BACKGROUND Occult breast cancer(OBC)has traditionally been considered to be a carcinoma of unknown primary origin with a favorable prognosis and can be treated as stage II-III breast cancer.Due to the small number of ...BACKGROUND Occult breast cancer(OBC)has traditionally been considered to be a carcinoma of unknown primary origin with a favorable prognosis and can be treated as stage II-III breast cancer.Due to the small number of cases and limited clinical experience,treatments vary greatly around the world and no standardized treatment has yet been established.AIM To investigate the clinicopathological features,psychological status and prognostic features of patients with OBC.METHODS The clinicopathological data of 33 OBC patients diagnosed and treated in the Affiliated Hospital of Xuzhou Medical University and Xuzhou Central Hospital from November 2015 to November 2022 were retrospectively analyzed.The psychological status of OBC patients was evaluated by the Self-rating Anxiety Scale and Self-rating Depression Scale.Patients’emotions,stress perception and psychological resilience were evaluated by the Positive and Negative Affect Schedule,the Chinese Perceived Stress Scale,and the Connor-Davidson Resilience Scale(CD-RISC),respectively.Patient survival was calculated using the Kaplan-Meier method,and survival curves were plotted for analysis with the log-rank test.Univariate and multivariate survival analyses were performed using the Cox regression model.RESULTS The 33 OBC patients included 32 females and 1 male.Of the 33 patients,30(91%)had axillary tumors,3(9%)had a neck mass as the primary symptom;18(54.5%)had estrogen receptor-positive tumors,17(51.5%)had progesterone receptor-positive tumors,and 18(54.5%)had Her-2-positive tumors;24(72.7%)received surgical treatment,including 18 patients who underwent modified radical mastectomy,1 patient who underwent breast-conserving surgery plus axillary lymph node dissection(ALND),and 5 patients who underwent ALND alone;12 patients received preoperative neoadjuvant therapy.All 30 patients developed anxiety and depression,with low positive affect scores and high negative affect scores,accompanied by a high stress level and poor psychological resilience.There were no differences in the psychological status of patients according to age,body mass index,or menopausal status.The overall survival and disease-free survival(DFS)of all the patients were 83.3%and 55.7%,respectively.Univariate analysis demonstrated that the initial tumor site(P=0.021)and node stage(P=0.020)were factors that may affect patient prognosis.The 5-year DFS rate of OBC patients who received radiotherapy was greater(P<0.001),while the use of different surgical methods(P=0.687)had no statistically significant effect on patient outcomes.Multivariate analysis revealed that radiotherapy(P=0.031)was an independent prognostic factor.Receiving radiotherapy had a significant effect on the CD-RISC score(P=0.02).CONCLUSION OBC is a rare breast disease whose diagnosis and treatment are currently controversial.There was no significant difference in the efficacy of other less invasive surgical procedures compared to those of modified radical mastectomy.In addition,radiotherapy can significantly improve patient outcomes.We should pay attention to the psychological state of patients while they receive antitumor therapy.展开更多
BACKGROUND Reactivation of hepatitis B virus(HBV)infection is a well-known risk that can occur spontaneously or following immunosuppressive therapies,including cancer chemotherapy.HBV reactivation can cause significan...BACKGROUND Reactivation of hepatitis B virus(HBV)infection is a well-known risk that can occur spontaneously or following immunosuppressive therapies,including cancer chemotherapy.HBV reactivation can cause significant morbidity and even mortality,which are preventable if at-risk individuals are identified through screening and started on antiviral prophylaxis.AIM To determine the prevalence of chronic HBV(CHB)and occult HBV infection(OBI)among oncology and hematology-oncology patients undergoing chemo-therapy.METHODS In this observational study,the prevalence of CHB and OBI was assessed among patients receiving chemotherapy.Serological markers of HBV infection[hepatitis B surface antigen(HBsAg)/anti-hepatitis B core antigen(HBc)]were evaluated for all patients.HBV DNA levels were assessed in those who tested negative for HBsAg but positive for total anti-HBc.RESULTS The prevalence of CHB in the study cohort was determined to be 2.3%[95%confidence interval(95%CI):1.0-4.2].Additionally,the prevalence of OBI among the study participants was found to be 0.8%(95%CI:0.2-2.3).CONCLUSION The findings of this study highlight the importance of screening for hepatitis B infection in oncology and hematology-oncology patients undergoing chemotherapy.Identifying individuals with CHB and OBI is crucial for implementing appropriate antiviral prophylaxis to prevent the reactivation of HBV infection,which can lead to increased morbidity and mortality.展开更多
