Large-field objective lens for multi-wavelength microscopy at mesoscale and submicron resolution

Conventional microscopes designed for submicron resolution in biological research are hindered by a limited field of view,typically around 1 mm.This restriction poses a challenge when attempting to simultaneously analyze various parts of a sample,such as different brain areas.In addition,conventional objective lenses struggle to perform consistently across the required range of wavelengths for brain imaging in vivo.Here we present a novel mesoscopic objective lens with an impressive field of view of 8 mm,a numerical aperture of 0.5,and a working wavelength range from 400 to 1000 nm.We achieved a resolution of 0.74μm in fluorescent beads imaging.The versatility of this lens was further demonstrated through high-quality images of mouse brain and kidney sections in a wide-field imaging system,a confocal laser scanning system,and a two-photon imaging system.This mesoscopic objective lens holds immense promise for advancing multi-wavelength imaging of large fields of view at high resolution.

Performance in the Fundamentals of Laparoscopic Surgery: Does it reflect global rating scales in the Objective Structured Assessment of Technical Skills in porcine laparoscopic surgery?

Objective:To correlate the utility of the Fundamentals of Laparoscopic Surgery(FLS)manual skills program with the Objective Structured Assessment of Technical Skills(OSATS)global rating scale in evaluating operative performance.Methods:The Asian Urological Surgery Training and Educational Group(AUSTEG)Laparoscopic Upper Tract Surgery Course implemented and validated the FLS program for its usage in laparoscopic surgical training.Delegates’basic laparoscopic skills were assessed using three different training models(peg transfer,precision cutting,and intra-corporeal suturing).They also performed live porcine laparoscopic surgery at the same workshop.Live surgery skills were assessed by blinded faculty using the OSATS rating scale.Results:From March 2016 to March 2019,a total of 81 certified urologists participated in the course,with a median of 5 years of post-residency experience.Although differences in task time did not reach statistical significance,those with more surgical experience were visibly faster at completing the peg transfer and intra-corporeal suturing FLS tasks.However,they took longer to complete the precision cutting task than participants with less experience.Overall OSATS scores correlated weakly with all three FLS tasks(peg transfer time:r=0.331,r^(2)=0.110;precision cutting time:r=0.240,r^(2)=0.058;suturing with intracorporeal knot time:r=0.451,r^(2)=0.203).Conclusion:FLS task parameters did not correlate strongly with OSATS globing rating scale performance.Although FLS task models demonstrated strong validity,it is important to assimilate the inconsistencies when benchmarking technical proficiency against real-life operative competence,as evaluated by FLS and OSATS,respectively.

Distributed Stochastic Optimization with Compression for Non-Strongly Convex Objectives

We are investigating the distributed optimization problem,where a network of nodes works together to minimize a global objective that is a finite sum of their stored local functions.Since nodes exchange optimization parameters through the wireless network,large-scale training models can create communication bottlenecks,resulting in slower training times.To address this issue,CHOCO-SGD was proposed,which allows compressing information with arbitrary precision without reducing the convergence rate for strongly convex objective functions.Nevertheless,most convex functions are not strongly convex(such as logistic regression or Lasso),which raises the question of whether this algorithm can be applied to non-strongly convex functions.In this paper,we provide the first theoretical analysis of the convergence rate of CHOCO-SGD on non-strongly convex objectives.We derive a sufficient condition,which limits the fidelity of compression,to guarantee convergence.Moreover,our analysis demonstrates that within the fidelity threshold,this algorithm can significantly reduce transmission burden while maintaining the same convergence rate order as its no-compression equivalent.Numerical experiments further validate the theoretical findings by demonstrating that CHOCO-SGD improves communication efficiency and keeps the same convergence rate order simultaneously.And experiments also show that the algorithm fails to converge with low compression fidelity and in time-varying topologies.Overall,our study offers valuable insights into the potential applicability of CHOCO-SGD for non-strongly convex objectives.Additionally,we provide practical guidelines for researchers seeking to utilize this algorithm in real-world scenarios.

