LRP6 Bidirectionally Regulates Insulin Sensitivity through Insulin Receptor and S6K Signaling in Rats with CG-IUGR

Objective Intrauterine growth restriction followed by postnatal catch-up growth(CG-IUGR)increases the risk of insulin resistance-related diseases.Low-density lipoprotein receptor-related protein 6(LRP6)plays a substantial role in glucose metabolism.However,whether LRP6 is involved in the insulin resistance of CG-IUGR is unclear.This study aimed to explore the role of LRP6 in insulin signaling in response to CG-IUGR.Methods The CG-IUGR rat model was established via a maternal gestational nutritional restriction followed by postnatal litter size reduction.The mRNA and protein expression of the components in the insulin pathway,LRP6/β-catenin and mammalian target of rapamycin(mTOR)/S6 kinase(S6K)signaling,was determined.Liver tissues were immunostained for the expression of LRP6 andβ-catenin.LRP6 was overexpressed or silenced in primary hepatocytes to explore its role in insulin signaling.Results Compared with the control rats,CG-IUGR rats showed higher homeostasis model assessment for insulin resistance(HOMA-IR)index and fasting insulin level,decreased insulin signaling,reduced mTOR/S6K/insulin receptor substrate-1(IRS-1)serine307 activity,and decreased LRP6/β-catenin in the liver tissue.The knockdown of LRP6 in hepatocytes from appropriate-for-gestational-age(AGA)rats led to reductions in insulin receptor(IR)signaling and mTOR/S6K/IRS-1 serine307 activity.In contrast,LRP6 overexpression in hepatocytes of CG-IUGR rats resulted in elevated IR signaling and mTOR/S6K/IRS-1 serine307 activity.Conclusion LRP6 regulated the insulin signaling in the CG-IUGR rats via two distinct pathways,IR and mTOR-S6K signaling.LRP6 may be a potential therapeutic target for insulin resistance in CG-IUGR individuals.

Acquisition Practice of High Signal-to-Noise Ratio in YTB Block of Sichuan Basin

YTB block in Sichuan basin is a favorable area to exploit oil and gas in shallow tight rock. 3D seismic project of this zone has two characteristics. Firstly, it has high requirements for the tolerance rate of the construction process and the acquisition of high signal-to-noise ratio seismic data;Second, there are widely obstacles and noises that lead to difficult acquisition construction organization. In acquisition practice, high signal-to-noise ratio seismic data was obtained by reasonable design of construction scheme, optimization of excitation parameters, improvement of receiving conditions and optimization of obstacle crossing observation system. .

Effects of restrictions on maternal feed intake on the immune indexes of umbilical cord blood and liver Toll-like receptor signaling pathways in fetal goats during pregnancy

Background: Liver has important immune function during fetal development and after birth.However,the effect of maternal malnutrition on immune function of the fetal liver is rarely reported.In this study,twelve pregnant goats(Xiangdong black goat,at d 45 of gestation) were assigned to the control group(fed 100% of nutritional requirements) and the restriction group(fed 60% of the intake of the control group) during gestation from d 55 to100.Fetal goats were harvested at d 100 of gestation and immune indexes and amino acid profiles of the umbilical cord blood and liver Toll-like receptors(TLRs) signaling pathways were measured.Results: Maternal body weight in the restriction group was lower than the control group(P < 0.05).Maternal feed intake restriction decreased(P < 0.05) heart weight,heart index,alkaline phosphatase and serum amyloid protein A in the umbilical cord blood(UCB).Moreover,only histidine was decreased in the restricted group(P = 0.084),and there were no differences in other amino acids contents in the UCB between the two groups(P > 0.05).The TLR2 and TLR4 mRNA expression in the fetal liver in the restriction group was greater(P < 0.05) than that in the control group.Furthermore,the mRNA expression levels of myeloid differentiation primary response 88(MyD88),TNF receptor associated factor 6,nuclear factor kappa B subunit 1,NFKB inhibitor alpha,IFN-β,TGF-β,TNF-α and IL-1β in the restricted group were upregulated(P < 0.05),and the expression of TLR3(P = 0.099) tended to be higher in the restricted group.However,protein levels of TLR2,TLR4,IκBα,phosphorylated IκBα,phosphorylated IκBα/total IκBα,TRIF and MyD88 were not affected(P > 0.05) by maternal intake restriction.Conclusions: These results revealed that the restriction of maternal feed intake influenced the development of heart and hepatic protein synthesis at the acute phase of fetal goats and upregulated the mRNA expression of genes involved in MyD88-dependent signaling pathways and of target cytokines.

