期1200-1212,共13页
A reasonable evaluation of unloading deformation characteristics is of great significance for the effective analysis of deformation and stability of surrounding rocks after underground excavation.In this study,the dam... A reasonable evaluation of unloading deformation characteristics is of great significance for the effective analysis of deformation and stability of surrounding rocks after underground excavation.In this study,the damage-controlled cyclic triaxial loading tests were conducted to investigate the pore compaction mechanism and its influences on the unloading deformation behavior of red sandstone,including Young’s modulus,Poisson’s ratio,volumetric strain,and irreversible strain.The experimental results show that the increases of volumetric and irreversible strains of rocks can be attributed to the compaction mechanism,which almost dominates the entire pre-peak deformation process.The unloading deformation consists of the reversible linear and nonlinear strains,and the irreversible strain under the influence of the porous grain structure.The pre-peak Young’s modulus tends to increase and then decrease due to the influence of the unloading irreversible strain.However,it hardly changes with the increasing volumetric strain compaction under the influence of reversible nonlinear strain.Instead,the initial unloading tangent modulus is highly related to the volumetric strain,and clearly reflects the compaction state of red sandstone.Furthermore,both the reversible nonlinear and irreversible unloading deformations are independent of confining pressure.This study is beneficial for the theoretical modeling and prediction of cyclic unloading deformation behavior of red sandstone. 展开更多
关键词 cyclic loading tests Compaction mechanism Volumetric strain Unloading tangent modulus Red sandstone
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Assessment of cyclic deformation and critical stress amplitude of jointed rocks via cyclic triaxial testing
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作者 Waranga Habaraduwa Peellage Behzad Fatahi Haleh Rasekh 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2023年第6期1370-1390,共21页
Jointed rock specimens with a natural replicated joint surface oriented at a mean dip angle of 60were prepared,and a series of cyclic triaxial tests was performed at different confining pressures and cyclic deviatoric... Jointed rock specimens with a natural replicated joint surface oriented at a mean dip angle of 60were prepared,and a series of cyclic triaxial tests was performed at different confining pressures and cyclic deviatoric stress amplitudes.The samples were subjected to 10,000 loading-unloading cycles with a frequency of 8 Hz.At each level of confining pressure,the applied cyclic deviatoric stress amplitude was increased incrementally until excessive deformation of the jointed rock specimen was observed.Analysis of the test results indicated that there existed a critical cyclic deviatoric stress amplitude(i.e.critical dynamic deviatoric stress)beyond which the jointed rock specimens yielded.The measured critical dynamic deviatoric stress was less than the corresponding static deviatoric stress.At cyclic deviatoric stress amplitudes less than the critical dynamic deviatoric stress,minor cumulative residual axial strains were observed,resulting in hysteretic damping.However,for cyclic deviatoric stresses beyond the critical dynamic deviatoric stress,the plastic strains increased promptly,and the resilient moduli degraded rapidly during the initial loading cycles.Cyclic triaxial test results showed that at higher confining pressures,the ultimate residual axial strain attained by the jointed rock specimen decreased,the steadystate dissipated energy density and steady-state damping ratio per load cycle decreased,while steadystate resilient moduli increased. 展开更多
关键词 cyclic triaxial test Jointed rock Joint surface Confining pressure cyclic deviatoric stress amplitude FAILURE Residual deformation Dissipated energy
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