Effect of low-degree astigmatism on the objective visual quality

AIM:To evaluate the effect of low-degree astigmatism on objective visual quality through the Optical Quality Analysis System(OQAS).METHODS:This study enrolled 46 participants(aged 23 to 30y,90 eyes)with normal or corrected-to-normal vision.The cylindrical lenses(0,0.5,0.75,1.0,and 1.25 D)were placed at the axial direction(180°,45°,90°,and 135°)in front of the eyes with the best correction to form 16 types of regular low-degree astigmatism.OQAS was used to detect the objective visual quality,recorded as the objective scattering index(OSI),OQAS values at contrasts of 100%,20%,and 9%predictive visual acuity(OV100%,OV20%,and OV9%),modulation transfer function cut-off(MTFcut-off)and Strehl ratio(SR).The mixed effect linear model was used to compare objective visual quality differences between groups and examine associations between astigmatic magnitude and objective visual quality parameters.RESULTS:Apparent negative relationships between the magnitude of low astigmatism and objective visual quality were observed.The increase of OSI per degree of astigmatism at 180°,45°,90°,and 135°axis were 0.38(95%CI:0.35,0.42),0.50(95%CI:0.46,0.53),0.49(95%CI:0.45,0.54)and 0.37(95%CI:0.34,0.41),respectively.The decrease of MTFcut-off per degree of astigmatism at 180°,45°,90°,and 135°axis were-10.30(95%CI:-11.43,-9.16),-12.73(95%CI:-13.62,-11.86),-12.75(95%CI:-13.79,-11.70),and-9.97(95%CI:-10.92,-9.03),respectively.At the same astigmatism degree,OSI at 45°and 90°axis were higher than that at 0°and 135°axis,while MTFcut-off were lower.CONCLUSION:Low astigmatism of only 0.50 D can significantly reduce the objective visual quality.

Objective Model Selection in Physics: Exploring the Finite Information Quantity Approach

Traditional methods for selecting models in experimental data analysis are susceptible to researcher bias, hindering exploration of alternative explanations and potentially leading to overfitting. The Finite Information Quantity (FIQ) approach offers a novel solution by acknowledging the inherent limitations in information processing capacity of physical systems. This framework facilitates the development of objective criteria for model selection (comparative uncertainty) and paves the way for a more comprehensive understanding of phenomena through exploring diverse explanations. This work presents a detailed comparison of the FIQ approach with ten established model selection methods, highlighting the advantages and limitations of each. We demonstrate the potential of FIQ to enhance the objectivity and robustness of scientific inquiry through three practical examples: selecting appropriate models for measuring fundamental constants, sound velocity, and underwater electrical discharges. Further research is warranted to explore the full applicability of FIQ across various scientific disciplines.

Eclipse计划系统MU Objective工具在鼻咽癌容积调强放射治疗计划中的应用研究

目的:探讨Varian Eclipse计划系统MU Objective工具在鼻咽癌容积调强放射治疗(VMAT)计划中的应用,旨在保证治疗计划质量的同时降低治疗计划的机器跳数(MU)。方法:选取已接受容积调强放射治疗技术的21例鼻咽癌患者,在未使用MU Objective工具的情况下给每例患者设计治疗参考计划(MU_(ref));将使用MU Objective工具对MU_(ref)进行重新优化,分别设置MU_(ref)的MU的30%、50%、70%、90%和120%,分别命名为MU_(30%)、MU_(50%)、MU_(70%)、MU_(90%)和MU_(120%)。将治疗计划MU_(30%)、MU_(50%)、MU_(70%)、MU_(90%)和MU_(120%)分别与MU_(ref)进行配对t检验统计分析,比较两种治疗计划的靶区、危及器官(OAR)剂量分布和计划的MU。结果:使用MU Objective工具对参考计划优化MU后,与参考计划相比部分靶区和OAR剂量体积参数差异虽有统计学意义,但无临床意义。治疗计划参数为MU_(30%)、MU_(50%)、MU_(70%)和MU_(90%)时,与MU_(ref)比较计划MU平均分别减少21.5%、19.5%、16.6%和8%,差异有统计学意义(t=9.652,t=8.843,t=8.963,t=11.323;P<0.05)。在MU_(120%)时,治疗计划MU平均增加1.7%,但未显著提高靶区剂量覆盖。结论:对于鼻咽癌VMAT计划,使用Eclipse计划系统的MU Objective工具在减少计划MU的同时可获得与参考计划相似的剂量分布。MU Objective工具可作为鼻咽癌或其他部位VMAT计划的常规使用工具,以保证计划质量同时减少放射治疗计划的MU。

Objective Identification and Climatic Characteristics of Heavy-Precipitation Northeastern China Cold Vortexes

The northeastern China cold vortex(NCCV)plays an important role in regional rainstorms over East Asia.Using the National Centers for Environmental Prediction Final reanalysis dataset and the Global Precipitation Measurement product,an objective algorithm for identifying heavy-precipitation NCCV(HPCV)events was designed,and the climatological features of 164 HPCV events from 2001 to 2019 were investigated.The number of HPCV events showed an upward linear trend,with the highest frequency of occurrence in summer.The most active region of HPCV samples was the Northeast China Plain between 40°–55°N.Most HPCV events lasted 3–5 days and had radii ranging from 250 to 1000 km.The duration of HPCV events with larger sizes was longer.About half of the HPCV events moved into(moved out of)the definition region(35°–60°N,115°–145°E),and half initiated(dissipated)within the region.The initial position was close to the western boundary of the definition region,and the final position was mainly near the eastern boundary.The locations associated with the precipitation were mostly concentrated within 2000 km southeast of the HPCV systems,and they were farther from the center in the cold season than in the warm season.