STABLE RECOVERY OF SPARSELY CORRUPTED SIGNALS THROUGH JUSTICE PURSUIT DE-NOISING

This paper considers a corrupted compressed sensing problem and is devoted to recover signals that are approximately sparse in some general dictionary but corrupted by a combination of interference having a sparse representation in a second general dictionary and measurement noise.We provide new restricted isometry property(RIP)analysis to achieve stable recovery of sparsely corrupted signals through Justice Pursuit De-Noising(JPDN)with an additional parameter.Our main tool is to adapt a crucial sparse decomposition technique to the analysis of the Justice Pursuit method.The proposed RIP condition improves the existing representative results.Numerical simulations are provided to verify the reliability of the JPDN model.

美国信号情报活动的最新指导:第14086号行政命令解析

[研究目的]拜登于2022年10月发布了第14086号行政命令《加强对美国信号情报活动的防护》,对该文件进行细致梳理和研究,可以更加全面地理解美国信号情报工作的指导思想和原则。[研究方法]以第14086号行政命令文本为基础,采用文献研读和比较研究的方法,剖析了该行政命令出台的时代背景,系统梳理了其主要内容和创新之处,并进行了较全面的评价。[研究结论]第14086号行政命令是美国对信号情报工作的最新指导,提出了更加具体的工作规范。它继续坚持以美国国家安全利益为优先的理念,秉持区分国籍确定公民保护措施的原则,其内容既体现了应对当前形势的调整,又为未来信号情报工作保留了主动作为的空间。

脑白质高信号患者执行功能与脑血流量的相关性分析

目的应用三维动脉自旋标记技术(3D-ASL)探究脑白质高信号患者执行功能的脑灌注机制。方法选取2021年3月至2022年12月就诊于牡丹江医学院附属红旗医院神经内科,存在脑白质高信号的患者104例为病例组,同期与之匹配的健康人群52例为对照组。根据Fazekas分级,将病例组分为轻度组(0~2分)和中重度组(3~6分)。收集两组人群的基线资料,神经心理学评估,包括蒙特利尔评估表、画钟测试、连线测试。所有受试者进行常规序列及3D-ASL检查,同时获得各个脑叶感兴趣区的脑血流量(CBF)值。进行病例组与对照组间执行功能、各个脑叶皮层CBF值差异比较,并分析皮层CBF值与执行功能的相关性。结果轻度组在双侧额叶、丘脑的CBF值低于对照组,中重度组在双侧额叶、顶叶、颞叶、丘脑的CBF均低于其他两组,差异有统计学意义(P<0.05)。轻度组的左侧额叶CBF值与执行功能呈正相关(P<0.05);中重度组的左侧额叶、颞叶CBF值与执行功能呈正相关(P<0.05)。结论执行功能早期下降可能与左侧额叶CBF下降有关,为预测认知功能下降提供了影像学依据。

STABLE AND ROBUST RECOVERY OF APPROXIMATELY k-SPARSE SIGNALS WITH PARTIAL SUPPORT INFORMATION IN NOISE SETTINGS VIA WEIGHTED ℓ_(p)(0