Using the global navigation satellite system(GNSS) and radio occultation(RO) refractivity data from the Constellation Observing System for Meteorology Ionosphere and Climate-2(COSMIC-2) mission from January 2020 to De...Using the global navigation satellite system(GNSS) and radio occultation(RO) refractivity data from the Constellation Observing System for Meteorology Ionosphere and Climate-2(COSMIC-2) mission from January 2020 to December 2021, the spatial and temporal variability of Marine Boundary Layer Heights(MBLHs) over the tropical and subtropical oceans are investigated. The MBLH detection method is based on the wavelet covariance transform(WCT)algorithm, while the distinctness(DT) parameter, which reflects the significance of the maximum WCT function values, is introduced. For the refractivity profiles with indistinct maximum WCT function values, the available surrounding ROderived MBLHs are used as auxiliary information, which helps to improve the objectiveness of the inversion process. The RO-derived MBLHs are validated with the MBLHs derived from the collocated high-vertical-resolution radiosonde observations, and the seasonal distributions of the RO-derived MBLHs are presented. Further comparisons of the magnitudes and the distributions of the RO-derived MBLHs with those derived from two model datasets, the European Centre for Medium-Range Weather Forecasts(ECMWF) analyses and the National Centers for Environmental Prediction(NCEP) Aviation(AVN) 12-hour forecast data, reveal that although high correlations exist between the RO-derived and the model-derived MBLHs, the model-derived ones are generally lower than the RO-derived ones in most parts of the tropics and sub-tropic ocean areas during different seasons, which should be partially attributed to the limited vertical resolutions of the model datasets. The correlation analyses between the MBLHs and near-surface wind speeds demonstrate that over the Pacific Ocean, near-surface wind speed is an important factor that influences the variations of the MBLHs.展开更多
A new method applying an artificial neural network （ANN） to retrieve water vapor profiles in the troposphere is presented. In this paper, a fully-connected, three-layer network based on the backpropagation algorithm...A new method applying an artificial neural network （ANN） to retrieve water vapor profiles in the troposphere is presented. In this paper, a fully-connected, three-layer network based on the backpropagation algorithm is constructed. Month, latitude, altitude and bending angle are chosen as the input vectors and water vapor pressure as the output vector. There are 130 groups of occultation measurements from June to November 2002 in the dataset. Seventy pairs of bending angles and water vapor pressure profiles are used to train the ANN, and the sixty remaining pairs of profiles are applied to the validation of the retrieval. By comparing the retrieved profiles with the corresponding ones from the Information System and Data Center of the Challenging Mini-Satellite Payload for Geoscientific Research and Application （CHAMP-ISDC）, it can be concluded that the ANN is relatively convenient and accurate. Its results can be provided as the first guess for the iterative methods or the non-linear optimal estimation inverse method.展开更多
In recent years, radio occultation （RO） technology making use of global positioning system （GPS） signals has been exploited to obtain profiles of atmospheric parameters in the neutral atmosphere. In this paper, th...In recent years, radio occultation （RO） technology making use of global positioning system （GPS） signals has been exploited to obtain profiles of atmospheric parameters in the neutral atmosphere. In this paper, the RO refractivity profiles obtained from the Constellation Observing System for Meteorology, Ionosphere and Climate （COSMIC） mission are statistically compared with the observations of 38 radiosonde stations provided by the Australian Bureau of Meteorology during the period from 15 July 2006 through 15 July 2007. Different collocation criteria are compared at first, and COSMIC RO soundings that occur within 3 hours and 300 km of radiosonde measurements are used for the final statistical comparison. The overall results show that the agreements between the COSMIC refractivity profiles and the radiosonde soundings from the 38 stations are very good at 0-30 km altitude, with mean absolute relative refractivity deviations of less than 0.5%. Latitudinal comparisons indicate that there are negative refractivity deviations in the lower troposphere over the low latitude and middle latitude regions and large standard deviations exist in the lower troposphere of low latitude regions, which can reach up to ～6%. The comparisons of COSMIC RO refractivity profiles and radiosonde observations for 3 polar stations in four different seasons indicate that the accuracy of GPS RO profiles is better in the Austral summer and autumn than in the Austral spring and winter during the year from September 2006 to August 2007.展开更多
