Composite drug membranes of gelatin/chitosan for therapy of glaucoma by trabeculectomy were prepared through solvent volatilization, using triamcinolone acetonide as a model drug. The membranes were characterized tr...Composite drug membranes of gelatin/chitosan for therapy of glaucoma by trabeculectomy were prepared through solvent volatilization, using triamcinolone acetonide as a model drug. The membranes were characterized try FT-IR, X-RD and SEM. Their degradability and swelling ability and biocompatibilhy were studied. The results showed that biocompatibilhy, flexibility, swelling ability and degradabilhy of the composhe films were better than pure film of chitosan. The composite membrane containing 25% （ w/ w ） of gelatin was best. The drug was loaded in fdm in crystallite. The rabbit eyes experiment after 8 weeks should that the form of follicle was all right, and ophthalmotonus maintain in the pesfect level.展开更多
文摘Composite drug membranes of gelatin/chitosan for therapy of glaucoma by trabeculectomy were prepared through solvent volatilization, using triamcinolone acetonide as a model drug. The membranes were characterized try FT-IR, X-RD and SEM. Their degradability and swelling ability and biocompatibilhy were studied. The results showed that biocompatibilhy, flexibility, swelling ability and degradabilhy of the composhe films were better than pure film of chitosan. The composite membrane containing 25% （ w/ w ） of gelatin was best. The drug was loaded in fdm in crystallite. The rabbit eyes experiment after 8 weeks should that the form of follicle was all right, and ophthalmotonus maintain in the pesfect level.
