The aetiology of OAL is undefined, although much attention has been recently focused on determining whether OAL is caused by an autoimmune disorder, chronic antigenic stimulation or both. It is becoming evident that i...The aetiology of OAL is undefined, although much attention has been recently focused on determining whether OAL is caused by an autoimmune disorder, chronic antigenic stimulation or both. It is becoming evident that infectious agents underlying chronic eye infection, as Chlamydia, may play a role in ocular lymphomagenesis. The high prevalence of Chlamydophila psittaci in patients with OAL has suggested a potential oncogenic role for its tendency to cause chronic and persistent infections, although it has been documented an evident geographical variability and response to antibiotic treatment. For C. pneumoniae, the findings so far obtained are very limited not only for identification in OAL but also for the specific treatment with antibiotics. The recent molecular and cultural evidence of C. trachomatis in patients with OAL, seems to suggest that also this pathogen may contribute to pathogenesis of such lymphoma. The potential application of bacteria-eradicating therapy at local and systemic level may ultimately result in safer and more efficient therapeutic option for patients affected by these malignancies. Moreover, a close collaboration between experts in ophthalmology, infectious diseases and hematology will help, in the future, to effectively manage this disease. This review attempts to weigh the currently available evidence regarding the role that Chlamydia play in development of OAL and focuses on patients with OAL observed at our Institution.展开更多
目的:探讨眼附属器包括眼睑、眼眶、泪腺等部位黏膜相关淋巴组织淋巴瘤(lymphphoma of mucosa-associated lymph-oid tissue,MALT)的临床、病理学特征与治疗方法。方法:分析24例眼附属器MALT淋巴瘤的临床、病理学及免疫组化结果,以及手...目的:探讨眼附属器包括眼睑、眼眶、泪腺等部位黏膜相关淋巴组织淋巴瘤(lymphphoma of mucosa-associated lymph-oid tissue,MALT)的临床、病理学特征与治疗方法。方法:分析24例眼附属器MALT淋巴瘤的临床、病理学及免疫组化结果,以及手术后治疗与预后情况。结果:24例眼附属器MALT淋巴瘤患者经影像学检查后均行手术治疗,其中16例行放疗,2例行化疗。20例随访3mo～7a后均存活。结论:影像学检查可辅助诊断眼附属器MALT淋巴瘤、术后病理活检及免疫组化分型检查可确诊本病,眼结膜MALT淋巴瘤预后较好,伴全身淋巴瘤转移术后辅以化疗或放疗。展开更多
目的:研究农村转诊中心到访以病人机械性眼损伤模式。方法:本研究在Dr.Rajendra Prasad Government Medical College(RPGMC),Kangra(Himachal Pradesh)眼科进行。研究从2013-01-01/2013-12-31,周期12mo,包括数据收集、整理、描述、分析...目的:研究农村转诊中心到访以病人机械性眼损伤模式。方法:本研究在Dr.Rajendra Prasad Government Medical College(RPGMC),Kangra(Himachal Pradesh)眼科进行。研究从2013-01-01/2013-12-31,周期12mo,包括数据收集、整理、描述、分析和解释,然后进行为期1mo的随访。前瞻性研究,包括200例机械性眼损伤的患者,所有患者都接受了问卷调查,并进行详细的眼部检查。根据国际眼损伤类型分为开放性眼球损伤和闭合性眼部损伤。受损的眼睑、泪腺以及颅神经麻痹视为独立存在,通过MSExcel 2007表格使用Epiinfo7软件进行数据分析。结果:在研究期间,共接收门诊患者21710例,其中200例为机械性眼损伤,占门诊总人数的0.921%。患者年龄为1~80(平均33.12±20.48)岁。151(75.5%)例男性,49(24.5%)例女性患者,男女比例为3:1。200例受试者中,眼部损伤情况分别为:家中(100眼)、运动场所(29眼)、职业损伤(29眼)、道路交通事故(38眼)、暴力冲突(10眼)、学校(3眼)、宗教场所踩踏事故(1眼)。就诊时视力达到6/12的有47%,<6/12~6/36有13.5%,<6/36~1/60有6%,<1/60~光感有22%,无光感的4%。7.5%患者视力无法通过国际标准视力表评估。大多数患者为闭合性眼部损伤(54.5%),涉及眼睑、泪腺(23%),开放性眼部损伤为19.5%,3%累及颅神经。结论:眼部机械性损伤是造成单眼失明的常见病因,具有可预防性。展开更多