Multi‐objective particle swarm optimisation of complex product change plan considering service performance

Design change is an inevitable part of the product development process.This study proposes an improved binary multi‐objective PSO algorithm guided by problem char-acteristics(P‐BMOPSO)to solve the optimisation problem of complex product change plan considering service performance.Firstly,a complex product multi‐layer network with service performance is established for the first time to reveal the impact of change effect propagation on the product service performance.Secondly,the concept of service performance impact(SPI)is defined by decoupling the impact of strongly associated nodes on the service performance in the process of change affect propagation.Then,a triple‐objective selection model of change nodes is established,which includes the three indicators:SPI degree,change cost,and change time.Furthermore,an integer multi‐objective particle swarm optimisation algorithm guided by problem characteristics is developed to solve the model above.Experimental results on the design change problem of a certain type of Skyworth TV verify the effectiveness of the established optimisation model and the proposed P‐BMOPSO algorithm.

Multi-Objective Optimization with Artificial Neural Network Based Robust Paddy Yield Prediction Model

Agriculture plays a vital role in the food production process that occupies nearly one-third of the total surface of the earth.Rice is propagated from the seeds of paddy and it is a stable food almost used byfifty percent of the total world population.The extensive growth of the human population alarms us to ensure food security and the country should take proper food steps to improve the yield of food grains.This paper concentrates on improving the yield of paddy by predicting the factors that influence the growth of paddy with the help of Evolutionary Computation Techniques.Most of the researchers used to relay on historical records of meteorological parameters to predict the yield of paddy.There is a lack in analyzing the day to day impact of meteorological parameters such as direction of wind,relative humidity,Instant Wind Speed in paddy cultivation.The real time meteorological data collected and analysis the impact of weather parameters from the day of paddy sowing to till the last day of paddy harvesting with regular time series.A Robust Optimized Artificial Neural Network(ROANN)Algorithm with Genetic Algorithm(GA)and Multi Objective Particle Swarm Optimization Algorithm(MOPSO)proposed to predict the factors that to be concentrated by farmers to improve the paddy yield in cultivation.A real time paddy data collected from farmers of Tamilnadu and the meteorological parameters were matched with the cropping pattern of the farmers to construct the database.The input parameters were optimized either by using GA or MOPSO optimization algorithms to reconstruct the database.Reconstructed database optimized by using Artificial Neural Network Back Propagation Algorithm.The reason for improving the growth of paddy was identified using the output of the Neural Network.Performance metrics such as Accuracy,Error Rate etc were used to measure the performance of the proposed algorithm.Comparative analysis made between ANN with GA and ANN with MOPSO to identify the recommendations for improving the paddy yield.

Salient Object Detection Based on a Novel Combination Framework Using the Perceptual Matching and Subjective-Objective Mapping Technologies

The integrity and fineness characterization of non-connected regions and contours is a major challenge for existing salient object detection.The key to address is how to make full use of the subjective and objective structural information obtained in different steps.Therefore,by simulating the human visual mechanism,this paper proposes a novel multi-decoder matching correction network and subjective structural loss.Specifically,the loss pays different attentions to the foreground,boundary,and background of ground truth map in a top-down structure.And the perceived saliency is mapped to the corresponding objective structure of the prediction map,which is extracted in a bottom-up manner.Thus,multi-level salient features can be effectively detected with the loss as constraint.And then,through the mapping of improved binary cross entropy loss,the differences between salient regions and objects are checked to pay attention to the error prone region to achieve excellent error sensitivity.Finally,through tracking the identifying feature horizontally and vertically,the subjective and objective interaction is maximized.Extensive experiments on five benchmark datasets demonstrate that compared with 12 state-of-the-art methods,the algorithm has higher recall and precision,less error and strong robustness and generalization ability,and can predict complete and refined saliency maps.

Multi Objective Decision Making Method Based on Evaluation Criterion for Problems with Linear Value Function

A class of interactive multi objective decision making method by means of evaluation criterion is proposed for problems with linear value function,in which case,the decision maker(DM) usually has only unwhole information of weights for objectives. The concept of fault measure of the evaluation criterion is proposed to measure the deviation of the evaluation criterion from the DMs preference structure.The approach to obtain an upper boundary of fault measure of an evaluation criterion,and the approach to modify the evaluation criterion to be one with smaller fault measure,and the approach to obtain a pre optimized objective set by evaluation criterion with certain fault measure are also proposed.