The electromagnetic satellite Zhangheng 01(ZH-01) was successfully launched on February 2, 2018. The GNSS Radio Occultation(GRO) receiver on board the satellite is able to observe the occultation events of GPS and Bei...The electromagnetic satellite Zhangheng 01(ZH-01) was successfully launched on February 2, 2018. The GNSS Radio Occultation(GRO) receiver on board the satellite is able to observe the occultation events of GPS and BeiDou navigation satellites. We analyzed the data acquired during the in-orbit testing period. We concludes that the GRO ionosphere inversion results are reasonable,the trend is correct, the satellite can observe about 600 ionosphere occultation events each day. The global coverage of more than 30000 consecutive GRO events in more than two months were analyzed and compared with COSMIC observations: both the GRO and COSMIC occultation can realize global coverage: the Nm F2 and Hm F2 global distributions are similar and change obviously with latitude. We used three digisondes at different latitudes to analyze and compare the spatio-temporally consistent GRO data: the RMSE of GRO Nm F2 relative to digisonde is better than 9.41%, the correlation coefficient is better than 0.8682: the relative RMSE of Hm F2 is better than 7.80% and the correlation coefficient is better than 0.7066.展开更多
The Martian ionosphere is produced by a number of controlling processes, including solar extreme ultraviolet radiation (EUV) and X-ray ionization, impact ionization by precipitating electrons, and day-to-night transpo...The Martian ionosphere is produced by a number of controlling processes, including solar extreme ultraviolet radiation (EUV) and X-ray ionization, impact ionization by precipitating electrons, and day-to-night transport. This study investigates the structural variability of the Martian ionosphere with the aid of the radio occultation (RO) experiments made on board the recent Mars Atmosphere and Volatile Evolution (MAVEN) spacecraft. On the dayside, the RO electron density profiles are described by the superposition of two Chapman models, representing the contributions from both the primary layer and the low-altitude secondary layer. The inferred subsolar peak electron densities and altitudes are 1.24×10^5 cm^-3 and 127 km for the former, and 4.28×10^4 cm^-3 and 97 km for the latter, respectively, in general agreement with previous results appropriate for the low solar activity conditions. Our results strengthen the role of solar EUV and X-ray ionization as the driving source of plasma on the dayside of Mars. Beyond the terminator, a systematic decline in ionospheric total electron content is revealed by the MAVEN RO measurements made from the terminator crossing up to a solar zenith angle of 120°. Such a trend is indicative of day-to-night plasma transport as an important source for the nightside Martian ionosphere.展开更多
BACKGROUND Occult thyroid papillary carcinoma(OTPC)is typically characterized by initial presentation with cervical lymph node metastasis and can be detected through ultrasound.However,the initial and sole manifestati...BACKGROUND Occult thyroid papillary carcinoma(OTPC)is typically characterized by initial presentation with cervical lymph node metastasis and can be detected through ultrasound.However,the initial and sole manifestation was a submandibular solid-cystic mass.High-frequency ultrasound,enhanced multislice computed tomography(CT)scan,and thyroid function tests revealed no abnormalities,which is relatively uncommon.CASE SUMMARY A 24-year-old Chinese female,who studied at a university in Shandong Province,presented to the clinic in June 2019 with a right submandibular mass that she had noticed 2 mo earlier.Clinical examination revealed a 2-cm,nontender,movable solid-cystic mass in the submandibular region,with no palpable thyroid mass observed.Ultrasonography revealed a 2.0 cm×1.1 cm solid-cystic mass in the right submandibular region,and the thyroid gland showed no abnormalities.CT scan and 131I whole body follow-up scan showed that there were no abnormalities in the thyroid.However,cytology and pathology showed papillary tumor cell clusters,consistent with papillary thyroid carcinoma.Thus,we performed total thyroidectomy and right neck lymph node dissection.The pathology revealed the thyroid was detected as classical thyroid micropapillary carcinoma,and lymph nodes of levels VI central and levels II,III,IV,V on the right side showed no tumor metastasis.The patient was followed up for 2 years without significant recurrence.CONCLUSION The presentation of a submandibular solid-cystic mass as the primary and solitary indication of OTPC is relatively uncommon.Fine needle aspiration is advised for evaluating neck masses.展开更多