In the existing work,the recovery of strictly k-sparse signals with partial support information was derived in theℓ2 bounded noise setting.In this paper,the recovery of approximately k-sparse signals with partial support information in two noise settings is investigated via weightedℓp(0<p≤1)minimization method.The restricted isometry constant(RIC)conditionδt k<1 pη2 p−1+1 on the measurement matrix for some t∈[1+2−p 2+pσ,2]is proved to be sufficient to guarantee the stable and robust recovery of signals under sparsity defect in noisy cases.Herein,σ∈[0,1]is a parameter related to the prior support information of the original signal,andη≥0 is determined by p,t andσ.The new results not only improve the recent work in[17],but also include the optimal results by weightedℓ1 minimization or by standardℓp minimization as special cases.

REQUIRED NUMBER OF ITERATIONS FOR SPARSE SIGNAL RECOVERY VIA ORTHOGONAL LEAST SQUARES

In countless applications,we need to reconstruct a K-sparse signal x∈R n from noisy measurements y=Φx+v,whereΦ∈R^(m×n)is a sensing matrix and v∈R m is a noise vector.Orthogonal least squares(OLS),which selects at each step the column that results in the most significant decrease in the residual power,is one of the most popular sparse recovery algorithms.In this paper,we investigate the number of iterations required for recovering x with the OLS algorithm.We show that OLS provides a stable reconstruction of all K-sparse signals x in[2.8K]iterations provided thatΦsatisfies the restricted isometry property(RIP).Our result provides a better recovery bound and fewer number of required iterations than those proposed by Foucart in 2013.

董事高管责任保险与企业金融化

董事高管责任保险对于管理者是激励还是自利,一直是公司治理领域研究的热点话题。基于2005—2019年中国A股上市公司数据,分别从激励观、外部监督、机会主义、信号传递等角度,分析董事高管责任保险对企业金融化的影响,考察董责险公司治理的有效性。研究发现,董事高管责任保险发挥了激励效应和监督效应,鼓励管理者积极进取,并约束了其逐利行为,进而抑制了企业的金融化水平,在内生性检验之后,该结论仍然成立。异质性检验发现,董事高管责任保险对企业金融化的影响存在异质性特征,在国有企业、薪酬激励不足和非高新技术企业中,董事高管责任保险对企业金融化的抑制作用更加显著。进一步研究发现,企业投保董事高管责任保险能够鼓励管理者积极进取,提升企业投资效率,优化资源配置结构,同时有利于加强外部对于企业的监管,缓解内外部信息不对称,提升公司的治理水平。研究发现,董事高管责任保险对企业金融资产配置具有抑制作用,支持了该保险积极的治理作用。研究结论对于推进董事高管责任保险在中国上市公司中的发展,健全中国资本市场的监管环境,引导经济“脱虚向实”具有启示意义。

基于毫米波传感器与激光雷达信号融合的自动驾驶障碍物感知方法

由于自动驾驶无法准确感知障碍物信息,且感知误差较高,为了提高自动驾驶避障能力,提出基于毫米波传感器与激光雷达信号融合的自动驾驶障碍物感知方法。将毫米波传感器内置于自动驾驶装置中,采集自动驾驶装置与障碍物之间的激光雷达回波信号,采用匹配滤波器进行干扰滤波处理,提取传感信号的功率谱密度特征量,采用小波多尺度分解的方法实现信号时频转换,通过Wigner-Vill分布检测和多分辨特征聚类,分析自动驾驶激光雷达毫米波传感信号回波特征,根据波束形成和信号融合结果实现对障碍物感知和自适应定位。测试结果表明,采用该方法进行自动驾驶障碍物感知的准确性较高,感知误差较低,最低为0.01,响应速度较快,最快为0.1 s,收敛迭代步数较小,定位能力较强,提高了自动驾驶的环境适应性。

A sharp recovery condition for block sparse signals by block orthogonal multi-matching pursuit

We consider the block orthogonal multi-matching pursuit(BOMMP) algorithm for the recovery of block sparse signals.A sharp condition is obtained for the exact reconstruction of block K-sparse signals via the BOMMP algorithm in the noiseless case,based on the block restricted isometry constant(block-RIC).Moreover,we show that the sharp condition combining with an extra condition on the minimum l_2 norm of nonzero blocks of block K-sparse signals is sufficient to ensure the BOMMP algorithm selects at least one true block index at each iteration until all true block indices are selected in the noisy case.The significance of the results we obtain in this paper lies in the fact that making explicit use of block sparsity of block sparse signals can achieve better recovery performance than ignoring the additional structure in the problem as being in the conventional sense.