Objective and subjective measures for sleep disorders

Subjective and objective measures of sleep structure or quality could help to characterize the chronic sleep disturbances, with relation to patients＇ risk factor profiles and co-morbidities. Studies have shown that discrepancies can occur between subjective data regarding sleep disturbances and the impact of insomnia and objective assays, and surrogate markers of sleep and sleep disturbances. Both objective and subjective measures should be incorporated into clinic studies. It seems likely that sleep quality is represented by a combination of more than one subjective sleep parameter. Objective and subjective assessments of sleep quality may relate to different parameters. Future studies incorporated both subjective and objective measures could help to address the sleep disorders.

A multi-objective fuzzy optimization model for cropping structure and water resources and its method

Cropping structure has a close relationship with the optimal allocation of agricultural water resources. Based on the analysis of the relationship between agricultural water resources and sustainable development, this paper presents a multi objective fuzzy optimization model for cropping structure and water allocation, which overcomes the shortcoming of current models that only considered the economic objective,and ignored the social and environmental objectives. During the process, a new method named fuzzy deciding weight is developed to decide the objective weight. A case study shows that the model is reliable, the method is simple and objective, and the results are reasonable. This model is useful for agricultural management and sustainable development.

Objectives of and Approaches to Ecological City Construction

It has become a trend of the city development in the world to build up the ecological city with an ecological system that is balanced in structure,high-efficient in service function.Taking Suzhou as a case,the authors believe that the construction of an ecological city is a process of the progressive and well-organized systematic development and of the ecological function consummation,which will require five stages to complete,including ecological hygiene,ecological security,ecological industry,ecological landscape,and ecological culture.The problems presently encountered in the construction of ecological city in Suzhou can be solved through the following approaches:(1) To rebuild the relationship between man and nature when the planning is worked out;(2) To observe the principle of ecology in city design;(3) To choose the local plant species in city afforestation;(4) To choose those plantlets with vigorous growth,good shape,and high survival rate,observing the growth rule of plant and paying much attention to forest landscape,ecological system and biological diversity,rationally allocating the plant species resources;(5) To aim at the implementation of the less-labor management even the zero-labor management.

Hierarchical Algorithms of Large-Scale Systems with Nonseparable Multiobjective

A class of large-scale hierarchical control systems is considered, the overall objective function is a nonlinear and nonseparable function of multiple quadratic performance indices.The separation strategy of the multiobjective optimization technique and the three-level objective coordination method are applied to the large -sacle systems, and a four-level hierarchical algorithms of optimization control is obtained.

Overview of multi-objective optimization methods

To assist readers to have a comprehensive understanding, the classical and intelligent methods roundly based on precursory research achievements are summarized in this paper. First, basic conception and description about multi-objective (MO) optimization are introduced. Then some definitions and related terminologies are given. Furthermore several MO optimization methods including classical and current intelligent methods are discussed one by one succinctly. Finally evaluations on advantages and disadvantages about these methods are made at the end of the paper.

基于Stingray Objective Studio的防空C^3I显控系统界面开发

文中提出了用 Stingray Objective Studio 工具集来进行防空显控系统界面开发,使得开发人员将大量的时间和精力用于系统结构和数据处理算法上,这样不光降低了开发难度,也增强了系统的功能和稳定性。

Objective increment based metaheuristic for total flowtime minimization in no-wait flowshops

To solve the NP-complete no-wait flowshop problems, objective increment properties are analyzed and proved for fundamental operations of heuristics. With these properties, whether a new generated schedule is better or worse than the original one is only evaluated by objective increments, instead of completely calculating objective values as the traditional algorithms do, so that the computational time can be considerably reduced. An objective increment-based hybrid genetic algorithm （IGA） is proposed by integrating the genetic algorithm （GA） with an improved various neighborhood search （VNS）as a local search. An initial solution generation heuristic（ISG） is constructed to generate one individual of the initial population. An expectation value-based selection mechanism and a crossover operator are introduced to the mating process. The IGA is compared with the traditional GA and two best-so-far algorithms for the considered problem on 110 benchmark instances. An experimental results show that the IGA outperforms the others in effectiveness although with a little more time consumption.

MULTI OBJECTIVE OPTIMIZATION USING GENETIC ALGORITHM WITH LOCAL SEARCH

In this paper,we propose a hybrid algorithm for finding a set of non dominated solutions of a multi objective optimization problem.In the proposed algorithm,a local search procedure is applied to each solution generated by genetic operations.The aim of the proposed algorithm is not to determine a single final solution but to try to find all the non dominated solutions of a multi objective optimization problem.The choice of the final solution is left to the decision makers preference.High search ability of the proposed algorithm is demonstrated by computer simulation.

Two-Stage Interactive Multi-Objective Decision-Making Method Based on the Satisfactoriness Criterion

In this paper, for multi objective decision making, the defects on the commonly used interactive methods based on the satisfactoriness criterion is studied. Then a class of two stage interactive method based on the satisfactoriness criterion is proposed for improvement with the satisfactoriness criterion being determined through the collection of the decision makers preference information. An application example is presented for illustration of applicability of the method.