Atmospheric stellar occultation observation technology is an advanced space-based detection technology that can measure the vertical distribution of trace gas composition,temperature,and aerosol content in a planet’s...Atmospheric stellar occultation observation technology is an advanced space-based detection technology that can measure the vertical distribution of trace gas composition,temperature,and aerosol content in a planet’s atmosphere.In this study,an inversion algorithm of the onion-peeling method was constructed to invert the transmittance obtained from the forward mask.The method used a three-dimensional ray-tracing simulation to obtain the transmission path of the light in the Earth’s atmosphere.The relevant parameters were then combined in the high-resolution transmission molecular absorption(HITRAN)database,and line-by-line integration was performed to calculate the atmospheric transmittance.The transmittance value was then used as an input to calculate the vertical distribution of oxygen molecules when using the single-wavelength inversion of the onion-peeling method.Finally,the oxygen molecule content was compared with the value attained by the Mass Spectrometer and Incoherent Scatter Radar Extended(MSISE00)atmospheric model to determine the relative error of our model.The maximum error was found to be 0.3%,which is low enough to verify the reliability of our algorithm.Using Global-scale Observations of the Limb and Disk(GOLD)measured data to invert the oxygen number density,we calculated its relative deviation from the published result to further verify the algorithm.The inversion result was affected by factors such as prior data,the absorption spectral line type,the ellipticity of the Earth,and the accuracy of the orbit.Analysis of these error-influencing factors showed that the seasons and the Earth’s ellipticity affected the accuracy of the model only 0.001%and could therefore be ignored.However,latitude and solar activity had a greater impact on accuracy,on the order of 0.1%.The absorption line type affected the accuracy of the model by as much as 1%.All three of these factors therefore need to be considered during the inversion process.展开更多
基金Supported by Jiangsu Provincial Health Commission’s 2020 High-Level Health Talents“Six Ones Project”Top-Notch Talent Research Project,No.LGY20200062021 Youth Medical Science Innovation Project of Xuzhou Health Commission,No.XWKYHT20210580.
文摘BACKGROUND Occult breast cancer(OBC)has traditionally been considered to be a carcinoma of unknown primary origin with a favorable prognosis and can be treated as stage II-III breast cancer.Due to the small number of cases and limited clinical experience,treatments vary greatly around the world and no standardized treatment has yet been established.AIM To investigate the clinicopathological features,psychological status and prognostic features of patients with OBC.METHODS The clinicopathological data of 33 OBC patients diagnosed and treated in the Affiliated Hospital of Xuzhou Medical University and Xuzhou Central Hospital from November 2015 to November 2022 were retrospectively analyzed.The psychological status of OBC patients was evaluated by the Self-rating Anxiety Scale and Self-rating Depression Scale.Patients’emotions,stress perception and psychological resilience were evaluated by the Positive and Negative Affect Schedule,the Chinese Perceived Stress Scale,and the Connor-Davidson Resilience Scale(CD-RISC),respectively.Patient survival was calculated using the Kaplan-Meier method,and survival curves were plotted for analysis with the log-rank test.Univariate and multivariate survival analyses were performed using the Cox regression model.RESULTS The 33 OBC patients included 32 females and 1 male.Of the 33 patients,30(91%)had axillary tumors,3(9%)had a neck mass as the primary symptom;18(54.5%)had estrogen receptor-positive tumors,17(51.5%)had progesterone receptor-positive tumors,and 18(54.5%)had Her-2-positive tumors;24(72.7%)received surgical treatment,including 18 patients who underwent modified radical mastectomy,1 patient who underwent breast-conserving surgery plus axillary lymph node dissection(ALND),and 5 patients who underwent ALND alone;12 patients