EXECUTER2 modulates the EXECUTER1 signalosome through its singlet oxygen-dependent oxidation

Oxidative post-translational modifications of specific chloroplast proteins contribute to the initiation of retrograde signaling.The Arabidopsis thaliana EXECUTER1(EX1)protein,a chloroplast-localized singlet oxygen(^(1)O_(2))sensor,undergoes tryptophan(Trp)643 oxidation by^(1)O_(2),a chloroplast-derived and light-dependent reactive oxygen species.The indole side chain of Trp is vulnerable to^(1)O_(2),leading to the generation of oxidized Trp variants and priming EX1 for degradation by a membrane-bound FtsH protease.The perception of^(1)O_(2)via Trp643 oxidation and subsequent EX1 proteolysis facilitate chloroplast-to-nucleus retrograde signaling.In this study,we discovered that the EX1-like protein EX2 also undergoes^(1)O_(2)-dependent Trp530 oxidation and FtsH-dependent turnover,which attenuates^(1)O_(2)signaling by decelerating EX1-Trp643 oxidation and subsequent EX1 degradation.Consistent with this finding,the loss of EX2 function reinforces EX1-dependent retrograde signaling by accelerating EX1-Trp643 oxidation and subsequent EX1 proteolysis,whereas overexpression of EX2 produces molecular phenotypes opposite to those observed in the loss-of-function mutants of EX2.Intriguingly,phylogenetic analysis suggests that EX2 may have emerged evolutionarily to attenuate the sensitivity of EX1 toward^(1)O_(2).Collectively,these results suggest that EX2 functions as a negative regulator of the EX1 signalosome through its own^(1)O_(2)-dependent oxidation,providing a new mechanistic insight into the regulation of EX1-mediated^(1)O_(2)signaling.

1O2-Mediated and EXECUTER-Dependent Retrograde Plastid-to-Nucleus Signaling in Norflurazon-Treated Seedlings of Arabidopsis thaliana

Chloroplast development depends on the synthesis and import of a large number of nuclear-encoded pro- teins. The synthesis of some of these proteins is affected by the functional state of the plastid via a process known as retrograde signaling. Retrograde plastid-to-nucleus signaling has been often characterized in seedlings of Arabidopsis thaliana exposed to norflurazon （NF）, an inhibitor of carotenoid biosynthesis. Results of this work suggested that, throughout seedling development, a factor is released from the plastid to the cytoplasm that indicates a perturbation of plastid homeostasis and represses nuclear genes required for normal chloroplast development. The identity of this factor is still under debate. Reactive oxygen species （ROS） were among the candidates discussed as possible retrograde signals in NF-treated plants. In the present work, this proposed role of ROS has been analyzed. In seedlings grown from the very beginning in the presence of NF, ROS-dependent signaling was not detectable, whereas, in seedlings first exposed to NF after light-dependent chloroplast formation had been completed, enhanced ROS production occurred and, among oth- ers, 1O2-mediated and EXECUTER-dependent retrograde signaling was induced. Hence, depending on the developmental stage at which plants are exposed to NF, different retrograde signaling pathways may be activated, some of which are also active in non-treated plants under light stress.