文摘The aetiology of OAL is undefined, although much attention has been recently focused on determining whether OAL is caused by an autoimmune disorder, chronic antigenic stimulation or both. It is becoming evident that infectious agents underlying chronic eye infection, as Chlamydia, may play a role in ocular lymphomagenesis. The high prevalence of Chlamydophila psittaci in patients with OAL has suggested a potential oncogenic role for its tendency to cause chronic and persistent infections, although it has been documented an evident geographical variability and response to antibiotic treatment. For C. pneumoniae, the findings so far obtained are very limited not only for identification in OAL but also for the specific treatment with antibiotics. The recent molecular and cultural evidence of C. trachomatis in patients with OAL, seems to suggest that also this pathogen may contribute to pathogenesis of such lymphoma. The potential application of bacteria-eradicating therapy at local and systemic level may ultimately result in safer and more efficient therapeutic option for patients affected by these malignancies. Moreover, a close collaboration between experts in ophthalmology, infectious diseases and hematology will help, in the future, to effectively manage this disease. This review attempts to weigh the currently available evidence regarding the role that Chlamydia play in development of OAL and focuses on patients with OAL observed at our Institution.
文摘目的:探讨眼附属器包括眼睑、眼眶、泪腺等部位黏膜相关淋巴组织淋巴瘤(lymphphoma of mucosa-associated lymph-oid tissue,MALT)的临床、病理学特征与治疗方法。方法:分析24例眼附属器MALT淋巴瘤的临床、病理学及免疫组化结果,以及手术后治疗与预后情况。结果:24例眼附属器MALT淋巴瘤患者经影像学检查后均行手术治疗,其中16例行放疗,2例行化疗。20例随访3mo～7a后均存活。结论:影像学检查可辅助诊断眼附属器MALT淋巴瘤、术后病理活检及免疫组化分型检查可确诊本病,眼结膜MALT淋巴瘤预后较好,伴全身淋巴瘤转移术后辅以化疗或放疗。
文摘目的:研究农村转诊中心到访以病人机械性眼损伤模式。方法:本研究在Dr.Rajendra Prasad Government Medical College(RPGMC),Kangra(Himachal Pradesh)眼科进行。研究从2013-01-01/2013-12-31,周期12mo,包括数据收集、整理、描述、分析和解释,然后进行为期1mo的随访。前瞻性研究,包括200例机械性眼损伤的患者,所有患者都接受了问卷调查,并进行详细的眼部检查。根据国际眼损伤类型分为开放性眼球损伤和闭合性眼部损伤。受损的眼睑、泪腺以及颅神经麻痹视为独立存在,通过MSExcel 2007表格使用Epiinfo7软件进行数据分析。结果:在研究期间,共接收门诊患者21710例,其中200例为机械性眼损伤,占门诊总人数的0.921%。患者年龄为1~80(平均33.12±20.48)岁。151(75.5%)例男性,49(24.5%)例女性患者,男女比例为3:1。200例受试者中,眼部损伤情况分别为:家中(100眼)、运动场所(29眼)、职业损伤(29眼)、道路交通事故(38眼)、暴力冲突(10眼)、学校(3眼)、宗教场所踩踏事故(1眼)。就诊时视力达到6/12的有47%,<6/12~6/36有13.5%,<6/36~1/60有6%,<1/60~光感有22%,无光感的4%。7.5%患者视力无法通过国际标准视力表评估。大多数患者为闭合性眼部损伤(54.5%),涉及眼睑、泪腺(23%),开放性眼部损伤为19.5%,3%累及颅神经。结论:眼部机械性损伤是造成单眼失明的常见病因,具有可预防性。