received preoperative neoadjuvant therapy.All 30 patients developed anxiety and depression,with low positive affect scores and high negative affect scores,accompanied by a high stress level and poor psychological resilience.There were no differences in the psychological status of patients according to age,body mass index,or menopausal status.The overall survival and disease-free survival(DFS)of all the patients were 83.3%and 55.7%,respectively.Univariate analysis demonstrated that the initial tumor site(P=0.021)and node stage(P=0.020)were factors that may affect patient prognosis.The 5-year DFS rate of OBC patients who received radiotherapy was greater(P<0.001),while the use of different surgical methods(P=0.687)had no statistically significant effect on patient outcomes.Multivariate analysis revealed that radiotherapy(P=0.031)was an independent prognostic factor.Receiving radiotherapy had a significant effect on the CD-RISC score(P=0.02).CONCLUSION OBC is a rare breast disease whose diagnosis and treatment are currently controversial.There was no significant difference in the efficacy of other less invasive surgical procedures compared to those of modified radical mastectomy.In addition,radiotherapy can significantly improve patient outcomes.We should pay attention to the psychological state of patients while they receive antitumor therapy.
文摘BACKGROUND Reactivation of hepatitis B virus(HBV)infection is a well-known risk that can occur spontaneously or following immunosuppressive therapies,including cancer chemotherapy.HBV reactivation can cause significant morbidity and even mortality,which are preventable if at-risk individuals are identified through screening and started on antiviral prophylaxis.AIM To determine the prevalence of chronic HBV(CHB)and occult HBV infection(OBI)among oncology and hematology-oncology patients undergoing chemo-therapy.METHODS In this observational study,the prevalence of CHB and OBI was assessed among patients receiving chemotherapy.Serological markers of HBV infection[hepatitis B surface antigen(HBsAg)/anti-hepatitis B core antigen(HBc)]were evaluated for all patients.HBV DNA levels were assessed in those who tested negative for HBsAg but positive for total anti-HBc.RESULTS The prevalence of CHB in the study cohort was determined to be 2.3%[95%confidence interval(95%CI):1.0-4.2].Additionally,the prevalence of OBI among the study participants was found to be 0.8%(95%CI:0.2-2.3).CONCLUSION The findings of this study highlight the importance of screening for hepatitis B infection in oncology and hematology-oncology patients undergoing chemotherapy.Identifying individuals with CHB and OBI is crucial for implementing appropriate antiviral prophylaxis to prevent the reactivation of HBV infection,which can lead to increased morbidity and mortality.
基金supported by the National Natural Science Foundation of China (Grant Nos. 42174017, 42074027, 41774033, and 41774032)。
文摘Using the global navigation satellite system(GNSS) and radio occultation(RO) refractivity data from the Constellation Observing System for Meteorology Ionosphere and Climate-2(COSMIC-2) mission from January 2020 to December 2021, the spatial and temporal variability of Marine Boundary Layer Heights(MBLHs) over the tropical and subtropical oceans are investigated. The MBLH detection method is based on the wavelet covariance transform(WCT)algorithm, while the distinctness(DT) parameter, which reflects the significance of the maximum WCT function values, is introduced. For the refractivity profiles with indistinct maximum WCT function values, the available surrounding ROderived MBLHs are used as auxiliary information, which helps to improve the objectiveness of the inversion process. The RO-derived MBLHs are validated with the MBLHs derived from the collocated high-vertical-resolution radiosonde observations, and the seasonal distributions of the RO-derived MBLHs are presented. Further comparisons of the magnitudes and the distributions of the RO-derived MBLHs with those derived from two model datasets, the European Centre for Medium-Range Weather Forecasts(ECMWF) analyses and the National Centers for Environmental Prediction(NCEP) Aviation(AVN) 12-hour forecast data, reveal that although high correlations exist between the RO-derived and the model-derived MBLHs, the model-derived ones are generally lower than the RO-derived ones in most parts of the tropics and sub-tropic ocean areas during different seasons, which should be partially attributed to the limited vertical resolutions of the model datasets. The correlation analyses between the MBLHs and near-surface wind speeds demonstrate that over the Pacific Ocean, near-surface wind speed is an important factor that influences the variations of the MBLHs.