多联锁共享室外信号设备切换控制电路设计

在信号专业实训基地建设中,需实现多套联锁切换控制同一室外站场信号设备功能,减少室外设备重复建设、场地占用和资金投入。采用继电逻辑电路的方法,设计切换控制电路实现了5套联锁共享同一室外站场信号设备、多套联锁之间物理互斥、同一时间仅有一套联锁控制室外站场信号设备的功能,切换控制电路故障时每一套联锁均能独立工作;设计按钮电路实现双按钮切换选择及控制;设计表示灯电路显示当前控制室内、外设备的联锁类型及状态。经试验表明,该电路满足多联锁共享室外信号设备切换控制需要,具有一定推广价值。

铁路线路属性对信号系统的影响及解决方案

根据《铁路技术管理规程》(高速铁路部分)(TG/01-2014)对正线的定义、信号显示的规定以及《列控系统临时限速技术规范》(Q/CR 662-2018)对临时限速设计的规定,分析工程中因线路设计与信号设计对站内正线处理不统一,导致无法下达正线限速的原因,探讨合理的解决方案。

CBTC系统点式模式下临时限速方案分析

为提升列车在基于通信的列车控制系统点式模式下通过临时限速区段的安全和效率,首先对点式模式下传统临时限速实现方式存在的问题做分析。然后以杭州至海宁城际铁路(以下简称杭海线)CBTC系统点式模式下临时限速方案为例,提出计算机联锁档位的(共三档:25 km/h、40 km/h、60 km/h)临时限速方案,并对该临时限速方案涉及的信号系统各子系统功能分配和接口协议变化进行阐述。该方案将临时限速信息的传递、确认、执行、反馈由人控转变为机控,在实际运营生产中取得良好的应用效果。

全自动限速运行模式方案研究

列车在全自动运行驾驶模式下会出现丢失定位的故障情况,需快速获取定位或者运行至就近站台区域。结合列车在正线区间、折返轨、车辆段运行等场景,对全自动限速运行模式的申请流程、移动授权距离、场景处置等进行全面分析研究,并提出解决方案。

THE EXACT RECOVERY OF SPARSE SIGNALS VIA ORTHOGONAL MATCHING PURSUIT

This paper aims to investigate sufficient conditions for the recovery of sparse signals via the orthogonal matching pursuit （OMP） algorithm. In the noiseless case, we present a novel sufficient condition for the exact recovery of all k-sparse signals by the OMP algorithm, and demonstrate that this condition is sharp. In the noisy case, a sufficient condition for recovering the support of k-sparse signal is also presented. Generally, the computation for the restricted isometry constant （RIC） in these sufficient conditions is typically difficult, therefore we provide a new condition which is not only computable but also sufficient for the exact recovery of all k-sparse signals.

IO卡件自动测试系统的设计与实现

阐述一种自动测试系统的框架,该系统框架采用分层结构和模块化,结合IO卡件的测试流程及现有生产技术条件,实现一种可用于IO卡件烧录测试的自动化测试系统。测试系统包含控制软件、信号源测试机箱及相关部件,可配套离线版测试工装或自动化产线使用,实现对待测单板开展烧录、校准和功能测试以及待测成品的完整功能测试。该测试系统的部署实施可以提高生产测试效率,完成重复性劳动的自动化处理,并可同步生成测试报告,实现生产测试数据档案的电子化,从而使企业规模化生产的管理水平和管理质量得到提升。

压缩感知中测量矩阵构造综述

压缩感知测量矩阵构造方式多样并不断发展,为梳理现有研究成果,掌握测量矩阵发展动态,对压缩感知测量矩阵构造进行系统介绍。首先,针对传统信号采集理论存在的信息冗余问题,阐述了压缩感知理论在信号采集过程中资源利用率高、存储空间小的优势;其次,以压缩感知理论框架为基础,从测量矩阵构造原则、测量矩阵产生方法、测量矩阵结构设计、测量矩阵优化方法四个方面,对压缩感知测量矩阵构造进行分析,讨论了测量矩阵构造过程中不同原则、结构、方法的优势;最后,在总结现有研究成果的基础上,对测量矩阵的发展方向进行了展望。