基金The authors wish to thank the anonymous reviewers who gave us useful suggestions，and we also thank CHAMP—ISDC for providing the occultation data This work was supported by the National Science Foundation of China under No．40333034 an d the Chinese Academy of Science under No．KZCX3-S、v_217．
文摘A new method applying an artificial neural network （ANN） to retrieve water vapor profiles in the troposphere is presented. In this paper, a fully-connected, three-layer network based on the backpropagation algorithm is constructed. Month, latitude, altitude and bending angle are chosen as the input vectors and water vapor pressure as the output vector. There are 130 groups of occultation measurements from June to November 2002 in the dataset. Seventy pairs of bending angles and water vapor pressure profiles are used to train the ANN, and the sixty remaining pairs of profiles are applied to the validation of the retrieval. By comparing the retrieved profiles with the corresponding ones from the Information System and Data Center of the Challenging Mini-Satellite Payload for Geoscientific Research and Application （CHAMP-ISDC）, it can be concluded that the ANN is relatively convenient and accurate. Its results can be provided as the first guess for the iterative methods or the non-linear optimal estimation inverse method.
基金supported by the National Natural Science Foundation of China(Grant Nos.40904002 and 40804004)the China-Australia Special Fund of International Collaborative Scientific Research Project(Grant No.40911120024)+1 种基金the National Basic Research Program of China(973 Project,Grant No.2006CB701301)the National High Technology Research and Development Program of China(863 Project,Grant No.2007AA12Z339)
文摘In recent years, radio occultation （RO） technology making use of global positioning system （GPS） signals has been exploited to obtain profiles of atmospheric parameters in the neutral atmosphere. In this paper, the RO refractivity profiles obtained from the Constellation Observing System for Meteorology, Ionosphere and Climate （COSMIC） mission are statistically compared with the observations of 38 radiosonde stations provided by the Australian Bureau of Meteorology during the period from 15 July 2006 through 15 July 2007. Different collocation criteria are compared at first, and COSMIC RO soundings that occur within 3 hours and 300 km of radiosonde measurements are used for the final statistical comparison. The overall results show that the agreements between the COSMIC refractivity profiles and the radiosonde soundings from the 38 stations are very good at 0-30 km altitude, with mean absolute relative refractivity deviations of less than 0.5%. Latitudinal comparisons indicate that there are negative refractivity deviations in the lower troposphere over the low latitude and middle latitude regions and large standard deviations exist in the lower troposphere of low latitude regions, which can reach up to ～6%. The comparisons of COSMIC RO refractivity profiles and radiosonde observations for 3 polar stations in four different seasons indicate that the accuracy of GPS RO profiles is better in the Austral summer and autumn than in the Austral spring and winter during the year from September 2006 to August 2007.
文摘The electromagnetic satellite Zhangheng 01(ZH-01) was successfully launched on February 2, 2018. The GNSS Radio Occultation(GRO) receiver on board the satellite is able to observe the occultation events of GPS and BeiDou navigation satellites. We analyzed the data acquired during the in-orbit testing period. We concludes that the GRO ionosphere inversion results are reasonable,the trend is correct, the satellite can observe about 600 ionosphere occultation events each day. The global coverage of more than 30000 consecutive GRO events in more than two months were analyzed and compared with COSMIC observations: both the GRO and COSMIC occultation can realize global coverage: the Nm F2 and Hm F2 global distributions are similar and change obviously with latitude. We used three digisondes at different latitudes to analyze and compare the spatio-temporally consistent GRO data: the RMSE of GRO Nm F2 relative to digisonde is better than 9.41%, the correlation coefficient is better than 0.8682: the relative RMSE of Hm F2 is better than 7.80% and the correlation coefficient is better than 0.7066.
基金support from the National Natural Science Foundation of China (NSFC) through grant numbers 41525015 and 41774186
文摘The Martian ionosphere is produced by a number of controlling processes, including solar extreme ultraviolet radiation (EUV) and X-ray ionization, impact ionization by precipitating electrons, and day-to-night transport. This study investigates the structural variability of the Martian ionosphere with the aid of the radio occultation (RO) experiments made on board the recent Mars Atmosphere and Volatile Evolution (MAVEN) spacecraft. On the dayside, the RO electron density profiles are described by the superposition of two Chapman models, representing the contributions from both the primary layer and the low-altitude secondary layer. The inferred subsolar peak electron densities and altitudes are 1.24×10^5 cm^-3 and 127 km for the former, and 4.28×10^4 cm^-3 and 97 km for the latter, respectively, in general agreement with previous results appropriate for the low solar activity conditions. Our results strengthen the role of solar EUV and X-ray ionization as the driving source of plasma on the dayside of Mars. Beyond the terminator, a systematic decline in ionospheric total electron content is revealed by the MAVEN RO measurements made from the terminator crossing up to a solar zenith angle of 120°. Such a trend is indicative of day-to-night plasma transport as an important source for the nightside Martian ionosphere.
文摘BACKGROUND Occult thyroid papillary carcinoma(OTPC)is typically characterized by initial presentation with cervical lymph node metastasis and can be detected through ultrasound.However,the initial and sole manifestation was a submandibular solid-cystic mass.High-frequency ultrasound,enhanced multislice computed tomography(CT)scan,and thyroid function tests revealed no abnormalities,which is relatively uncommon.CASE SUMMARY A 24-year-old Chinese female,who studied at a university in Shandong Province,presented to the clinic in June 2019 with a right submandibular mass that she had noticed 2 mo earlier.Clinical examination revealed a 2-cm,nontender,movable solid-cystic mass in the submandibular region,with no palpable thyroid mass observed.Ultrasonography revealed a 2.0 cm×1.1 cm solid-cystic mass in the right submandibular region,and the thyroid gland showed no abnormalities.CT scan and 131I whole body follow-up scan showed that there were no abnormalities in the thyroid.However,cytology and pathology showed papillary tumor cell clusters,consistent with papillary thyroid carcinoma.Thus,we performed total thyroidectomy and right neck lymph node dissection.The pathology revealed the thyroid was detected as classical thyroid micropapillary carcinoma,and lymph nodes of levels VI central and levels II,III,IV,V on the right side showed no tumor metastasis.The patient was followed up for 2 years without significant recurrence.CONCLUSION The presentation of a submandibular solid-cystic mass as the primary and solitary indication of OTPC is relatively uncommon.Fine needle aspiration is advised for evaluating neck masses.
基金supported in part by the National Natural Science Foundation of China(NSFC)under Grant 61971385.
文摘Atmospheric stellar occultation observation technology is an advanced space-based detection technology that can measure the vertical distribution of trace gas composition,temperature,and aerosol content in a planet’s atmosphere.In this study,an inversion algorithm of the onion-peeling method was constructed to invert the transmittance obtained from the forward mask.The method used a three-dimensional ray-tracing simulation to obtain the transmission path of the light in the Earth’s atmosphere.The relevant parameters were then combined in the high-resolution transmission molecular absorption(HITRAN)database,and line-by-line integration was performed to calculate the atmospheric transmittance.The transmittance value was then used as an input to calculate the vertical distribution of oxygen molecules when using the single-wavelength inversion of the onion-peeling method.Finally,the oxygen molecule content was compared with the value attained by the Mass Spectrometer and Incoherent Scatter Radar Extended(MSISE00)atmospheric model to determine the relative error of our model.The maximum error was found to be 0.3%,which is low enough to verify the reliability of our algorithm.Using Global-scale Observations of the Limb and Disk(GOLD)measured data to invert the oxygen number density,we calculated its relative deviation from the published result to further verify the algorithm.The inversion result was affected by factors such as prior data,the absorption spectral line type,the ellipticity of the Earth,and the accuracy of the orbit.Analysis of these error-influencing factors showed that the seasons and the Earth’s ellipticity affected the accuracy of the model only 0.001%and could therefore be ignored.However,latitude and solar activity had a greater impact on accuracy,on the order of 0.1%.The absorption line type affected the accuracy of the model by as much as 1%.All three of these factors therefore need to be considered during the inversion process.
